المؤلفون: Jeremy N. Skepper, Dirk Saerens, Senthil Kumar A. Natesan, Lea Brys, Mark C. Field, Alexandros Nikolaou, Serge Muyldermans, Stefan Magez, Etienne Pays, David Perez-Morga, Katja Conrath, Benoit Stijlemans, Patrick De Baetselier, Guy Caljon

المساهمون: Cellular and Molecular Immunology, Molecular and Biochemical Pharmacology

المصدر: Vrije Universiteit Brussel
PLoS Pathogens, Vol 7, Iss 6, p e1002072 (2011)
PLoS Pathogens
P L o S Pathogens, 7 (6

مصطلحات موضوعية: Models, Molecular, Trypanocidal Agents -- pharmacology -- therapeutic use, Antibody Affinity, Antibodies, Protozoan, Epitope, Mice, Trypanosome brucei, Down-Regulation -- drug effects, Molecular Cell Biology, Biology (General), Cells, Cultured, chemistry.chemical_classification, 0303 health sciences, biology, trypanosomiasis therapeutics, Trypanosoma brucei brucei -- immunology -- metabolism -- physiology -- ultrastructure, Sciences bio-médicales et agricoles, Trypanocidal Agents, nanobodies, Endocytosis, 3. Good health, Cell biology, Antibodies, Protozoan -- immunology -- pharmacology -- therapeutic use, Antibody, Endocytosis -- drug effects, Variant Surface Glycoproteins, Trypanosoma, Sciences exactes et naturelles, Research Article, Biotechnology, trypanolytic agent, Trypanosomiasis, African -- immunology -- metabolism -- therapy, QH301-705.5, Immunology, Molecular Sequence Data, Trypanosoma brucei brucei, Down-Regulation, Trypanosoma brucei, Microbiology, Models, Biological, 03 medical and health sciences, Virology, parasitic diseases, Genetics, Antigenic variation, Animals, Humans, Amino Acid Sequence, variant-specific surface glycoprotein, Molecular Biology, Biology, 030304 developmental biology, 030306 microbiology, Variant Surface Glycoproteins, Trypanosoma -- immunology, RC581-607, biology.organism_classification, Molecular biology, Complement system, Mice, Inbred C57BL, Trypanosomiasis, African, chemistry, biology.protein, Trypanosoma, Nanoparticles, Parasitology, Immunologic diseases. Allergy, Glycoprotein

وصف الملف: 1 full-text file(s): application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b0c24441acd735f0e34b460deb7685
https://doi.org/10.1371/journal.ppat.1002072

المؤلفون: Inês Loureiro, Jane MacDougall, Isbaal. Ramos, Paul Kong Thoo-Lin, Meritxell Roura, Anabela Cordeiro-da-Silva, Alain Pruvost, Joana Tavares, David Costa, Hadjer Loukil, Nuno A. G. Graça, Luís Gaspar, Ian K. Pemberton

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: 0301 basic medicine, Pentamidine/pharmacology, Naphthalimides/pharmacology, Neurons/metabolism, Mitochondria, Liver, Microsomes, Liver/metabolism, Pharmacology, Parasite load, Parasite Load, Neurons/cytology, Mice, 0302 clinical medicine, Macrophages/drug effects, Drug Stability, Trypanocidal Agents/chemical synthesis, Liver/drug effects, Trypanosoma brucei brucei/drug effects, Pharmacology (medical), African trypanosomiasis, Trypanosoma brucei brucei/metabolism, Hepatocytes/cytology, Neurons, Mice, Inbred BALB C, biology, Trypanosoma brucei brucei/growth & development, Trypanocidal Agents, 3. Good health, Naphthalimides, Infectious Diseases, Liver, Microsomes, Liver, Female, Trypanosomiasis, African/parasitology, Hepatocytes/drug effects, medicine.drug, Liver/metabolism, 030231 tropical medicine, Trypanosoma brucei brucei, Primary Cell Culture, Mitochondria, Liver/metabolism, Trypanosoma brucei, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, Inhibitory Concentration 50, Macrophages/metabolism, medicine, Mitochondria, Liver/drug effects, Structure–activity relationship, Animals, Humans, Experimental Therapeutics, Pentamidine, Trypanocidal agent, Naphthalimides/chemical synthesis, Trypanosomiasis, African/mortality, business.industry, Macrophages, Hepatocytes/metabolism, Macrophages/cytology, medicine.disease, biology.organism_classification, Neurons/drug effects, Survival Analysis, 030104 developmental biology, Trypanosomiasis, African, Cell culture, Trypanosomiasis, African/pathology, Immunology, Hepatocytes, Trypanosomiasis, African/drug therapy, Microsomes, Liver/drug effects, business, Trypanosomiasis, Trypanocidal Agents/pharmacology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fa525ec4ee871c187c8e2ab92ea4a7
https://repositorio-aberto.up.pt/handle/10216/118203

المؤلفون: Susan Wyllie, Paul G. Wyatt, Alan H. Fairlamb, Malcolm F. G. Stevens, Geoffrey Wells, Janine König

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Amide Synthases/metabolism, Time Factors, Spermidine, Thioredoxin reductase, Trypanothione, Protozoan Proteins, Amide Synthases/genetics, Biochemistry, chemistry.chemical_compound, Thioredoxins, Cysteine/metabolism, Trypanosomiasis/drug therapy, Trypanosoma brucei brucei/metabolism, Thioredoxins/genetics, biology, Glutathione/genetics, Drug Action, Thioredoxins/metabolism, Glutathione, Trypanocidal Agents, Trypanosoma brucei brucei/genetics, Tryparedoxin Peroxidase, Thiol, Drug, medicine.symptom, Thioredoxin, Antineoplastic Agents/pharmacology, Peroxidase, Protozoan Proteins/metabolism, Trypanosomiasis/genetics, Cysteine/genetics, Glutathione/analogs & derivatives, Trypanosoma brucei brucei, Trypanosomiasis/metabolism, Antineoplastic Agents, Trypanosoma brucei, Trypanosome, Dose-Response Relationship, Amide Synthases, Trypanosomiasis, medicine, Spermidine/analogs & derivatives, Animals, Benzothiazoles/pharmacology, Benzothiazoles, Cysteine, Molecular Biology, Hydroquinones/pharmacology, Dose-Response Relationship, Drug, Cell Biology, biology.organism_classification, Glutathione/metabolism, Spermidine/metabolism, Hydroquinones, Metabolism, Mechanism of action, chemistry, biology.protein, Peroxiredoxin, Trypanocidal Agents/pharmacology, Quinol

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644701f01b2fea36b4b7629a41fa03c3
http://europepmc.org/articles/PMC3048735

المؤلفون: Munirathinam Sundaramoorthy, Etienne Pays, Michael R. Waterman, W. David Nes, Benoit Vanhollebeke, Joel M. Harp, Hee Won Park, Minu Chaudhuri, Tatiana Y. Hargrove, Fernando Villalta, Zdzislaw Wawrzak, Galina I. Lepesheva

المصدر: The Journal of biological chemistry, 285 (3

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Trypanocidal Agents -- therapeutic use, Enzyme Inhibitors -- metabolism, Crystallography, X-Ray, Ligands, Biochemistry, Substrate Specificity, Sterol 14-Demethylase, Protein structure, Cytochrome P-450 Enzyme System, Enzyme Inhibitors -- pharmacology, Cytochrome P-450 Enzyme Inhibitors, Benzamides -- pharmacology, Enzyme Inhibitors -- therapeutic use, Trypanocidal Agents -- chemistry, Trypanosoma brucei brucei -- drug effects, Trypanosoma brucei brucei -- enzymology, Enzyme Inhibitors, Benzamides -- metabolism, Cytochrome P-450 Enzyme System -- metabolism, biology, Sciences bio-médicales et agricoles, Trypanosomiasis, African -- drug therapy, Trypanocidal Agents, Sterols, Protein Structure and Folding, Benzamides, Trypanocidal Agents -- metabolism, Antiparasitic, medicine.drug_class, Trypanosoma brucei brucei, Trypanosoma brucei, Benzamides -- therapeutic use, Trypanocidal Agents -- pharmacology, Enzyme activator, Enzyme Inhibitors -- chemistry, Microsomes, medicine, Humans, Amino Acid Sequence, Molecular Biology, Benzamides -- chemistry, Active site, Cell Biology, biology.organism_classification, Sterol, Microsomes -- enzymology, Trypanosomiasis, African, Cytochrome P-450 Enzyme System -- chemistry, Drug Design, Sterols -- biosynthesis, biology.protein, Biocatalysis, Cytochrome P-450 Enzyme System -- antagonists & inhibitors

وصف الملف: 2 full-text file(s): application/pdf; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10f25cf6d7a799ccbb98ab7ab7cd026
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51605