المؤلفون: Gutierrez-Rodrigues F; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, 20892-1202, USA., Masri N; LAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Zahar Street, Achrafieh, Beirut, 1110, Lebanon., Chouery E; Unité de Génétique Médicale, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon., Diamond C; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, 20892-1202, USA., Jalkh N; Unité de Génétique Médicale, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon., Vicente A; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, 20892-1202, USA., Kajigaya S; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, 20892-1202, USA., Abillama F; LAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Zahar Street, Achrafieh, Beirut, 1110, Lebanon., Bejjani N; LAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Zahar Street, Achrafieh, Beirut, 1110, Lebanon., Serhal W; LAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Zahar Street, Achrafieh, Beirut, 1110, Lebanon., Calado RT; Department of Medical Imaging, Hematology, and Clinical Oncology, University of São Paulo, Ribeirão Preto, SP, Brazil., Young NS; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, 20892-1202, USA., Farhat H; LAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Zahar Street, Achrafieh, Beirut, 1110, Lebanon. hussein.farhat@laumcrh.com., Coussa ML; LAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Zahar Street, Achrafieh, Beirut, 1110, Lebanon.

المصدر: Human genetics [Hum Genet] 2019 Dec; Vol. 138 (11-12), pp. 1323-1330. Date of Electronic Publication: 2019 Nov 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7613873 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1203 (Electronic) Linking ISSN: 03406717 NLM ISO Abbreviation: Hum Genet Subsets: MEDLINE

مواضيع طبية MeSH: Consanguinity* , Homozygote* , Mutation*, DNA Helicases/*genetics , Genetic Diseases, Inborn/*epidemiology , Telomere/*genetics, Adolescent ; Adult ; Female ; Genetic Diseases, Inborn/genetics ; Humans ; Lebanon/epidemiology ; Male ; Middle Aged ; Pedigree ; Phenotype ; Young Adult

المؤلفون: Gutierrez-Rodrigues F; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.; Department of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil., Donaires FS; Department of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil., Pinto A; Department of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil., Vicente A; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Dillon LW; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Clé DV; Department of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil., Santana BA; Department of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil., Pirooznia M; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Ibanez MDPF; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Townsley DM; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Kajigaya S; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Hourigan CS; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Cooper JN; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Calado RT; Department of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil. rtcalado@usp.br., Young NS; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.

المصدر: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2019 Jul; Vol. 21 (7), pp. 1594-1602. Date of Electronic Publication: 2018 Dec 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE

مواضيع طبية MeSH: Promoter Regions, Genetic*, Telomerase/*genetics , Telomere/*pathology, Adolescent ; Adult ; Aged ; Anemia, Aplastic/genetics ; Blood Cell Count ; Bone Marrow Diseases/genetics ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Idiopathic Pulmonary Fibrosis/genetics ; Liver Diseases/genetics ; Male ; Middle Aged ; Retrospective Studies ; Telomerase/deficiency ; Young Adult

المؤلفون: Kapuria D; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Ben-Yakov G; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Ortolano R; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Cho MH; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.; Department of Internal Medicine, Medstar Washington Hospital Center, Washington, DC., Kalchiem-Dekel O; Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Takyar V; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Lingala S; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Gara N; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Tana M; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Kim YJ; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Kleiner DE; Laboratory of Pathology, National Cancer Institute, Bethesda, MD., Young NS; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Townsley DM; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Koh C; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Heller T; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2019 Jun; Vol. 69 (6), pp. 2579-2585. Date of Electronic Publication: 2019 Apr 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Diseases, Inborn/*epidemiology , Liver Diseases/*epidemiology , Liver Diseases/*genetics , Telomere/*genetics, Adolescent ; Adult ; Age Distribution ; Aged ; Biopsy, Needle ; Cohort Studies ; Comorbidity ; Female ; Genetic Diseases, Inborn/diagnosis ; Genetic Testing ; Genetic Variation ; Humans ; Immunohistochemistry ; Liver Diseases/diagnosis ; Liver Function Tests ; Male ; Middle Aged ; Mutation/genetics ; Prevalence ; Prognosis ; Prospective Studies ; Risk Assessment ; Sex Distribution ; Survival Analysis

المؤلفون: Wand T; Center for Human Immunology, Autoimmunity, and Inflammation, National Institutes of Health, Bethesda, Maryland, 28092., Fang M; Hematology Branch, National Heart Lung and Blood Institute National Institutes of Health, Bethesda, Maryland, 28092., Chen C; Hematology Branch, National Heart Lung and Blood Institute National Institutes of Health, Bethesda, Maryland, 28092., Hardy N; Hematology Branch, National Heart Lung and Blood Institute National Institutes of Health, Bethesda, Maryland, 28092., McCoy JP Jr; Flow Cytometry Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, 28092., Dumitriu B; Hematology Branch, National Heart Lung and Blood Institute National Institutes of Health, Bethesda, Maryland, 28092., Young NS; Center for Human Immunology, Autoimmunity, and Inflammation, National Institutes of Health, Bethesda, Maryland, 28092.; Hematology Branch, National Heart Lung and Blood Institute National Institutes of Health, Bethesda, Maryland, 28092., Biancotto A; Center for Human Immunology, Autoimmunity, and Inflammation, National Institutes of Health, Bethesda, Maryland, 28092. biancoa@mail.nih.gov.

المصدر: Cytometry. Part A : the journal of the International Society for Analytical Cytology [Cytometry A] 2016 Oct; Vol. 89 (10), pp. 914-921. Date of Electronic Publication: 2016 Sep 22.

نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 101235694 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4930 (Electronic) Linking ISSN: 15524922 NLM ISO Abbreviation: Cytometry A Subsets: MEDLINE

مواضيع طبية MeSH: Flow Cytometry/*methods , In Situ Hybridization, Fluorescence/*methods , Leukocytes, Mononuclear/*chemistry , Real-Time Polymerase Chain Reaction/*methods , Telomere/*chemistry, Adult ; Aged ; Cell Line ; DNA/chemistry ; Female ; Fluorescein/chemistry ; Fluorescence ; Humans ; Male ; Middle Aged ; Peptide Nucleic Acids/chemistry ; Propidium/chemistry ; Single-Cell Analysis/methods ; Young Adult

المؤلفون: Townsley DM, Dumitriu B, Young NS

المصدر: The New England journal of medicine [N Engl J Med] 2016 Sep 15; Vol. 375 (11), pp. 1095-6.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE

مواضيع طبية MeSH: Danazol* , Telomere*, Estrogen Antagonists/therapeutic use ; Humans

المؤلفون: Zhao X; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: zhaox10@nhlbi.nih.gov., Ueda Y; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Kajigaya S; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Alaks G; Department of Conservation Science, Chicago Zoological Society, Brookfield, IL, USA., Desierto MJ; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Townsley DM; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Dumitriu B; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Chen J; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Lacy RC; Department of Conservation Science, Chicago Zoological Society, Brookfield, IL, USA., Young NS; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

المصدر: Gene [Gene] 2015 Aug 15; Vol. 568 (1), pp. 8-18. Date of Electronic Publication: 2015 May 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE

مواضيع طبية MeSH: Peromyscus/*genetics , Telomerase/*genetics , Telomere/*genetics, Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Base Sequence ; Cloning, Molecular ; Female ; Gene Expression ; Male ; Molecular Sequence Data ; Organ Specificity ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Telomerase/chemistry ; Telomerase/metabolism ; Telomere Homeostasis ; Testis/enzymology

المؤلفون: Balakumaran A; Skeletal Biology Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research., Mishra PJ; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, and., Pawelczyk E; Laboratory of Diagnostic Radiology Research, Warren G. Magnuson Clinical Center, National Institutes of Health, Department of Health and Human Services, Bethesda, MD;, Yoshizawa S; Skeletal Biology Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research., Sworder BJ; Skeletal Biology Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research., Cherman N; Skeletal Biology Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research., Kuznetsov SA; Skeletal Biology Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research., Bianco P; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; and., Giri N; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute and., Savage SA; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute and., Merlino G; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, and., Dumitriu B; Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD., Dunbar CE; Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD., Young NS; Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD., Alter BP; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute and., Robey PG; Skeletal Biology Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research.

المصدر: Blood [Blood] 2015 Jan 29; Vol. 125 (5), pp. 793-802. Date of Electronic Publication: 2014 Dec 12.

نوع المنشور: Clinical Trial; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Bone Marrow Cells/*metabolism , Dyskeratosis Congenita/*genetics , Mesenchymal Stem Cells/*metabolism , RNA/*genetics , Telomerase/*genetics , Telomere/*metabolism, Adolescent ; Adult ; Animals ; Base Sequence ; Bone Marrow Cells/pathology ; Cell Differentiation ; Cell Proliferation ; Cellular Senescence ; Child ; Child, Preschool ; Colony-Forming Units Assay ; DNA Helicases/genetics ; DNA Helicases/metabolism ; Dyskeratosis Congenita/pathology ; Female ; Hematopoiesis/genetics ; Humans ; Male ; Mesenchymal Stem Cells/pathology ; Mice ; Middle Aged ; Molecular Sequence Data ; Mutation ; RNA/antagonists & inhibitors ; RNA/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Telomerase/antagonists & inhibitors ; Telomerase/metabolism ; Telomere/chemistry ; Telomere-Binding Proteins/genetics ; Telomere-Binding Proteins/metabolism

المؤلفون: Townsley DM; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Dumitriu B; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Young NS; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

المصدر: Blood [Blood] 2014 Oct 30; Vol. 124 (18), pp. 2775-83. Date of Electronic Publication: 2014 Sep 18.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Bone Marrow/*pathology , Bone Marrow Diseases/*pathology , Telomere/*pathology, Animals ; Bone Marrow Diseases/diagnosis ; Bone Marrow Diseases/therapy ; Genetic Association Studies ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Telomerase/metabolism

المؤلفون: Sellers SE; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Dumitriu B; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Morgan MJ; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Hughes WM; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Wu CO; Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Raghavarchari N; DNA Sequencing and Genomics Core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Yang Y; DNA Sequencing and Genomics Core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Uchida N; Molecular and Clinical Hematology Branch, National Heart, Lung and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA., Tisdale JF; Molecular and Clinical Hematology Branch, National Heart, Lung and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA., An DS; Department of Microbiology, Immunology and Molecular Genetics, David Geffen Schools of Medicine, Los Angeles, California, USA., Chen IS; Department of Microbiology, Immunology and Molecular Genetics, David Geffen Schools of Medicine, Los Angeles, California, USA., Hematti P; Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA., Donahue RE; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Larochelle A; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Young NS; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Calado RT; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Dunbar CE; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2014 Jan; Vol. 22 (1), pp. 52-8. Date of Electronic Publication: 2013 Jul 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression* , Hematopoietic Stem Cell Transplantation* , Telomere* , Transduction, Genetic*, Genetic Vectors/*genetics , Hematopoietic Stem Cells/*metabolism , Lentivirus/*genetics, Animals ; Antigens, CD34/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Leukocytes, Mononuclear/metabolism ; Macaca mulatta ; Transcriptome ; Transgenes

المؤلفون: Winkler T; Hematology Branch, National Heart Lung and Blood Institute (NHLBI), NIH, Bethesda, Maryland 0892-1202, USA., Hong SG, Decker JE, Morgan MJ, Wu C, Hughes WM 5th, Yang Y, Wangsa D, Padilla-Nash HM, Ried T, Young NS, Dunbar CE, Calado RT

المصدر: The Journal of clinical investigation [J Clin Invest] 2013 May; Vol. 123 (5), pp. 1952-63. Date of Electronic Publication: 2013 Apr 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Anemia, Aplastic/*metabolism , Hematopoiesis/*physiology , Induced Pluripotent Stem Cells/*cytology , Telomerase/*metabolism , Telomere/*ultrastructure, Animals ; Cell Differentiation ; DNA Mutational Analysis ; Environment ; Fibroblasts/cytology ; Hematopoietic Stem Cells/cytology ; Humans ; Immunohistochemistry ; Leukocytes/cytology ; Mice ; Mutation ; Phenotype ; Transgenes