المؤلفون: Di Bella DJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Habibi E; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Stickels RR; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Scalia G; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Brown J; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yadollahpour P; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yang SM; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Abbate C; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Biancalani T; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Macosko EZ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chen F; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com., Arlotta P; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. paola_arlotta@harvard.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. paola_arlotta@harvard.edu.

المصدر: Nature [Nature] 2021 Jul; Vol. 595 (7868), pp. 554-559. Date of Electronic Publication: 2021 Jun 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Neurogenesis*, Neocortex/*cytology, Animals ; Cell Differentiation ; DNA-Binding Proteins/genetics ; Embryo, Mammalian ; Gene Expression Regulation, Developmental ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neocortex/embryology ; Nerve Tissue Proteins/genetics ; Sequence Analysis, RNA ; Single-Cell Analysis ; Transcriptome

المؤلفون: Quadrato G; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA., Nguyen T; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA., Macosko EZ; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Sherwood JL; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA., Min Yang S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA., Berger DR; Department of Cellular and Molecular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA., Maria N; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA., Scholvin J; Departments of Biological Engineering and Brain and Cognitive Sciences, MIT Media Lab and McGovern Institute, MIT, Cambridge, Massachusetts 02139, USA., Goldman M; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Kinney JP; LeafLabs, LLC, Cambridge, Massachusetts 02139, USA., Boyden ES; Departments of Biological Engineering and Brain and Cognitive Sciences, MIT Media Lab and McGovern Institute, MIT, Cambridge, Massachusetts 02139, USA., Lichtman JW; Department of Cellular and Molecular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA., Williams ZM; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., McCarroll SA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Arlotta P; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.

المصدر: Nature [Nature] 2017 May 04; Vol. 545 (7652), pp. 48-53. Date of Electronic Publication: 2017 Apr 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Neurogenesis*, Brain/*cytology , Neural Pathways/*physiology , Organoids/*cytology , Organoids/*radiation effects, Cell Line ; Cell Separation ; Cerebral Cortex/cytology ; Cerebral Cortex/metabolism ; Dendrites ; Gene Expression Profiling ; Humans ; In Vitro Techniques ; Light ; Nerve Net/cytology ; Nerve Net/radiation effects ; Neural Pathways/cytology ; Neural Pathways/radiation effects ; Organ Specificity ; Organoids/growth & development ; Photoreceptor Cells, Vertebrate/cytology ; Pluripotent Stem Cells/cytology ; Retina/cytology ; Retina/metabolism ; Sequence Analysis, RNA ; Single-Cell Analysis ; Time Factors ; Transcriptome