المؤلفون: Xu Tang, Shi Peng Dang, Fu Yi, Dai-Min Zhang, Ling Ling Qian, Hon Chi Lee, Min Pan, Man Qing Sun, Xiao Xi Zhao, Tong Lu, Yuan Ji, Ying Wu, Liu Xiaoyu, Ru Xing Wang, Qiang Chai, Wen Wang

المصدر: Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacology

مصطلحات موضوعية: 0301 basic medicine, Epoxygenase, BK channel, medicine.medical_specialty, Potassium, chemistry.chemical_element, 03 medical and health sciences, Internal medicine, medicine, Pharmacology (medical), Patch clamp, EC50, Original Research, Pharmacology, biology, Phospholipase C, Chemistry, lcsh:RM1-950, Cytochrome P450, food and beverages, coronary arterial smooth muscle cells, docosahexaenoic acid, PLC–IP3 signal pathway, cytosolic calcium, 030104 developmental biology, Endocrinology, lcsh:Therapeutics. Pharmacology, Docosahexaenoic acid, biology.protein, lipids (amino acids, peptides, and proteins)

الوصف: Aim: Docosahexaenoic acid (DHA) is known to activate the vascular large-conductance calcium-activated potassium (BK) channels and has protective effects on the cardiovascular system. However, the underlying mechanisms through which DHA activates BK channels remain unclear. In this study, we determined such mechanisms by examining the effects of different concentrations of DHA on BK channels in freshly isolated rat coronary arterial smooth muscle cells (CASMCs) using patch clamp techniques.Methods and Results: We found that BK channels are the major potassium currents activated by DHA in rat CASMCs and the effects of DHA on BK channels are concentration dependent with a bimodal distribution. At concentrations of

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7040f686c783ed62943d110746124d
http://journal.frontiersin.org/article/10.3389/fphar.2018.00223/full