المؤلفون: Zhao WM, Shi R, Wang P, He J, Chen Y, Feng YT, Pan HF, Wang DG

المصدر: Journal of Inflammation Research, Vol Volume 15, Pp 3467-3475 (2022)

مصطلحات موضوعية: adverse events, covid-19, inactivated sars-cov-2 vaccine, igm and igg antibody, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

الوصف: Wen-Man Zhao,1,* Rui Shi,1,* Peng Wang,2,* Jun He,3,4,* Yue Chen,5,6 Ya-Ting Feng,5,6 Hai-Feng Pan,5,6 De-Guang Wang1 1Department of Nephrology, The Second Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Hefei, People’s Republic of China; 3Anhui Provincial Center for Disease Control and Prevention, Hefei, People’s Republic of China; 4Public Health Research Institute of Anhui Province, Hefei, People’s Republic of China; 5Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People’s Republic of China; 6Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hai-Feng Pan, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People’s Republic of China, Tel +86 13865972319, Email panhaifeng@ahmu.edu.cn De-Guang Wang, Department of Nephrology, The Second Hospital of Anhui Medical University, Hefei, People’s Republic of China, Tel +86 13865808366, Email wangdeguang@ahmu.edu.cnPurpose: To detect antibody responses to inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in patients undergoing hemodialysis and to investigate vaccine-related adverse events.Patients and Methods: A total of 120 hemodialysis (HD) patients and 24 healthy controls (HCs) who had not been previously infected with SARS-CoV-2 and had received their first dose of the inactivated vaccine (CoronaVac; Sinovac Biotech Ltd) were recruited for this study. All participants were scheduled to receive a second dose of inactivated SARS-CoV-2 vaccine. Serum-specific immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against the SARS-CoV-2 were detected at least 14 days after the second dose of vaccine using a commercial kit. Positive and negative results were defined as a sample/cutoff (S/CO) ratio≥ 1.00 and < 1.00, respectively. Vaccination-related adverse events were assessed using a standardized questionnaire.Results: There were no significant differences regarding the seroprevalences of IgG and IgM antibodies against SARS-CoV-2 and the self-reported vaccination-related adverse events between HD patients and HCs. The analysis results for HD patients suggest that 82 (68.3%) and 27 (22.5%) tested positive for IgG and IgM, respectively. The levels of IgG were higher than IgM levels (P< 0.0001). In addition, the IgG-positive group had significantly higher serum albumin levels than the IgG-negative group (P< 0.05). Only mild vaccine-related adverse events were observed in two patients (1.66%) and in one healthy individual (4.2%).Conclusion: The seroprevalences of IgG and IgM antibodies against SARS-CoV-2 and vaccination-related adverse effects are similar between HD and HCs. The inactivated SARS-CoV-2 vaccine is effective and safe in inducing near-term immunity in hemodialysis patients.Keywords: adverse events, COVID-19, inactivated SARS-CoV-2 vaccine, IgM and IgG antibody

وصف الملف: electronic resource

Relation: https://www.dovepress.com/early-humoral-responses-of-hemodialysis-patients-after-inactivated-sar-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

URL الوصول: https://doaj.org/article/019caa5aeff34f86a8b1564abbabf89b

المؤلفون: Zhao, L, Chen, X, Feng, YT, Wang, GS, Nawaz, I, Hu, LF, Liu, PF

المصدر: CANCER MEDICINE. 8(18):7762-7773

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:142191352

المؤلفون: Guo, K, Ma, ZQ, Zhang, YJ, Han, L, Shao, CJ, Feng, YT, Gao, F, Di, SY, Zhang, ZP, Zhang, J, Tabbo, F, Ekman, S, Suda, K, Cappuzzo, F, Han, J, Li, XF, Yan, XL

المصدر: Journal of experimental & clinical cancer research : CR. 41(1):91

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:149037243

المؤلفون: Liu, PF, Feng, YT, Chen, X, Wang, GS, Nawaz, I, Hu, LF, Zhao, L

المصدر: Life sciences. 230:45-54

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:141109348

المؤلفون: Feng Yt, Rui Gu, Feng Gao, Liangjie Du, Hu Am, Xin Zhang, He Jg, Wu Yy, Mingliang Yang, Chu Hy, De-Gang Yang, Jun Li, Wei Sun

المصدر: Spinal Cord. 51:673-678

مصطلحات موضوعية: Indoles, Time Factors, Behavior, Animal, Traumatic spinal cord injury, business.industry, Recovery of Function, General Medicine, Time optimal, Axons, Microvascular Decompression Surgery, Rats, Rats, Sprague-Dawley, Sprague dawley, Microscopy, Electron, Text mining, Neurology, Blood-Brain Barrier, Anesthesia, Animals, Medicine, Neurology (clinical), business, Locomotion, Myelin Sheath, Spinal Cord Injuries

الوصف: Pathophysiological mechanisms underlying spinal cord injury (SCI) partially involve edema and formation of a hematoma. Myelotomy seems to be a promising intervention. However, the appropriate timing of myelotomy is still unknown in SCI. Here we aimed to determine the timing of microsurgical myelotomy in an animal model of SCI.The SCI model was contusion-induced with a new york university impactor. Sixty-five adult female rats were randomly divided into the following groups: laminectomy alone (the 'sham group', SG), laminectomy plus contusion (the 'contusion group', CG) or laminectomy plus contusion followed by myelotomy at 8, 24 or 48 h (8 h-MTG [myelotomy-treated group], 24 h-MTG or 48 h-MTG). Functional recovery was evaluated via the open field test and the inclined plane test every week after SCI. The percentage of spared white matter area (SWMA) and ultrastructure characteristics of the injured dorsolateral spinal cord were determined on the 42nd day after SCI.Compared with the CG, myelotomy at 8 h-MTG or 24 h-MTG greatly improved the BASSO-BEATTIE- BRESNAHAN scores (P0.008), whereas the 48 h-MTG showed less efficacy (P=0.023). All myelotomy groups showed higher mean angle values in an inclined plane test (P0.005) and had greater percentages of SWMA than the CG. Rats in the 24 h-MTG showed a higher intra-axonal fraction and myelin fraction than those in 48 h-MTG (P0.005).Myelotomy up to 48 h after SCI improves recovery in rats. The potential time window of myelotomy may be between 8 and 24 h after SCI.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcde6f433b00cba11fe3555e0bb2d53b
https://doi.org/10.1038/sc.2013.56

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