المؤلفون: Pigi Dikaiou, Jon Edqvist, Jesper Lagergren, Martin Adiels, Lena Björck, Annika Rosengren

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract It is unclear how increasing body mass index (BMI) influences risk of cancer in young women. We used data from the Medical Birth, Patient and Cause of Death registers collected between 1982 and 2014 to determine the risk of obesity-related cancer types, breast cancer, all cancer and cancer-related death in relation to BMI in 1,386,725 women, aged between 18 and 45 years, in Sweden. During a median follow-up of 16.3 years (IQR 7.7–23.5), 9808 women developed cancer. The hazard ratio (HR) of endometrial and ovarian cancer increased with higher BMI from 1.08 (95% CI 0.93–1.24) and 1.08 (95% CI 0.96–1.21) among women with BMI 22.5–

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/018bf2e85fa44a0eb2fe81b00044a9db

المؤلفون: Annika Rosengren, Maria Schaufelberger, Anna-Karin Wikström, Teresia Svanvik, Karl Bergman, Carmen Basic, Tatiana Zverkova Sandström, Jimmy Celind, Helen Sjöland, Erik Thunström

المصدر: Open Heart, Vol 11, Iss 1 (2024)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Background and aims Pre-eclampsia complicates 3–5% of pregnancies worldwide and is associated with adverse outcomes for the mother and the offspring. Pre-eclampsia and heart failure have common risk factors, including hypertension, obesity and diabetes. It is not known whether heart failure increases the risk of pre-eclampsia. This study examines whether pregestational heart failure increases the risk of pre-eclampsia.Methods In a registry-based case–cohort study that included all pregnancies in Sweden (n=3 125 527) between 1990 and 2019, all pregnancies with pre-eclampsia (n=90 354) were identified and up to five control pregnancies (n=451 466) for each case were chosen, matched on the mother’s birth year. Multiple logistic regression analysis was used to evaluate the impact of heart failure on the risk of pre-eclampsia, with adjustment for established risk factors and other cardiovascular diseases.Results Women with heart failure had no increased risk for pre-eclampsia, OR 1.02 (95% CI 0.69 to 1.50). Women with valvular heart disease had an increased OR of preterm pre-eclampsia, with an adjusted OR of 1.78 (95% CI 1.04 to 3.06). Hypertension and diabetes were independent risk factors for pre-eclampsia. Obesity, multifetal pregnancies, in vitro fertilisation, older age, Nordic origin and nulliparity were more common among women who developed pre-eclampsia compared with controls.Conclusion Women with heart failure do not have an increased risk of pre-eclampsia. However, women with valvular heart disease prior to pregnancy have an increased risk of developing preterm pre-eclampsia independent of other known risk factors.

وصف الملف: electronic resource

Relation: https://openheart.bmj.com/content/11/1/e002728.full; https://doaj.org/toc/2053-3624

URL الوصول: https://doaj.org/article/436ef16980b64fbe8f65780aae89f1ae

المؤلفون: Alina Skultecka, Fredrik Nyberg, Lauren Lissner, Maria Rosvall, Dag S. Thelle, Anna-Carin Olin, Kjell Torén, Lena Björck, Annika Rosengren, Kirsten Mehlig

المصدر: Metabolism Open, Vol 23, Iss , Pp 100292- (2024)

مصطلحات موضوعية: Alcohol, Metabolic syndrome, Population-based study, Observational study, Confounding, Physiology, QP1-981, Biochemistry, QD415-436

الوصف: Background: While prevalence estimates differ by definition of metabolic syndrome (MetS), it is less clear how different definitions affect associations with alcohol consumption. Methods: We included 3051 adults aged 25–77 from the baseline examination of the Swedish INTERGENE cohort (2001–2004). Using multiple logistic regression, we investigated cross-sectional associations between ethanol intake and MetS defined according to the Adult Treatment Panel III (ATP III), the International Diabetes Federation (IDF), and the Joint Interim Statement (JIS). Alcohol exposure categories comprised abstinence, and low, medium, and high consumption defined via sex-specific tertiles of ethanol intake among current consumers. Covariates included sociodemographics, health, and lifestyle factors. Results: MetS prevalence estimates varied between 13.9 % (ATP III) and 25.3 % (JIS), with higher prevalence in men than women. Adjusted for age and sex, medium-high alcohol consumption was associated with lower odds of MetS compared to low consumption, while no difference was observed for abstainers. Only the most specific (and thus severe) definition of MetS (ATP III) showed decreasing odds for ethanol intake when adjusted for all covariates. Conclusion: Our study shows that alcohol-related associations differ by definition of MetS. The finding that individuals with the most stringently defined MetS may benefit from alcohol consumption calls for further well-controlled studies.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589936824000240; https://doaj.org/toc/2589-9368

URL الوصول: https://doaj.org/article/5a22ed2e4c094f419839d7978b365270

المؤلفون: Josefina Robertson, Anders Muszta, Martin Lindgren, Agnes af Geijerstam, Jenny Nyberg, Lauren Lissner, Mats Börjesson, Magnus Gisslén, Annika Rosengren, Martin Adiels, Maria Åberg

المصدر: Obesity Science & Practice, Vol 10, Iss 1, Pp n/a-n/a (2024)

مصطلحات موضوعية: body‐mass index, cardiovascular disease, infections, physical fitness, pulmonary disease, Internal medicine, RC31-1245

الوصف: Abstract Objective Since obesity and poor fitness appear to be unfavorable for both cardiovascular health and coping with viral infections such as COVID‐19, they are of specific interest in light of the increased risk of cardiovascular and respiratory events now seen after infection with SARS‐CoV‐2. Therefore, the aim of the present study was to investigate how body mass index (BMI) and cardiorespiratory fitness (CRF) in late adolescence are associated with the risk of cardiovascular disease (CVD), respiratory disease, and mortality after COVID‐19. Methods In this study, 1.5 million 18‐year‐old Swedish men with BMI and CRF measured during enlistment for military service 1968–2005 were included. Hospitalized and non‐hospitalized COVID‐19 cases were identified through the Patient Register or positive polymerase chain reaction tests, and age‐matched with non‐infected controls. CVD, respiratory disease, and mortality after COVID‐19 were divided into 180days post‐infection. Cox regression models were used. Results Hospitalized COVID‐19 cases (n = 9839), compared to controls, had >10‐fold, 50 to 70‐fold, and >70‐fold hazards of CVD, respiratory disease, and mortality over the initial 60 days post‐infection with little variation across BMI or CRF categories. The elevated risks persisted at declining levels >180 days. For non‐hospitalized COVID‐19 cases (n = 181,822), there was a 4‐ to 7‐fold increased acute mortality risk, and high CRF was associated with lower risk of post‐infectious respiratory disease. Conclusions The high hazards of adverse outcomes during the first two months after COVID‐19 hospitalization, and across BMI and CRF categories, declined rapidly but were still elevated after six months. Adolescent CRF was associated with respiratory disease after COVID‐19 without hospitalization, which gives further support to the health benefits of physical activity.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2055-2238

URL الوصول: https://doaj.org/article/9a54bcac9e704486802d1df39070031e

المؤلفون: Silvana Kontogeorgos, Tatiana Zverkova Sandström, Annika Rosengren, Michael Fu

المصدر: ESC Heart Failure, Vol 10, Iss 5, Pp 2973-2981 (2023)

مصطلحات موضوعية: Heart failure, Incidence rate, Rehospitalizations, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Aims The impact of hospital readmissions on the outcomes of heart failure (HF) patients is well known. However, data on temporal trends of cause‐specific hospital readmissions in these patients are limited. Methods and results From 1987 to 2014, we identified and followed up for 1 year 608 135 patients ≥18 years hospitalized with HF according to the International Classification of Diseases (ICD) 9 and 10 from the National Inpatient Register. Readmissions for cardiovascular (CVD) and non‐CVD causes and co‐morbidities were defined according to ICD‐9 and ICD‐10 codes. We analysed trends in the incidence rate of readmissions, the median time to the first rehospitalization, and the time to readmission, stratified by sex, age groups and cause of rehospitalization using linear regression. During our study, 1 year all‐cause mortality decreased (β = −4.93, P

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2055-5822

URL الوصول: https://doaj.org/article/4a2523f032d34293aee914fb0a88e3c1

المؤلفون: Carl Johan Östgren, Julia Otten, Karin Festin, Oskar Angerås, Göran Bergström, Kerstin Cederlund, Gunnar Engström, Maria J. Eriksson, Mats Eriksson, Tove Fall, Anders Gummesson, Emil Hagström, Urban Hellman, Stefan K. James, Tomas Jernberg, Johan Kihlberg, David Kylhammar, Hanna Markstad, Peter Nilsson, Anders Persson, Margaretha Persson, Carlo Pirazzi, Rebecka Renklint, Annika Rosengren, Stefan Söderberg, Johan Sundström

المصدر: Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-13 (2023)

مصطلحات موضوعية: Atherosclerosis, Carotid arteries, Coronary arteries, Coronary computed tomography angiography, Diabetes, Prediabetes, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Background Patients with type 2 diabetes have an increased risk of death and cardiovascular events and people with diabetes or prediabetes have been found to have increased atherosclerotic burden in the coronary and carotid arteries. This study will estimate the cross-sectional prevalence of atherosclerosis in the coronary and carotid arteries in individuals with prediabetes and diabetes, compared with normoglycaemic individuals in a large population-based cohort. Methods The 30,154 study participants, 50–64 years, were categorized according to their fasting glycaemic status or self-reported data as normoglycaemic, prediabetes, and previously undetected or known diabetes. Prevalence of affected coronary artery segments, severity of stenosis and coronary artery calcium score (CACS) were determined by coronary computed tomography angiography. Total atherosclerotic burden was assessed in the 11 clinically most relevant segments using the Segment Involvement Score and as the presence of any coronary atherosclerosis. The presence of atherosclerotic plaque in the carotid arteries was determined by ultrasound examination. Results Study participants with prediabetes (n = 4804, 16.0%) or diabetes (n = 2282, 7.6%) had greater coronary artery plaque burden, more coronary stenosis and higher CACS than normoglycaemic participants (all, p

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-2840

URL الوصول: https://doaj.org/article/cb8eda233cab4b149981ec8d50466e76

المؤلفون: Ahmad Mahmoud, Katarina Glise Sandblad, Christina E. Lundberg, Gustaf Hellsén, Per Olof Hansson, Martin Adiels, Annika Rosengren

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Overweight and obesity rates have increased in recent decades, particularly among the younger population. The long-term consequences of obesity with respect to early venous thromboembolism (VTE) in women have not been established. The aim was to investigate the association between body mass index (BMI) in early pregnancy as a proxy for non-pregnant weight and long-term post-pregnancy risk of VTE in women. This registry-based prospective cohort study analysed data from the Swedish Medical Birth Registry, linked to the National Patient and the National Cause of Death Registries for information on post-pregnancy long-term risk of VTE. Cox proportional hazards model were used to determine the association between BMI at baseline and VTE events during follow-up starting 1 year after baseline. The mean age at registration was 27.5 (standard deviation, 4.9) years. During a median follow-up duration of 12 years (interquartile range, 6–21 years) starting 1 year after the first antenatal visit, 1765 and 2549 women had a deep vein thrombosis and/or pulmonary embolism. The risk of VTE linearly increased with increasing BMI. Compared to women with 20 ≤ BMI

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/9e9ffb23f2b84cf492838d17e20e8723

المؤلفون: Annika Rosengren, Kristina Jakobsson, Mia Söderberg, Maria Magnusson, Juhaina Swaid

المصدر: BMJ Open, Vol 13, Iss 12 (2023)

مصطلحات موضوعية: Medicine

الوصف: Objectives To investigate work and living conditions as determinants of COVID-19 infection risks in foreign-born workers in non-healthcare occupations.Design Data were collected according to a qualitative design, using semistructured interviews. Verbatim transcripts of these interviews were analysed according to systematic text condensation.Participants We recruited foreign-born workers (n=15) and union representatives (n=6) among taxi drivers, bus and tram drivers, pizza bakers, cleaners and property caretakers, all indicated as risk occupations during COVID-19 in Sweden.Results Four overarching themes were found: ‘virus exposure at work’, ‘aspects of low status and undervalued work’, ‘lack of access to information’ and ‘foreign-born persons’ position’. Virus exposure was frequent due to many social interactions over a workday, out of which several were physically close, sometimes to the point of touching. The respondents fulfilled important societal functions, but their work was undervalued due to low job status, and they had little influence on improving safety at work. Lack of health literacy limited foreign-born workers to access information about COVID-19 infection risks and protection, since most information from health organisations and employers was only available in Swedish and not adapted to their living conditions or disseminated through unknown channels. Instead, many turned to personal contacts or social media, through which a lot of misinformation was spread. Foreign-born persons were also subjected to exploitation since a Swedish residency permit could depend on maintaining employment, making it almost impossible to make demands for improved safety at work.Conclusions Structural factors and a lack of adapted information manifested themselves as fewer possibilities for protection against COVID-19. In a globalised world, new widespread diseases are likely to occur, and more knowledge is needed to protect all workers equally. Our results are transferable to similar contexts and bring forth aspects that can be tried in quantitative studies or public health interventions.Cite Now

وصف الملف: electronic resource

Relation: https://bmjopen.bmj.com/content/13/12/e069838.full; https://doaj.org/toc/2044-6055

URL الوصول: https://doaj.org/article/68297f9e0d4e47779bba1b7479ea6250

المؤلفون: Kwadwo Boakye, Marit Bovbjerg, John Schuna, Adam Branscum, Ravi Prasad Varma, Rosnah Ismail, Olga Barbarash, Juan Dominguez, Yuksel Altuntas, Ranjit Mohan Anjana, Rita Yusuf, Roya Kelishadi, Patricio Lopez-Jaramillo, Romaina Iqbal, Pamela Serón, Annika Rosengren, Paul Poirier, P. V. M. Lakshmi, Rasha Khatib, Katarzyna Zatonska, Bo Hu, Lu Yin, Chuangshi Wang, Karen Yeates, Jephat Chifamba, Khalid F Alhabib, Álvaro Avezum, Antonio Dans, Scott A Lear, Salim Yusuf, Perry Hystad

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Urbanization may influence physical activity (PA) levels, although little evidence is available for low- and middle- income countries where urbanization is occurring fastest. We evaluated associations between urbanization and total PA, as well as work-, leisure-, home-, and transport-specific PA, for 138,206 adults living in 698 communities across 22 countries within the Prospective Urban and Rural Epidemiology (PURE) study. The 1-week long-form International PA Questionnaire was administered at baseline (2003–2015). We used satellite-derived population density and impervious surface area estimates to quantify baseline urbanization levels for study communities, as well as change measures for 5- and 10-years prior to PA surveys. We used generalized linear mixed effects models to examine associations between urbanization measures and PA levels, controlling for individual, household and community factors. Higher community baseline levels of population density (− 12.4% per IQR, 95% CI − 16.0, − 8.7) and impervious surface area (− 29.2% per IQR, 95% CI − 37.5, − 19.7), as well as the rate of change in 5-year population density (− 17.2% per IQR, 95% CI − 25.7, − 7.7), were associated with lower total PA levels. Important differences in the associations between urbanization and PA were observed between PA domains, country-income levels, urban/rural status, and sex. These findings provide new information on the complex associations between urbanization and PA.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/0ca31816d0bb4d8fba9da2730ca7d17e

المؤلفون: Maria Wideqvist, Annika Rosengren, Maria Schaufelberger, Aldina Pivodic, Michael Fu

المصدر: ESC Heart Failure, Vol 9, Iss 6, Pp 3931-3941 (2022)

مصطلحات موضوعية: Heart failure, Prevalence, Incidence, Mortality, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Aim Heart failure (HF) is predominantly a disorder of the elderly. During the last decades, cardiovascular primary and secondary prevention and life expectancy have improved. Accordingly, trends in incidence and prevalence of HF are dynamic and may differ over time by age and gender. We aim to investigate the overall and age‐specific and sex‐specific trends, in incidence, prevalence, and the proportion with co‐morbidities of HF over a 10 year period in Region Västra Götaland, Sweden. Methods and results The VEGA database is an administrative database of all patients managed in hospital and/or in primary care (private and public) living in Region Västra Götaland. All patients with a main or contributory diagnosis of HF (I50) aged 18 years or older between 2008 and 2017 were included. Incidence and prevalence of HF were calculated based on the entire adult population of Region Västra Götaland. The adult population in Region Västra Götaland increased by 8% from 2008 (n = 1 234 609) to 2017 (n = 1 338 906). Half the population was female and 69% 75 years. A constantly higher incidence of HF was seen for men compared with women in all age categories, RR 1.46 (95% CI 1.44–1.49), P 85 years of age who had a prevalence of 16.5% (men) and 14.6% (women) in 2008 and 23.5% (men) and 21.5% (women) in 2017. The overall 1 year mortality rate was 22.7%. When adjusted for age, women had a lower risk for death by 13% compared with men [hazard ratio 0.87 (95% CI 0.84–0.90, P 85 years. Our findings emphasize the need for implementation of effective preventive strategies for HF.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2055-5822

URL الوصول: https://doaj.org/article/c03007898d58491688ada08f8fc4cbf1