عنوان ترانسليتريتد: Raschet struktury universal'nogo farmakofora, opredeliaiushchego élementy stereotipii v deĭstvii lekarstv.

المؤلفون: Poda GI, Tetko IV, Luĭk AI, Mogilevich SE, Kukhar' VP

المصدر: Doklady Akademii nauk SSSR [Dokl Akad Nauk SSSR] 1991; Vol. 317 (2), pp. 488-91.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Akademiia Nauk Sssr Country of Publication: Russia (Federation) NLM ID: 7505465 Publication Model: Print Cited Medium: Print ISSN: 0002-3264 (Print) Linking ISSN: 00023264 NLM ISO Abbreviation: Dokl Akad Nauk SSSR Subsets: MEDLINE

مواضيع طبية MeSH: Pharmacology*, 3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; Adenylyl Cyclases/metabolism ; Calcium/metabolism ; Phosphatidylinositols/metabolism ; Structure-Activity Relationship

المؤلفون: Bereza UL, Brewer GJ, Mizukami I

المصدر: Biochimica et biophysica acta [Biochim Biophys Acta] 1982 Nov 08; Vol. 692 (2), pp. 305-14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Elsevier Pub. Co Country of Publication: Netherlands NLM ID: 0217513 Publication Model: Print Cited Medium: Print ISSN: 0006-3002 (Print) Linking ISSN: 00063002 NLM ISO Abbreviation: Biochim Biophys Acta Subsets: MEDLINE

مواضيع طبية MeSH: Pharmacology*, 3',5'-Cyclic-AMP Phosphodiesterases/*blood , Calcium-Binding Proteins/*antagonists & inhibitors , Calcium-Transporting ATPases/*blood , Calmodulin/*antagonists & inhibitors , Erythrocyte Membrane/*physiology , Erythrocytes/*physiology, Antipsychotic Agents/pharmacology ; Haloperidol/pharmacology ; Hemolysis/drug effects ; Humans ; Imipramine/pharmacology ; Lysergic Acid Diethylamide/pharmacology ; Phenothiazines ; Zinc/pharmacology

المؤلفون: West, Toni M, Wang, Qingtong, Deng, Bingqing, Zhang, Yu, Barbagallo, Federica, Reddy, Gopireddy R, Chen, Dana, Phan, Kyle S, Xu, Bing, Isidori, Andres, Xiang, Yang K

المصدر: Journal of the American Heart Association. 8(15)

مصطلحات موضوعية: Medical Physiology, Biomedical and Clinical Sciences, Nutrition, Heart Disease, Diabetes, Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Animals, Cyclic Nucleotide Phosphodiesterases, Type 5, Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies, Heart, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Phosphodiesterase 5 Inhibitors, Receptors, Adrenergic, beta-2, Sildenafil Citrate, cardiac myocyte, cell signaling, diabetic cardiomyopathy, EC coupling, echocardiography, pathophysiology, pharmacology, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/06s7588k

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المصدر: Health & Medicine Week; 71/9/2024, p1567-1567, 1p

مصطلحات موضوعية: COENZYMES, PEPTIDES, GROWTH plate, SHORT stature, PHOSPHODIESTERASES

المؤلفون: Deping, Li, Yan, Li, Xiaowen, Jiang, Wenwu, Liu, Qingchun, Zhao

المصدر: Mini-Reviews in Medicinal Chemistry. 22:2680-2701

مصطلحات موضوعية: Cyclic Nucleotide Phosphodiesterases, Type 5, Pharmacology, General Medicine, Quinolones, Histone Deacetylases, Alkaloids, DNA Topoisomerases, Type II, DNA Topoisomerases, Type I, Tubulin, Butyrylcholinesterase, Drug Discovery, Quinazolines, Humans, Sirtuins, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bebc6f18442937512b229420abb79b5
https://doi.org/10.2174/1389557522666220404090835

المؤلفون: Xiaoyu, Pan, Ling, Chen, Chunyan, Shan, Lisha, Cai, Yue, Wang, Yue, Chen, Ming, Gu, Kaiping, Liu, Pihong, Li, Jianchun, Pan

المصدر: International Journal of Neuropsychopharmacology. 25:936-945

مصطلحات موضوعية: Pharmacology, Alcohol Drinking, Ethanol, Phosphoric Diester Hydrolases, Brain-Derived Neurotrophic Factor, Cyclic Nucleotide Phosphodiesterases, Type 2, Stress Disorders, Post-Traumatic, Mice, Alcoholism, Disease Models, Animal, Psychiatry and Mental health, Anti-Anxiety Agents, Animals, Pharmacology (medical), Cyclic AMP Response Element-Binding Protein, Cyclic GMP

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff58c5eeb93c7015883995c02b6bb67c
https://doi.org/10.1093/ijnp/pyac064

المؤلفون: Longming Liang, Hansi Chen, Ping Mao, Yuyu Li, Lijun Xu, Yujie He, Yunping Mu, Allan Z. Zhao, Sujin Zhou, Zhenggang Zhao, Fanghong Li

المصدر: Investigational New Drugs. 40:875-883

مصطلحات موضوعية: Pharmacology, Mice, Nude, Apoptosis, Triple Negative Breast Neoplasms, Xenograft Model Antitumor Assays, Cyclic Nucleotide Phosphodiesterases, Type 4, Mice, Oncology, Cell Line, Tumor, Animals, Humans, Pharmacology (medical), Phosphodiesterase 4 Inhibitors, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a184354683c387779578c3c8a521da
https://doi.org/10.1007/s10637-022-01258-y

المؤلفون: Jos Prickaerts, Melissa Schepers, Tim Vanmierlo, Ben Rombaut, Dean Paes, Daniel L.A. van den Hove

المصدر: Pharmacological Reviews. 73:1016-1049

مصطلحات موضوعية: Gene isoform, N-TERMINAL REGION, 4-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)-2-PYRROLIDONE ZK 62711, AREA POSTREMA NEURONS, SPLICE VARIANTS, PDE4 INHIBITORS, Computational biology, Phosphodiesterase-4, SIGNALING SCAFFOLD PROTEINS, AMP-SPECIFIC PHOSPHODIESTERASE, Humans, Protein Isoforms, Enzyme family, CAMP-SPECIFIC PHOSPHODIESTERASE, PDE4 Inhibitors, Molecular Biology, AFFINITY ROLIPRAM BINDING, Pharmacology, chemistry.chemical_classification, CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES, Cyclic Nucleotide Phosphodiesterases, Type 4, Safety profile, Enzyme, chemistry, Second messenger system, Molecular Medicine, Phosphodiesterase 4 Inhibitors, Signal transduction, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5445a4a14915242d7041cdc62d2a31
https://doi.org/10.1124/pharmrev.120.000273

المؤلفون: Zhihao, Liu, Mingjian, Liu, Zhenqing, Cao, Pengsen, Qiu, Gaopeng, Song

المصدر: Expert Opinion on Therapeutic Patents. 32:261-278

مصطلحات موضوعية: Patents as Topic, Pharmacology, Drug Discovery, Humans, Phosphodiesterase 4 Inhibitors, General Medicine, Nervous System Diseases, Cyclic Nucleotide Phosphodiesterases, Type 4

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a299fd2d947ea112c6785db833b619
https://doi.org/10.1080/13543776.2022.2026328