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1دورية أكاديمية
المؤلفون: Raquel Sánchez, Carme Boqué, Constantino Fondevila, David Nicolás, Wen Zhong, Ariadna Sánchez, Eva Pueyo-Périz, Elena Ramírez-Maldonado, Marta Rodrigo-Rodrigo, Sandra Lopez Gordo, Daniel Coronado Llanos, Joao Vaz, Rosa Jorba-Martin, Sonia Babiloni, Laia Blanco, Sandra M Bacca, Joaquim Balsells, Pablo Collera Ormazabal, Ignasi Elizalde, Laia Estalella, Maria Teresa Fernández Planas, Lidia Florit Serra, Inmaculada Fonoll, Nil Gómez Vallvé, Sergio González, Jimy Jara, Jiazhen Li, Erik Llàcer-Millán, Rui Pedro Major Branco, Robert Memba, Carme Mias, Elizabeth Pando, Mihai-Calin Pavel, Jing Quiao, Teresa Soriano, Eva Vaquero, Marina Vila Tura, Pengyu Wu, Heng Xi
المصدر: BMJ Open, Vol 13, Iss 6 (2023)
مصطلحات موضوعية: Medicine
الوصف: Introduction Acute pancreatitis (AP) is the third most common gastrointestinal disease resulting in hospital admission, with over 70% of AP admissions being mild cases. In the USA, it costs 2.5 billion dollars annually. The most common standard management of mild AP (MAP) still is hospital admission. Patients with MAP usually achieve complete recovery in less than a week and the severity predictor scales are reliable. The aim of this study will be to compare three different strategies for the management of MAP.Methods/design This is a randomised, controlled, three-arm multicentre trial. Patients with MAP will be randomly assigned to group A (outpatient), B (home care) or C (hospital admission). The primary endpoint of the trial will be the treatment failure rate of the outpatient/home care management for patients with MAP compared with that of hospitalised patients. The secondary endpoints will be pain relapse, diet intolerance, hospital readmission, hospital length of stay, need for intensive care unit admission, organ failure, complications, costs and patient satisfaction. The general feasibility, safety and quality checks required for high-quality evidence will be adhered to.Ethics and dissemination The study (version 3.0, 10/2022) has been approved by the Scientific and Research Ethics Committee of the ‘Institut d’Investigació Sanitaria Pere Virgili-IISPV’ (093/2022). This study will provide evidence as to whether outpatient/home care is similar to usual management of AP. The conclusions of this study will be published in an open-access journal.Trial registration number ClinicalTrials.gov Registry (NCT05360797).
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Ana García-Rodríguez, Yael Tudela, Henry Córdova, Sabela Carballal, Ingrid Ordás, Leticia Moreira, Eva Vaquero, Oswaldo Ortiz, Liseth Rivero, F. Javier Sánchez, Miriam Cuatrecasas, Maria Pellisé, Jorge Bernal, Glòria Fernández-Esparrach
المصدر: Endoscopy International Open, Vol 10, Iss 09, Pp E1201-E1207 (2022)
مصطلحات موضوعية: Diseases of the digestive system. Gastroenterology, RC799-869
الوصف: Background and study aims Artificial intelligence is currently able to accurately predict the histology of colorectal polyps. However, systems developed to date use complex optical technologies and have not been tested in vivo. The objective of this study was to evaluate the efficacy of a new deep learning-based optical diagnosis system, ATENEA, in a real clinical setting using only high-definition white light endoscopy (WLE) and to compare its performance with endoscopists. Methods ATENEA was prospectively tested in real life on consecutive polyps detected in colorectal cancer screening colonoscopies at Hospital Clínic. No images were discarded, and only WLE was used. The in vivo ATENEA’s prediction (adenoma vs non-adenoma) was compared with the prediction of four staff endoscopists without specific training in optical diagnosis for the study purposes. Endoscopists were blind to the ATENEA output. Histology was the gold standard. Results Ninety polyps (median size: 5 mm, range: 2–25) from 31 patients were included of which 69 (76.7 %) were adenomas. ATENEA correctly predicted the histology in 63 of 69 (91.3 %, 95 % CI: 82 %–97 %) adenomas and 12 of 21 (57.1 %, 95 % CI: 34 %–78 %) non-adenomas while endoscopists made correct predictions in 52 of 69 (75.4 %, 95 % CI: 60 %–85 %) and 20 of 21 (95.2 %, 95 % CI: 76 %–100 %), respectively. The global accuracy was 83.3 % (95 % CI: 74%–90 %) and 80 % (95 % CI: 70 %–88 %) for ATENEA and endoscopists, respectively. Conclusion ATENEA can accurately be used for in vivo characterization of colorectal polyps, enabling the endoscopist to make direct decisions. ATENEA showed a global accuracy similar to that of endoscopists despite an unsatisfactory performance for non-adenomatous lesions.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Joan Llach, Paula Aguilera, Ariadna Sánchez, Angels Ginès, Glòria Fernández-Esparrach, Guillem Soy, Oriol Sendino, Eva Vaquero, Sabela Carballal, Fabio Ausania, Juan Ramón Ayuso, Anna Darnell, María Pellisé, Sergi Castellví-Bel, Susana Puig, Francesc Balaguer, Leticia Moreira
المصدر: Cancers, Vol 15, Iss 6, p 1690 (2023)
مصطلحات موضوعية: pancreatic cancer, surveillance, hereditary, CDKN2A, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Three percent of patients with pancreatic ductal adenocarcinoma (PDAC) present a germline pathogenic variant (GPV) associated with an increased risk of this tumor, CDKN2A being one of the genes associated with the highest risk. There is no clear consensus on the recommendations for surveillance in CDKN2A GPV carriers, although the latest guidelines from the International Cancer of the Pancreas Screening Consortium recommend annual endoscopic ultrasound (EUS) or magnetic resonance imaging (MRI) regardless of family history. Our aim is to describe the findings of the PDAC surveillance program in a cohort of healthy CDKN2A GPV heterozygotes. This is an observational analysis of prospectively collected data from all CDKN2A carriers who underwent screening for PDAC at the high-risk digestive cancer clinic of the “Hospital Clínic de Barcelona” between 2013 and 2021. A total of 78 subjects were included. EUS or MRI was performed annually with a median follow-up of 66 months. Up to 17 pancreatic findings were described in 16 (20.5%) individuals under surveillance, although most of them were benign. No significant precursor lesions were identified, but an early PDAC was detected and treated. While better preventive strategies are developed, we believe that annual surveillance with EUS and/or MRI in CDKN2A GPV heterozygotes may be beneficial.
وصف الملف: electronic resource
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المؤلفون: Núria Lluís, Horacio Asbun, Sandra Basso, Natalia Corzo-Zamora, Andrés Gelrud, Edson Guzmán-Calderón, Edgard E. Lozada-Hernández, Carla Mancilla, Rodrigo Mansilla-Vivar, Analía V. Pasqua, Mario Peláez-Luna, Guido Villa-Gómez Roig, Pedro Zapater, Félix Lluís, Eva Vaquero, José Manuel Ramia, Enrique de Madaria
المصدر: Gastroenterología y Hepatología.
مصطلحات موضوعية: Hepatology, Gastroenterology
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المؤلفون: Jaume, Boadas, Joaquin, Balsells, Juli, Busquets, Antoni, Codina-B, Anna, Darnell, Francisco, Garcia-Borobia, Àngels, Ginés, Joan, Gornals, Guillem, Gruartmoner, Lucas, Ilzarbe, Xavier, Merino, Lluís, Oms, Ignasi, Puig, Valentí, Puig-Diví, Eva, Vaquero, Francesc, Vida, Xavier, Molero
المصدر: Gastroenterologia y hepatologia. 38(2)
مصطلحات موضوعية: Cholangiopancreatography, Endoscopic Retrograde, Nutritional Support, Multiple Organ Failure, Disease Management, Prognosis, Necrosis, Pancreatitis, Cholelithiasis, Risk Factors, Acute Disease, Pancreatic Pseudocyst, Drainage, Humans, Thrombophilia, Exocrine Pancreatic Insufficiency, Analgesia, Intra-Abdominal Hypertension
الوصف: The incidence of acute pancreatitis (AP) is increasing. AP is one of the gastrointestinal diseases that most frequently requires hospital admission in affected individuals. In the last few years, considerable scientific evidence has led to substantial changes in the medical and surgical treatment of this disease. New knowledge of the physiopathology of AP indicates that its severity is influenced by its systemic effects (organ failure), especially if the disease is persistent, and also by local complications (fluid collections or necrosis), especially if these become infected. Treatment should be personalized and depends on the patient's clinical status, the location of the necrosis, and disease stage.
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المؤلفون: Salvador, Navarro, Joana, Ferrer, Josep Antoni, Bombí, Miguel Angel, López-Boado, Juan Ramón, Ayuso, Angels, Ginés, Gloria, Fernández-Esparrach, Eva, Vaquero, Miriam, Cuatrecasas, Laureano, Fernández-Cruz
المصدر: Medicina clinica. 138(3)
مصطلحات موضوعية: Adult, Pancreatic Neoplasms, Ki-67 Antigen, Pancreatectomy, Humans, Female, Middle Aged, Carcinoma, Papillary, Follow-Up Studies, Retrospective Studies
الوصف: Solid pseudopapillary neoplasms (SPNs) are rare tumours of the exocrine pancreas. Although they can develop metastasis, the prognosis is good. The aim of this study was to describe the characteristics of these tumours attended in our hospital.All cases of SPN in the database of the Pathology Department between 1991 and 2010 were included. Age, sex, symptoms, type of surgery, pathologic and immunohistochemical characteristics, and clinical evolution were analyzed.Six cases were identified; all of them were women with a median age of 27.5 years. One patient presented haemoperitoneum, 2 abdominal pain and 3 were diagnosed incidentally. The most frequent localization was the pancreatic tail (n=4) and the median size was 7.7 cm. Four tumours were benign and 2 carcinomas. One of them had liver and lymph node metastases. Ki-67 proliferation index was low (1-3%). After a median follow-up of 33.5 months, all patients were alive and without evidence of relapse.SPNs occur in young women. In most cases surgical resection is curative. A low mitotic index confers a good prognosis and a long survival.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e2d75dc2f9dc6e90465ae1a2be17f852
https://pubmed.ncbi.nlm.nih.gov/22036462 -
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المؤلفون: Salvador, Navarro, Eva, Vaquero, Joan, Maurel, Josep Antoni, Bombí, Carmen, De Juan, Jaime, Feliu, Laureano, Fernández Cruz, Angels, Ginés, Enrique, Girela, Ricardo, Rodríguez, Luis, Sabater, Antonio, Zarco
المصدر: Medicina clinica. 134(14)
مصطلحات موضوعية: Diagnostic Imaging, Male, Biopsy, Incidence, Adenocarcinoma, Prognosis, Neoplasm Proteins, Pancreatic Neoplasms, Genes, ras, Pancreatectomy, Risk Factors, Biomarkers, Tumor, Humans, Keratins, Mass Screening, Female, Neoplasm Staging
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المؤلفون: Salvador, Navarro, Joaquín, Amador, Lidia, Argüello, Carmen, Ayuso, Jaume, Boadas, Gonzalo, de Las Heras, Antonio, Farré, Laureano, Fernández-Cruz, Angels, Ginés, Luisa, Guarner, Antonio, López Serrano, Josep, Llach, Félix, Lluis, Enrique, de Madaria, Juan, Martínez, Raúl, Mato, Xavier, Molero, Lluís, Oms, Miguel, Pérez-Mateo, Eva, Vaquero
المصدر: Gastroenterologia y hepatologia. 31(6)
مصطلحات موضوعية: Cholangiopancreatography, Endoscopic Retrograde, Necrosis, Critical Care, Pancreatitis, Nutritional Support, Acute Disease, Humans, Pancreas
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