المؤلفون: Camberlein E; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Cohen JM; Infectious Diseases & Microbiology Unit, UCL Institute for Child Health, London, United Kingdom., José R; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Hyams CJ; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Callard R; Immunobiology Unit, UCL Institute of Child Health, London, United Kingdom., Chimalapati S; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Yuste J; Centro Nacional de Microbiologia, Instituto de Salud Carlos III, and CIBER de Enfermedades Respiratorias, Madrid, Spain., Edwards LA; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Marshall H; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., van Rooijen N; Vrije Universiteit, VUMC, Department of Molecular Cell Biology, Faculty of Medicine, Amsterdam, The Netherlands., Noursadeghi M; Division of Infection and Immunity, University College London, London, United Kingdom., Brown JS; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom jeremy.brown@ucl.ac.uk.

المصدر: Infection and immunity [Infect Immun] 2015 Mar; Vol. 83 (3), pp. 1181-9. Date of Electronic Publication: 2015 Jan 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

مواضيع طبية MeSH: Immunity, Innate* , Models, Statistical*, Lung/*immunology , Macrophages, Alveolar/*immunology , Pneumonia, Pneumococcal/*immunology , Streptococcus pneumoniae/*immunology, 4-Aminobenzoic Acid/metabolism ; Animals ; Bacterial Capsules/immunology ; Bacterial Load/immunology ; Female ; Half-Life ; Lung/microbiology ; Lung/pathology ; Macrophages, Alveolar/microbiology ; Macrophages, Alveolar/pathology ; Male ; Mice ; Mice, Inbred Strains ; Mutation ; Phagocytosis ; Pneumonia, Pneumococcal/microbiology ; Pneumonia, Pneumococcal/pathology ; Severity of Illness Index ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/growth & development ; Time Factors

المؤلفون: Tomlinson G; Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom;, Chimalapati S; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Pollard T; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Lapp T; Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom;, Cohen J; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom; Infectious Diseases and Microbiology Unit, University College London Institute of Child Health, London WC1N 1Eh, United Kingdom;, Camberlein E; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Stafford S; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Periselneris J; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Aldridge C; Centre for Bacterial Cell Biology, Newcastle University Medical School, Newcastle upon Tyne NE2 4AX, United Kingdom;, Vollmer W; Centre for Bacterial Cell Biology, Newcastle University Medical School, Newcastle upon Tyne NE2 4AX, United Kingdom;, Picard C; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Sorbonne Paris Cité, Paris 75015, France; Study Center for Primary Immunodeficiencies, Public Assistance-Paris Hospitals, Necker Enfants Malades Hospital, Paris 75743, France; and., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Sorbonne Paris Cité, Paris 75015, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065., Noursadeghi M; Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom;, Brown J; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom; jeremy.brown@ucl.ac.uk.

المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Oct 01; Vol. 193 (7), pp. 3736-45. Date of Electronic Publication: 2014 Aug 29.

نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*immunology , Gene Expression Regulation, Bacterial/*immunology , Lipoproteins/*immunology , Pneumonia, Pneumococcal/*immunology , Streptococcus pneumoniae/*immunology , Toll-Like Receptor 2/*immunology, Animals ; Bacterial Proteins/genetics ; Disease Models, Animal ; Female ; Gene Expression Regulation, Bacterial/genetics ; HEK293 Cells ; Humans ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/pathology ; Interleukin-1 Receptor-Associated Kinases/genetics ; Interleukin-1 Receptor-Associated Kinases/immunology ; Lipoproteins/genetics ; Macrophages/immunology ; Macrophages/pathology ; Male ; Mice ; Mice, Knockout ; NF-kappa B/genetics ; NF-kappa B/immunology ; Pneumonia, Pneumococcal/genetics ; Pneumonia, Pneumococcal/pathology ; Primary Immunodeficiency Diseases ; Streptococcus pneumoniae/genetics ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology

SCR Disease Name: IRAK4 Deficiency

المؤلفون: Cohen JM; Centre for Respiratory Research, Department of Medicine, UCL, London, United Kingdom. j.cohen@ucl.ac.uk, Chimalapati S, de Vogel C, van Belkum A, Baxendale HE, Brown JS

المصدر: Vaccine [Vaccine] 2012 Jun 22; Vol. 30 (30), pp. 4453-9. Date of Electronic Publication: 2012 May 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Capsules/*immunology , Lipoproteins/*immunology , Nasopharynx/*microbiology , Pneumonia, Pneumococcal/*immunology, Animals ; Antibodies, Bacterial/blood ; Bacterial Proteins/immunology ; Immunoglobulin G/blood ; Mice ; Nasopharynx/immunology ; Pneumococcal Vaccines/immunology ; Pneumonia, Pneumococcal/prevention & control ; Vaccines, Attenuated/immunology