-
1دورية أكاديمية
المؤلفون: Brice S. Reynolds, Valerie Chetboul, Jonathan Elliott, Jeremy Laxalde, Patrick Nguyen, Isabelle Testault, Laëticia Dorso, Jérôme Abadie, Hervé P. Lefebvre, Vincent Biourge
المصدر: Journal of Veterinary Internal Medicine, Vol 38, Iss 1, Pp 285-299 (2024)
مصطلحات موضوعية: blood pressure, cardiovascular health, glomerular filtration rate, kidney health, sodium chloride, urolithiasis, Veterinary medicine, SF600-1100
الوصف: Abstract Background High‐salt diets promote urine dilution and decrease urolithiasis risk. Objective Prospectively evaluate the safety of chronic high dietary salt intake (randomized controlled trial). Animals Twenty research colony neutered, healthy aged cats (11.5 years [10.0‐11.6], median [interquartile range]). Methods Healthy cats were randomized to control or high‐salt dry diets (sodium: 1.02 ± 0.16 [mean, SD] and 3.26 ± 0.30 g/Mcal metabolizable energy [ME], respectively; chloride: 2.26 ± 0.33 and 5.71 ± 0.28 g/Mcal ME, respectively), fed for up to 60 months. Assessments included CBC, plasma biochemistry, urinalysis, glomerular filtration rate (GFR), blood pressure, renal and cardiac (conventional Doppler and 2‐dimensional color tissue Doppler) imaging, annually. Cats that died or were euthanized underwent necropsy. Diet effects over time were evaluated with linear mixed models. Results Follow‐up duration (median [Interquartile range]) was similar between the control (38.7 months [28.6‐48.2]) and high‐salt group (51.4 months [45.7‐59.0]). Diet had no significant effect on changes in GFR, blood pressure, plasma creatinine concentration, end‐diastolic left ventricular (LV) wall thicknesses, LV internal diameters, LV systolic function, left atrial size, or systolic and diastolic Doppler variables. One control cat developed hypertension. One high‐salt group cat developed persistent azotemia. Serial plasma biochemistry and urine specific gravity suggested early chronic kidney disease in 4 nonazotemic cats (2 per group), consistent with necropsy findings. Conclusions and Clinical Importance In healthy aged cats, a commercial veterinary diet containing 3.26 ± 0.30 g/Mcal ME sodium was safe with regard to renal and cardiac function for up to 5 years.
وصف الملف: electronic resource
-
2دورية أكاديمية
المؤلفون: Jean Bassanino, Sophie Palierne, Margaux Blondel, Brice S Reynolds
المصدر: Journal of Feline Medicine and Surgery Open Reports, Vol 5 (2019)
مصطلحات موضوعية: Veterinary medicine, SF600-1100
الوصف: Case summary A 1-year-old male neutered cat was presented with a right-sided swelling of the floor of the oral cavity, causing dysphagia and hypersialorrhoea for 2 months. Fine-needle aspiration of the mass and CT were suggestive of a right sublingual sialocoele with no obvious cause. Surgical resection of the ipsilateral sublingual–mandibular salivary gland complex, as well as marsupialisation of the mucocoele, was performed. The cat recovered uneventfully. Histopathological examination of the resected specimen confirmed the diagnosis. No sign of recurrence was reported 7 months after surgery. Relevance and novel information Overall, sialocoeles are rare in cats but sublingual mucocoele is the most common form. Diagnosis is usually straightforward and the use of CT to help localise the affected site and possibly identify a cause has been infrequently described. Surgical treatment recommendations have been updated, which also makes a refresher of this uncommon condition likely to be of interest to the feline practitioner.
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2055-1169
-
3
المصدر: Journal of Feline Medicine and Surgery. 25:1098612X2311714
مصطلحات موضوعية: Small Animals
الوصف: Objectives The aim of the study was to compare the diagnostic performances of a smartphone-based colorimetric method (SBCM) for urinalysis with a semi-automated point-of-care (POC) analyser using standardised solutions and cat urine. Methods Artificial solutions (negative and positive quality controls, and purposely designed artificial urine) and natural urine from 216 cats were used. Two urine reagent strips were simultaneously dipped in each sample. One dipstick was read by the SBCM and the other by the POC analyser at the same time. Results for pH, proteins, bilirubin, ‘blood’, glucose and ketones were considered. Overall agreement and sensitivity, specificity and accuracy of the SBCM were determined based on selected cut-offs. Results For the artificial solutions, 80 comparisons were obtained for each analyte and each expected concentration. The overall agreement (exactly the same result) between the two methods was 78.4%. SBCM sensitivity, specificity and accuracy were 99.0%, 100% and 99.3%, respectively. The correlation between the two methods was almost perfect (Cohen’s kappa coefficient = 0.9851). For natural urine samples, the overall agreement (including pH) was 68.6%. Using optimal cut-offs for the SBCM determined from the results of analysis of artificial solutions, the sensitivity, specificity and accuracy of the SBCM were 100%, 76.02% and 80.5%, respectively. In this situation, the correlation between the two methods was moderate (Cohen’s kappa coefficient = 0.5401). This was mostly due to a high rate of false-positive results for bilirubin (61.1%). Conclusions and relevance With proper cut-off use (ie, considering positive or negative results) the SBCM evaluated here has a perfect sensitivity and appropriate diagnostic performances for proteins, ‘blood’, glucose and ketones. Based on these experimental data, this method appears suitable for dipstick urinalysis but positive results for bilirubin and proteins have to be confirmed.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::48240c66a35381f6daa2075fe29b9adf
https://doi.org/10.1177/1098612x231171434 -
4
المؤلفون: Jevgenija Kondratjeva, Charline Pressanti, Brice S Reynolds, Catherine Trumel, Maxence Delverdier, Anne-Cécile Normand, Nicolas Soetart, Jacques Guillot, Marie Christine Cadiergues
المصدر: Journal of Feline Medicine and Surgery Open Reports. 9:205511692311646
مصطلحات موضوعية: Small Animals
الوصف: Case summary A 3-year-old neutered domestic shorthair cat with a long history of idiopathic immune-mediated haemolytic anaemia and thrombocytopenia treated with ciclosporin and prednisolone was referred 2 months after the appearance of nodular dermatitis. A single pigmented nodule was present in the lateral carpal region of the right foreleg. The lesion was 7 mm in diameter, non-exudative and cutaneous to subcutaneous. Fine-needle aspiration of the mass revealed the presence of pigmented fungal elements. Excisional surgery was planned; in the meantime, a plaque-like lesion developed in the interorbital region. Histopathological examination confirmed the presumptive diagnosis of phaeohyphomycosis, and Exophiala spinifera was identified as the aetiological agent. Itraconazole, given orally at a dose of 10 mg/kg for 8 weeks following surgery, enabled clinical resolution despite continued use of immunosuppressants. The follow-up was carried out over 14 weeks. Relevance and novel information This case report provides the first evidence of multifocal cutaneous phaeohyphomycosis caused by E spinifera with clinical resolution after combined surgical and itraconazole treatment in an immunocompromised cat.
-
5
المؤلفون: Maria Zacharopoulou, Céline Bleuart, Nathalie Bourgès-Abella, Marie-Noëlle Lucas, Nicolas Gaide, Elise Guillaume, Lhorane Lobjois, Maxence Delverdier, Rachel Lavoué, Brice S Reynolds, Luca Aresu
المساهمون: Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, University of Turin, Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Régional d'Exploration Fonctionnelle et Ressources Expérimentales (CREFRE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Recherche en Santé Digestive (IRSD ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
المصدر: Journal of Comparative Pathology
Journal of Comparative Pathology, Elsevier, 2021, 188, pp.37-43. ⟨10.1016/j.jcpa.2021.08.005⟩مصطلحات موضوعية: Pathology, medicine.medical_specialty, 040301 veterinary sciences, Kidney Glomerulus, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Cat Diseases, Kidney, Stain, Pathology and Forensic Medicine, 0403 veterinary science, 03 medical and health sciences, Collagen Type III, chemistry.chemical_compound, Glomerulopathy, Microscopy, Eosinophilic, transmission electron microscopy, medicine, Animals, Trichrome stain, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, feline, 030304 developmental biology, 0303 health sciences, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, General Veterinary, Chemistry, 04 agricultural and veterinary sciences, medicine.disease, Congo red, Second Harmonic Generation Microscopy, Cats, Immunohistochemistry, Female, Kidney Diseases, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
الوصف: International audience; A 1.5-year-old neutered female Domestic Shorthair cat was euthanized after the diagnosis of end-stage proteinlosing nephropathy associated with the onset of nephrotic syndrome. At necropsy, both kidneys were diffusely pale and swollen with a granular cortex. Histologically, glomeruli had diffuse global mesangial and capillary wall expansion by homogeneous pale eosinophilic material. This material was Congo red negative, blue with Masson's trichrome stain, weakly positive with periodic acid-Schiff stain, bright red with Picrosirius red and birefringent under polarized light. Transmission electron microscopy and second harmonic generation (SHG) microscopy revealed mesangial and subendothelial collagen fibril deposition. Type III collagen deposition was confirmed by immunohistochemistry. This study provides an original and complete description of feline collagen type III glomerulopathy and emphasizes the possibility of directly diagnosing glomerular collagen deposition on unstained slides through SHG microscopy.
-
6
المؤلفون: Anaïs Combes, Mathieu R Faucher, Didier Concordet, Brice S Reynolds, Jade Renard
المساهمون: Clinique Vétérinaire Alliance [Bordeaux] (CVA), Innovations Thérapeutiques et Résistances (InTheRes), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
المصدر: Journal of Feline Medicine and Surgery
Journal of Feline Medicine and Surgery, SAGE Publications, 2021, pp.1098612X2110012. ⟨10.1177/1098612X211001273⟩مصطلحات موضوعية: 040301 veterinary sciences, [SDV]Life Sciences [q-bio], Cat Diseases, 0403 veterinary science, Machine Learning, 03 medical and health sciences, chemistry.chemical_compound, medicine, Animals, Renal Insufficiency, Chronic, Small Animals, 2. Zero hunger, Creatinine, business.industry, 030503 health policy & services, 04 agricultural and veterinary sciences, medicine.disease, Prognosis, chemistry, Cats, 0305 other medical science, business, Algorithm, Algorithms, Kidney disease
الوصف: Objectives The aim of this study was to develop an algorithm capable of predicting short- and medium-term survival in cases of intrinsic acute-on-chronic kidney disease (ACKD) in cats. Methods The medical record database was searched to identify cats hospitalised for acute clinical signs and azotaemia of at least 48 h duration and diagnosed to have underlying chronic kidney disease based on ultrasonographic renal abnormalities or previously documented azotaemia. Cases with postrenal azotaemia, exposure to nephrotoxicants, feline infectious peritonitis or neoplasia were excluded. Clinical variables were combined in a clinical severity score (CSS). Clinicopathological and ultrasonographic variables were also collected. The following variables were tested as inputs in a machine learning system: age, body weight (BW), CSS, identification of small kidneys or nephroliths by ultrasonography, serum creatinine at 48 h (Crea48), spontaneous feeding at 48 h (SpF48) and aetiology. Outputs were outcomes at 7, 30, 90 and 180 days. The machine-learning system was trained to develop decision tree algorithms capable of predicting outputs from inputs. Finally, the diagnostic performance of the algorithms was calculated. Results Crea48 was the best predictor of survival at 7 days (threshold 1043 µmol/l, sensitivity 0.96, specificity 0.53), 30 days (threshold 566 µmol/l, sensitivity 0.70, specificity 0.89) and 90 days (threshold 566 µmol/l, sensitivity 0.76, specificity 0.80), with fewer cats still alive when their Crea48 was above these thresholds. A short decision tree, including age and Crea48, predicted the 180-day outcome best. When Crea48 was excluded from the analysis, the generated decision trees included CSS, age, BW, SpF48 and identification of small kidneys with an overall diagnostic performance similar to that using Crea48. Conclusions and relevance Crea48 helps predict short- and medium-term survival in cats with ACKD. Secondary variables that helped predict outcomes were age, CSS, BW, SpF48 and identification of small kidneys.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a716a0115a621600c50298a4084b1f3
https://hal.inrae.fr/hal-03280301 -
7
المؤلفون: Katherine A. Briscoe, Salva Cervantes Sala, Jenny Carter, Brice S Reynolds, Andy Sparkes, Brian A. Scansen, Samantha Taylor, Rosanne E. Jepson
المصدر: Journal of Feline Medicine and Surgery. 19:288-303
مصطلحات موضوعية: Veterinary Medicine, medicine.medical_specialty, 040301 veterinary sciences, MEDLINE, Secondary hypertension, Cat Diseases, Essential hypertension, 0403 veterinary science, Intervention (counseling), medicine, Adjuvant therapy, Animals, Amlodipine, Renal Insufficiency, Chronic, Small Animals, Intensive care medicine, Societies, Medical, business.industry, 0402 animal and dairy science, Blood Pressure Determination, 04 agricultural and veterinary sciences, medicine.disease, 040201 dairy & animal science, Surgery, Blood pressure, Hypertension, Cats, Essential Hypertension, business, Kidney disease, medicine.drug
الوصف: Practical relevance: Feline hypertension is a common disease in older cats that is frequently diagnosed in association with other diseases such as chronic kidney disease and hyperthyroidism (so-called secondary hypertension), although some cases of apparent primary hypertension are also reported. The clinical consequences of hypertension can be severe, related to ‘target organ damage’ (eye, heart and vasculature, brain and kidneys), and early diagnosis followed by appropriate therapeutic management should help reduce the morbidity associated with this condition. Clinical challenges: Despite being a common disease, routine blood pressure (BP) monitoring is generally performed infrequently, probably leading to underdiagnosis of feline hypertension in clinical practice. There is a need to: (i) ensure BP is measured as accurately as possible with a reproducible technique; (ii) identify and monitor patients at risk of developing hypertension; (iii) establish appropriate criteria for therapeutic intervention; and (iv) establish appropriate therapeutic targets. Based on current data, amlodipine besylate is the treatment of choice to manage feline hypertension and is effective in the majority of cats, but the dose needed to successfully manage hypertension varies between individuals. Some cats require long-term adjuvant therapy and, occasionally, additional therapy is necessary for emergency management of hypertensive crises. Evidence base: These Guidelines from the International Society of Feline Medicine (ISFM) are based on a comprehensive review of the currently available literature, and are aimed at providing practical recommendations to address the challenges of feline hypertension for veterinarians. There are many areas where more data is required which, in the future, will serve to confirm or modify some of the recommendations in these Guidelines.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9330c6405af2202cb1c2aca49d49c881
https://doi.org/10.1177/1098612x17693500 -
8
المؤلفون: Sophie Palierne, Margaux Blondel, Brice S Reynolds, Jean Bassanino
المصدر: Journal of Feline Medicine and Surgery Open Reports, Vol 5 (2019)
JFMS Open Reportsمصطلحات موضوعية: medicine.medical_specialty, 040301 veterinary sciences, Sublingual sialocele, Case Report, Computed tomography, Salivary glands, Oral cavity, 0403 veterinary science, 03 medical and health sciences, 0302 clinical medicine, salivary mucocoele, medicine, Small Animals, soft tissue surgery, lcsh:Veterinary medicine, sialocoele, medicine.diagnostic_test, business.industry, computed tomography, 030206 dentistry, 04 agricultural and veterinary sciences, Dysphagia, Surgery, lcsh:SF600-1100, medicine.symptom, business
الوصف: Case summary A 1-year-old male neutered cat was presented with a right-sided swelling of the floor of the oral cavity, causing dysphagia and hypersialorrhoea for 2 months. Fine-needle aspiration of the mass and CT were suggestive of a right sublingual sialocoele with no obvious cause. Surgical resection of the ipsilateral sublingual–mandibular salivary gland complex, as well as marsupialisation of the mucocoele, was performed. The cat recovered uneventfully. Histopathological examination of the resected specimen confirmed the diagnosis. No sign of recurrence was reported 7 months after surgery. Relevance and novel information Overall, sialocoeles are rare in cats but sublingual mucocoele is the most common form. Diagnosis is usually straightforward and the use of CT to help localise the affected site and possibly identify a cause has been infrequently described. Surgical treatment recommendations have been updated, which also makes a refresher of this uncommon condition likely to be of interest to the feline practitioner.
-
9
المؤلفون: Mathieu R Faucher, Marie-Laure Théron, Brice S Reynolds
المصدر: Journal of Feline Medicine and Surgery. 19:484-492
مصطلحات موضوعية: Male, Abdominal pain, medicine.medical_specialty, Fever, 040301 veterinary sciences, Biopsy, Fine-Needle, 030232 urology & nephrology, Cat Diseases, Diagnosis, Differential, 0403 veterinary science, 03 medical and health sciences, Lethargy, 0302 clinical medicine, Biopsy, medicine, Animals, Small Animals, Abscess, Retrospective Studies, medicine.diagnostic_test, business.industry, Retrospective cohort study, 04 agricultural and veterinary sciences, medicine.disease, Comorbidity, Abdominal Pain, Anti-Bacterial Agents, Surgery, Renal Abscess, Urinary Tract Infections, Nephromegaly, Cats, Female, Kidney Diseases, medicine.symptom, business
الوصف: Case series summarySix cats were diagnosed with renal abscesses. Common clinical findings were lethargy, dehydration, abdominal pain and nephromegaly. Fever was noted in half of the cases. Diagnosis was established by ultrasonography, cytological examination and bacterial culture of abscess aspirates. At least one possible contributing factor could be identified in all cases. Antibiotics were consistently used and in two cats the abscess was surgically drained. The short-term outcome was fair but the long-term outcome was dependent on the underlying condition.Relevance and novel informationThe results of this small case series suggest that renal abscess should be considered when nephromegaly and/or abdominal discomfort are noted. Diagnosis of renal abscess is straightforward when ultrasonography and fine-needle aspirate analysis can be performed. Medical treatment is assumed to be preferable but surgical treatment may be warranted on a case-by-case basis. Given that almost every affected cat was diagnosed with at least one comorbidity, a thorough evaluation is recommended for all cats with renal abscesses.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028404d8ef89d2a4c359cc88afcd8a3f
https://doi.org/10.1177/1098612x15613388 -
10
المؤلفون: Patrick Nguyen, Hervé P. Lefebvre, Jérôme Abadie, Valérie Chetboul, Vincent Biourge, Didier Concordet, Brice S. Reynolds, Isabelle Testault, Jonathan Elliott, Emilie Trehiou-Sechi, C. Carlos Sampedrano
المساهمون: Reynolds, B S
المصدر: Journal of Veterinary Internal Medicine 3 (27), 507-515. (2013)
مصطلحات موضوعية: Male, Aging, medicine.medical_specialty, Urinary system, Physiology, Renal function, Cat Diseases, Kidney, chemistry.chemical_compound, Internal medicine, medicine, Animals, Sodium Chloride, Dietary, Salt intake, Aldosterone, Creatinine, Dose-Response Relationship, Drug, General Veterinary, business.industry, Diet, Endocrinology, Blood pressure, medicine.anatomical_structure, chemistry, Renal physiology, Cats, Female, Kidney Diseases, Feline lower urinary tract disease, business
الوصف: Background Increasing salt intake to promote diuresis has been suggested in the management of feline lower urinary tract disease. However, high dietary salt intake might adversely affect blood pressure and renal function. Objectives The objective of this study was to assess the long-term effects of increased salt intake on renal function in healthy aged cats. Methods This study was controlled, randomized, and blinded. Twenty healthy neutered cats (10.1 ± 2.4 years) were randomly allocated into 2 matched groups. One group was fed a high salt diet (3.1 g/Mcal sodium, 5.5 g/Mcal chloride) and the other a control diet of same composition except for salt content (1.0 g/Mcal sodium, 2.2 g/Mcal chloride). Clinical examination, glomerular filtration rate, blood pressure measurement, cardiac and kidney ultrasonography, and urinary and blood tests were performed before and over 24 months after diet implementation. Statistics were performed using a general linear model. Results Sixteen cats completed the 2 year study. The only variables affected by dietary salt intake were plasma aldosterone and urinary sodium/creatinine ratio, respectively, higher and lower in the control group all over the study period and urinary specific gravity, lower in the high salt diet group at 3 months. Conclusions and Clinical Importance Glomerular filtration rate (GFR), blood pressure, and other routine clinical pathological variables in healthy aged cats were not affected by dietary salt content. The results of this 2 year study do not support the suggestion that chronic increases in dietary salt intake are harmful to renal function in older cats.
وصف الملف: application/pdf
Full Text Finder