نتائج البحث - "Abdul-Ghani R"

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Unraveling Key Chloroquine Resistance-Associated Alleles Among Plasmodium falciparum Isolates in South Darfur State, Sudan Twelve Years After Drug Withdrawal

المؤلفون: Magboul AM, Nour BY, Tamomh AG, Abdul-Ghani R, Albushra SM, Eltahir HB

المصدر: Infection and Drug Resistance, Vol Volume 17, Pp 221-227 (2024)

مصطلحات موضوعية: chloroquine, drug resistance, molecular markers, pfcrt, pfmdr1, sudan, Infectious and parasitic diseases, RC109-216

الوصف: Abdalmoneim M Magboul,1 Bakri YM Nour,2 Abdelhakam G Tamomh,1 Rashad Abdul-Ghani,3,4 Sayed Mustafa Albushra,5 Hanan Babiker Eltahir6 1Department of Parasitology & Medical Entomology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan; 2Department of Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Madani, Sudan; 3Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 4Tropical Disease Research Center, Faculty of Medicine and Health Sciences, University of Science and Technology, Sana’a, Yemen; 5Department of Internal Medicine, Faculty of Medicine, University of Gezira, Wad Madani, Sudan; 6Department of Biochemistry, Faculty of Medicine, University of El Imam El Mahdi, Kosti, SudanCorrespondence: Abdelhakam G Tamomh, Email abdelhakam738@gmail.com; abdelhakam738@mahdi.edu.sdBackground: Due to the increasing resistance of Plasmodium falciparum to chloroquine (CQ) in Sudan, a shift from CQ to artesunate combined with sulfadoxine/pyrimethamine as a first-line treatment for uncomplicated falciparum malaria was adopted in 2004. This study aimed to determine the frequency distribution of K76T and N86Y mutations in P. falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes as key markers of resistance to CQ among P. falciparum isolates from patients in Nyala district of South Darfur state, west of Sudan.Methods: A descriptive, cross-sectional study was conducted among 75 P. falciparum isolates from Sudanese patients diagnosed with falciparum malaria mono-infection. Parasite DNA was extracted from dried blood spots and amplified using a nested polymerase chain reaction (PCR). Then, restriction fragment length polymorphism (RFLP) was used to detect the genetic polymorphisms in codons 76 of pfcrt and 86 of pfmdr1. PCR-RFLP products were analyzed using 1.5% gel electrophoresis to identify the genetic polymorphisms in the studied codons. The wild-type (pfcrt K76 and pfmdr1 N86), mutant (pfcrt 76T and pfmdr1 86Y) and mixed-type (pfcrt K76T and pfmdr1 N86Y) alleles were expressed as frequencies and proportions.Results: The wild-type pfcrt K76 allele was observed among 34.7% of isolates and the mutant 76T allele among 20% of isolates, while the mixed-type K76T allele was observed among 45.3% of isolates. On the other hand, 54.7% of isolates harbored the wild-type pfmdr1 N86 allele and 5.3% of isolates had the mutant 86Y allele, while the mixed-type N86Y allele was observed among 40% of isolates.Conclusion: The key molecular markers associated with CQ resistance (pfcrt 76T and pfmdr1 86Y) are still circulating in high frequency among P. falciparum isolates in South Darfur state, about twelve years after the official withdrawal of the drug as a treatment for uncomplicated falciparum malaria.Keywords: chloroquine, drug resistance, molecular markers, pfcrt, pfmdr1, Sudan

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Relation: https://www.dovepress.com/unraveling-key-chloroquine-resistance-associated-alleles-among-plasmod-peer-reviewed-fulltext-article-IDR; https://doaj.org/toc/1178-6973

URL الوصول: https://doaj.org/article/21615307555d41df8a5f831043da06ba

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Antimalarial drug efficacy and resistance in malaria-endemic countries in HANMAT-PIAM_net countries of the Eastern Mediterranean Region 2016-2020: Clinical and genetic studies

المصدر: Tropical Medicine & International Health. 28(10):817-829

الوصف: Introduction The World Health Organization recommends regular monitoring of the efficacy of nationally recommended antimalarial drugs. We present the results of studies on the efficacy of recommended antimalarials and molecular markers of artemisinin and partner resistance in Afghanistan, Pakistan, Somalia, Sudan and Yemen.Methods Single-arm prospective studies were conducted to evaluate the efficacy of artesunate-sulfadoxine-pyrimethamine (ASSP) in Afghanistan and Pakistan, artemether-lumefantrine (AL) in all countries, or dihydroartemisinin-piperaquine (DP) in Sudan for the treatment of Plasmodium falciparum. The efficacy of chloroquine (CQ) and AL for the treatment of Plasmodium vivax was evaluated in Afghanistan and Somalia, respectively. Patients were treated and monitored for 28 (CQ, ASSP and AL) or 42 (DP) days. Polymerase chain reaction (PCR)-corrected cure rate and parasite positivity rate at Day 3 were estimated. Mutations in the P. falciparum kelch 13 (Pfk13) gene and amplifications of plasmepsin (Pfpm2) and multidrug resistance-1 (Pfmdr-1) genes were also studied.Results A total of 1680 (249 for ASSP, 1079 for AL and 352 for DP) falciparum cases were successfully assessed. A PCR-adjusted ASSP cure rate of 100% was observed in Afghanistan and Pakistan. For AL, the cure rate was 100% in all but four sites in Sudan, where cure rates ranged from 92.1% to 98.8%. All but one patient were parasite-free at Day 3. For P. vivax, cure rates were 98.2% for CQ and 100% for AL. None of the samples from Afghanistan, Pakistan and Yemen had a Pfk13 mutation known to be associated with artemisinin resistance. In Sudan, the validated Pfk13 R622I mutation accounted for 53.8% (14/26) of the detected non-synonymous Pfk13 mutations, most of which were repeatedly detected in Gadaref. A prevalence of 2.7% and 9.3% of Pfmdr1 amplification was observed in Pakistan and Yemen, respectively.Conclusion High efficacy of ASSP, AL and DP in the treatment of uncomplicated falciparum infection and of CQ and AL in the treatment of P. vivax was observed in the respective countries. The repeated detection of a relatively high rate of Pfk13 R622I mutation in Sudan underscores the need for close monitoring of the efficacy of recommended ACTs, parasite clearance rates and Pfk13 mutations in Sudan and beyond. Registration numbers of the trials: ACTRN12622000944730 and ACTRN12622000873729 for Afghanistan, ACTRN12620000426987 and ACTRN12617001025325 for Pakistan, ACTRN12618001224213 for Somalia, ACTRN12617000276358, ACTRN12622000930785 and ACTRN12618001800213 for Sudan and ACTRN12617000283370 for Yemen.

URL الوصول: https://gup.ub.gu.se/publication/331687

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The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1

المؤلفون: Abdul-Ghani, R, Serra, V, Györffy, B, Jürchott, K, Solf, A, Dietel, M, Schäfer, R^{Aff1, ID1209201_cor7}

المصدر: Oncogene. 25(12):1743-1752

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Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

المؤلفون: Perkovic, V., Jardine, M. J., Neal, B., Bompoint, S., Heerspink, H. J. L., Charytan, D. M., Edwards, R., Agarwal, R., Bakris, G., Bull, S., Cannon, C. P., Capuano, G., Chu, P. -L., De Zeeuw, D., Greene, T., Levin, A., Pollock, C., Wheeler, D. C., Yavin, Y., Zhang, H., Zinman, B., Meininger, G., Brenner, B. M., Mahaffey, K. W., Perkovic, V, Mahaffey, Kw, Agarwal, R, Bakris, G, Brenner, Bm, Cannon, Cp, Charytan, Dm, de Zeeuw, D, Greene, T, Jardine, Mj, Heerspink, Hjl, Levin, A, Meininger, G, Neal, B, Pollock, C, Wheeler, Dc, Zhang, H, Zinman, B, Mcguire, Dk, Holman, R, Home, P, Scharfstein, D, Parfrey, P, Shahinfar, S, August, P, Chang, T, Sinha, Ad, Januzzi, J, Kolansky, D, Amerena, J, Hillis, G, Gorelick, P, Kissela, B, Kasner, S, Lindley, R, Fulcher, G, Ounadjela, S, Hufert, K, von Ingersleben, G, Gaglia, J, Harris, R, Hudson, M, Turchin, A, Cheifetz, A, Sheth, S, Feuerstein, J, Cohen, S, Jardine, M, Li, N, Kolesnyk, I, Aizenberg, D, Pecoits-Filho, R, Cherney, D 3rd, Obrador, G, Chertow, G, Hawley, C, Ji, L, Wada, T, Jha, V, Lim, Sk, Lim-Abrahan, Ma, Santos, F, Chae, Dw, Hwang, Sj, Vazelov, E, Rychlík, I, Hadjadj, S, Krane, V, Rosivall, L, De Nicola, L, Dreval, A, Nowicki, M, Schiller, A, Distiller, L, Górriz, Jl, Kolesnyk, M, Morren, F, Goykhman, S, David, C, Yost, L, Wang, H, Hettiarachchi, M, Thimmaiah, R, Koppolu, D, George, S, Schmidt, M, Ignjatovic, J, Chapin, L, Travis, K, Destree, M, Sood, V, Coffee, L, De Brouwer, K, Zaviriukha, V, Starzec, A, Koizumi, M, Lin, G, Chen, E, Lin, P, Leia, C, Mascaro, D, Amigo, A, Limos, A, Abrahamsen, I, Jaffer, S, Ahuad Guerrero RA, Albisu, Jp, Alvarisqueta, A, Bartolacci, I, Berli, Ma, Bordonava, A, Calella, P, Cantero, Mc, Cartasegna, Lr, Cercos, E, Coloma, Gc, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, Ca, Cusumano, Am, Douthat, Wg, Dran, Rd, Farias, E, Fernandez, Mf, Finkelstein, H, Fragale, G, Fretes, Jo, Garcia, Nh, Gastaldi, A, Gelersztein, E, Glenny, Ja, Gonzalez, Jp, Gonzalez Colaso PDC, Goycoa, C, Greloni, Gc, Guinsburg, A, Hermida, S, Juncos, Li, Klyver, Mi, Kraft, F, Krynski, F, Lanchiotti, Pv, Leon de la Fuente RA, Marchetta, N, Mele, P, Nicolai, S, Novoa, Pa, Orio, Si, Otreras, F, Oviedo, A, Raffaele, P, Resk, Jh, Rista, L, Rodriguez Papini, N, Sala, J, Santos, Jc, Schiavi, Lb, Sessa, H, Smith Casabella, T, Ulla, Mr, Valdez, M, Vallejos, A, Villarino, A, Visco, Ve, Wassermann, A, Zaidman, Cj, Cheung, Nw, Droste, C, Fraser, I, Johnson, D, Mah, Pm, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, Ra, Alves da Costa FA, Amodeo, C, Andreotti Turatti LA, Bregman, R, Camelo Sanches FC, Canani, Lh, Chacra, Ar, Cunha Borges JL, Cunha Vêncio SA, da Silva Franco RJ, D'Avila, D, de Souza Portes, E, de Souza, P, Deboni, Lm, Filho, Ff, Geloneze Neto, B, Gomes, M, Kohara, Sk, Keitel, E, Kerr Saraiva JF, Kurtz Lisboa HR, de Carvalho Contieri FL, Milagres, R, Montenegro Junior, R, Moreira de Brito, C, Nazzer Hissa, M, Nazario Sabbag ÂR, Noronha, I, Panarotto, D, Pecoits Filho, R, Pereira, Ma, Saporito, W, Scotton, As, Schuch, T, Simões de Almeida, R, Slompo Ramos, C, Soares Felício, J, Thomé, F, Tibes Hachmann JC, Yamada, S, Yoiti Hayashida, C, Zanata Petry TB, Zanella, Mt, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, 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L, Drasnar, T, Ferkl, R, Halciakova, K, Klokocnikova, V, Kovar, R, Lastuvka, J, Lukac, M, Pesickova, S, Peterka, K, Pumprla, J, Rychlik, I, Saudek, F, Tesar, V, Valis, M, Weiner, P, Zemek, S, Alamartine, E, Borot, S, Cariou, B, Dussol, B, Fauvel, Jp, Gourdy, P, Klein, A, Le Meur, Y, Penfornis, A, Roussel, R, Saulnier, Pj, Thervet, E, Zaoui, P, Burst, V, Faghih, M, Faulmann, G, Haller, H, Jerwan-Keim, R, Maxeiner, S, Paschen, B, Plassmann, G, Rose, L, Gonzalez Orellana RA, Haase, Fp, Moreira Diaz JP, Ramirez Roca LA, Sánchez Arenales JA, Sanchez Polo JV, Turcios Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Abraham, O, Bhushan, Rs, Deepak, D, Edwin, Fm, Gopalakrishnan, N, Gracious, N, Hansraj, A, Jain, D, Keshavamurthy, Cb, Khullar, D, Manisha, S, Peringat, J, 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Soto, Mb, Ramos, Jc, Wong, Ac, Correa Rotter JR, Diaz Escalante, T, Enriquez Sosa FE, Flores Lozano, F, Flota Cervera LF, Frenk Baron, P, Garcia Ballesteros, C, Gomez Rangel JD, Herrera Jimenez LE, Irizar Santana SS, Jimenez Florez, F, Laviada Molina, H, Luna Ceballos RI, Martin Del Camp Blanco, B, Morales Franco, G, Moreno Loza OT, Mustieles Rocha, C, Obrador Vera, G, Orozco Castellanos, R, Peralta Calcaneo, J, Reyes Rosano MA, Rodriguez Pattzi, H, Rosas Guzman, J, Rucker Joerg IE, Saaveddra Sanchez SB, Sanchez Mijangos JH, Serrano Sanson, P, Tamayo, Y Orozco JA, Tellez Chavez, E, Valdes Depeda, A, Venegas Carrillo, L, Villagordoa Mesa, J, Zamarripa Escobedo, R, Baker, J, Noonan, P, Scott, R, Walker, R, Watson, E, Williams, M, Young, S, Abejuela, Z, Agra, J, Aquitania, G, Caringal, C, Comia, Rs, Delos Santos, L, Gomez, O, Jimeno, C, Tan, G, Tolentino, M, Yao, C, Yap, Ye, Ygpuara, Mdl, Bijata-Bronisz, R, Hotlos, L, Januszewicz, A, Kaczmarek, B, Kaminska, A, Lazuka, L, Madej, A, Mazur, S, Mlodawska-Choluj, D, Orlowska-Kowalik, G, Popenda, G, Rewerska, B, Sowinski, D, Angelescu, Lm, Anghel, V, Avram, Ri, Busegeanu, Mm, Cif, A, Cosma, D, Crisan, C, Demian, Ld, Ferariu, Ie, Halmagyi, I, Hancu, N, Munteanu, M, Negru, D, Onaca, Ag, Petrica, L, Popa, Ar, Ranetti, Ae, Serafinceanu, C, Toarba, C, Agafyina, A, Barbarash, O, Barysheva, O, Chizhov, D, Dobronravov, V, Glinkina, I, Grineva, E, Khirmanov, V, Kolmakova, E, Koroleva, T, Kvitkova, L, Marasaev, V, Mkrtumyan, A, Morugova, T, Nagibovich, G, Nagibovich, O, Nedogoda, S, Osipova, I, Raskina, T, Samoylova, Y, Sazonova, O, Shamkhalova, M, Shutemova, E, Shwartz, Y, Uriasyev, O, Vorobyev, S, Zateyshchikova, A, Zateyshshikov, D, Zykova, T, Antic, S, Djordjevic, M, Kendereski, A, Lalic, K, Lalic, N, Popovic-Radinovic, V, Babikova, J, Benusova, O, Buganova, I, Culak, J, Dzupina, A, Dzuponova, J, Fulop, P, Ilavska, A, Martinka, E, Ochodnicka, Z, Pella, D, Smatanova, I, Ahmed, F, Badat, A, Breedt, J, Govender, V, Govender, R, 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(PEGET)

المصدر: NEW ENGLAND JOURNAL OF MEDICINE
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
New England Journal of Medicine, 380(24), 2295-2306. MASSACHUSETTS MEDICAL SOC

مصطلحات موضوعية: Aged, Canagliflozin, Cardiovascular Diseases, Creatinine, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Double-Blind Method, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Kidney Failure, Chronic, Male, Middle Aged, Sodium-Glucose Transporter 2 Inhibitors, Type 2 diabetes, 030204 cardiovascular system & hematology, Diabetic nephropathy, Kidney Failure, chemistry.chemical_compound, 0302 clinical medicine, 030212 general & internal medicine, 03.02. Klinikai orvostan, Dapagliflozin, Chronic, 11 Medical and Health Sciences, EMPAGLIFLOZIN, General Medicine, Life Sciences & Biomedicine, Type 2, medicine.drug, medicine.medical_specialty, Nephropathy, 03 medical and health sciences, Medicine, General & Internal, Internal medicine, Diabetes mellitus, General & Internal Medicine, CREDENCE Trial Investigators, medicine, Diabetes Mellitus, Science & Technology, business.industry, urogenital system, diabetic nephropathy, Type 2 Diabetes Mellitus, KIDNEY-DISEASE, medicine.disease, chemistry, business, Kidney disease

الوصف: BACKGROUND: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin-angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69fdb280519f3278698922ae350aabdb
https://pubmed.ncbi.nlm.nih.gov/33565484

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The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics

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المساهمون: Groningen Kidney Center (GKC), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Abdallah, J, Abdul Ghani, R, Abdul Kadir, K, Abdullah, R, Abejuela, Z, Abraham, O, Abramowitz, M, Abusnana, S, Accini Mendoza, Jl, Acosta, I, Agafyina, A, Aggarwal, N, Ahmed, F, Ahuad Guerrero, Ra, Aiello, J, Ainsworth, P, Aizenberg, D, Akiyama, H, Akright, L, Akyea-Djamson, A, Alamartine, E, Alappan, R, Ali, N, Ali, Z, Alicic, R, Al-Karadsheh, A, Alpizar Salazar, M, Alvarez Garcia, P, Alvarisqueta, A, Amodeo, C, Andreeva, V, Andreotti Turatti, La, Angelescu, Lm, Angelova, A, Anghel, V, Antic, S, Aoki, H, Aquitania, G, Arauz-Pacheco, C, Arce-Nunez, E, Arcos Palma, Eg, Arfeen, S, Arif, A, Aronson, R, Arutchelvam, V, Asano, A, Atray, N, Avram, Ri, Awad, A, Baas Cruz, J, Babikova, J, Badat, A, Bajaj, H, Baker, J, Bakris, G, Barbarash, O, Barna, O, Barnard, M, Barranco, E, Barrera, C, Bartaskova, D, Bartolacci, I, Barysheva, O, Behara, V, Bellary, S, Belo, D, Bentley-Lewis, R, Benusova, O, Berenguer, R, Berli, Ma, Bernardo, M, Biscoveanu, M, Bordonava, Ap, Borot, S, Botsyurko, V, Bowman-Stroud, C, Brandon, D, Bregman, R, Brusco, O, Buganova, I, Burgos Soto, M, Busch, R, Busegeanu, Mm, Calella, P, Camelo Sanches, Fc, Canaan, Y, Canani, Lh, Cantero, Mc, Cariou, B, Cartasegna, Lr, Castellino, P, Cereto Castro, F, Certow, G, Chacra, Ar, Chae, Dw, Chang, Ct, Chang, T, Che Yusof, Md, Chen, N, Chen, Q, Cherney, D, Cheung, Nw, Chevaile Ramos, J, Chew Wong, A, Chiovato, L, Chizhov, D, Cho, Ym, Christiano, C, Christofides, E, Chuang, Lm, Chuateco, C, Cif, A, Cigarran Guldris, S, Cohen, K, Cohen, R, Coloma, Gc, Comia, R, Commendatore, V, Conway, J, Cook, C, Cosma, D, Cournoyer, S, Coyne, D, Crisan, C, Csecsei, G, Csiky, B, Cuadrado, J, Cuneo, Ca, Cunha Borges, Jl, Cunha Vêncio, Sa, Cusumano, Am, da Silva Franco, Rj, Daboul, N, Danos, P, Daroza, G, Davies, E, Davies, M, Davies, S, Dawson, A, De Cosmo, S, De Nicola, L, De Serres, S, de Souza Portes, E, Deak, L, Deck, K, Deepak, D, Derosa, G, Desouza, C, Dev, D, Dhillon, M, DI CARLO, Alfonso, Di Cianni, G, Diaz Escalante, T, Dimitrov, S, Distiller, L, Djordjevic, M, Dobronravov, V, Dohnalova, L, Dominguez Lopez, M, Douthat, Wg, Dran, Rd, Drasnar, T, Dreval, A, Droste, C, Dua, S, Dube, F, Dudar, I, Dudas, M, Dussol, B, Dzupina, A, Eder, F, Egido de Los Rios, J, El Kossi, M, El-Shahawy, M, English, P, Enriquez Sosa, Fe, Ervin, J, Esquenazi, A, Evans, J, Faghih, M, Farias, E, Faulmann, G, Fauvel, Jp, Ferariu, Ie, Fernandez, Mf, Fernandez Fresnedo, G, Fernandez Montenegro, Ma, Finkelstein, H, Flores Lozano, F, Flota Cervera, L, Fraige Filho, F, Fraser, D, Frenk Baron, P, Fretes, Jo, Frias, J, Fuiano, G, Fulop, P, Fushtey, I, Galan Serrano, A, Galphin, C, Gan, S, Gan, Cl, Garcia, Nh, Garcia, I, Garcia Ballesteros, C, Garcia Ortiz, Lh, Garrido, N, Gastaldi, A, Gelersztein, E, Geloneze Neto, B, Genadieva, V, Genova-Hristova, G, Genovese, S, Ghazi, A, Giorda, C, Glenny, Ja, Glinkina, I, Godlevska, O, Godoy Jorquera, Jg, Goldenberg, R, Golovchenko, O, Gomes Bastos, M, Gomez, O, Gomez Rangel, Jd, Gonzalez, E, Gonzalez Dorado, A, Gonzalez Martinez, Fj, Gonzalez Orellana, Ra, Gopalakrishnan, N, Gorriz, Jl, Gorson, D, Govender, V, Gracious, N, Greco, B, Gregar, R, Greloni, Gc, Grineva, E, Guinsburg, A, Gulati, R, Gunstone, A, Gupta, A, Gupta, M, Gyrina, O, Hadjadj, S, Halciakova, K, Hall, T, Haller, H, Halmagyi, I, Hammoud, J, Hancu, N, Hanif, W, Hansraj, A, Hawley, C, Henein, S, Hermida, S, Hernandez Triana, E, Herrera Jimenez, Le, Hershon, K, Higuera Cobos, Jd, Hiser, D, Hocking, S, Hon, G, Hristozov, K, Hsieh, Ch, Hura, C, Hwang, Sj, Ilavska, A, Irizar Santana, S, Ismail, M, Jackson, A, Jain, D, Jamal, A, Januszewicz, A, Jeong, Ik, Jha, V, Jimenez Flores, F, Jodar Gimeno, Je, Johnson, A, Joseph, F, Joshi, M, Juncos, Li, Jurgens, J, Kajiyama, S, Kaminska, A, Kashine, S, Kaupke, C, Kawada, T, Keiko Kohara, S, Keitel, E, Keltai, K, Kendereski, A, Keresztesi, S, Kern, E, Kerr Saraiva, Jf, Keshavamurthy, Cb, Khandwala, H, Khanna, R, Khitan, Z, Khullar, D, Kim, Sg, Kim, Yh, Kim, S, Kiss, K, Klein, A, Klyver, Mi, Kodera, T, Kolesnyk, M, Kolmakova, E, Komisarenko, I, Kong, Y, Kong, Wy, Kono, H, Konyves, L, Kopyt, N, Korzh, O, Kovar, R, Kovesdy, C, Koyama, K, Kozloviene, D, Kraft, F, Krane, V, Kravchun, N, Krishna, G, Krishnan, S, Kropp, Jj, Kumar, A, Kumar, J, Kumeda, Y, Kumwenda, M, Kurtz Lisboa, Hr, Kvitkova, L, Kwon, H, Kwon, Mj, Lalic, K, Lalic, N, Lanchiotti, Pv, Lastuvka, J, Laviada Molina, H, Lawrence, M, Le Meur, Y, Lee, Ly, Lee, Bw, Lee, J, Lee, Mk, Legun, O, Leiter, L, Lentz, J, Leon de la Fuente, Ra, Levin, A, Lewis, D, Li, D, Li, W, Li, X, Lim, Sk, Lin, H, Lin, Cc, Liss, K, Liu, J, Loh, Cl, Lombard, L, Lopez Mendoza, M, Lopez Tarabay, C, Lorenzoni d'avila, Do, Loss de Carvalho Contieri, F, Lu, W, Lu, Yc, Luna Ceballos, R, M., Edwin F, Macdougall, I, Macedo de Souza, Pa, Madej, A, Madore, F, Magalhaes Montenegro Junior, R, Mah, Pm, Maheshwari, 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المصدر: American Journal of Nephrology, 46(6), 462-472. KARGER
AMERICAN JOURNAL OF NEPHROLOGY
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname

مصطلحات موضوعية: medicine.medical_specialty, ALBUMINURIA, Urology, Renal function, 030209 endocrinology & metabolism, PROGRESSION, Type 2 diabetes, Diabetic nephropathy, 030204 cardiovascular system & hematology, GLOMERULAR-FILTRATION-RATE, CARDIOVASCULAR OUTCOMES, Nephropathy, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Chronic kidney disease, medicine, 03.02. Klinikai orvostan, Renal outcome, Canagliflozin, Science & Technology, ATRIAL-NATRIURETIC-PEPTIDE, IRBESARTAN, GFR DECLINE, business.industry, 1103 Clinical Sciences, KIDNEY-DISEASE, Urology & Nephrology, medicine.disease, Renal outcomes, Nephrology, COLLABORATIVE METAANALYSIS, Albuminuria, Original Report: Patient-Oriented, Translational Research, LOSARTAN, medicine.symptom, business, Life Sciences & Biomedicine, CREDENCE study investigators, medicine.drug, Kidney disease

الوصف: Background: People with diabetes and kidney disease have a high risk of cardiovascular events and progression of kidney disease. Sodium glucose co-transporter 2 inhibitors lower plasma glucose by reducing the uptake of filtered glucose in the kidney tubule, leading to increased urinary glucose excretion. They have been repeatedly shown to induce modest natriuresis and reduce HbA1c, blood pressure, weight, and albuminuria in patients with type 2 diabetes. However, the effects of these agents on kidney and cardiovascular events have not been extensively studied in patients with type 2 diabetes and established kidney disease. Methods: The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial aims to compare the efficacy and safety of canagliflozin versus placebo at preventing clinically important kidney and cardiovascular outcomes in patients with diabetes and established kidney disease. CREDENCE is a randomized, double-blind, event-driven, placebo-controlled trial set in in 34 countries with a projected duration of ∼5.5 years and enrolling 4,401 adults with type 2 diabetes, estimated glomerular filtration rate ≥30 to 2, and albuminuria (urinary albumin:creatinine ratio >300 to ≤5,000 mg/g). The study has 90% power to detect a 20% reduction in the risk of the primary outcome (α = 0.05), the composite of end-stage kidney disease, doubling of serum creatinine, and renal or cardiovascular death. Conclusion: CREDENCE will provide definitive evidence about the effects of canagliflozin on renal (and cardiovascular) outcomes in patients with type 2 diabetes and established kidney disease. Trial Registration: EudraCT number: 2013-004494-28; ClinicalTrials.gov identifier: NCT02065791.

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3150a4589d029408893a3870ee0bbdd3
https://research.rug.nl/en/publications/fdcc1bee-cdda-43f1-8ef9-114daac3c396

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