المؤلفون: Durmort C; Institut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, Grenoble, France claire.durmort@ibs.fr., Ercoli G; Centre for Inflammation and Tissue Repair, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom., Ramos-Sevillano E; Centre for Inflammation and Tissue Repair, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom., Chimalapati S; Centre for Inflammation and Tissue Repair, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom., Haigh RD; Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., De Ste Croix M; Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Gould K; Institute for Infection and Immunity, St. George's University of London, London, United Kingdom., Hinds J; Institute for Infection and Immunity, St. George's University of London, London, United Kingdom., Guerardel Y; Univ. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France., Vernet T; Institut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, Grenoble, France., Oggioni M; Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom., Brown JS; Centre for Inflammation and Tissue Repair, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom.

المصدر: MBio [mBio] 2020 Mar 31; Vol. 11 (2). Date of Electronic Publication: 2020 Mar 31.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

مواضيع طبية MeSH: Alleles* , Gene Deletion*, Bacterial Proteins/*genetics , Carrier Proteins/*genetics , DNA Restriction-Modification Enzymes/*genetics , Lipoproteins/*genetics , Streptococcus pneumoniae/*physiology, Bacterial Capsules/genetics ; Bacterial Capsules/metabolism ; Bacterial Proteins/metabolism ; Carrier Proteins/metabolism ; Complement System Proteins/immunology ; DNA Restriction-Modification Enzymes/metabolism ; Gene Expression Regulation, Bacterial ; Genome, Bacterial ; Genomics/methods ; Lipoproteins/metabolism ; Mutation ; Phagocytosis ; Transcriptome ; Virulence

المؤلفون: Periselneris J; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Ercoli G; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Pollard T; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Chimalapati S; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Camberlein E; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Szylar G; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Hyams C; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Tomlinson G; Division of Infection and Immunity, University College London, London, United Kingdom., Petersen FC; Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway., Floto RA; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom., Noursadeghi M; Division of Infection and Immunity, University College London, London, United Kingdom., Brown JS; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom jeremy.brown@ucl.ac.uk.

المصدر: MBio [mBio] 2019 Sep 24; Vol. 10 (5). Date of Electronic Publication: 2019 Sep 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*physiology , Host Microbial Interactions/*physiology , Inflammation/*physiopathology , Macrophages/*physiology , Signal Transduction/*physiology , Streptococcus pneumoniae/*genetics , Streptococcus pneumoniae/*pathogenicity, Humans

المؤلفون: Camberlein E; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Cohen JM; Infectious Diseases & Microbiology Unit, UCL Institute for Child Health, London, United Kingdom., José R; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Hyams CJ; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Callard R; Immunobiology Unit, UCL Institute of Child Health, London, United Kingdom., Chimalapati S; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Yuste J; Centro Nacional de Microbiologia, Instituto de Salud Carlos III, and CIBER de Enfermedades Respiratorias, Madrid, Spain., Edwards LA; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Marshall H; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., van Rooijen N; Vrije Universiteit, VUMC, Department of Molecular Cell Biology, Faculty of Medicine, Amsterdam, The Netherlands., Noursadeghi M; Division of Infection and Immunity, University College London, London, United Kingdom., Brown JS; Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom jeremy.brown@ucl.ac.uk.

المصدر: Infection and immunity [Infect Immun] 2015 Mar; Vol. 83 (3), pp. 1181-9. Date of Electronic Publication: 2015 Jan 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

مواضيع طبية MeSH: Immunity, Innate* , Models, Statistical*, Lung/*immunology , Macrophages, Alveolar/*immunology , Pneumonia, Pneumococcal/*immunology , Streptococcus pneumoniae/*immunology, 4-Aminobenzoic Acid/metabolism ; Animals ; Bacterial Capsules/immunology ; Bacterial Load/immunology ; Female ; Half-Life ; Lung/microbiology ; Lung/pathology ; Macrophages, Alveolar/microbiology ; Macrophages, Alveolar/pathology ; Male ; Mice ; Mice, Inbred Strains ; Mutation ; Phagocytosis ; Pneumonia, Pneumococcal/microbiology ; Pneumonia, Pneumococcal/pathology ; Severity of Illness Index ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/growth & development ; Time Factors

المؤلفون: Tomlinson G; Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom;, Chimalapati S; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Pollard T; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Lapp T; Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom;, Cohen J; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom; Infectious Diseases and Microbiology Unit, University College London Institute of Child Health, London WC1N 1Eh, United Kingdom;, Camberlein E; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Stafford S; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Periselneris J; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;, Aldridge C; Centre for Bacterial Cell Biology, Newcastle University Medical School, Newcastle upon Tyne NE2 4AX, United Kingdom;, Vollmer W; Centre for Bacterial Cell Biology, Newcastle University Medical School, Newcastle upon Tyne NE2 4AX, United Kingdom;, Picard C; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Sorbonne Paris Cité, Paris 75015, France; Study Center for Primary Immunodeficiencies, Public Assistance-Paris Hospitals, Necker Enfants Malades Hospital, Paris 75743, France; and., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Sorbonne Paris Cité, Paris 75015, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065., Noursadeghi M; Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom;, Brown J; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom; jeremy.brown@ucl.ac.uk.

المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Oct 01; Vol. 193 (7), pp. 3736-45. Date of Electronic Publication: 2014 Aug 29.

نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*immunology , Gene Expression Regulation, Bacterial/*immunology , Lipoproteins/*immunology , Pneumonia, Pneumococcal/*immunology , Streptococcus pneumoniae/*immunology , Toll-Like Receptor 2/*immunology, Animals ; Bacterial Proteins/genetics ; Disease Models, Animal ; Female ; Gene Expression Regulation, Bacterial/genetics ; HEK293 Cells ; Humans ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/pathology ; Interleukin-1 Receptor-Associated Kinases/genetics ; Interleukin-1 Receptor-Associated Kinases/immunology ; Lipoproteins/genetics ; Macrophages/immunology ; Macrophages/pathology ; Male ; Mice ; Mice, Knockout ; NF-kappa B/genetics ; NF-kappa B/immunology ; Pneumonia, Pneumococcal/genetics ; Pneumonia, Pneumococcal/pathology ; Primary Immunodeficiency Diseases ; Streptococcus pneumoniae/genetics ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology

SCR Disease Name: IRAK4 Deficiency

المؤلفون: Basavanna S; Department of Microbiology and Molecular Genetics, University of Texas-Houston Medical School, Houston, Texas, United States of America., Chimalapati S, Maqbool A, Rubbo B, Yuste J, Wilson RJ, Hosie A, Ogunniyi AD, Paton JC, Thomas G, Brown JS

المصدر: PloS one [PLoS One] 2013; Vol. 8 (1), pp. e49638. Date of Electronic Publication: 2013 Jan 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Methionine/*biosynthesis , Methionine/*metabolism , Streptococcus pneumoniae/*growth & development , Streptococcus pneumoniae/*pathogenicity, ATP-Binding Cassette Transporters/deficiency ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/immunology ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/immunology ; Bacterial Proteins/metabolism ; Bacterial Vaccines/genetics ; Bacterial Vaccines/immunology ; Bacterial Vaccines/metabolism ; Biological Transport ; Genetic Loci/genetics ; Lipoproteins/deficiency ; Lipoproteins/genetics ; Lipoproteins/immunology ; Lipoproteins/metabolism ; Mice ; Phenotype ; Sequence Alignment ; Sequence Deletion ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/metabolism ; Virulence

المؤلفون: Hyams C; Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom., Trzcinski K, Camberlein E, Weinberger DM, Chimalapati S, Noursadeghi M, Lipsitch M, Brown JS

المصدر: Infection and immunity [Infect Immun] 2013 Jan; Vol. 81 (1), pp. 354-63. Date of Electronic Publication: 2012 Nov 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Capsules/*immunology , Complement C3/*immunology , Complement C3b/*immunology , Complement Factor H/*immunology , Pneumococcal Infections/*immunology , Pneumococcal Infections/*microbiology , Streptococcus pneumoniae/*immunology, Adult ; Antibodies, Bacterial/immunology ; Antibodies, Bacterial/metabolism ; Bacterial Capsules/metabolism ; Bacterial Proteins/immunology ; Bacterial Proteins/metabolism ; Child ; Complement C3/metabolism ; Complement C3b/metabolism ; Complement Factor H/metabolism ; Humans ; Mutation/immunology ; Neutrophils/immunology ; Neutrophils/metabolism ; Pneumococcal Infections/metabolism ; Protein Binding/immunology ; Serotyping/methods ; Streptococcus pneumoniae/isolation & purification ; Streptococcus pneumoniae/metabolism ; Streptococcus pneumoniae/pathogenicity

المؤلفون: Chimalapati S; Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom., Cohen JM, Camberlein E, MacDonald N, Durmort C, Vernet T, Hermans PW, Mitchell T, Brown JS

المصدر: PloS one [PLoS One] 2012; Vol. 7 (7), pp. e41393. Date of Electronic Publication: 2012 Jul 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Gene Deletion*, ATP-Binding Cassette Transporters/*metabolism , Genes, Bacterial/*genetics , Streptococcus pneumoniae/*enzymology , Streptococcus pneumoniae/*growth & development , Transferases/*genetics, Animals ; Bronchoalveolar Lavage Fluid/microbiology ; Carbohydrates/pharmacology ; Cations/metabolism ; Deoxycholic Acid/pharmacology ; Female ; Humans ; Intracellular Space/microbiology ; Mice ; Neutrophils/drug effects ; Neutrophils/microbiology ; Operon/genetics ; Phenotype ; Protein Transport/drug effects ; Sequence Alignment ; Spectrophotometry, Atomic ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/genetics ; Virulence/drug effects

المؤلفون: Chimalapati S; Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London WC1E 6JF, United Kingdom., Cohen J, Camberlein E, Durmort C, Baxendale H, de Vogel C, van Belkum A, Brown JS

المصدر: Infection and immunity [Infect Immun] 2011 Dec; Vol. 79 (12), pp. 4965-76. Date of Electronic Publication: 2011 Sep 26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Bacterial/*biosynthesis , Bacterial Proteins/*metabolism , Pneumococcal Infections/*immunology , Pneumococcal Infections/*microbiology , Streptococcus pneumoniae/*genetics , Streptococcus pneumoniae/*pathogenicity, Animals ; Antigens, Bacterial/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/immunology ; Bacterial Vaccines/immunology ; Female ; Mice ; Pneumococcal Infections/prevention & control ; Streptococcus pneumoniae/immunology ; Time Factors ; Vaccination ; Virulence

المؤلفون: Bayle L; CEA, Institut de Biologie Structurale Jean-Pierre Ebel, Grenoble, 41 Rue Jules Horowitz, 38027 Grenoble cedex 1, France., Chimalapati S, Schoehn G, Brown J, Vernet T, Durmort C

المصدر: Molecular microbiology [Mol Microbiol] 2011 Nov; Vol. 82 (4), pp. 904-16. Date of Electronic Publication: 2011 Oct 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8712028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2958 (Electronic) Linking ISSN: 0950382X NLM ISO Abbreviation: Mol Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: ATP-Binding Cassette Transporters/*metabolism , Bacterial Proteins/*metabolism , Membrane Transport Proteins/*metabolism , Streptococcus pneumoniae/*cytology , Streptococcus pneumoniae/*pathogenicity , Virulence Factors/*metabolism , Zinc/*metabolism, ATP-Binding Cassette Transporters/genetics ; Animals ; Bacterial Proteins/genetics ; Bronchoalveolar Lavage Fluid/microbiology ; Cell Division ; Culture Media/chemistry ; Disease Models, Animal ; Humans ; Membrane Transport Proteins/genetics ; Mice ; Microbial Viability ; Nasopharynx/microbiology ; Pneumococcal Infections/microbiology ; Sepsis/microbiology ; Serum/microbiology ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/metabolism ; Virulence ; Virulence Factors/genetics

المؤلفون: Loisel E; CEA, Institut de Biologie Structurale Jean-Pierre Ebel, Grenoble, France., Chimalapati S, Bougault C, Imberty A, Gallet B, Di Guilmi AM, Brown J, Vernet T, Durmort C

المصدر: Biochemistry [Biochemistry] 2011 May 03; Vol. 50 (17), pp. 3551-8. Date of Electronic Publication: 2011 Apr 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*metabolism , Carrier Proteins/*metabolism , Cation Transport Proteins/*metabolism , Hydrolases/*metabolism , Streptococcus pneumoniae/*metabolism , Zinc/*metabolism, Amino Acid Motifs ; Bacterial Proteins/chemistry ; Carrier Proteins/chemistry ; Cation Transport Proteins/chemistry ; Hydrolases/chemistry ; Lipoproteins/chemistry ; Lipoproteins/metabolism ; Recombinant Proteins/chemistry