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1كتاب إلكتروني
الوصف: The medical device industry has experienced tremendous innovation and growth in recent years, with more than 200 million medical devices in use globally. For those seeking to bring medical devices to market, this exciting expansion also comes with pronounced risks and challenges, particularly on the legal front. Authored by experts with decades of collective expertise and familiarity with both government and private sectors, Bringing Medical Devices to Market will guide practitioners and professionals on the entire process, covering intellectual property issues at proof-of-concept stage, regulatory barriers, rules of engagement regarding promotion, contract considerations, compliance in all phases, and more.
المؤلفون: Charlene Cho
نوع المادة: eBook.
الموضوعات: Medical instruments and apparatus--Law and legislation--United States, Medical technology--Law and legislation--United States, New products--Law and legislation--United States
تصنيفات: LAW / Health, LAW / Administrative Law & Regulatory Practice, LAW / Government / Federal, LAW / Medical Law & Legislation
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المؤلفون: Wesley M. Cohen, John P. Walsh, Charlene Cho
المصدر: Research Policy. 36:1184-1203
مصطلحات موضوعية: Competition (economics), Management of Technology and Innovation, Strategy and Management, Excludability, Restricted access, Business, Management Science and Operations Research, Intellectual property, Marketing
الوصف: On the basis of survey responses from 507 academic biomedical researchers, we examine the impact of patents on access to the knowledge and material inputs that are used in subsequent research. We observe that access to knowledge inputs is largely unaffected by patents. Accessing other researchers’ materials and/or data, such as cell lines, reagents, or unpublished information is, however, more problematic. The main factors associated with restricted access to materials and/or data include scientific competition, the cost of providing materials, a history of commercial activity on the part of the prospective supplier, and whether the material in question is itself a drug. © 2007 Elsevier B.V. All rights reserved.
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المؤلفون: Charlene Cho, Richard J. Miller, Seog Bae Oh
المصدر: Methods. 29:335-344
مصطلحات موضوعية: Nervous system, Chemokine, Patch-Clamp Techniques, Time Factors, Neurotransmission, Biology, General Biochemistry, Genetics and Molecular Biology, Cell Line, Chemokine receptor, GTP-Binding Proteins, medicine, Animals, Humans, Patch clamp, Receptor, Molecular Biology, Neurons, Reverse Transcriptase Polymerase Chain Reaction, Cell Membrane, Brain, Electrophysiology, medicine.anatomical_structure, Spinal Cord, nervous system, Immunology, biology.protein, Receptors, Chemokine, Signal transduction, Neuroscience, Signal Transduction
الوصف: Several studies have shown that neurons in the central and peripheral nervous systems express a variety of chemokine receptors (CKRs). Activation of these receptors can influence neuronal signaling by regulating synaptic transmission and neuronal excitability. This article presents electrophysiological methods that are currently used to study the normal and pathophysiological role for CKRs in the nervous system. Conventional electrophysiological methods such as patch-clamp recording of isolated neurons, brain slices, and heterologous expression systems are described. In addition, single-cell reverse transcription-polymerase chain reaction is discussed as a technique that can be used in conjunction with patch-clamp recording to further investigate the molecular basis of neuronal CKR activation.
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المؤلفون: Charlene Cho, Richard J. Miller
المصدر: Journal of Neurovirology. 8:573-584
مصطلحات موضوعية: Neurons, CCR1, Nervous system, Chemokine, biology, Cell Survival, Neuroimmunomodulation, Cellular and Molecular Neuroscience, Chemokine receptor, medicine.anatomical_structure, nervous system, Neurology, Virology, biology.protein, medicine, Humans, Receptors, Chemokine, Neurology (clinical), CXC chemokine receptors, Signal transduction, Receptor, Neuroscience, G protein-coupled receptor
الوصف: Numerous studies have demonstrated that chemokines play an integral role in diseases marked by inflammation. Recently, it has also been shown that chemokines and their receptors are widely expressed in the central nervous system by all types of cells, including neurons. The functions of neuronal chemokine receptors have yet to be fully defined. However, there are indications that neuronal chemokine receptors play an integral role in the development of the nervous system, in the regulation of neuronal excitability and in the signal transduction pathways that regulate neuronal survival. This review explores these topics and discusses the overall impact that chemokines may have on neuronal function.
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5دورية أكاديمية
المؤلفون: Alex M. Kasman, Bogdana Schmidt, Kyle Spradling, Charlene Chow, Rebecca Hunt, Mechele Wu, Alexa Sockol, Joseph Liao, John T. Leppert, Jay Shah, Simon L. Conti
المصدر: Current Urology, Vol 15, Iss 3, Pp 176-180 (2021)
مصطلحات موضوعية: Diseases of the genitourinary system. Urology, RC870-923
الوصف: Abstract. Background:. Opioids are commonly prescribed after ureteroscopy. With an increasing adoption of ureteroscopy for management of urolithiasis, this subset of patients is at high risk for opioid dependence. We sought to pilot an opioid-free discharge protocol for patients undergoing ureteroscopy for urolithiasis. Materials and methods:. A prospective cohort study was performed of all patients undergoing ureteroscopy for urolithiasis and compared them to a historical control group. An opioid-free discharge protocol was initiated targeting all areas of surgical care from June 20th, 2019 to September 20th, 2019 as part of an institutional quality improvement initiative. Demographic and surgical data were collected as were morphine equivalent doses (MEDs) prescribed at discharge, postoperative measures including phone calls, clinic visits, and emergency room visits for pain. Results:. Between October 1st, 2017 and February 1st, 2018, a total of 54 patients who underwent ureteroscopy were identified and comprised the historical control cohort while 54 prospective patients met the inclusion criteria since institution of the quality improvement initiative. There were no statistically significant differences in baseline patient demographics or surgical characteristics between the 2 patient groups. Total 37% of the intervention group had a preexisting opioid prescription versus 42.6% of the control group with no difference in preoperative MED (p = 0.55). The intervention group had a mean MED of 12.03 at discharge versus 110.5 in the control cohort (p ≤ 0.001). At discharge 3.7% of the intervention group received an opioid prescription versus 88.9% of the control group (p
وصف الملف: electronic resource
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المؤلفون: John P. Walsh, Wesley M. Cohen, Charlene Cho
مصطلحات موضوعية: Political science, Patent thicket, Corporate law, Bayh–Dole Act, Public administration, Nuclear factor kappa b
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2181c7e3b2db22b4ce44646c2faa7a1d
https://doi.org/10.1017/cbo9781139051262.020 -
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المؤلفون: J. P. Kim, Charlene Cho, Norka Ruiz Bravo
المصدر: Sourcebook of Models for Biomedical Research ISBN: 9781588299338
مصطلحات موضوعية: Knowledge management, Extant taxon, business.industry, Research community, Political science, Related research, Sample (statistics), Public relations, business
الوصف: The National Institutes of Health (NIH) has long recognized that the sharing of research materials and data is critically important to the progress of biomedical research. Effective sharing of research resources benefits the public by facilitating and promoting discovery across the full spectrum of the research community. In this spirit, the NIH Model Organism Sharing Policy builds upon extant NIH sharing policies to allow the NIH to continue to support and promote broad and enabling research effectively and efficiently. This chapter provides guidance, sample plans, approaches, and other resources for investigators considering how best to share model organisms and related research resources with the research community.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::34608a2bd690cd20fa600aa1d9b0ed1c
https://doi.org/10.1007/978-1-59745-285-4_6 -
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المؤلفون: John P. Walsh, Wesley M. Cohen, Charlene Cho
المصدر: Science. 309:2002-2003
مصطلحات موضوعية: Upstream (petroleum industry), Focus (computing), Multidisciplinary, business.industry, Scientific progress, media_common.quotation_subject, Restricted access, ComputingMilieux_LEGALASPECTSOFCOMPUTING, Intellectual property, Competition (economics), business, Welfare, Biomedicine, Industrial organization, media_common
الوصف: In light of concerns that the growing number of patents on research inputs may impose significant costs on upstream, noncommercial research, Walsh et al. examine the effects of patents on access to both intellectual property and materials required by academic biomedical researchers. They found that patents generally are not used to deny access to knowledge inputs, but that access to others9 research materials is more difficult. This restricted access to materials appears to be the result of academics9 commercial activities, scientific competition, the time and effort required to satisfy requests, and whether the material in question is a drug. Policy debates about scientific progress in biomedicine may benefit from shifting the focus away from patents and toward the welfare effects of restricted access to research materials.
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9دورية أكاديمية
المؤلفون: Walsh, John P.; Cohen, Wesley M.; Cho, Charlene
المصدر: Research policy : Amsterdam [u.a.], vol 36, issue 8, pg. 1184-1203. 10/2007
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