المؤلفون: Hutter MC; Center for Bioinformatics, Saarland University, Campus Building E2.1, 66123, Saarbrücken, Germany, michael.hutter@bioinformatik.uni-saarland.de., Brengel C, Negri M, Henn C, Zimmer C, Hartmann RW, Empting M, Steinbach A

المصدر: Journal of molecular modeling [J Mol Model] 2014 Jun; Vol. 20 (6), pp. 2255. Date of Electronic Publication: 2014 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9806569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0948-5023 (Electronic) Linking ISSN: 09485023 NLM ISO Abbreviation: J Mol Model Subsets: MEDLINE

مواضيع طبية MeSH: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/*metabolism , Bacterial Proteins/*metabolism , Coenzyme A/*metabolism , Hydroxyquinolines/*metabolism , Pseudomonas aeruginosa/*enzymology , ortho-Aminobenzoates/*metabolism, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/antagonists & inhibitors ; 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/chemistry ; 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/genetics ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Binding Sites ; Catalysis ; Coenzyme A/chemistry ; Computer-Aided Design ; Drug Design ; Enzyme Inhibitors/pharmacology ; Hydroxyquinolines/chemistry ; Molecular Dynamics Simulation ; Molecular Structure ; Molecular Targeted Therapy ; Mutation ; Protein Binding ; Protein Conformation ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/genetics ; Quorum Sensing ; Spectrometry, Mass, Electrospray Ionization ; Structure-Activity Relationship ; Substrate Specificity ; ortho-Aminobenzoates/chemistry

المؤلفون: Zender M; Department of Drug Design and Optimization, Helmholtz-Institute for Pharmaceutical Research Saarland , Campus C2.3, 66123 Saarbrücken, Germany., Klein T, Henn C, Kirsch B, Maurer CK, Kail D, Ritter C, Dolezal O, Steinbach A, Hartmann RW

المصدر: Journal of medicinal chemistry [J Med Chem] 2013 Sep 12; Vol. 56 (17), pp. 6761-74. Date of Electronic Publication: 2013 Aug 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Bacterial Proteins/*antagonists & inhibitors , Oxadiazoles/*pharmacology , Pseudomonas aeruginosa/*pathogenicity, Biophysics ; Surface Plasmon Resonance ; Virulence

المؤلفون: Klein T; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Campus C2.3, 66123 Saarbrücken, Germany., Henn C, de Jong JC, Zimmer C, Kirsch B, Maurer CK, Pistorius D, Müller R, Steinbach A, Hartmann RW

المصدر: ACS chemical biology [ACS Chem Biol] 2012 Sep 21; Vol. 7 (9), pp. 1496-501. Date of Electronic Publication: 2012 Jul 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*chemistry , Anti-Bacterial Agents/*pharmacology , Bacterial Proteins/*genetics , Gene Expression Regulation, Bacterial/*drug effects , Pseudomonas aeruginosa/*genetics , Small Molecule Libraries/*chemistry , Small Molecule Libraries/*pharmacology, Bacterial Proteins/antagonists & inhibitors ; Humans ; Mutagenesis, Site-Directed ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/metabolism ; Quinolones/metabolism ; Thermodynamics

المؤلفون: Henn C; Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research (HZI), D-66123 Saarbrücken, Germany., Boettcher S, Steinbach A, Hartmann RW

المصدر: Analytical biochemistry [Anal Biochem] 2012 Sep 01; Vol. 428 (1), pp. 28-30. Date of Electronic Publication: 2012 Jun 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Biocatalysis*, Bacterial Proteins/*metabolism , Biosensing Techniques/*instrumentation , Mass Spectrometry/*methods , Pseudomonas aeruginosa/*enzymology , Surface Plasmon Resonance/*methods, Chromatography, High Pressure Liquid ; Enzymes, Immobilized/metabolism

المؤلفون: Lu C; Helmholtz Institute for Pharmaceutical Research Saarland, Campus C2.3, 66123 Saarbrücken, Germany., Kirsch B, Zimmer C, de Jong JC, Henn C, Maurer CK, Müsken M, Häussler S, Steinbach A, Hartmann RW

المصدر: Chemistry & biology [Chem Biol] 2012 Mar 23; Vol. 19 (3), pp. 381-90.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9500160 Publication Model: Print Cited Medium: Internet ISSN: 1879-1301 (Electronic) Linking ISSN: 10745521 NLM ISO Abbreviation: Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: 4-Quinolones/*pharmacology , Bacterial Proteins/*antagonists & inhibitors , Pseudomonas aeruginosa/*drug effects , Pseudomonas aeruginosa/*metabolism , Quorum Sensing/*drug effects, 4-Quinolones/chemical synthesis ; 4-Quinolones/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Drug Design ; Genes, Reporter ; Kinetics ; Pyocyanine/biosynthesis