المؤلفون: Kaitlin J Mayne, Jennifer S Lees, Elaine Rutherford, Peter C Thomson, Jamie P Traynor, Vishal Dey, Ninian N Lang, Patrick B Mark

المصدر: Clinical Kidney Journal. 16:512-520

مصطلحات موضوعية: Transplantation, Nephrology

الوصف: BackgroundLymphocyte ratios reflect inflammation and have been associated with adverse outcomes in a range of diseases. We sought to determine any association between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and mortality in a haemodialysis cohort, including a coronavirus disease 2019 (COVID-19) infection subpopulation.MethodsA retrospective analysis was performed of adults commencing hospital haemodialysis in the West of Scotland during 2010–21. NLR and PLR were calculated from routine samples around haemodialysis initiation. Kaplan–Meier and Cox proportional hazards analyses were used to assess mortality associations.ResultsIn 1720 haemodialysis patients over a median of 21.9 (interquartile range 9.1–42.9) months, there were 840 all-cause deaths. NLR but not PLR was associated with all-cause mortality after multivariable adjustment [adjusted hazard ratio (aHR) for in participants with baseline NLR in quartile 4 (NLR ≥8.23) versus quartile 1 (NLR ConclusionsNLR is strongly associated with mortality in haemodialysis patients while the association between PLR and adverse outcomes is weaker. NLR is an inexpensive, readily available biomarker with potential utility in risk stratification of haemodialysis patients.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b9185a825635fbbea7bb4c9446707843
https://doi.org/10.1093/ckj/sfac248

المؤلفون: Anna Kolb, Jacqueline Campbell, Bryan R. Conway, Emily P. McQuarrie, Samira Bell, Jamie P. Traynor, Michael Kelly, Wendy Metcalfe, Annette V.M. Alfonzo, Nicola Joss, James R Smith, Robert W. Hunter, Shahzad Shah, Colin C. Geddes, Vishal Dey, Martin O’Neill, Peter J. Gallacher

المصدر: Kidney International Reports
Kolb, A, Gallacher, P J, Campbell, J, O’neill, M, Smith, J R, Bell, S, Conway, B R, Metcalfe, W, Joss, N, Dey, V, Alfonzo, A, Kelly, M, Shah, S, Mcquarrie, E, Geddes, C, Traynor, J & Hunter, R W 2021, ' A National Registry Study of Patient and Renal Survival in Adult Nephrotic Syndrome ', Kidney International Reports, vol. 6, no. 2, pp. 449-459 . https://doi.org/10.1016/j.ekir.2020.10.033
Kidney International Reports, Vol 6, Iss 2, Pp 449-459 (2021)

مصطلحات موضوعية: medicine.medical_specialty, Population, 030232 urology & nephrology, glomerular disease, minimal-change nephropathy, 030204 cardiovascular system & hematology, lcsh:RC870-923, 03 medical and health sciences, 0302 clinical medicine, Clinical Research, cardiovascular disease, Internal medicine, medicine, education, Cause of death, education.field_of_study, ESKD, business.industry, nephrotic syndrome, Incidence (epidemiology), Mortality rate, Acute kidney injury, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, mortality, Nephrology, Death certificate, business, Nephrotic syndrome, Kidney disease

الوصف: Introduction We aimed to determine the mortality rate, cause of death, and rate of end-stage kidney disease (ESKD) in adults with nephrotic syndrome (NS). Methods We conducted a national registry–based study, including all 522 adults who had a kidney biopsy for NS in Scotland in 2014–2017. We linked the Scottish Renal Registry to death certificate data. We performed survival and Cox proportional hazards analyses, accounting for competing risks of death and ESKD. We compared mortality rates with those in the age- and sex-matched general population. Results A total of 372 patients had primary NS; 150 had secondary NS. Over a median follow-up of 866 days, 110 patients (21%) died. In patients with primary NS, observed versus population 3-year mortality was 2.1% (95% CI 0.0%–4.6%) versus 0.9% (0.8%–1.0%) in patients aged
Graphical abstract

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3644d82444a58a18a35150718451968e
http://europepmc.org/articles/PMC7879209

المؤلفون: Tariq E. Farrah, Jamie P. Traynor, Sue Robertson, Vishal Dey, Colin C. Geddes, Elaine Spalding

المصدر: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 32(7)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Population, 030232 urology & nephrology, urologic and male genital diseases, Peritoneal dialysis, 03 medical and health sciences, chemistry.chemical_compound, Fractures, Bone, Young Adult, 0302 clinical medicine, Renal Dialysis, Risk Factors, Internal medicine, medicine, Prevalence, Humans, 030212 general & internal medicine, Renal replacement therapy, Prospective Studies, education, Kidney transplantation, Aged, Retrospective Studies, Transplantation, education.field_of_study, Bone Density Conservation Agents, business.industry, Hydroxycholecalciferols, Alfacalcidol, Bone fracture, Middle Aged, medicine.disease, Surgery, Renal Replacement Therapy, chemistry, Scotland, Nephrology, Kidney Failure, Chronic, Female, Hemodialysis, business

الوصف: Background Bone fractures are an important cause of morbidity and mortality in patients on renal replacement therapy (RRT). The aim of this multicentre observational study was to quantify the incidence of radiologically proven bone fracture by anatomical site in prevalent RRT groups and study its relationship to potential risk factors. Methods We performed a retrospective analysis of electronic records of all 2096 adults prevalent on RRT in the West of Scotland on 7 July 2010 across all hospitals (except one where inception was 1 August 2011) to identify all subsequent radiologically proven fractures during a median 3-year follow-up. Results There were 340 fractures, with an incidence of 62.8 per 1000 patient-years. The incidences were 37.6, 99.2 and 57.6 per 1000 patient-years in the transplant, haemodialysis (HD) and peritoneal dialysis (PD) groups, respectively (P < 0.05). In the multivariable model, age and HD (relative to transplant or PD) were independently associated with increased risk of fractures, while primary glomerular disease, increasing serum albumin and taking alfacalcidol or lanthanum were associated with decreased risk. In a multivariable model of only HD patients, age was independently associated with an increased risk of fractures, while glomerular disease, high serum albumin and being on alfacalcidol and lanthanum were associated with decreased risk. In a multivariable model in transplant patients, there were no significant independent predictors of fracture. Conclusions The risk of symptomatic bone fracture is high in RRT patients and is ∼2.5 times higher in HD than in renal transplant patients, with the increased risk being independent of baseline factors. Fracture risk increases with age and lower serum albumin and is reduced if the primary renal diagnosis is glomerular disease. The possible protective role of alfacalcidol and lanthanum in HD patients deserves further exploration.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5b91f34a13d3ee2da7ba11c88f0e2e
https://pubmed.ncbi.nlm.nih.gov/27257273

المؤلفون: Mario Hair, Vishal Dey, Dianne Z. Hillyard, Audrey Jones, Elaine Spalding, Alan G. Jardine, Kate Stevens

المصدر: Nephrology Dialysis Transplantation. 32:iii627-iii627

مصطلحات موضوعية: Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine.medical_treatment, medicine, Urology, business, Peritoneal dialysis, Clearance

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7301ad8874719c14a4db63f2987da3e4
https://doi.org/10.1093/ndt/gfx176

المؤلفون: Elaine Spalding, Vishal Dey, Kate Stevens, Dianne Z. Hillyard, Alan G. Jardine

المصدر: Nephrology Dialysis Transplantation. 32:iii682-iii682

مصطلحات موضوعية: Transplantation, medicine.medical_specialty, Nephrology, business.industry, Emergency medicine, medicine, Session (computer science), Dialysis (biochemistry), business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2e935da582fa9772b0d692931801e56d
https://doi.org/10.1093/ndt/gfx179.mp684

المؤلفون: Vishal Dey, Colin C. Geddes, Tariq E. Farrah, Elaine Spalding, Jamie P. Traynor, Sue Robertson

المصدر: Nephrology Dialysis Transplantation. 30:iii207-iii208

مصطلحات موضوعية: Fracture risk, Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine.medical_treatment, medicine, Renal replacement therapy, business, Surgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b3ca427522c47fd7462d61bd00f844bd
https://doi.org/10.1093/ndt/gfv177.09

المؤلفون: Audrey Jones, Vishal Dey, Elaine Spalding

المصدر: Nephrology Dialysis Transplantation. 30:iii326-iii326

مصطلحات موضوعية: Transplantation, medicine.medical_specialty, business.industry, medicine.medical_treatment, Telehealth, Patient-centered care, medicine.disease, Peritoneal dialysis, Nephrology, Intervention (counseling), medicine, Medical emergency, Intensive care medicine, business, Patient centred

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bab371db9e09c28f13057ed8a63cca07
https://doi.org/10.1093/ndt/gfv183.65