المؤلفون: Xiao, G., Wu, Q., Chen, H., Da, D., Guo, J., Gong, Z.

المصدر: IEEE Transactions on Industrial Informatics IEEE Trans. Ind. Inf. Industrial Informatics, IEEE Transactions on. 16(4):2290-2300 Apr, 2020

المؤلفون: Liu Y, Tang J, Qiu X, Teng LA, Sriwastva MK, Han X, Li Z, Liu M, Liu S, Da D, Zhen L, Ren Y

المصدر: Breast Cancer: Targets and Therapy, Vol Volume 15, Pp 403-419 (2023)

مصطلحات موضوعية: extracellular vehicles, exosomes, breast cancer lung metastasis, mir-200c, rab1a, mirna sorting, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Yuting Liu,1,* Jie Tang,1,* Xiaolan Qiu,1,* Lucy A Teng,2 Mukesh K Sriwastva,2 Xuedong Han,1 Zhi Li,1 Minmin Liu,1 Shuangyue Liu,1 Dongzhu Da,1 Zhi Li,1 Linlin Zhen,1 Yi Ren1 1Department of Breast and Thyroid Surgery, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, People’s Republic of China; 2Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA*These authors contributed equally to this workCorrespondence: Yi Ren; Linlin Zhen, Department of Breast and Thyroid Surgery, The Affiliated Huai’an No. 1 People’s Hospital, Nanjing Medical University, Huai’an, Jiangsu, People’s Republic of China, Email only_renyi@163.com; simu1027@sina.comBackground: Recent therapeutic approaches have improved survival rate for women with breast cancer, but the survival rate for metastatic breast cancer is still low. Exosomes released by various cells are involved in all steps of breast cancer development.Methods: We established the multimodal imaging report expression in breast cancer cells with lentivirus vectors pGluc and pBirA to investigate the secreted exosomes. Comparative microRNA (miRNA) analysis was performed with miRNA qPCR array in mice with breast cancer lung metastasis. The co-immunoprecipitation and chromatin immunoprecipitation assays were used to identify the mechanism of miRNA sorting to exosomes. The potential therapeutic strategy using an anti-sorting antibody was used to investigate breast cancer lung metastasis.Results: We identified 26 high- and 32 low-expression level miRNAs in exosomes from metastasis compared to those from primary tumors and normal tissues. The tumor suppressors, including miR-200c and let-7a, were reduced in tumor tissues and metastasis but increased in the respective exosomes compared to normal tissues. Furthermore, the Ras-related protein (Rab1A) facilitated miR-200c sorting to exosomes circumventing the influence of tumor suppressor miR-200c on tumor cells, while the metastatic exosome cargo miR-200c inhibited F4/80+ macrophage immune response. Administration of anti-Rab1A antibody significantly repressed the trafficking of miR-200c to exosomes and breast cancer lung metastasis.Conclusion: Our study has identified a novel molecular mechanism for breast cancer lung metastasis mediated by exosome cargo miRNAs and provided a new therapeutic strategy for cancer immunotherapy.Graphical Abstract: Keywords: extracellular vehicles, exosomes, breast cancer lung metastasis, miR-200c, Rab1A, miRNA sorting

وصف الملف: electronic resource

Relation: https://www.dovepress.com/rab1a-mediated-exosomal-sorting-of-mir-200c-enhances-breast-cancer-lun-peer-reviewed-fulltext-article-BCTT; https://doaj.org/toc/1179-1314

URL الوصول: https://doaj.org/article/9f0fc7d103c443f2bf77a107df832592

المؤلفون: Tong X, Li Y, Yang G, Zhang H, Jiang Y, Yu J, Da D, Zeng X, Liu Y

المصدر: Nature and Science of Sleep, Vol Volume 14, Pp 1867-1875 (2022)

مصطلحات موضوعية: dentofacial growth, malocclusion, tonsil enlargement, sleep-disordered breathing, osa-18, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495

الوصف: Xianqin Tong,1,2,* Yuanyuan Li,2,4,* Gang Yang,1,2 Hao Zhang,2,3 Yiwei Jiang,2,3 Jin Yu,2,3 Dongxin Da,2,3 Xiaoli Zeng,2,3 Yuehua Liu1,2 1Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, People’s Republic of China; 3Department of Pediatric Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, People’s Republic of China; 4Department of Preventive Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoli Zeng, Department of Preventive Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, People’s Republic of China, Email lylyz97@163.com Yuehua Liu, Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, People’s Republic of China, Email liuyuehua@fudan.edu.cnPurpose: The prevalence of dentofacial deformity was reportedly higher than decades ago, to which upper airway (UA) obstruction-induced sleep-disordered breathing (SDB) might contribute a lot. Tonsil hypertrophy appears relatively common in the population of young children. Given that the association between tonsil hypertrophy and pediatric dentofacial deformity remained controversial, this cross-sectional research was designed to explore the internal relationship of those among young children in Shanghai, China.Patients and Methods: A stratified cluster sampling procedure was adopted, and a representative sample of 715 young children (8– 10 years old) was recruited. The OSA-18 quality-of-life questionnaires (OSA-18) were finished by their guardians, and well-trained orthodontists performed the oral examinations. After collecting the valuable information, the descriptions and analyses were run by statistical software (SPSS, version 26.0).Results: 715 participants (334 boys and 381 girls) were involved in the analyses. As calculated, the current prevalence of malocclusion identified by Angle’s classification was 45.6% in this sample. No evident relation between OSA-18 scores and dentofacial abnormalities (P > 0.05) was found. With the enlargement of tonsil size, the proportion of children with triangular dental arch form (P < 0.05) and high vault palate (P < 0.001) was increasingly higher. More children with protruding profiles and fewer upright profiles were observed as the tonsil size increased, although it did not show a statistical difference (P = 0.103).Conclusion: Dental and craniofacial growth deficiency has become more prevalent among children, demanding more concerns from health authorities. Tonsil hypertrophy plays an essential role in the direction of dentofacial development. More efforts from local health authorities should be made to enhance public propaganda and education on the prevention and interruption of tonsil hypertrophy and related dentofacial abnormalities.Keywords: dentofacial growth, malocclusion, tonsil enlargement, sleep-disordered breathing, OSA-18

وصف الملف: electronic resource

Relation: https://www.dovepress.com/the-association-of-tonsil-hypertrophy-with-pediatric-dentofacial-devel-peer-reviewed-fulltext-article-NSS; https://doaj.org/toc/1179-1608

URL الوصول: https://doaj.org/article/9a58005513ef40639b8b24f212f53481

المؤلفون: Zou An, A., Zhao Hui, H., Ma Yehan, Y., Li Da, D.

المصدر: Proceedings of the 33rd Chinese Control Conference Control Conference (CCC), 2014 33rd Chinese. :8091-8096 Jul, 2014

Relation: 2014 33rd Chinese Control Conference (CCC)

المؤلفون: Rotea, M.A., Corless, M., Da, D., Petersen, I.R.

المصدر: IEEE Transactions on Automatic Control IEEE Trans. Automat. Contr. Automatic Control, IEEE Transactions on. 38(5):799-803 May, 1993

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المؤلفون: Da, D., Corless, M.

المصدر: 1993 American Control Conference American Control Conference, 1993. :3101-3105 Jun, 1993

Relation: 1993 American Control Conference

المؤلفون: Ḥāṭūm, Daʻd Jahmī, author.

المؤلفون: Da, D., Corless, M.

المصدر: 1992 American Control Conference American Control Conference, 1992. :1824-1828 Jun, 1992

Relation: 1992 American Control Conference

المؤلفون: Da, D., Corless, M.

المصدر: 1991 American Control Conference American Control Conference, 1991. :1697-1702 Jun, 1991

Relation: 1991 American Control Conference