المؤلفون: Ricci MMC; Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Orenberg A; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Ohayon L; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Gau D; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Wills RC; Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bae Y; Department of Pathology and Anatomical Science, University at Buffalo, Buffalo, New York, USA., Das T; Tavotek Biotherapeutics, Spring House, Pennsylvania, USA., Koes D; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hammond GRV; Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: ghammond@pitt.edu., Roy P; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: par19@pitt.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105583. Date of Electronic Publication: 2023 Dec 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Phosphatidylinositols*/metabolism , Profilins*/metabolism, Epidermal Growth Factor/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/metabolism ; Humans ; HEK293 Cells

المؤلفون: Gau D; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: dmg40@pitt.edu., Daoud A; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Allen A; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Joy M; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Sagan A; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lee S; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lucas PC; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Duensing S; Department of Urology, University of Heidelberg School of Medicine, Heidelberg, Germany., Boone D; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Osmanbeyoglu HU; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Roy P; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: par19@pitt.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2023 Aug; Vol. 299 (8), pp. 105044. Date of Electronic Publication: 2023 Jul 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Renal Cell*/genetics , Kidney Neoplasms*/genetics , Profilins*/genetics , Profilins*/metabolism , Tumor Microenvironment*, Animals ; Humans ; Mice ; Endothelial Cells/metabolism ; Disease Progression

المؤلفون: Allen A; Bioengineering, University of Pittsburgh., Gau D; Bioengineering, University of Pittsburgh., Roy P; Bioengineering, University of Pittsburgh.; Pathology, University of Pittsburgh, 306 Center for Bioengineering, University of Pittsburgh, 300 Technology Drive, Pittsburgh, PA 15219, USA.

المصدر: Journal of cell science [J Cell Sci] 2021 May 01; Vol. 134 (9). Date of Electronic Publication: 2021 May 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review

بيانات الدورية: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cardiovascular Diseases*/genetics , Profilins*/genetics, Actin Cytoskeleton/genetics ; Actins/genetics ; Humans ; Microfilament Proteins

المؤلفون: Allen A; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Gau D; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Francoeur P; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Sturm J; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Wang Y; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Martin R; Department of Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Maranchie J; Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Duensing A; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kaczorowski A; Department of Urology, Heidelberg School of Medicine, Heidelberg, Germany., Duensing S; Department of Urology, Heidelberg School of Medicine, Heidelberg, Germany., Wu L; Department of Urology, University of California, Los Angeles, Los Angeles, California, USA., Lotze MT; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania USA., Koes D; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Storkus WJ; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania USA; Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania USA., Roy P; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: Partha.Roy@pitt.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2020 Nov 13; Vol. 295 (46), pp. 15636-15649. Date of Electronic Publication: 2020 Sep 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Renal Cell/*pathology , Kidney Neoplasms/*pathology , Profilins/*metabolism, Actins/antagonists & inhibitors ; Actins/metabolism ; Animals ; CapZ Actin Capping Protein/genetics ; CapZ Actin Capping Protein/metabolism ; Carcinoma, Renal Cell/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cofilin 1/genetics ; Cofilin 1/metabolism ; Databases, Genetic ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Humans ; Kidney Neoplasms/metabolism ; Mice ; Mice, Inbred BALB C ; Profilins/antagonists & inhibitors ; Profilins/genetics ; Prognosis ; RNA Interference ; RNA, Small Interfering/metabolism ; Tumor Microenvironment ; Up-Regulation

المؤلفون: Gau D; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Vignaud L; Institut de la Vision, Sorbonne Université, INSERM, Paris, France., Allen A; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Guo Z; Department of Nephrology, Southern Medical University, Guangzhou, China., Sahel J; Institut de la Vision, Sorbonne Université, INSERM, Paris, France.; Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Boone D; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Koes D; Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Guillonneau X; Institut de la Vision, Sorbonne Université, INSERM, Paris, France xavier.guillonneau@inserm.fr par19@pitt.edu Partha.Roy@pitt.edu., Roy P; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA xavier.guillonneau@inserm.fr par19@pitt.edu Partha.Roy@pitt.edu.; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

المصدر: The Journal of biological chemistry [J Biol Chem] 2020 Jul 10; Vol. 295 (28), pp. 9618-9629. Date of Electronic Publication: 2020 May 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cell Movement* , Cell Proliferation*, Endothelial Cells/*metabolism , Profilins/*metabolism , Retinal Neovascularization/*metabolism, Animals ; Cell Line ; Disease Models, Animal ; Endothelial Cells/pathology ; Humans ; Mice ; Mice, Knockout ; Oxygen/metabolism ; Profilins/genetics ; Retinal Neovascularization/genetics ; Retinal Neovascularization/pathology ; Retinal Neovascularization/therapy

المؤلفون: Gau D; From the Department of Bioengineering, University of Pittsburgh and., Veon W; From the Department of Bioengineering, University of Pittsburgh and., Shroff SG; From the Department of Bioengineering, University of Pittsburgh and., Roy P; From the Department of Bioengineering, University of Pittsburgh and par19@pitt.edu Partha.Roy@pitt.edu.; the Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.

المصدر: The Journal of biological chemistry [J Biol Chem] 2019 Apr 26; Vol. 294 (17), pp. 6972-6985. Date of Electronic Publication: 2019 Feb 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cell Adhesion* , Cell Movement*, Cell Adhesion Molecules/*metabolism , Cyclic AMP-Dependent Protein Kinases/*metabolism , Microfilament Proteins/*metabolism , Phosphoproteins/*metabolism , Profilins/*metabolism, HEK293 Cells ; Humans ; Phosphorylation ; Profilins/chemistry ; Protein Binding ; Serine/metabolism

المؤلفون: Chakraborty S; Bioengineering, University of Pittsburgh, Pittsburgh, USA., Jiang C; Bioengineering, University of Pittsburgh, Pittsburgh, USA.; Harvard Medical School, Boston, MA, USA., Gau D; Bioengineering, University of Pittsburgh, Pittsburgh, USA., Oddo M; Bioengineering, University of Pittsburgh, Pittsburgh, USA., Ding Z; Bioengineering, University of Pittsburgh, Pittsburgh, USA.; Janssen Scientific Affairs, New Jersey, Raritan, USA., Vollmer L; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, USA., Joy M; Bioengineering, University of Pittsburgh, Pittsburgh, USA.; NSABP, Pittsburgh, PA, USA., Schiemann W; Case Western Reserve University, Cleveland, USA., Stolz DB; Cell Biology, University of Pittsburgh, Pittsburgh, USA., Vogt A; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, USA., Ghosh S; Center for Computational Biology, Duke-NUS Medical School, Singapore, Singapore., Roy P; Bioengineering, University of Pittsburgh, Pittsburgh, USA. par19@pitt.edu.; Pathology, University of Pittsburgh, Pittsburgh, USA. par19@pitt.edu.

المصدر: British journal of cancer [Br J Cancer] 2018 Oct; Vol. 119 (9), pp. 1106-1117. Date of Electronic Publication: 2018 Oct 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer

مواضيع طبية MeSH: Up-Regulation*, Breast Neoplasms/*pathology , Cell Culture Techniques/*methods , Profilins/*deficiency , Smad3 Protein/*genetics, Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasm Grading ; Prognosis ; Signal Transduction ; Survival Analysis ; Tissue Array Analysis ; Tumor Microenvironment

المؤلفون: Gau D; From the Departments of Bioengineering., Lewis T; Chemistry., McDermott L; Computational and Systems Biology., Wipf P; From the Departments of Bioengineering.; Chemistry., Koes D; Computational and Systems Biology., Roy P; From the Departments of Bioengineering, Partha.Roy@pitt.edu par19@pitt.edu.; Cell Biology, and.; Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.

المصدر: The Journal of biological chemistry [J Biol Chem] 2018 Feb 16; Vol. 293 (7), pp. 2606-2616. Date of Electronic Publication: 2017 Dec 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Actins/*metabolism , Profilins/*metabolism , Small Molecule Libraries/*chemistry, Actin Cytoskeleton/genetics ; Actin Cytoskeleton/metabolism ; Actins/antagonists & inhibitors ; Actins/genetics ; Animals ; Aorta, Thoracic/metabolism ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Crystallography, X-Ray ; Drug Evaluation, Preclinical ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; Polymerization/drug effects ; Profilins/antagonists & inhibitors ; Profilins/chemistry ; Profilins/genetics ; Protein Binding/drug effects ; Small Molecule Libraries/pharmacology

المؤلفون: Joy M; Departments of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219., Gau D; Departments of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219., Castellucci N; Departments of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219., Prywes R; Department of Biological Sciences, Columbia University, New York, New York 10027., Roy P; Departments of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219. Electronic address: par19@pitt.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2017 Jul 14; Vol. 292 (28), pp. 11777-11791. Date of Electronic Publication: 2017 May 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation*, Profilins/*metabolism , STAT1 Transcription Factor/*metabolism , Trans-Activators/*metabolism, Cell Line, Tumor ; Cell Movement ; HEK293 Cells ; Humans ; Oligopeptides/genetics ; Oligopeptides/metabolism ; Profilins/genetics ; Protein Interaction Domains and Motifs ; Protein Transport ; RNA Interference ; RNA, Messenger/metabolism ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; STAT1 Transcription Factor/antagonists & inhibitors ; STAT1 Transcription Factor/genetics ; Serum Response Factor/antagonists & inhibitors ; Serum Response Factor/genetics ; Serum Response Factor/metabolism ; Trans-Activators/antagonists & inhibitors ; Trans-Activators/genetics

المؤلفون: Jiang C; a Bioengineering , University of Pittsburgh , PA , USA., Ding Z; a Bioengineering , University of Pittsburgh , PA , USA., Joy M; a Bioengineering , University of Pittsburgh , PA , USA., Chakraborty S; a Bioengineering , University of Pittsburgh , PA , USA., Kim SH; b University of Pittsburgh Cancer Institute , PA , USA., Bottcher R; c Department of Molecular Medicine , Max-Planck Institute of Biochemistry , Martinsried , Germany., Condeelis J; d Anatomy and Structural Biology , Albert Einstein College of Medicine , Bronx , NY , USA., Singh S; b University of Pittsburgh Cancer Institute , PA , USA., Roy P; a Bioengineering , University of Pittsburgh , PA , USA.; e Cell Biology , University of Pittsburgh , PA , USA.; f Pathology , University of Pittsburgh , PA , USA.

المصدر: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2017; Vol. 16 (24), pp. 2366-2373.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137841 Publication Model: Print Cited Medium: Internet ISSN: 1551-4005 (Electronic) Linking ISSN: 15514005 NLM ISO Abbreviation: Cell Cycle Subsets: MEDLINE

مواضيع طبية MeSH: Profilins/*metabolism, Animals ; Carcinogens ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mucin-1/metabolism ; Neoplastic Stem Cells/metabolism ; Profilins/antagonists & inhibitors ; Profilins/genetics ; RNA Interference ; RNA, Small Interfering/metabolism ; STAT3 Transcription Factor/metabolism ; Transplantation, Heterologous ; Triple Negative Breast Neoplasms/mortality ; Triple Negative Breast Neoplasms/pathology