المؤلفون: Gulei D; Research Center for Advanced Medicine - MedFUTURE, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania., Drula R; Research Center for Advanced Medicine - MedFUTURE, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania., Ghiaur G; Research Center for Advanced Medicine - MedFUTURE, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.; Department of Oncology, The Johns Hopkins Hospital, Johns Hopkins Medicine, Baltimore, Maryland., Buzoianu AD; Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania., Kravtsova-Ivantsiv Y; The Rappaport-Technion Integrated Cancer Center (R-TICC) and The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel., Tomuleasa C; Research Center for Advanced Medicine - MedFUTURE, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.; Department of Hematology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.; Department of Hematology, 'Prof. Dr. Ion Chiricuta' Clinical Cancer Center, Cluj-Napoca, Romania., Ciechanover A; Research Center for Advanced Medicine - MedFUTURE, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.; The Rappaport-Technion Integrated Cancer Center (R-TICC) and The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel.

المصدر: Cancer research [Cancer Res] 2023 Jun 02; Vol. 83 (11), pp. 1762-1767.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms* , NF-kappa B*/metabolism, Humans ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination

المؤلفون: Goldhirsh G; Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 3109601, Israel.; Rappaport Technion Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3109601, Israel., Kravtsova-Ivantsiv Y; Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 3109601, Israel.; Rappaport Technion Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3109601, Israel., Satish G; Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200008, Israel., Ziv T; Smoler Proteomics Center, Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel., Brik A; Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200008, Israel; abrik@technion.ac.il aaroncie@tx.technion.ac.il., Ciechanover A; Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 3109601, Israel; abrik@technion.ac.il aaroncie@tx.technion.ac.il.; Rappaport Technion Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3109601, Israel.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Dec 07; Vol. 118 (49).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: NF-kappa B/*metabolism , NF-kappa B p50 Subunit/*metabolism , Ubiquitin-Protein Ligases/*genetics, Binding Sites ; Cell Line, Tumor ; Cell Proliferation/physiology ; Humans ; NF-kappa B/genetics ; Neoplasms ; Peptide Hydrolases/genetics ; Peptide Hydrolases/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding/genetics ; Protein Processing, Post-Translational/physiology ; Proteolysis ; Signal Transduction/physiology ; Transcription Factor RelA/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination/genetics

المؤلفون: Iida Y; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Ciechanover A; The David and Janet Polak Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Bat-Galim, Haifa, Israel., Marzese DM; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Hata K; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Bustos M; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Ono S; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Wang J; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Salomon MP; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Tran K; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Lam S; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Hsu S; John Wayne Cancer Institute Genome Sequencing Center, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Nelson N; John Wayne Cancer Institute Genome Sequencing Center, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California., Kravtsova-Ivantsiv Y; The David and Janet Polak Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Bat-Galim, Haifa, Israel., Mills GB; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Davies MA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Hoon DSB; Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California. hoond@jwci.org.; John Wayne Cancer Institute Genome Sequencing Center, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2017 Aug 15; Vol. 23 (16), pp. 4831-4842. Date of Electronic Publication: 2017 Apr 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Epigenesis, Genetic*, Melanoma/*genetics , NF-kappa B/*genetics , Ubiquitin-Protein Ligases/*genetics, Cell Line, Tumor ; Cell Proliferation/genetics ; Cohort Studies ; DNA Methylation ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Melanoma/metabolism ; Melanoma/pathology ; MicroRNAs/genetics ; NF-kappa B/metabolism ; Promoter Regions, Genetic/genetics ; RNA Interference ; Signal Transduction/genetics ; Ubiquitin-Protein Ligases/metabolism

المؤلفون: Amir RE; Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel., Haecker H, Karin M, Ciechanover A

المصدر: Oncogene [Oncogene] 2004 Apr 01; Vol. 23 (14), pp. 2540-7.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print Cited Medium: Print ISSN: 0950-9232 (Print) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

مواضيع طبية MeSH: Protein Processing, Post-Translational*, Ligases/*metabolism , Lysine/*metabolism , NF-kappa B/*metabolism , Protein Precursors/*metabolism , Ubiquitins/*metabolism, Baculoviridae/genetics ; Cell Cycle Proteins/metabolism ; Cell Line ; HeLa Cells ; Humans ; I-kappa B Proteins/chemistry ; I-kappa B Proteins/metabolism ; Mutagenesis, Site-Directed ; NEDD8 Protein ; NF-kappa B/chemistry ; Phosphorylation ; Point Mutation ; Protein Precursors/chemistry ; Protein Structure, Tertiary ; RNA, Small Interfering/metabolism ; Recombinant Proteins/metabolism ; beta-Transducin Repeat-Containing Proteins/metabolism

المؤلفون: Amir RE; Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel., Iwai K, Ciechanover A

المصدر: The Journal of biological chemistry [J Biol Chem] 2002 Jun 28; Vol. 277 (26), pp. 23253-9. Date of Electronic Publication: 2002 Apr 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: NF-kappa B/*biosynthesis , NF-kappa B/*metabolism , Peptide Synthases/*physiology , Protein Precursors/*metabolism , Ubiquitin/*metabolism , Ubiquitins/*physiology, Animals ; COS Cells ; I-kappa B Kinase ; NF-kappa B p50 Subunit ; Protein Serine-Threonine Kinases/physiology ; SKP Cullin F-Box Protein Ligases

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المؤلفون: Haecker, Hans, Karin, Michael, Ciechanover, Aaron, Amir, Ruthie E.

المصدر: Oncogene; 4/1/2004, Vol. 23 Issue 14, p2540-2547, 8p, 7 Diagrams, 1 Chart

مصطلحات موضوعية: NF-kappa B, UBIQUITIN, IMMUNE response, LYMPHOID tissue, PHOSPHORYLATION, LYSINE

المؤلفون: Orian, Amir, Gonen, Hedva, Bercovich, Beatrice, Fajerman, Ifat, Eytan, Esther, Israël, Alain, Mercurio, Frank, Iwai, Kazuhiro, Schwartz, Alan L., Ciechanover, Aaron

المصدر: EMBO Journal; 6/1/2000, Vol. 19 Issue 11, p2580-2591, 12p

مصطلحات موضوعية: PROTEIN precursors, PROTEIN kinases, NF-kappa B, PHOSPHORYLATION, UBIQUITIN, DNA-binding proteins