المؤلفون: Md Navid Akbar, Mathew Yarossi, Sumientra Rampersad, Kyle Lockwood, Aria Masoomi, Eugene Tunik, Dana Brooks, Deniz Erdogmus

المصدر: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol 32, Pp 1455-1465 (2024)

مصطلحات موضوعية: Transcranial magnetic stimulation (TMS), electromyography (EMG), 3D convolutional neural network (3D CNN), inverse imaging, generative modeling, Medical technology, R855-855.5, Therapeutics. Pharmacology, RM1-950

الوصف: Transcranial magnetic stimulation (TMS) is often applied to the motor cortex to stimulate a collection of motor evoked potentials (MEPs) in groups of peripheral muscles. The causal interface between TMS and MEP is the selective activation of neurons in the motor cortex; moving around the TMS ‘spot’ over the motor cortex causes different MEP responses. A question of interest is whether a collection of MEP responses can be used to identify the stimulated locations on the cortex, which could potentially be used to then place the TMS coil to produce chosen sets of MEPs. In this work we leverage our previous report on a 3D convolutional neural network (CNN) architecture that predicted MEPs from the induced electric field, to tackle an inverse imaging task in which we start with the MEPs and estimate the stimulated regions on the motor cortex. We present and evaluate five different inverse imaging CNN architectures, both conventional and generative, in terms of several measures of reconstruction accuracy. We found that one architecture, which we propose as M2M-InvNet, consistently achieved the best performance.

وصف الملف: electronic resource

Relation: https://ieeexplore.ieee.org/document/10473158/; https://doaj.org/toc/1558-0210

URL الوصول: https://doaj.org/article/59b96e6f26a44faf86453f1d4a1dd09c

المؤلفون: Justine Magnuson, Mehmet A Ozdemir, Elon Mathieson, Sofia Kirkman, Brice Passera, Sumientra Rampersad, Alyssa B Dufour, Dana Brooks, Alvaro Pascual-Leone, Peter J Fried, Mouhsin M Shafi, Recep A Ozdemir

المصدر: PLoS ONE, Vol 18, Iss 6, p e0286465 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: BackgroundRepetitive transcranial magnetic stimulation (rTMS) is widely used in both research and clinical settings to modulate human brain function and behavior through the engagement of the mechanisms of plasticity. Based upon experiments using single-pulse TMS as a probe, the physiologic mechanism of these effects is often assumed to be via changes in cortical excitability, with 10 Hz rTMS increasing and 1 Hz rTMS decreasing the excitability of the stimulated region. However, the reliability and reproducibility of these rTMS protocols on cortical excitability across and within individual subjects, particularly in comparison to robust sham stimulation, have not been systematically examined.ObjectivesIn a cohort of 28 subjects (39 ± 16 years), we report the first comprehensive study to (1) assess the neuromodulatory effects of traditional 1 Hz and 10 Hz rTMS on corticospinal excitability against both a robust sham control, and two other widely used patterned rTMS protocols (intermittent theta burst stimulation, iTBS; and continuous theta burst stimulation, cTBS), and (2) determine the reproducibility of all rTMS protocols across identical repeat sessions.ResultsAt the group level, neither 1 Hz nor 10 Hz rTMS significantly modulated corticospinal excitability. 1 Hz and 10 Hz rTMS were also not significantly different from sham and both TBS protocols. Reproducibility was poor for all rTMS protocols except for sham. Importantly, none of the real rTMS and TBS protocols demonstrated greater neuromodulatory effects or reproducibility after controlling for potential experimental factors including baseline corticospinal excitability, TMS coil deviation and the number of individual MEP trials.ConclusionsThese results call into question the effectiveness and reproducibility of widely used rTMS techniques for modulating corticospinal excitability, and suggest the need for a fundamental rethinking regarding the potential mechanisms by which rTMS affects brain function and behavior in humans.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/b6977b0b5767438ba2182b0e9bf517bc

المؤلفون: Sumientra Rampersad, Biel Roig-Solvas, Mathew Yarossi, Alan Dorval, Dana Brooks

المصدر: Brain Stimulation, Vol 16, Iss 1, Pp 138- (2023)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1935861X23000773; https://doaj.org/toc/1935-861X

URL الوصول: https://doaj.org/article/ccee9712b304435abdfd276e571d7786

المؤلفون: Justine Magnuson, Elon Mathieson, Sofia Kirkman, Brice Passera, Sumientra Rampersad, Alyssa B. Dufour, Dana Brooks, Alvaro Pascual-Leone, Peter Fried, Mouhsin Shafi, Recep Ozdemir

المصدر: Brain Stimulation, Vol 16, Iss 1, Pp 350- (2023)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1935861X23006757; https://doaj.org/toc/1935-861X

URL الوصول: https://doaj.org/article/70ac93ea3a484aee85e6a60622f49ad4

المؤلفون: Kurt Weaver, Sumientra Rampersad, Chantel Marie Charlebois, Tyler Davis, Courtnie Paschall, Jeff Herron, Andrew Ko, Dana Brooks, Jeff Ojemann, John Rolston, Chuck Dorval

المصدر: Brain Stimulation, Vol 16, Iss 1, Pp 380- (2023)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1935861X2300757X; https://doaj.org/toc/1935-861X

URL الوصول: https://doaj.org/article/b43a6c4b36ad4ad39bf71b336d1628f9

المؤلفون: Sumientra Rampersad, Biel Roig-Solvas, Mathew Yarossi, Alan Dorval, Dana Brooks

المصدر: Brain Stimulation, Vol 14, Iss 6, Pp 1619- (2021)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1935861X21003466; https://doaj.org/toc/1935-861X

URL الوصول: https://doaj.org/article/ac9e3fa5999e4e06b0f0d329355dc947

المؤلفون: Jess Tate, Sumientra Rampersad, Chantel Charlebois, Zexin Liu, Jake Bergquist, Dan White, Lindsay Rupp, Dana Brooks, Akil Narayan, Rob MacLeod

المصدر: Brain Stimulation, Vol 14, Iss 6, Pp 1659-1660 (2021)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1935861X21004721; https://doaj.org/toc/1935-861X

URL الوصول: https://doaj.org/article/ba53e9484d844f35b3ecaa3e171bfc6c

المؤلفون: Jess Tate, Karli Gillette, Brett Burton, Wilson Good, Brian Zenger, Jaume Coll-Font, Dana Brooks, Rob MacLeod

المصدر: Frontiers in Physiology, Vol 9 (2018)

مصطلحات موضوعية: ECG imaging, ECG forward simulation, cardiac source sampling, epicardial potentials, body-surface potentials, Physiology, QP1-981

الوصف: A continuing challenge in validating electrocardiographic imaging (ECGI) is the persistent error in the associated forward problem observed in experimental studies. One possible cause of this error is insufficient representation of the cardiac sources; cardiac source measurements often sample only the ventricular epicardium, ignoring the endocardium and the atria. We hypothesize that measurements that completely cover the pericardial surface are required for accurate forward solutions. In this study, we used simulated and measured cardiac potentials to test the effect of different levels of spatial source sampling on the forward simulation. Not surprisingly, increasing the source sampling over the atria reduced the average error of the forward simulations, but some sampling strategies were more effective than others. Uniform and random distributions of samples across the atrial surface were the most efficient strategies in terms of lowest error with the fewest sampling locations, whereas “single direction” strategies, i.e., adding to the atrioventricular (AV) plane or atrial roof only, were the least efficient. Complete sampling of the atria is needed to eliminate errors from missing cardiac sources, but while high density sampling that covers the entire atria yields the best results, adding as few as 11 electrodes on the atria can significantly reduce these errors. Future validation studies of the ECG forward simulations should use a cardiac source sampling that takes these considerations into account, which will, in turn, improve validation and understanding of ECGI.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphys.2018.01304/full; https://doaj.org/toc/1664-042X

URL الوصول: https://doaj.org/article/d97b5d680aee48958b3285cf97bdb035

المؤلفون: Axel Westerwick, Daniel Sude, Dana Brooks, Berkay Kaplan, Silvia Knobloch-Westerwick

المصدر: Mass Communication and Society. 26:300-325

مصطلحات موضوعية: Communication

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::70a7e88562e090fbb0814ac3d6e9d17a
https://doi.org/10.1080/15205436.2022.2056854

المؤلفون: Kimia Shayestehfard, Dana Brooks, Stratis Ioannidis

المصدر: Proceedings of the 2023 SIAM International Conference on Data Mining (SDM) ISBN: 9781611977653

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3ae058144d13ad59a29d78035a36c1d7
https://doi.org/10.1137/1.9781611977653.ch31