المؤلفون: Brautigam H; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53706., Moreno CL; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Steele JW; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Cellular and Molecular Medicine,University of California San Diego, La Jolla, CA 92037.; Department of Preclinical Biology, OrPhi Therapeutics, Carlsbad, CA 92008., Bogush A; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, PA 19104., Dickstein DL; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Kwok JB; Neuroscience Research Australia, Sydney, NSW 2031, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Schofield PR; Neuroscience Research Australia, Sydney, NSW 2031, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Thinakaran G; Departments of Neurobiology, Neurology, and Pathology, The University of Chicago, IL 60637., Mathews PM; Department of Psychiatry, New York University School of Medicine, New York, NY 10016.; Nathan Kline Institute Center for Dementia Research, Orangeburg, NY 10962., Hof PR; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Gandy S; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; James J. Peters VA Medical Center, Bronx, NY 10468., Ehrlich ME; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

المصدر: Scientific reports [Sci Rep] 2015 Nov 26; Vol. 5, pp. 17042. Date of Electronic Publication: 2015 Nov 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid Precursor Protein Secretases/*metabolism , Exons/*genetics , Membrane Glycoproteins/*metabolism , Presenilin-1/*genetics, Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Amyloid beta-Peptides/genetics ; Animals ; Brain/metabolism ; Embryo, Mammalian/metabolism ; Endoplasmic Reticulum/metabolism ; Fluorescence ; HEK293 Cells ; Humans ; Immunoprecipitation ; Mice, Knockout ; Motor Activity ; Phenotype ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Presenilin-1/deficiency ; Presenilin-1/metabolism ; Protein Binding ; Sequence Deletion/genetics ; Transgenes

المؤلفون: Sproul AA; The New York Stem Cell Foundation, New York, New York, United States of America., Jacob S; The New York Stem Cell Foundation, New York, New York, United States of America., Pre D; Department of Pathology & Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America., Kim SH; Departments of Neurology and Psychiatry and the Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Nestor MW; The New York Stem Cell Foundation, New York, New York, United States of America., Navarro-Sobrino M; Department of Psychiatry, Columbia University, New York, New York, United States of America., Santa-Maria I; Department of Pathology & Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America., Zimmer M; The New York Stem Cell Foundation, New York, New York, United States of America., Aubry S; Department of Pathology & Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America., Steele JW; Departments of Neurology and Psychiatry and the Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Kahler DJ; The New York Stem Cell Foundation, New York, New York, United States of America., Dranovsky A; Department of Psychiatry, Columbia University, New York, New York, United States of America., Arancio O; Department of Pathology & Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America., Crary JF; Department of Pathology & Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America., Gandy S; Departments of Neurology and Psychiatry and the Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America ; James J Peters Veterans Administration Medical Center, Bronx, New York, United States of America., Noggle SA; The New York Stem Cell Foundation, New York, New York, United States of America.

المصدر: PloS one [PLoS One] 2014 Jan 08; Vol. 9 (1), pp. e84547. Date of Electronic Publication: 2014 Jan 08 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*pathology , Induced Pluripotent Stem Cells/*metabolism , Neural Stem Cells/*metabolism , Presenilin-1/*metabolism, Adaptor Proteins, Signal Transducing/genetics ; Amyloid beta-Peptides/biosynthesis ; Animals ; Apolipoproteins E/genetics ; Apoptosis Regulatory Proteins ; Base Sequence ; Brain/cytology ; Brain/pathology ; Cell Differentiation ; Cell Line ; Eye Proteins/genetics ; Gene Expression Profiling ; Gene Expression Regulation ; Genotype ; Humans ; Mutation ; Nerve Tissue Proteins/genetics ; Neurons/cytology ; Neurons/pathology ; Peptide Fragments/biosynthesis ; Presenilin-1/genetics ; Rats ; Suppressor of Cytokine Signaling Proteins/genetics