المؤلفون: Jana Christina Müller, Lars Schwabe, Franziska Magdalena Kausche, Gundula Zerbes, Lea Kampermann, Christian Büchel, Klaus Wiedemann

المصدر: European Neuropsychopharmacology. 43:71-81

مصطلحات موضوعية: Hydrocortisone, Stimulation, Stimulus (physiology), Generalization, Psychological, Arousal, Norepinephrine, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, medicine, Humans, Pharmacology (medical), Fear conditioning, Biological Psychiatry, Pharmacology, Antagonist, Yohimbine, Fear, 030227 psychiatry, Psychiatry and Mental health, Neurology, Anxiety, Neurology (clinical), medicine.symptom, Psychology, Neuroscience, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326012438152d82f4bc3ce49e358e9a0
https://doi.org/10.1016/j.euroneuro.2020.11.015

المؤلفون: Barbara J. Sahakian, Herta Flor, Qi Zhao, Christian Büchel, Qiang Luo, Gunter Schumann, Juliane H. Fröhner, Tomáš Paus, Sylvane Desrivières, Penny A. Gowland, Frauke Nees, Sabina Millenet, Arun L.W. Bokde, Michael N. Smolka, Andreas Heinz, Jianfeng Feng, Tobias Banaschewski, Dimitri Papadopoulos Orfanos, Marie-Laure Paillère-Martinot, Tianye Jia, Jean-Luc Martinot, Eric Artiges, Fei Li, Robert Whelan, Erin Burke Quinlan, Chun Shen, Vincent Frouin, Hugh Garavan, Luise Poustka, Henrik Walter, Bernd Ittermann

المصدر: American journal of psychiatry
Shen, C, Luo, Q, Jia, T, Zhao, Q, Desrivières, S, Quinlan, E B, Banaschewski, T, Millenet, S, Bokde, A L W, Büchel, C, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J L, Artiges, E, Paillère-Martinot, M L, Nees, F, Orfanos, D P, Paus, T, Poustka, L, Fröhner, J H, Smolka, M N, Walter, H, Whelan, R, Li, F, Feng, J, Schumann, G & Sahakian, B J 2020, ' Neural Correlates of the Dual-Pathway Model for ADHD in Adolescents ', American Journal of Psychiatry, vol. 177, no. 9, pp. 844-854 . https://doi.org/10.1176/appi.ajp.2020.19020183

مصطلحات موضوعية: Male, Adolescent, Prefrontal Cortex, Neuroimaging, Behavioral Symptoms, Neuropsychological Tests, Risk Assessment, 03 medical and health sciences, Cognition, 0302 clinical medicine, mental disorders, medicine, Humans, Attention deficit hyperactivity disorder, Longitudinal Studies, Gray Matter, Dual pathway, Motivation, Neural correlates of consciousness, Biobehavioral Sciences, Organ Size, medicine.disease, 030227 psychiatry, Neuroanatomical Tract-Tracing Techniques, Psychiatry and Mental health, medicine.anatomical_structure, Attention Deficit Disorder with Hyperactivity, Female, Occipital Lobe, Psychology, Neuroscience, 030217 neurology & neurosurgery, Neuroanatomy

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372d29f880267b2c4b35eb7e6102311d
https://doi.org/10.1176/appi.ajp.2020.19020183

المؤلفون: Rachel Sjouwerman, Alfons O. Hamm, Christian Büchel, Tina B. Lonsdorf, Manuel Kuhn, Julia Wendt

المصدر: Biological Psychiatry. 87:548-558

مصطلحات موضوعية: 0301 basic medicine, Reflex, Startle, medicine.diagnostic_test, Electromyography, Reproducibility of Results, Fear, Affective neuroscience, Magnetic Resonance Imaging, Amygdala, Fear-potentiated startle, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Moro reflex, medicine, Pupillary response, Humans, Valence (psychology), Functional magnetic resonance imaging, Psychology, Neuroscience, Facial electromyography, 030217 neurology & neurosurgery, Biological Psychiatry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644a428960425e394180f07946632b93
https://doi.org/10.1016/j.biopsych.2019.07.028

المؤلفون: Alexandra Tinnermann, Christian Sprenger, Christian Büchel

مصطلحات موضوعية: medicine.drug_class, business.industry, Analgesic, Remifentanil, Spinal cord, Somatosensory system, Periaqueductal gray, medicine.anatomical_structure, Opioid, Opioid receptor, medicine, Prefrontal cortex, business, Neuroscience, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::82c59f96b2f0f0da6677ecca8aa2e578
https://doi.org/10.1101/2021.05.11.443635

المؤلفون: Alexandra Tinnermann, Christian Büchel, Jan Haaker

المصدر: Science Advances

مصطلحات موضوعية: Brain activation, 0303 health sciences, Multidisciplinary, business.industry, Cognitive Neuroscience, SciAdv r-articles, Social Sciences, Stimulation, Heat pain, Dorsolateral, Spinal cord, Physiological responses, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Medicine, business, Social information, Neuroscience, Research Articles, 030217 neurology & neurosurgery, Research Article, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3eb4eef2ff6d2150f8f17f124a2f6d9
https://doi.org/10.1126/sciadv.abe8444

المؤلفون: Mareike M. Menz, Stefanie Brassen, Judith Beck, Lena J. Tiedemann, Christian Büchel, Paul Francke

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Lateral hypothalamus, Dopamine, lcsh:Medicine, Overweight, Nucleus accumbens, Biology, Article, Body Mass Index, 03 medical and health sciences, Eating, Food Preferences, 0302 clinical medicine, medicine, Limbic System, Animals, Humans, lcsh:Science, Multidisciplinary, Dopaminergic, lcsh:R, Brain, White Matter, Preference, Ventral tegmental area, 030104 developmental biology, medicine.anatomical_structure, Incentive salience, lcsh:Q, medicine.symptom, Body mass index, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe948af20edf02a83bd0af96a1bdd8b
http://link.springer.com/article/10.1038/s41598-019-40935-6

المؤلفون: Ali Khatibi, Véronique Marchand-Pauvert, Shahabeddin Vahdat, Jürgen Finsterbusch, Ovidiu Lungu, Christian Büchel, Julien Doyon, Julien Cohen-Adad

المساهمون: Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), University of Florida [Gainesville] (UF), McGill University = Université McGill [Montréal, Canada], University of Birmingham [Birmingham], Université du Québec à Montréal = University of Québec in Montréal (UQAM), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), École Polytechnique de Montréal (EPM), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), This work was funded through funding from the Natural Sciences and Engineering Research Council of Canada (NSERC): Grant #RGPIN-2014-06318, https://www.nserc-crsng.gc.ca, as well as the Courtois Foundation, https://www.canadahelps.org/en/charities/fondationcourtois, to JD, the senior author., Bodescot, Myriam

المصدر: PLoS Biology
PLoS Biology, Public Library of Science, 2020, 18 (7), pp.e3000789. ⟨10.1371/journal.pbio.3000789⟩
PLoS Biology, 2020, 18 (7), pp.e3000789. ⟨10.1371/journal.pbio.3000789⟩
PLoS Biology, Vol 18, Iss 7, p e3000789 (2020)

مصطلحات موضوعية: 0301 basic medicine, Central Nervous System, Male, Cerebellum, Brain mapping, Nervous System, Diagnostic Radiology, 0302 clinical medicine, Short Reports, Thalamus, Functional Magnetic Resonance Imaging, Medicine and Health Sciences, Biology (General), Right Hemisphere, Cerebral Cortex, Brain Mapping, medicine.diagnostic_test, General Neuroscience, Radiology and Imaging, Brain, Magnetic Resonance Imaging, medicine.anatomical_structure, Spinal Cord, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Anatomy, General Agricultural and Biological Sciences, Adult, Computer and Information Sciences, Cord, Neural Networks, QH301-705.5, Imaging Techniques, Rest, Central nervous system, Sensory system, Neuroimaging, Biology, Research and Analysis Methods, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Diagnostic Medicine, medicine, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], General Immunology and Microbiology, Resting state fMRI, Biology and Life Sciences, Spinal cord, Neuroanatomy, 030104 developmental biology, Nerve Net, Functional magnetic resonance imaging, Neuroscience, Cerebral Hemispheres, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ac83ac7f699c0c63b8100f3af0bcd1
https://www.hal.inserm.fr/inserm-02908648/file/journal.pbio.3000789.pdf

المؤلفون: Dimitri Papadopoulos Orfanos, Michael N. Smolka, Juliane H. Fröhner, Robert Whelan, Chao Xie, Gareth J. Barker, Andreas Heinz, Tianye Jia, Frauke Nees, Erin Burke Quinlan, Penny A. Gowland, Tobias Banaschewski, Bernd Ittermann, Gunter Schumann, Henrik Walter, Marie-Laure Paillère Martinot, Herta Flor, Antoine Grigis, Trevor W. Robbins, Christian Büchel, Hugh Garavan, Luise Poustka, Sylvane Desrivières, Arun L.W. Bokde, Jianfeng Feng, Jean-Luc Martinot

المساهمون: Gestionnaire, Hal Sorbonne Université, Fudan University [Shanghai], King‘s College London, Heidelberg University, Trinity College Dublin, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), University of Mannheim, Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Vermont [Burlington], University of Nottingham, UK (UON), Humboldt University Of Berlin, Physikalisch-Technische Bundesanstalt [Berlin] (PTB), CB - Centre Borelli - UMR 9010 (CB), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité), Service de Psychiatrie de l'Enfant et de l'Adolescent [CHU Pitié-Salpêtrière] (SPEA), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Universität Heidelberg [Heidelberg], University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein (UKSH), Kiel University, University Medical Center Göttingen (UMG), Technische Universität Dresden = Dresden University of Technology (TU Dresden), University of Potsdam = Universität Potsdam, University of Cambridge [UK] (CAM), University of Warwick [Coventry], Zhejiang Normal University, Humboldt-Universität zu Berlin, Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université de Paris (UP), University of Potsdam, Universität Mannheim, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Universität Heidelberg [Heidelberg] = Heidelberg University

المصدر: Science Advances
Science Advances, 2021, 7 (6), pp.eabd4074. ⟨10.1126/sciadv.abd4074⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (6), pp.eabd4074. ⟨10.1126/sciadv.abd4074⟩

مصطلحات موضوعية: Adolescent, [SDV]Life Sciences [q-bio], Prefrontal Cortex, Biology, Nucleus accumbens, Impulsivity, Periaqueductal gray, 03 medical and health sciences, 0302 clinical medicine, Biological neural network, medicine, Humans, Periaqueductal Gray, Research Articles, Cerebral Cortex, Multidisciplinary, medicine.diagnostic_test, Central nucleus of the amygdala, Alcohol dependence, SciAdv r-articles, Magnetic Resonance Imaging, 030227 psychiatry, [SDV] Life Sciences [q-bio], Alcoholism, Orbitofrontal cortex, Neural Networks, Computer, medicine.symptom, Functional magnetic resonance imaging, Neuroscience, 030217 neurology & neurosurgery, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a818ad9b810734632d663c4ff58cef52
https://pubmed.ncbi.nlm.nih.gov/33536210

المؤلفون: Tomáš Paus, Nicholas G. Martin, Congying Chu, Henry Brodaty, Eric Artiges, Tomas J. Ekström, Perminder S. Sachdev, Anbupalam Thalamuthu, Greig I. de Zubicaray, Ian J. Deary, David Ames, Rick Jansen, Lachlan T. Strike, Henrik Walter, Rachel M. Brouwer, Juliane H. Fröhner, Dimitri Papadopoulos Orfanos, Jean Shin, Margaret J. Wright, Neda Jahanshad, Vince D. Calhoun, Jenny van Dongen, Jiyang Jiang, Jalmar Teeuw, Karen A. Mather, Tobias Banaschewski, Michael N. Smolka, Peter R. Schofield, Tianye Jia, Barbara Ruggeri, Paul M. Thompson, Daniil Sarkisyan, Stefan Ehrlich, Robert Whelan, Jacqueline Hoare, Joanna M. Wardlaw, Michelle Luciano, Jingyu Liu, Benedicto Crespo-Facorro, Luise Poustka, Elisabeth B. Binder, Uli Bromberg, Gunter Schumann, Wei Wen, Allan F. McRae, Anouk den Braber, Roberto Roiz Santianez, Diana Tordesillas Gutierrez, Zdenka Pausova, Katie L. McMahon, Mathew A. Harris, Christian Büchel, Kim Sungeun, Roel A. Ophoff, Penny A. Gowland, Herta Flor, Julian N. Trollor, Anil P.S. Ori, Bernd Ittermann, Vincent Frouin, Evangelos Papastergios, Wiepke Cahn, John B.J. Kwok, Dennis van 't Ent, Philipp G. Sämann, Liana G. Apostolova, Dan J. Stein, Dorret I. Boomsma, Mark E. Bastin, Andreas Heinz, Andrew J. Saykin, Erin Burke Quinlan, Hilleke E. Hulshoff Pol, Yun Liu, Jean-Luc Martinot, Sylvane Desrivières, Arun L.W. Bokde, Frauke Nees, Georgy Bakalkin, Tania Carrillo-Roa, Nicola J. Armstrong, Hugh Garavan

المساهمون: Biological Psychology, APH - Mental Health, APH - Personalized Medicine, Stochastics, APH - Methodology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Brain Imaging, Neurology, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics

المصدر: Jia, T, Chu, C, Liu, Y, van Dongen, J, Papastergios, E, Armstrong, N J, Bastin, M E, Carrillo-roa, T, den Braber, A, Harris, M, Jansen, R, Liu, J, Luciano, M, Ori, A P S, Roiz-Santianez, R, Ruggeri, B, Sarkisyan, D, Shin, J, Sungeun, K, Tordesillas-Gutierrez, D, Van't Ent, D, Ames, D, Artiges, E, Bakalkin, G, Banaschewski, T, Bokde, A L W, Brodaty, H, Bromberg, U, Brouwer, R M, Büchel, C, Quinlan, E B, Cahn, W, de Zubicaray, G I, Ehrlich, S, Ekström, T J, Flor, H, Fröhner, J H, Frouin, V, Garavan, H, Gowland, P A, Heinz, A, Hoare, J, Ittermann, B, Jahanshad, N, Jiang, J, Kwok, J B J, Martin, N G, Martinot, J-L, Mather, K A, McMahon, K L, Mcrae, A F, Nees, F, Papadopoulos Orfanos, D, Paus, T, Poustka, L, Sämann, P G, Schofield, P R, Smolka, M N, Stein, D J, Strike, L T, Teeuw, J, Thalamuthu, A, Trollor, J N, Walter, H, Wardlaw, J M, Wen, W, Whelan, R, Apostolova, L G, Binder, E B, Boomsma, D, Calhoun, V D, Crespo-Facorro, B, Deary, I J, Hulshoff Pol, H E, Ophoff, R A, Pausova, Z, Sachdev, P S, Saykin, A J, Wright, M J, Thompson, P M, Schumann, G & Desrivières, S 2019, ' Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes : findings from the ENIGMA Epigenetics Working Group ', Molecular Psychiatry, vol. N/A, pp. 1-12 . https://doi.org/10.1038/s41380-019-0605-z
Molecular psychiatry
Molecular psychiatry, vol 26, iss 8
Jia, T, Chu, C, Liu, Y, van Dongen, J, Papastergios, E, Armstrong, N J, Bastin, M E, Carrillo-Roa, T, den Braber, A, Harris, M, Jansen, R, Liu, J, Luciano, M, Ori, A P S, Roiz Santiañez, R, Ruggeri, B, Sarkisyan, D, Shin, J, Sungeun, K, Tordesillas Gutiérrez, D, van’t Ent, D, Ames, D, Artiges, E, Bakalkin, G, Banaschewski, T, Bokde, A L W, Brodaty, H, Bromberg, U, Brouwer, R, Büchel, C, Burke Quinlan, E, Cahn, W, de Zubicaray, G I, Ehrlich, S, Ekström, T J, Flor, H, Fröhner, J H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Hoare, J, Ittermann, B, Jahanshad, N, Jiang, J, Kwok, J B, Martin, N G, Martinot, J L, Schumann, G & Desrivières, S 2019, ' Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes : findings from the ENIGMA Epigenetics Working Group ', Molecular Psychiatry, vol. 26, no. 8, pp. 1-12 . https://doi.org/10.1038/s41380-019-0605-z
Jia, T, van Dongen, J, Armstrong, N J, den Braber, A, Jansen, R, Brouwer, R, Boomsma, D I, van t Ent, D, Desrivières, S & ENIGMA Epigenetics Working Group 2021, ' Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes : findings from the ENIGMA Epigenetics Working Group ', Molecular Psychiatry, vol. 26, no. 8, pp. 3884-3895 . https://doi.org/10.1038/s41380-019-0605-z
Molecular Psychiatry, 26(8), 3884-3895. Nature Publishing Group
Molecular Psychiatry
Molecular Psychiatry, 10. Nature Publishing Group
Jia, T, Chu, C, Liu, Y, van Dongen, J, Papastergios, E, Armstrong, N J, Bastin, M E, Carrillo-Roa, T, den Braber, A, Harris, M, Jansen, R, Liu, J, Luciano, M, Ori, A P S, Roiz Santiañez, R, Ruggeri, B, Sarkisyan, D, Shin, J, Sungeun, K, Tordesillas Gutiérrez, D, van’t Ent, D, Ames, D, Artiges, E, Bakalkin, G, Banaschewski, T, Bokde, A L W, Brodaty, H, Bromberg, U, Brouwer, R, Büchel, C, Burke Quinlan, E, Cahn, W, de Zubicaray, G I, Ehrlich, S, Ekström, T J, Flor, H, Fröhner, J H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Hoare, J, Ittermann, B, Jahanshad, N, Jiang, J, Kwok, J B, Martin, N G, Martinot, J-L, Mather, K A, McMahon, K L, McRae, A F, Nees, F, Papadopoulos Orfanos, D, Paus, T, Poustka, L, Sämann, P G, Schofield, P R, Smolka, M N, Stein, D J, Strike, L T, Teeuw, J, Thalamuthu, A, Trollor, J, Walter, H, Wardlaw, J M, Wen, W, Whelan, R, Apostolova, L G, Binder, E B, Boomsma, D I, Calhoun, V, Crespo-Facorro, B, Deary, I J, Hulshoff Pol, H, Ophoff, R A, Pausova, Z, Sachdev, P S, Saykin, A, Wright, M J, Thompson, P M, Schumann, G & Desrivières, S 2020, ' Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes : findings from the ENIGMA Epigenetics Working Group ', Molecular Psychiatry, vol. 10 . https://doi.org/10.1038/s41380-019-0605-z

مصطلحات موضوعية: Netherlands Twin Register (NTR), 0301 basic medicine, Biology, Neurodegenerative, Medical and Health Sciences, Article, Epigenesis, Genetic, Epigenome, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Genetics, Humans, 2.1 Biological and endogenous factors, molecular biology, genetics, Epigenetics, Biomarker discovery, Molecular Biology, Gene, Genetic association, Medicinsk genetik, Psychiatry, Human Genome, Diabetes, Psychology and Cognitive Sciences, Neurosciences, DNA Methylation, Biological Sciences, Psychiatry and Mental health, 030104 developmental biology, Differentially methylated regions, Mental Health, DNA methylation, Neurological, CpG Islands, Human genome, Medical Genetics, 030217 neurology & neurosurgery, Neuroscience, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edff2cb98a01cae71e517c3c4bb6548
https://hdl.handle.net/20.500.11820/a64712da-7e0b-4eaf-b9ed-27d45481bcb4

المؤلفون: Stephan Geuter, Alexandra Tinnermann, Christian Büchel, Christian Sprenger, Jürgen Finsterbusch

المصدر: Science. 358:105-108

مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, Nocebo, business.industry, Spinal cord, Nocebo Effect, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Functional neuroimaging, Cortex (anatomy), Hyperalgesia, medicine, Brainstem, medicine.symptom, Prefrontal cortex, business, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad067d723beac038ad0eba54d9b283a0
https://doi.org/10.1126/science.aan1221