المؤلفون: Wagner JB; Ward Family Heart Center (J.B.W.) and Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation (J.B.W., J.S.L.), Children's Mercy, Kansas City, Missouri; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri (J.B.W., J.S.L.); and Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas (M.R., B.H.) jbwagner@cmh.edu., Ruggiero M; Ward Family Heart Center (J.B.W.) and Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation (J.B.W., J.S.L.), Children's Mercy, Kansas City, Missouri; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri (J.B.W., J.S.L.); and Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas (M.R., B.H.)., Leeder JS; Ward Family Heart Center (J.B.W.) and Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation (J.B.W., J.S.L.), Children's Mercy, Kansas City, Missouri; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri (J.B.W., J.S.L.); and Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas (M.R., B.H.)., Hagenbuch B; Ward Family Heart Center (J.B.W.) and Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation (J.B.W., J.S.L.), Children's Mercy, Kansas City, Missouri; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri (J.B.W., J.S.L.); and Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas (M.R., B.H.).

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2020 Nov; Vol. 48 (11), pp. 1192-1198. Date of Electronic Publication: 2020 Sep 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacokinetics , Liver-Specific Organic Anion Transporter 1/*metabolism , Pravastatin/*pharmacokinetics, Biological Variation, Population/genetics ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/chemistry ; Inhibitory Concentration 50 ; Liver-Specific Organic Anion Transporter 1/genetics ; Mutagenesis, Site-Directed ; Pharmacogenomic Variants ; Pravastatin/chemistry ; Stereoisomerism

المؤلفون: Wagner JB; Ward Family Heart Center, Children's Mercy, Kansas City, Missouri, USA.; Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA., Abdel-Rahman S; Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA., Gaedigk R; Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA., Gaedigk A; Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA., Raghuveer G; Ward Family Heart Center, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA., Staggs VS; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Health Services & Outcomes Research, Children's Mercy, Kansas City, Missouri, USA., Kauffman R; Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA., Van Haandel L; Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA., Leeder JS; Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2019 Jun; Vol. 105 (6), pp. 1501-1512. Date of Electronic Publication: 2019 Feb 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Variation/*genetics , Hydroxymethylglutaryl-CoA Reductase Inhibitors/*blood , Hypercholesterolemia/*blood , Hypercholesterolemia/*genetics , Liver-Specific Organic Anion Transporter 1/*genetics , Pravastatin/*blood, Adolescent ; Child ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypercholesterolemia/drug therapy ; Male ; Pravastatin/therapeutic use

المؤلفون: van Haandel L; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO, United States; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, United States. Electronic address: lvanhaandel@cmh.edu., Gibson KT; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO, United States., Leeder JS; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO, United States; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, United States., Wagner JB; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO, United States; Ward Family Heart Center, Children's Mercy Hospital, Kansas City, MO, United States; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, United States.

المصدر: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2016 Feb 15; Vol. 1012-1013, pp. 169-77. Date of Electronic Publication: 2016 Jan 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

مواضيع طبية MeSH: Chromatography, High Pressure Liquid/*methods , Lactones/*blood , Pravastatin/*blood , Tandem Mass Spectrometry/*methods, Adolescent ; Child ; Female ; Humans ; Isomerism ; Lactones/chemistry ; Lactones/pharmacokinetics ; Linear Models ; Male ; Pravastatin/chemistry ; Pravastatin/pharmacokinetics ; Reproducibility of Results ; Sensitivity and Specificity