المؤلفون: Tan CH; Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia., Sim DSY; Department of Chemistry, Faculty of Science, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia., Lim SH; Department of Chemistry, Faculty of Science, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia., Mohd Mohidin TB; Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia., Mohan G; Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia., Low YY; Department of Chemistry, Faculty of Science, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia., Kam TS; Department of Chemistry, Faculty of Science, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia., Sim KS; Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia.

المصدر: Planta medica [Planta Med] 2022 Nov; Vol. 88 (14), pp. 1325-1340. Date of Electronic Publication: 2022 Jan 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: George Thieme Country of Publication: Germany NLM ID: 0066751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0221 (Electronic) Linking ISSN: 00320943 NLM ISO Abbreviation: Planta Med Subsets: MEDLINE

مواضيع طبية MeSH: Tabernaemontana*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Ibogaine*/pharmacology , Adenocarcinoma* , Colorectal Neoplasms*/drug therapy, Humans ; HT29 Cells ; Molecular Docking Simulation ; Drug Screening Assays, Antitumor ; Molecular Structure ; Indole Alkaloids/pharmacology ; Indole Alkaloids/chemistry ; Apoptosis ; Microtubules ; Cell Line, Tumor

المؤلفون: Sim DS; Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, 50603, Malaysia., Tang SY; Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, 50603, Malaysia., Low YY; Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, 50603, Malaysia., Lim SH; Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, 50603, Malaysia. Electronic address: shlim80@um.edu.my., Kam TS; Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, 50603, Malaysia. Electronic address: tskam@um.edu.my.

المصدر: Phytochemistry [Phytochemistry] 2022 Nov; Vol. 203, pp. 113384. Date of Electronic Publication: 2022 Aug 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Alkaloids* , Antineoplastic Agents, Phytogenic*/chemistry , Tabernaemontana*/chemistry , Vincamine*, Drug Screening Assays, Antitumor ; Indole Alkaloids/chemistry ; Molecular Structure ; Plant Extracts

المؤلفون: Sim DS; Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia., Navanesan S; Institute of Biological Sciences, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia., Sim KS; Institute of Biological Sciences, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia., Gurusamy S; School of Chemical and Life Sciences , Nanyang Polytechnic , Singapore 569830 , Singapore., Lim SH; Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia., Low YY; Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia., Kam TS; Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia.

المصدر: Journal of natural products [J Nat Prod] 2019 Apr 26; Vol. 82 (4), pp. 850-858. Date of Electronic Publication: 2019 Mar 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

مواضيع طبية MeSH: Aspidosperma/*chemistry , Cell Proliferation/*drug effects , Indole Alkaloids/*pharmacology , Tabernaemontana/*chemistry, Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Indole Alkaloids/chemistry ; Molecular Structure ; Spectrum Analysis/methods

المؤلفون: Sim DS; Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia., Teoh WY; Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia., Sim KS; Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia., Lim SH; Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia., Thomas NF; Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia., Low YY; Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia., Kam TS; Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia.

المصدر: Journal of natural products [J Nat Prod] 2016 Apr 22; Vol. 79 (4), pp. 1048-55. Date of Electronic Publication: 2016 Feb 26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents, Phytogenic/*isolation & purification , Antineoplastic Agents, Phytogenic/*pharmacology , Indole Alkaloids/*isolation & purification , Indole Alkaloids/*pharmacology , Tabernaemontana/*chemistry, Antineoplastic Agents, Phytogenic/chemistry ; Drug Screening Assays, Antitumor ; HCT116 Cells ; HT29 Cells ; Humans ; Indole Alkaloids/chemistry ; KB Cells ; Malaysia ; Molecular Structure ; Plant Leaves/chemistry

المؤلفون: Sim DS; Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia., Chong KW, Nge CE, Low YY, Sim KS, Kam TS

المصدر: Journal of natural products [J Nat Prod] 2014 Nov 26; Vol. 77 (11), pp. 2504-12. Date of Electronic Publication: 2014 Oct 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents, Phytogenic/*isolation & purification , Antineoplastic Agents, Phytogenic/*pharmacology , Indole Alkaloids/*isolation & purification , Indole Alkaloids/*pharmacology , Plants, Medicinal/*chemistry , Tabernaemontana/*chemistry, Antineoplastic Agents, Phytogenic/chemistry ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Humans ; Indole Alkaloids/chemistry ; Indoles/chemistry ; Indoles/isolation & purification ; Indoles/pharmacology ; Malaysia ; Molecular Conformation ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pausinystalia ; Tryptamines/chemistry ; Tryptamines/isolation & purification ; Tryptamines/pharmacology

المؤلفون: Tan, Chun Hoe, Sim, Dawn Su Yin, Heng, Mok Piew, Lim, Siew Huah, Low, Yun Yee, Kam, Toh Seok, Sim, Kae Shin

المصدر: ChemistrySelect; 12/18/2020, Vol. 5 Issue 47, p14839-14843, 5p

مصطلحات موضوعية: COLON cancer, TABERNAEMONTANA, DNA topoisomerase I, HYDROPHOBIC interactions, CANCER cells, BINDING constant, IRINOTECAN, ISOQUINOLINE alkaloids