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المؤلفون: Ruili Huang, Andrew J. Li, Carleen Klumpp-Thomas, Srilatha Sakamuru, Tuan Xu, Shuaizhang Li, Jameson Travers, Menghang Xia
المصدر: Slas Discovery
مصطلحات موضوعية: 01 natural sciences, Biochemistry, Analytical Chemistry, colorimetric BChE assay, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Alzheimer Disease, Catalytic Domain, Terbutaline, Choline, Humans, Butyrylcholinesterase, 030304 developmental biology, Cholinesterase, Original Research, chemistry.chemical_classification, 0303 health sciences, biology, 010405 organic chemistry, BChE inhibitors, molecular docking, 0104 chemical sciences, Molecular Docking Simulation, Enzyme, chemistry, biology.protein, Acetylcholinesterase, Molecular Medicine, Cholinergic, qHTS, Cholinesterase Inhibitors, Function (biology), Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fdc5f754e89c651b64769b60f3bedd
http://europepmc.org/articles/PMC8637366 -
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المؤلفون: Obinna N. Obianom, Hong Yang, Menghang Xia, Srilatha Sakamuru, Yingjun Li, Yong Ai, Dong Guo, Yan Shu, Wei Yang, Fengtian Xue
المصدر: Journal of Medicinal Chemistry. 62:727-741
مصطلحات موضوعية: Mice, Obese, Pharmacology, Carbohydrate metabolism, Diet, High-Fat, 01 natural sciences, Article, Mice, Structure-Activity Relationship, 03 medical and health sciences, Metabolic Diseases, Drug Discovery, medicine, Animals, Humans, Obesity, Wnt Signaling Pathway, beta Catenin, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Glucose tolerance test, medicine.diagnostic_test, Chemistry, HEK 293 cells, Wnt signaling pathway, Fatty acid, Glucose Tolerance Test, Triazoles, Lipid Metabolism, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Glucose, HEK293 Cells, Toxicity, Hepatocytes, Molecular Medicine, Signal transduction, Lithium Chloride, Diet-induced obese
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المؤلفون: Menghang Xia, Scott Heyward, Ruili Huang, Srilatha Sakamuru, Hongbing Wang, Caitlin Lynch, Linhao Li, Bryan Mackowiak
المصدر: Toxicological sciences : an official journal of the Society of Toxicology. 167(1)
مصطلحات موضوعية: 0301 basic medicine, Cytoplasm, Rimcazole, Cell Culture Techniques, Receptors, Cytoplasmic and Nuclear, Toxicology, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, CYP2B6 Gene, Tox21 SCREENING FOR CAR RECEPTOR ACTIVATION, Constitutive androstane receptor, Structure–activity relationship, Humans, Drug Interactions, Receptor, Cells, Cultured, Constitutive Androstane Receptor, Cell Nucleus, Pregnane X receptor, Molecular Structure, Chemistry, Cell biology, High-Throughput Screening Assays, Protein Transport, 030104 developmental biology, Nuclear receptor, Hepatocytes, 030217 neurology & neurosurgery, Drug metabolism
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493d20a1196b6e52757f695dc68f80ad
https://pubmed.ncbi.nlm.nih.gov/30247703 -
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المؤلفون: Menghang Xia, Ruili Huang, Anton Simeonov, Srilatha Sakamuru, Jinghua Zhao, Sampada A. Shahane, Tongan Zhao, Matias S. Attene-Ramos, Christopher P. Austin
المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Human toxicity, Prioritization, Science, General Physics and Astronomy, In vivo toxicity, Computational biology, Pharmacology, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, Toxicity Tests, Structure–activity relationship, Humans, Organic Chemicals, Multidisciplinary, Chemistry, In vitro toxicology, food and beverages, General Chemistry, Models, Theoretical, In vitro, 030104 developmental biology, Toxicity, Stress response pathway
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المؤلفون: Menghang Xia, Hannah Lu, Daniel L. Svoboda, Raymond R. Tice, Jui-Hua Hsieh, B. Alex Merrick, Shiuan Chen, Li-Yu Hsin, Keith R. Shockley, Noriko Kanaya, Scott S. Auerbach, Christina T. Teng, Ruili Huang, Srilatha Sakamuru, Kristine L. Witt
المصدر: Toxicological Sciences. 147:446-457
مصطلحات موضوعية: medicine.drug_class, High-throughput screening, Pharmacology, Toxicology, Chemical library, Small Molecule Libraries, Structure-Activity Relationship, chemistry.chemical_compound, medicine, Animals, Humans, Testosterone, Aromatase, Cytotoxicity, chemistry.chemical_classification, High Throughput Testing of Aromatase Inhibition, Estradiol, biology, Aromatase Inhibitors, High-Throughput Screening Assays, Enzyme, chemistry, Estrogen, MCF-7 Cells, biology.protein, Estrogen receptor alpha
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdefb7a588e34b43bcfba5f3a52ad6d
https://doi.org/10.1093/toxsci/kfv141 -
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المؤلفون: Jing Zhang, Cheri A. Koetzner, Laura D. Kramer, Zhong Li, Menghang Xia, Matthew Brecher, Qing Yu Zhang, Srilatha Sakamuru, Haiying Chen, Ruili Huang, Hongmin Li, Jia Zhou, Cheng-Feng Qin
المصدر: Antiviral research. 150
مصطلحات موضوعية: 0301 basic medicine, Gene Expression Regulation, Viral, Models, Molecular, Proteases, viruses, Molecular Conformation, Dengue virus, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, Virus, Article, Zika virus, Flavivirus Infections, 03 medical and health sciences, Structure-Activity Relationship, Virology, medicine, Humans, Protease inhibitor (pharmacology), Protease Inhibitors, Cells, Cultured, Pharmacology, NS3, biology, Dose-Response Relationship, Drug, Flavivirus, Serine Endopeptidases, virus diseases, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, 030104 developmental biology, Erythrosine, RNA Helicases, Protein Binding
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المؤلفون: Rick G. Schnellmann, Ruili Huang, Matias S. Attene-Ramos, Louie Shou, Gyda C. Beeson, Christopher P. Austin, Raymond R. Tice, Craig Beeson, Kristine L. Witt, Srilatha Sakamuru, Menghang Xia
المصدر: Chemical Research in Toxicology. 26:1323-1332
مصطلحات موضوعية: Dose-Response Relationship, Drug, Molecular Structure, High-throughput screening, In vitro toxicology, Hep G2 Cells, General Medicine, Biology, Toxicology, medicine.disease, Bioinformatics, Article, Chemical space, High-Throughput Screening Assays, Structure-Activity Relationship, Mitochondrial toxicity, Biochemistry, Mitochondrial Membranes, Toxicity, Tumor Cells, Cultured, medicine, Humans, Structure–activity relationship, Environmental Pollutants, Plate reader
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المؤلفون: James Inglese, Srilatha Sakamuru, Wenwei Huang, Erika Englund, Matias S. Attene-Ramos, Menghang Xia, Christopher P. Austin, Ruili Huang
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5239-5243
مصطلحات موضوعية: Molecular Structure, Transcriptional factor, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Stereoisomerism, Chemistry Techniques, Synthetic, Hypoxia-Inducible Factor 1, alpha Subunit, Biochemistry, Molecular biology, Article, High-Throughput Screening Assays, Structure-Activity Relationship, Hypoxia-inducible factors, Drug Discovery, Cancer cell, Molecular Medicine, Molecular Biology, Quinazolinones
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المؤلفون: Timothy Moeller, Douglas S. Auld, Sunita J. Shukla, Menghang Xia, Danielle VanLeer, Paul Shinn, Srilatha Sakamuru, Ruili Huang, Christopher P. Austin
المصدر: Drug Metabolism and Disposition. 39:151-159
مصطلحات موضوعية: Receptors, Steroid, Pharmaceutical Science, Pharmacology, Biology, digestive system, Xenobiotics, Small Molecule Libraries, Structure-Activity Relationship, chemistry.chemical_compound, Species Specificity, Cell Line, Tumor, Cytochrome P-450 CYP3A, Animals, Humans, Structure–activity relationship, Drug Interactions, Receptor, chemistry.chemical_classification, Pregnane X receptor, CYP3A4, Pregnane, Pregnane X Receptor, Transporter, Hep G2 Cells, Articles, digestive system diseases, Rats, Enzyme, Pharmaceutical Preparations, chemistry, Hepatocytes
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bc9fe01b206dd3d076d708395250da
https://doi.org/10.1124/dmd.110.035105 -
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المؤلفون: Weida Tong, Tongan Zhao, Kristine L. Witt, Anton Simeonov, Matthew T. Martin, Daniel M. Rotroff, Paul Shinn, Christopher P. Austin, Keith A. Houck, David J. Dix, Ruili Huang, Richard S. Judson, Jui-Hua Hsieh, Robert J. Kavlock, Srilatha Sakamuru, David M. Reif, Warren Casey, Raymond R. Tice, Patricia Ceger, Keith R. Shockley, Jennifer Fostel, Menghang Xia
المصدر: Scientific Reports
مصطلحات موضوعية: Reporter gene, Multidisciplinary, Ligand binding assay, HEK 293 cells, Estrogen Receptor alpha, Biology, Pharmacology, Ligands, Molecular biology, Article, Cell Line, High-Throughput Screening Assays, Small Molecule Libraries, Structure-Activity Relationship, HEK293 Cells, Genes, Reporter, Humans, Structure–activity relationship, Signal transduction, Receptor, Estrogen receptor alpha, Protein Binding, Signal Transduction