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المؤلفون: Kyung Bin Joo, Ji Seon Oh, Seo Young Park, Bon San Koo, Tae-Hwan Kim, Ji Hui Shin, Bora Nam, Seunghun Lee
مصطلحات موضوعية: Ankylosing spondylitis, medicine.medical_specialty, biology, business.industry, Radiography, C-reactive protein, medicine.disease, Gastroenterology, Internal medicine, medicine, biology.protein, Tumor necrosis factor alpha, In patient, business
الوصف: Objectives: To determine the relationship between inflammation and radiographic progression over time in patients in clinical remission for ankylosing spondylitis (AS) after tumor necrosis factor inhibitor (TNFi) treatment.Method: Medical records data of AS patients with Bath Ankylosing Spondylitis Disease Activity Index scores Results: A total of 2,956 intervals were obtained from 333 patients. Among different lag times, the cumulative sum of log CRP in the previous 18–36 months and mSASSS showed significant beta coefficients. In the final linear mixed model that included clinical variables, the cumulative sum of log CRP in the previous 24 months was significantly associated with mSASSS at 24 months (β=0.043, 95% CI: 0.014–0.071, p=0.004). Conclusion: Remnant inflammation correlates with radiographic progression even in patients in clinical remission with TNFi treatment. CRP is a surrogate marker for radiographic progression despite clinical improvement with TNFi treatment.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::86bd1b79c11ef5335419d9ccb10f2af2
https://doi.org/10.21203/rs.3.rs-944518/v1 -
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المؤلفون: Mi-Ae Jang, Bora Nam, Sungsin Jo, Tae-Jong Kim, Tae-Hwan Kim, Subin Weon, Hyundeok Kang
مصطلحات موضوعية: Senescence, medicine.medical_specialty, Ankylosing spondylitis, animal structures, business.industry, Cell, Elevation, medicine.disease, medicine.anatomical_structure, Endocrinology, stomatognathic system, Internal medicine, medicine, business
الوصف: Background: WNT16 is critical for bone homeostasis, but the effect of WNT16 in ankylosing spondylitis (AS) is still unknown. Here, we investigated whether WNT16 influences bone formation and pathophysiological changes of AS in an in vitro model.Methods: Bone tissue from facet joints was obtained from five disease control and six AS patients. Primary osteoprogenitor cells of the facet joints were isolated using an outgrowth method. Isolated osteoprogenitor cells from both control and AS tissues were analysed by microarray, RT-qPCR, immunoblotting, and immunohistochemistry. Bone-forming activity of osteoprogenitor cells was assessed by various in vitro assays. β-galactosidase staining and senescence-associated secretory phenotype (SASP) using RT-qPCR were used to assess cell senescence.Results: In microarray analysis, WNT16 expression was significantly elevated in AS osteoprogenitor cells compared to the control. We also validated that WNT16 expression was elevated in AS-osteoprogenitor cells and human AS-bone tissues. WNT16 treatment inhibited bone formation in AS-osteoprogenitor cells but not in the control. Intriguingly, β-galactosidase for cell senescence was strongly stained in AS-osteoprogenitor cells treated with WNT16. Furthermore, in an H2O2 stress-induced premature senescence condition, WNT16 treatment increased cell senescence in AS-osteoprogenitor cells and WNT16 treatment under the H2O2 stress condition showed an increase in p21 protein and SASP mRNA expression. The WNT16-induced SASP expression in AS-osteoprogenitor cells was reduced in WNT16 knockdown cultures. Conclusion: WNT16 is highly expressed in AS and WNT16 treatment facilitated cell senescence in AS-osteoprogenitor cells during osteoblast differentiation accompanied by suppression of bone formation. The identified role of WNT16 in AS could reflect the bone loss in AS patients.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8d9c7f070fb082544b702be853e32356
https://doi.org/10.21203/rs.3.rs-714612/v1 -
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المؤلفون: Joshua D. Grill, Quyen Vuong, Joon Bang, Ladson Hinton, Jeanette Zhu, Alka M. Kanaya, Bora Nam, Van M. Ta Park, Nhi Cristina Y. Nguyen, Janice Y. Tsoh, Dolores Gallagher-Thompson, In Hyang Cho, Khue Nguyen, Oanh L. Meyer
المصدر: Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer's & dementia (New York, N. Y.), vol 7, iss 1
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)مصطلحات موضوعية: Gerontology, Joon, Vietnamese, caregiving, Asian Americans and Pacific Islanders, Ethnic group, Alzheimer's disease and related dementias, Neurodegenerative, Alzheimer's Disease, Clinical Research, Acquired Cognitive Impairment, RC346-429, Research Articles, Cultural group selection, aging, RC952-954.6, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Focus group, language.human_language, Brain Disorders, Outreach, Psychiatry and Mental health, research recruitment registry, Geriatrics, language, Pacific islanders, Samoan, Dementia, Neurology. Diseases of the nervous system, Neurology (clinical), Psychology, Research Article
الوصف: Author(s): Ta Park, Van; Grill, Joshua D; Zhu, Jeanette; Nguyen, Khue; Nam, Bora; Tsoh, Janice; Kanaya, Alka; Vuong, Quyen; Bang, Joon; Nguyen, Nhi Cristina Y; Cho, In Hyang; Gallagher-Thompson, Dolores; Hinton, Ladson; Meyer, Oanh L | Abstract: IntroductionThis study elicited Asian Americans and Pacific Islanders' (AAPI) perspectives about recruitment strategies/messaging for participation in an aging, Alzheimer's disease and related dementias (ADRD), and caregiving research recruitment registry.MethodsUsing a mixed methods design, CARE (Collaborative Approach for AAPI Research and Education) conducted 14 focus groups (Nn=n123) with AAPI cultural groups (Asian Indian, Chinese, Filipino, Japanese, Korean, Samoan, Vietnamese) in different languages. Descriptive statistics and thematic qualitative analyses were conducted.ResultsMean age of participants was 54 years (median: 61; range 18-80), 66% were female, and 81% were foreign-born. Themes of consideration for recruitment emerged: (1) culturally/linguistically appropriate outreach in culturally specific spaces, (2) motivations for research participation, and (3) approaches to outreach and recruitment methods. Within each of these themes, there were ethnic differences in specific strategies/approaches reflected as subthemes.DiscussionRecruitment and messaging strategies should be tailored uniquely for each targeted AAPI group, with a thorough understanding of the cultural/linguistic factors that facilitate research participation to increase AAPI participation in ADRD, aging, and caregiver-related research. .
وصف الملف: application/pdf
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المؤلفون: Yong-Gil Kim, Jinsung Park, Bora Nam, Jae Hyuk Yang, Hyosun Park, Young Lim Lee, Subin Weon, Tae-Hwan Kim, Sungsin Jo
المصدر: Experimental and Therapeutic Medicine
مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Hyaline cartilage, Chemistry, Inflammatory arthritis, chondrocytes, Articles, General Medicine, Osteoarthritis, medicine.disease, Chondrogenesis, Chondrocyte, medicine.anatomical_structure, Endocrinology, Immunology and Microbiology (miscellaneous), anti-TNFα inhibitor, Internal medicine, TNFα, medicine, Synovial fluid, chondrogenic differentiation, inflammatory arthritis, metabolic shift, Aggrecan, Hyaline
الوصف: Because damage to hyaline cartilage is irreversible, relieving progressive cartilage destruction is an important therapeutic approach for inflammatory arthritis. In the present study, human hyaline chondrocytes were isolated from total knee replacements of 15 patients with osteoarthritis (OA) and three with rheumatoid arthritis (RA). Synovial fluid of OA (n=25) and RA (n=34) were collected to measure tumor necrosis factor α (TNFα) using ELISA. Consistent with previous studies, the synovial fluid exhibited high TNFα levels and hyaline cartilage was severely destroyed in patients with RA. TNFα-treated chondrocytes were used as model for inflammatory arthritis. TNFα did not influence proliferation or extracellular matrix expression in chondrocytes, but induced matrix metalloproteinase (MMP)1, 3 and 13 expression levels in chondrocytes, which was accompanied by activation of nuclear factor-κB signaling. During chondrogenic differentiation, TNFα attenuated mRNA expression levels of anabolic factors (collagen type 2 and aggrecan) and enhanced mRNA expression of catabolic factors (MMP1, MMP3 and MMP13) in chondrocytes. Moreover, anti-TNFα agents (Golimumab) inhibited the TNFα-induced metabolic shift in chondrocytes and chondrogenic differentiation. The present study revealed a mechanism by which TNFα may induce metabolic shift in chondrocytes, leading to progressive chondrocyte destruction.
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المؤلفون: Bora Nam, Woonghee Lee, Hyun Park, Abhinav Bhise, Subramani Rajkumar, Jung Young Kim, Kiwoong Lee, Seongwhan Cho, Jeong Eun Lim, Kyo Chul Lee, Jeongsoo Yoo
المصدر: Nuclear Medicine and Biology. :S207
مصطلحات موضوعية: Cancer Research, Molecular Medicine, Radiology, Nuclear Medicine and imaging
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المؤلفون: Y Alicia Hong, Vyjeyanthi S. Periyakoil, In Hyang Cho, Bora Nam, Khue Nguyen, Amber Kim, Quyen Vuong, Van M. Ta Park
المصدر: JMIR mHealth and uHealth, Vol 9, Iss 3, p e23058 (2021)
JMIR mHealth and uHealthمصطلحات موضوعية: Vietnamese, Community organization, Health Informatics, Information technology, 03 medical and health sciences, 0302 clinical medicine, Humans, Social media, 030212 general & internal medicine, Precision Medicine, Medical education, Original Paper, mobile phone, Motivation, Text Messaging, texting, Asian, Population Health, Vietnamese Americans, Middle Aged, T58.5-58.64, Focus group, precision health, language.human_language, Health equity, Limited English proficiency, language, Pacific islanders, Public aspects of medicine, RA1-1270, Psychology, 030217 neurology & neurosurgery, qualitative research, Qualitative research
الوصف: Background The largest effort undertaken in precision health research is the Precision Medicine Initiative (PMI), also known as the All of Us Research Program, which aims to include 1 million or more participants to be a part of a diverse database that can help revolutionize precision health research studies. Research participation from Asian Americans and Pacific Islanders in precision health research is, however, limited; this includes Vietnamese Americans, especially those with limited English proficiency. PMI engagement efforts with underserved communities, including members of minority populations or individuals who have experienced health disparities such as Vietnamese Americans with limited English proficiency, may help to enrich the diversity of the PMI. Objective The aim of this study is to examine the attitudes towards and perceptions of precision health, motivations and barriers to participation in precision health research, and acceptability of SMS text messaging as a recruitment and intervention strategy among underserved Vietnamese Americans. Methods A community sample of 37 Vietnamese Americans completed a survey and participated in one of 3 focus groups classified by age (18-30, 31-59, and ≥60 years) on topics related to precision health, participation in precision health research, texting or social media use experience, and insights on how to use text messages for recruitment and intervention. Participants were recruited via community organizations that serve Vietnamese Americans, flyers, word of mouth, and Vietnamese language radio announcements. Results Most participants had little knowledge of precision health initially. After brief education, they had positive attitudes toward precision health, although the motivation to participate in precision health research varied by age and prior experience of research participation. The main motivators to participate included the desire for more knowledge and more representation of Vietnamese Americans in research. Participants were open to receiving text messages as part of their research participation and provided specific suggestions on the design and delivery of such messages (eg, simple, in both English and Vietnamese). Examples of barriers included misinterpretation of messages, cost (to send text messages), and preferences for different texting platforms across age groups. Conclusions This study represents one of the first formative research studies to recruit underserved Vietnamese Americans to precision health research. It is critical to understand target communities’ motivations and barriers to participation in research. Delivering culturally appropriate text messages via age-appropriate texting and social media platforms may be an effective recruitment and intervention strategy. The next step is to develop and examine the feasibility of a culturally tailored precision health texting strategy for Vietnamese Americans.
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المؤلفون: Yoon Kyoung Sung, Soo-Kyung Cho, Bora Nam, Yoonah Song, Bon San Koo, Ji Hui Shin, Tae-Hwan Kim, Seoung Wan Nam
المصدر: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 30(8)
مصطلحات موضوعية: Male, medicine.medical_specialty, Logistic regression, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, Quality of life, Internal medicine, Surveys and Questionnaires, Epidemiology, Republic of Korea, medicine, Humans, Spondylitis, Ankylosing, Depression (differential diagnoses), Ankylosing spondylitis, business.industry, Depression, 030503 health policy & services, Public Health, Environmental and Occupational Health, Odds ratio, medicine.disease, Confidence interval, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Quality of Life, Female, 0305 other medical science, business, Cohort study
الوصف: To identify predictors of low health-related quality of life (HRQoL) and depression in ankylosing spondylitis (AS) patients with a focus on gender differences. We conducted a cross-sectional cohort study. Both AS-related clinical data and contextual factors were obtained. HRQoL and depressive mood were assessed by EuroQol-5 dimension (EQ-5D) and the Center for Epidemiological Studies Depression Scale (CES-D), respectively. Gender-stratified multivariable logistic regression analyses were performed. Among 211 patients, 161 were males. Males had similar disease activity and higher radiographic damage compared with females. There was no significant difference in EQ-5D index score between genders. CES-D score was higher in females. Higher ASDAS-C-reactive protein (CRP) was associated with low HRQoL in both males (Odds ratio [OR] 4.25, 95% confidence interval [CI] 2.42–7.46) and females (OR 2.94, 95% CI 1.02–8.48). Being employed was associated with decreased possibility of having low HRQoL in males (OR 0.39, 95% CI 0.16–0.95). Regarding depression, higher ASDAS-CRP (OR 1.87, 95% CI 1.03–3.40), current smoking (OR 2.98, 95% CI 1.09–8.15), and being employed (OR 0.17, 95% CI 0.06–0.46) were associated with depression in males. For females, living with a partner was related to depression (OR 0.08, 95% CI 0.01–0.93). AS patients with high disease activity are likely to be suffering from low HRQoL. Both disease-related factors and contextual factors were associated with depression, and predictors showed some differences between genders. Awareness of gender differences in comprehensive assessment can lead us to better personalized management in AS patients.
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المؤلفون: Jin Ju Kim, Ji Hui Shin, Tae-Hwan Kim, Seunghun Lee, Tae Han Lee, Kyung Bin Joo, Bora Nam, Bon San Koo
المصدر: BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-8 (2021)
BMC Musculoskeletal Disordersمصطلحات موضوعية: medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, Sports medicine, Anti-tumor necrosis factor (anti-TNF), Severity of Illness Index, 03 medical and health sciences, Bath Ankylosing spondylitis disease activity index (BASDAI), 0302 clinical medicine, Rheumatology, Internal medicine, Epidemiology, medicine, Humans, Spondylitis, Ankylosing, Orthopedics and Sports Medicine, Disease activity, 030212 general & internal medicine, BASDAI, Retrospective Studies, 030203 arthritis & rheumatology, Ankylosing spondylitis, Tumor Necrosis Factor-alpha, business.industry, Retrospective cohort study, medicine.disease, Ankylosing spondylitis disease activity score (ASDAS), Discontinuation, C-Reactive Protein, Treatment Outcome, Orthopedic surgery, lcsh:RC925-935, business, Research Article
الوصف: Background The purpose of this study was to determine the prevalence of high disease activity as measured using the Ankylosing Spondylitis Disease Activity Score (ASDAS) in ankylosing spondylitis (AS) patients who nonetheless have low Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores after anti-tumor necrosis factor (TNF) treatment. Its clinical impact on anti-TNF survival was also investigated. Methods We conducted a single-centre retrospective cohort study of AS patients having low BASDAI scores ( Results Among 116 AS patients with low BASDAI scores after 3 months of anti-TNF treatment, 38.8% were grouped into the high-ASDAS group. The high-ASDAS group tended to have greater disease activity after 9 months of treatment (BASDAI 2.9 ± 1.1 vs. 2.3 ± 1.4, p=0.007; ASDAS-CRP 1.8 ± 0.6 vs. 1.5 ± 0.7, p=0.079; proportion of high ASDAS-CRP 27.8% vs. 13.8%, p=0.094) and greater risk of discontinuing anti-TNF treatment due to lack/loss of efficacy than the low-ASDAS group (p=0.011). Conclusions A relatively high proportion of AS patients with low BASDAI scores had high ASDAS-CRP. These low-BASDAI/high-ASDAS-CRP patients also had a greater risk for discontinuation of anti-TNF treatment due to low/lack of efficacy than the low-ASDAS group. The use of the ASDAS-CRP alone or in addition to the BASDAI may improve the assessment of AS patients treated with anti-TNF agents.
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المؤلفون: Young Joon Choi, Bora Nam
المصدر: Mycobiology, Vol 47, Iss 3, Pp 261-272 (2019)
Mycobiologyمصطلحات موضوعية: Oomycete, 0303 health sciences, biology, Ecology, biology.organism_classification, Microbiology, pythiales, Phytopythium, lcsh:QK1-989, 030308 mycology & parasitology, taxonomy, 03 medical and health sciences, Infectious Diseases, lcsh:Botany, Taxonomy (biology), Pythium, ecology, freshwater, Pythiales, Research Article, 030304 developmental biology
الوصف: Oomycetes are widely distributed in various environments, including desert and polar regions. Depending upon different habits and hosts, they have evolved with both saprophytic and pathogenic nutritional modes. Freshwater ecosystem is one of the most important habitats for members of oomycetes. Most studies on oomycete diversity, however, have been biased mostly towards terrestrial phytopathogenic species, rather than aquatic species, although their roles as saprophytes and parasites are essential for freshwater ecosystems. In this study, we isolated oomycete strains from soil sediment, algae, and decaying plant debris in freshwater streams of Korea. The strains were identified based on cultural and morphological characteristics, as well as molecular phylogenetic analyses of ITS rDNA, cox1, and cox2 mtDNA sequences. As a result, we discovered eight oomycete species previously unknown in Korea, namely Phytopythium chamaehyphon, Phytopythium litorale, Phytopythium vexans, Pythium diclinum, Pythium heterothallicum, Pythium inflatum, Pythium intermedium, and Pythium oopapillum. Diversity and ecology of freshwater oomycetes in Korea are poorly understood. This study could contribute to understand their distribution and ecological function in freshwater ecosystem.
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المؤلفون: Jae-Hun Sim, Joo Yun Kim, Jang Sung Sik, Jeung Woon Hee, Hyeon Ji Kim, Soo-Dong Park, Bora Nam, Jung-Lyoul Lee, Woo Nam
المصدر: Preventive Nutrition and Food Science. 24:136-143
مصطلحات موضوعية: 0301 basic medicine, Normal diet, 030209 endocrinology & metabolism, Gut flora, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oral administration, medicine, Food science, Nutrition and Dietetics, biology, Adiponectin, Leptin, digestive, oral, and skin physiology, nutritional and metabolic diseases, food and beverages, biology.organism_classification, medicine.disease, Obesity, Lactic acid, 030104 developmental biology, chemistry, hormones, hormone substitutes, and hormone antagonists, Lactobacillus plantarum, Food Science
الوصف: Obesity is a major health issue worldwide, and is associated with many diseases including type 2 diabetes. In this study, we evaluated the anti-obesity effects of combinations of two lactic acid bacteria (LAB), Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, and Cinnamomi Ramulus (CR) extract, and explored the mechanism through which they modulate gut microbiota using diet-induced obese mice. Male C57BL/6J mice were randomly divided into five groups that received a high-fat diet (HFD), HFD and LAB (HFD+LAB), HFD and CR extract (HFD+CR), HFD with LAB and CR extract (HFD+LAB+CR), or normal diet for 10 weeks. The mice in the HFD+LAB+CR group showed significant reductions in body weight gain, in particular epididymal fat and liver, blood leptin levels, and an increase in the levels of blood adiponectin. In addition, the LAB and CR extract altered the gut microbiota, mainly increasing the alpha diversity. These results demonstrate that a mixture of two LAB (Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032) and CR extracts alleviate HFD-induced obesity, and has potential of being used as a strategy for the treatment of obesity.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b39e04d6f744ce759ffa88864544bc5d
https://doi.org/10.3746/pnf.2019.24.2.136
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