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1دورية أكاديمية
المؤلفون: Elliott F. Miot, Brian M. Worthington, Kar Hon Ng, Lucy de Guilhem de Lataillade, Mac P. Pierce, Yunshi Liao, Ronald Ko, Marcus H. Shum, William Y. Cheung, Edward C. Holmes, Kathy S. Leung, Huachen Zhu, Leo L. Poon, Malik J. Peiris, Yi Guan, Gabriel M. Leung, Joseph T. Wu, Tommy T. Lam
المصدر: Emerging Infectious Diseases, Vol 28, Iss 2, Pp 467-470 (2022)
مصطلحات موضوعية: COVID-19, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, coronavirus disease, rodents, serosurveillance, Medicine, Infectious and parasitic diseases, RC109-216
الوصف: We report surveillance conducted in 217 pestiferous rodents in Hong Kong for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We did not detect SARS-CoV-2 RNA but identified 1 seropositive rodent, suggesting exposure to a virus antigenically similar to SARS-CoV-2. Potential exposure of urban rodents to SARS-CoV-2 cannot be ruled out.
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Fabien Aubry, Sofie Jacobs, Maïlis Darmuzey, Sebastian Lequime, Leen Delang, Albin Fontaine, Natapong Jupatanakul, Elliott F. Miot, Stéphanie Dabo, Caroline Manet, Xavier Montagutelli, Artem Baidaliuk, Fabiana Gámbaro, Etienne Simon-Lorière, Maxime Gilsoul, Claudia M. Romero-Vivas, Van-Mai Cao-Lormeau, Richard G. Jarman, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Johan Neyts, Laurent Nguyen, Suzanne J. F. Kaptein, Louis Lambrechts
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
مصطلحات موضوعية: Science
الوصف: Here, the authors compare seven low passage Zika virus (ZIKV) strains representing the recently circulating viral genetic diversity of African and Asian strains and find that African ZIKV strains have higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice.
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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3دورية أكاديمية
المؤلفون: Elodie Calvez, Elliott F. Miot, Sitsana Keosenhom, Vaekey Vungkyly, Souksakhone Viengphouthong, Phaithong Bounmany, Paul T. Brey, Sébastien Marcombe, Marc Grandadam
المصدر: Pathogens, Vol 12, Iss 1, p 31 (2022)
مصطلحات موضوعية: Chikungunya virus, Aedes aegypti, vector competence, Lao PDR, Medicine
الوصف: In 2012–2013, chikungunya virus (CHIKV) was the cause of a major outbreak in the southern part of Lao People’s Democratic Republic (Lao PDR). Since then, only a few imported cases, with isolates belonging to different lineages, were recorded between 2014 and 2020 in Vientiane capital and few autochthonous cases of ECSA-IOL lineage were detected in the south of the country in 2020. The CHIKV epidemiological profile contrasts with the continuous and intensive circulation of dengue virus in the country, especially in Vientiane capital. The study’s aim was to investigate the ability of the local field-derived Aedes aegypti population from Vientiane capital to transmit the Asian and ECSA-IOL lineages of CHIKV. Our results revealed that, for both CHIKV lineages, infection rates were low and dissemination rates were high. The transmission rates and efficiencies evidenced a low vector competence for the CHIKV tested. Although this population of Ae. aegypti showed a relatively modest vector competence for these two CHIKV lineages, several other factors could influence arbovirus emergence such as the longevity and density of female mosquitoes. Due to the active circulation of CHIKV in Southeast Asia, investigations on these factors should be done to prevent the risk of CHIKV emergence and spread in Lao PDR and neighboring countries.
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: Elliott F Miot, Fabien Aubry, Stéphanie Dabo, Ian H Mendenhall, Sébastien Marcombe, Cheong H Tan, Lee C Ng, Anna-Bella Failloux, Julien Pompon, Paul T Brey, Louis Lambrechts
المصدر: PLoS Neglected Tropical Diseases, Vol 13, Iss 10, p e0007783 (2019)
مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
الوصف: The case-fatality rate of yellow fever virus (YFV) is one of the highest among arthropod-borne viruses (arboviruses). Although historically, the Asia-Pacific region has remained free of YFV, the risk of introduction has never been higher due to the increasing influx of people from endemic regions and the recent outbreaks in Africa and South America. Singapore is a global hub for trade and tourism and therefore at high risk for YFV introduction. Effective control of the main domestic mosquito vector Aedes aegypti in Singapore has failed to prevent re-emergence of dengue, chikungunya and Zika viruses in the last two decades, raising suspicions that peridomestic mosquito species untargeted by domestic vector control measures may contribute to arbovirus transmission. Here, we provide empirical evidence that the peridomestic mosquito Aedes malayensis found in Singapore can transmit YFV. Our laboratory mosquito colony recently derived from wild Ae. malayensis in Singapore was experimentally competent for YFV to a similar level as Ae. aegypti controls. In addition, we captured Ae. malayensis females in one human-baited trap during three days of collection, providing preliminary evidence that host-vector contact may occur in field conditions. Finally, we detected Ae. malayensis eggs in traps deployed in high-rise building areas of Singapore. We conclude that Ae. malayensis is a competent vector of YFV and re-emphasize that vector control methods should be extended to target peridomestic vector species.
وصف الملف: electronic resource
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المؤلفون: Pauline C. Dufour, Elliott F. Miot, Tsz Chun So, Shun Long Tang, Emily E. Jones, Tsz Ching Kong, Felix Landry Yuan, Yik-Hei Sung, Caroline Dingle, Timothy C. Bonebrake
المصدر: Proceedings of the Royal Society B: Biological Sciences. 289
مصطلحات موضوعية: General Immunology and Microbiology, Endangered Species, Animals, Humans, Animals, Wild, Lizards, Biodiversity, Medicine, Traditional, General Medicine, General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, General Environmental Science
الوصف: The pet trade and Traditional Chinese Medicine (TCM) consumption are major drivers of global biodiversity loss. Tokay geckos ( Gekko gecko ) are among the most traded reptile species worldwide. In Hong Kong, pet and TCM markets sell tokay geckos while wild populations also persist. To clarify connections between trade sources and destinations, we compared genetics and stable isotopes of wild tokays in local and non-local populations to dried individuals from TCM markets across Hong Kong. We found that TCM tokays are likely not of local origin. Most wild tokays were related to individuals in South China, indicating a probable natural origin. However, two populations contained individuals more similar to distant populations, indicating pet trade origins. Our results highlight the complexity of wildlife trade impacts within trade hubs. Such trade dynamics complicate local legal regulation when endangered species are protected, but the same species might also be non-native and possibly damaging to the environment.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f686a4a0984f51e649e9b850250d6cf8
https://doi.org/10.1098/rspb.2022.1011 -
6دورية أكاديمية
المؤلفون: C. Massart, N. Giusti, R. Beauwens, J.E. Dumont, F. Miot, J. Van Sande
المصدر: FEBS Open Bio, Vol 4, Iss C, Pp 55-59 (2014)
مصطلحات موضوعية: Diphenyleneiodonium, O2 radical generation, NOX, DUOX, Iodide efflux, Thyroid, Biology (General), QH301-705.5
الوصف: NADPH oxidases (NOXes) and dual oxidases (DUOXes) generate O2.− and H2O2. Diphenyleneiodonium (DPI) inhibits the activity of these enzymes and is often used as a specific inhibitor. It is shown here that DPI, at concentrations similar to those which inhibit the generation of O2 derivatives, activated the efflux of radioiodide but not of its analog 99mTcO4− nor of the K+ cation mimic 86Rb+ in thyroid cells, in the PCCl3 rat thyroid cell line and in COS cell lines expressing the iodide transporter NIS. Effects obtained with DPI, especially in thyroid cells, should therefore be interpreted with caution.
وصف الملف: electronic resource
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المؤلفون: Rosemary Sang, Martin N. Mayanja, Van-Mai Cao-Lormeau, Julius J. Lutwama, Fabien Aubry, Oumar Faye, Veasna Duong, Louis Lambrechts, Sampson Otoo, Isabelle Dusfour, Elliott F. Miot, Joel Lutomiah, John-Paul Mutebi, Alain Kohl, Caroline Manet, Anna B. Crist, Artem Baidaliuk, Xavier Montagutelli, Alongkot Ponlawat, Sarah H. Merkling, Igor Filipović, Christophe Paupy, Claudia M. E. Romero-Vivas, Jewelna Akorli, Noah H. Rose, Cheikh Tidiane Diagne, Anubis Vega-Rúa, Richard G. Jarman, Laura B. Dickson, Ousmane Faye, Davy Jiolle, Victor O. Anyango, Carolyn S. McBride, Gordana Rašić, Daria Martynow, Stéphanie Dabo, Massamba Sylla, Amadou A. Sall
المساهمون: Interactions Virus-Insectes - Insect-Virus Interactions (IVI), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Génétique de la souris - Mouse Genetics, Institut Pasteur [Paris], QIMR Berghofer Medical Research Institute, Princeton University, Collège doctoral [Sorbonne universités], Sorbonne Université (SU), Universidad del Norte, Barranquilla, Unité Transmission, Réservoir et Diversité des Pathogènes [Pasteur Guadeloupe, France] (TReD-Path), Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française], Institut Pasteur de la Guyane, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre International de Recherches Médicales de Franceville (CIRMF), Uganda Virus Research Institute (UVRI), MRC - University of Glasgow Centre for Virus Research, Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Armed Forces Research Institute of Medical Sciences [Bangkok] (AFRIMS), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), University of Ghana, Kenya Medical Research Institute (KEMRI), Centers for Disease Control and Prevention, Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD), Walter Reed Army Institute of Research, Arbovirus et Virus de Fièvres Hémorragiques [Dakar, Sénégal], Institut Pasteur de Dakar, This work was primarily funded by the European Union’s Horizon 2020 research and innovation programme under ZikaPLAN grant agreement no. 734584 (to L.L.). This work was also supported by Agence Nationale de la Recherche (grants ANR-16-CE35-0004-01, ANR-17-ERC2-0016-01, and ANR-18-CE35-0003-01 to L.L.), the French Government’s Investissement d’Avenir program Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID to L.L. and X.M.), the Inception program (Investissement d’Avenir grant ANR-16-CONV-0005 to L.L.), the City of Paris Emergence(s) program in Biomedical Research (to L.L.), the QIMR Berghofer Medical Research Institute (Seed Funding Grant to G.R.), the Programme Opérationnel FEDER-Guadeloupe-Conseil Régional 2014-2020 (grant 2015-FED-192 to A.V.-R.), the European Union's Horizon 2020 research and innovation programme under ZIKALLIANCE grant agreement no. 734548 (to A.V.-R.), the U.S. National Institutes of Health (grant NIDCD R00-DC012069 to C.S.M.), a Helen Hay Whitney Postdoctoral Fellowship (to N.H.R.), the UK Medical Research Council (grant MC_UU_12014/8 to A.K.), and the CDC (J.-P.M.). C.S.M. is a New York Stem Cell Foundation—Robertson Investigator., ANR-16-CE35-0004,MOSQUIBIOTA,Contribution de la diversité bactérienne intestinale à la capacité vectorielle d'Aedes aegypti(2016), ANR-17-ERC2-0016,GxG,Base génétique de la spécificité génotype-génotype dans l'interaction naturelle entre un virus et son insecte vecteur(2017), ANR-18-CE35-0003,BAKOUMBA,Dissection de la base génétique d'un phénotype naturel de résistance à la dengue chez le moustique Aedes aegypti(2018), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), European Project: 734584,ZikaPLAN, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Collège Doctoral
المصدر: Science
Science, American Association for the Advancement of Science, 2020, 370 (6519), pp.991-996. ⟨10.1126/science.abd3663⟩
Science, 2020, 370 (6519), pp.991-996. ⟨10.1126/science.abd3663⟩مصطلحات موضوعية: viruses, [SDV]Life Sciences [q-bio], 030231 tropical medicine, Population, Zoology, Human pathogen, MESH: Zika Virus, Aedes aegypti, MESH: Host Microbial Interactions, Arbovirus, Zika virus, 03 medical and health sciences, 0302 clinical medicine, MESH: Zika Virus Infection, MESH: Mice, Inbred C57BL, Out of africa, parasitic diseases, medicine, MESH: Animals, Zoonotic virus, education, MESH: Mice, 030304 developmental biology, 0303 health sciences, education.field_of_study, Multidisciplinary, MESH: Humans, biology, fungi, virus diseases, MESH: Aedes, biology.organism_classification, medicine.disease, 3. Good health, Vector (epidemiology), MESH: Mosquito Vectors
الوصف: Domesticating Zika virus Why hasn't Zika virus (ZIKV) disease caused as much devastation in Africa, its continent of origin, as it has in the Americas? Outside of Africa, this flavivirus is transmitted by a ubiquitous mosquito subspecies, Aedes aegypti aegypti , which emerged from the African forerunner subspecies A. aegypti formosus and acquired a preference for human blood and a peridomestic lifestyle. Now, this subspecies colonizes many intertropical cities, aided by climate change and human trash. Aubry et al. tested 14 laboratory mosquito colonies for their relative susceptibility to ZIKV. Quantitative trait locus mapping showed differences on chromosome 2 between mosquitoes from Gabon and Guadeloupe. Mouse infection experiments revealed that African mosquitoes transmitted a smaller virus inoculum than the South American insects. Increased susceptibility coupled with the ability of A. aegypti aegypti to breed in any discarded object containing water has amplified the problematic nature of this virus as it has circumnavigated the world. Science , this issue p. 991
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f81cd7098feb66a6565b5e9911ebd7b
https://hal-pasteur.archives-ouvertes.fr/pasteur-03260288 -
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المؤلفون: Maïlis Darmuzey, Natapong Jupatanakul, Ousmane Faye, Suzanne J.F. Kaptein, Leen Delang, Caroline Manet, Maxime Gilsoul, Cheikh Tidiane Diagne, Richard G. Jarman, Stéphanie Dabo, Johan Neyts, Elliott F. Miot, Albin Fontaine, Fabiana Gámbaro, Artem Baidaliuk, Laurent Nguyen, Etienne Simon-Loriere, Sofie Jacobs, Xavier Montagutelli, Louis Lambrechts, Van-Mai Cao-Lormeau, Oumar Faye, Claudia M. E. Romero-Vivas, Sebastian Lequime, Amadou A. Sall, Fabien Aubry
مصطلحات موضوعية: Fetus, Microcephaly, medicine, Outbreak, Fetal loss, Biology, biology.organism_classification, Pathogenicity, medicine.disease, Virology, Virus, Zika virus, Immunocompetent mouse
الوصف: SummaryThe global emergence of Zika virus (ZIKV) in the last decade revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects such as microcephaly. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compared the transmissibility and pathogenicity of seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We found that recent African ZIKV strains largely outperformed their Asian counterparts in mosquito transmission kinetics experiments, which translated into a markedly higher epidemic potential in outbreak computer simulations. In addition, African ZIKV strains were significantly more lethal than Asian ZIKV strains in immunocompromised adult mice. Finally, prenatal infection of immunocompetent mouse embryos with an African ZIKV strain resulted in embryonic death whereas it caused microcephaly with Asian ZIKV strains. Together, our results demonstrate the high epidemic potential and pathogenicity of recent ZIKV strains from Africa. Importantly, they also imply that the African ZIKV lineage could more easily go unnoticed by public health surveillance systems than the Asian ZIKV lineage due to its propensity to cause fetal loss rather than birth defects.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::748f67109ae47e921843e669d3f614c2
https://doi.org/10.1101/2020.09.01.277673 -
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المؤلفون: Fabien, Aubry, Stéphanie, Dabo, Caroline, Manet, Igor, Filipović, Noah H, Rose, Elliott F, Miot, Daria, Martynow, Artem, Baidaliuk, Sarah H, Merkling, Laura B, Dickson, Anna B, Crist, Victor O, Anyango, Claudia M, Romero-Vivas, Anubis, Vega-Rúa, Isabelle, Dusfour, Davy, Jiolle, Christophe, Paupy, Martin N, Mayanja, Julius J, Lutwama, Alain, Kohl, Veasna, Duong, Alongkot, Ponlawat, Massamba, Sylla, Jewelna, Akorli, Sampson, Otoo, Joel, Lutomiah, Rosemary, Sang, John-Paul, Mutebi, Van-Mai, Cao-Lormeau, Richard G, Jarman, Cheikh T, Diagne, Oumar, Faye, Ousmane, Faye, Amadou A, Sall, Carolyn S, McBride, Xavier, Montagutelli, Gordana, Rašić, Louis, Lambrechts
المصدر: Science (New York, N.Y.). 370(6519)
مصطلحات موضوعية: Mice, Inbred C57BL, Mice, Host Microbial Interactions, Aedes, Zika Virus Infection, Animals, Humans, Mosquito Vectors, Zika Virus
الوصف: The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::9a6da8ae1fb41044e60c7a48e985e4ee
https://pubmed.ncbi.nlm.nih.gov/33214283 -
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المؤلفون: Stéphanie Dabo, Catherine Oke, Elodie Calvez, Louis Lambrechts, Elliott F. Miot, James G. Logan, Paul T. Brey, Fabien Aubry, Sébastien Marcombe, Marc Grandadam
المساهمون: Interactions Virus-Insectes - Insect-Virus Interactions (IVI), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Sorbonne Université (SU), Institut Pasteur du Laos, Réseau International des Instituts Pasteur (RIIP), London School of Hygiene and Tropical Medicine (LSHTM), This work was funded by the Institut Pasteur du Laos, the Institut Pasteur’s International Division (ACIP 2016-16), the Agence Nationale de la Recherche (grant ANR-17-ERC2-0016-01), the French Government’s Investissement d’Avenir program Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID), the City of Paris Emergence(s) program in Biomedical Research, and a JICA/AMED SATREPS project for 'the development of innovative research technique in genetic epidemiology of malaria and other parasitic diseases in the Lao PDR for containing their expanding endemicity.' The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication., ANR-17-ERC2-0016,GxG,Base génétique de la spécificité génotype-génotype dans l'interaction naturelle entre un virus et son insecte vecteur(2017), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.7750. ⟨10.1038/s41598-020-64696-9⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, 2020, 10 (1), pp.7750. ⟨10.1038/s41598-020-64696-9⟩مصطلحات موضوعية: 0301 basic medicine, Risk, Conservation of Natural Resources, [SDV]Life Sciences [q-bio], viruses, 030231 tropical medicine, Population, lcsh:Medicine, Zoology, Aedes aegypti, Mosquito Vectors, Dengue virus, medicine.disease_cause, Arbovirus, Article, 03 medical and health sciences, 0302 clinical medicine, Species Specificity, Aedes, medicine, Animals, Humans, lcsh:Science, education, Ecological epidemiology, education.field_of_study, Multidisciplinary, biology, lcsh:R, Yellow fever, virus diseases, biology.organism_classification, Blood feeding, medicine.disease, Aedes malayensis, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, 030104 developmental biology, Olfactometer, Laos, Viral infection, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Odorants, lcsh:Q, Arboviruses
الوصف: Many emerging arboviruses of global public health importance, such as dengue virus (DENV) and yellow fever virus (YFV), originated in sylvatic transmission cycles involving wild animals and forest-dwelling mosquitoes. Arbovirus emergence in the human population typically results from spillover transmission via bridge vectors, which are competent mosquitoes feeding on both humans and wild animals. Another related, but less studied concern, is the risk of ‘spillback’ transmission from humans into novel sylvatic cycles. We colonized a sylvatic population of Aedes malayensis from a forested area of the Nakai district in Laos to evaluate its potential as an arbovirus bridge vector. We found that this Ae. malayensis population was overall less competent for DENV and YFV than an urban population of Aedes aegypti. Olfactometer experiments showed that our Ae. malayensis colony did not display any detectable attraction to human scent in laboratory conditions. The relatively modest vector competence for DENV and YFV, combined with a lack of detectable attraction to human odor, indicate a low potential for this sylvatic Ae. malayensis population to act as an arbovirus bridge vector. However, we caution that opportunistic blood feeding on humans by sylvatic Ae. malayensis may occasionally contribute to bridge sylvatic and human transmission cycles.
وصف الملف: application/pdf
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