المؤلفون: V.S. Kiran Kumar S.T., Vishnu Lal Sharma, Pratibha Tiwari, Divya Singh, Jagdamba Prasad Maikhuri, Gopal Gupta, Man Mohan Singh

المصدر: Bioorganicmedicinal chemistry letters. 16(9)

مصطلحات موضوعية: Male, Serotonin reuptake inhibitor, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Fluvoxamine, Antitrichomonal Agents, Citalopram, Pharmacology, In Vitro Techniques, Spermatocidal Agents, Biochemistry, Structure-Activity Relationship, Fluoxetine, Sertraline, Drug Discovery, medicine, Trichomonas vaginalis, Animals, Humans, Molecular Biology, Molecular Structure, Chemistry, Spermicide, Organic Chemistry, Paroxetine, Spermatozoa, Antidepressive Agents, Molecular Medicine, Antidepressant, Selective Serotonin Reuptake Inhibitors, medicine.drug

الوصف: The study investigated spermicidal and antitrichomonas activities of selective serotonin reuptake inhibitor (SSRI) antidepressants with a view to generate new lead for development of dual-function spermicidal microbicides, which is an urgent global need. Fluoxetine, Sertraline, and Fluvoxamine exhibited both spermicidal and anti-STI (antitrichomonas) activities in vitro, whereas Paroxetine and Citalopram showed only the spermicidal activity. Fluoxetine exhibited better activity profile than the other antidepressant drugs with its spermicidal and antitrichomonas activities being comparable to that of the OTC contraceptive Nonoxynol-9. The non-detergent nature of Fluoxetine and a much lower spermicidal ED50 value (than N-9) may add considerably to its merit as a candidate for microbicidal contraceptive. Thus, the antidepressants exhibiting both spermicidal and antitrichomonas activities might provide useful lead for the development of novel, dual-function spermicidal contraceptives.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ed5877f462b8402b425e1c2f12fecb
https://pubmed.ncbi.nlm.nih.gov/16464584