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1دورية أكاديمية
المؤلفون: Laura A. Benjamin, Ross W. Paterson, Rachel Moll, Charis Pericleous, Rachel Brown, Puja R. Mehta, Dilan Athauda, Oliver J. Ziff, Judith Heaney, Anna M. Checkley, Catherine F. Houlihan, Michael Chou, Amanda J. Heslegrave, Arvind Chandratheva, Benedict D. Michael, Kaj Blennow, Vinojini Vivekanandam, Alexander Foulkes, Catherine J. Mummery, Michael P. Lunn, Stephen Keddie, Moira J. Spyer, Tom Mckinnon, Melanie Hart, Francesco Carletti, Hans Rolf Jäger, Hadi Manji, Michael S. Zandi, David J. Werring, Eleni Nastouli, Robert Simister, Tom Solomon, Henrik Zetterberg, Jonathan M. Schott, Hannah Cohen, Maria Efthymiou
المصدر: EClinicalMedicine, Vol 39, Iss , Pp 101070- (2021)
مصطلحات موضوعية: Medicine (General), R5-920
الوصف: Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear. Methods: This single-centre cross-sectional study included 106 adult patients: 30 hospitalised COVID-neurological cases, 47 non-neurological COVID-hospitalised controls, and 29 COVID-non-hospitalised controls, recruited between March and July 2020. We evaluated nine antiphospholipid antibodies: anticardiolipin antibodies [aCL] IgA, IgM, IgG; anti-beta-2 glycoprotein-1 [aβ2GPI] IgA, IgM, IgG; anti-phosphatidylserine/prothrombin [aPS/PT] IgM, IgG; and anti-domain I β2GPI (aD1β2GPI) IgG. Findings: There was a high prevalence of antiphospholipid antibodies in the COVID-neurological (73.3%) and non-neurological COVID-hospitalised controls (76.6%) in contrast to the COVID-non-hospitalised controls (48.2%). aPS/PT IgG titres were significantly higher in the COVID-neurological group compared to both control groups (p
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Emma-Jane Mallas, Francesco Carletti, Christopher A. Chaddock, James Woolley, Marco M. Picchioni, Sukhwinder S. Shergill, Fergus Kane, Matthew P.G. Allin, Gareth J. Barker, Diana P. Prata
المصدر: PeerJ, Vol 4, p e1570 (2016)
مصطلحات موضوعية: Genome-wide association, White matter, ZNF804A, Psychosis, Fractional anisotropy, Diffusion tensor imaging, Medicine, Biology (General), QH301-705.5
الوصف: Background. Schizophrenia (SZ) and bipolar disorder (BD) have both been associated with reduced microstructural white matter integrity using, as a proxy, fractional anisotropy (FA) detected using diffusion tensor imaging (DTI). Genetic susceptibility for both illnesses has also been positively correlated in recent genome-wide association studies with allele A (adenine) of single nucleotide polymorphism (SNP) rs1344706 of the ZNF804A gene. However, little is known about how the genomic linkage disequilibrium region tagged by this SNP impacts on the brain to increase risk for psychosis. This study aimed to assess the impact of this risk variant on FA in patients with SZ, in those with BD and in healthy controls. Methods. 230 individuals were genotyped for the rs1344706 SNP and underwent DTI. We used tract-based spatial statistics (TBSS) followed by an analysis of variance, with threshold-free cluster enhancement (TFCE), to assess underlying effects of genotype, diagnosis and their interaction, on FA. Results. As predicted, statistically significant reductions in FA across a widely distributed brain network (p < 0.05, TFCE-corrected) were positively associated both with a diagnosis of SZ or BD and with the double (homozygous) presence of the ZNF804A rs1344706 risk variant (A). The main effect of genotype was medium (d = 0.48 in a 44,054-voxel cluster) and the effect in the SZ group alone was large (d = 1.01 in a 51,260-voxel cluster), with no significant effects in BD or controls, in isolation. No areas under a significant diagnosis by genotype interaction were found. Discussion. We provide the first evidence in a predominantly Caucasian clinical sample, of an association between ZNF804A rs1344706 A-homozygosity and reduced FA, both irrespective of diagnosis and particularly in SZ (in overlapping brain areas). This suggests that the previously observed involvement of this genomic region in psychosis susceptibility, and in impaired functional connectivity, may be conferred through it inducing abnormalities in white matter microstructure.
وصف الملف: electronic resource
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المؤلفون: Charles Coughlan, Hans Rolf Jager, David Brealey, Francesco Carletti, Harpreet Hyare, Rajyabardhan Pattnaik, Praveen Sahu, Sanjib Mohanty, Sarah Logan, Angelika Hoffmann, Samuel Wassmer, Anna Checkley
المصدر: SSRN Electronic Journal.
مصطلحات موضوعية: History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::33db46d5b68341be8b08f21d00b98ffe
https://doi.org/10.2139/ssrn.4388035 -
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المؤلفون: Dilan Athauda, Hadi Manji, Michael S. Zandi, Ross W. Paterson, Moira J. Spyer, Amanda J. Heslegrave, Hannah Cohen, Tom Solomon, Henrik Zetterberg, Vinojini Vivekanandam, Jonathan M. Schott, Benedict D Michael, Alexander Foulkes, Melanie Hart, Michael P. Lunn, Rachel Moll, Hans Rolf Jäger, Robert Simister, Laura A Benjamin, Catherine J. Mummery, Puja Mehta, Stephen Keddie, Judith Heaney, Thomas A. J. McKinnon, Michael Chou, Kaj Blennow, Francesco Carletti, Catherine F Houlihan, Anna M. Checkley, David J. Werring, Maria Efthymiou, Arvind Chandratheva, Eleni Nastouli, Rachel Brown, Oliver J. Ziff, Charis Pericleous
المصدر: EClinicalMedicine
EClinicalMedicine, Vol 39, Iss, Pp 101070-(2021)مصطلحات موضوعية: medicine.medical_specialty, Medicine (General), Clinician scientist, Coronavirus disease 2019 (COVID-19), biology, Cross-sectional study, business.industry, European research, General Medicine, Single centre, Clinical research, R5-920, Internal medicine, medicine, biology.protein, Antibody, business, Dementia research, Research Paper
الوصف: Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear. Methods: This single-centre cross-sectional study included 106 adult patients: 30 hospitalised COVID-neurological cases, 47 non-neurological COVID-hospitalised controls, and 29 COVID-non-hospitalised controls, recruited between March and July 2020. We evaluated nine antiphospholipid antibodies: anticardiolipin antibodies [aCL] IgA, IgM, IgG; anti-beta-2 glycoprotein-1 [aβ2GPI] IgA, IgM, IgG; anti-phosphatidylserine/prothrombin [aPS/PT] IgM, IgG; and anti-domain I β2GPI (aD1β2GPI) IgG. Findings: There was a high prevalence of antiphospholipid antibodies in the COVID-neurological (73.3%) and non-neurological COVID-hospitalised controls (76.6%) in contrast to the COVID-non-hospitalised controls (48.2%). aPS/PT IgG titres were significantly higher in the COVID-neurological group compared to both control groups (p
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المؤلفون: Stephen Keddie, Robert Simister, Pedro Rosa-Neto, Ashvini Keshavan, Anna M. Checkley, Dilan Athauda, Amanda Heslegrave, Michael S. Zandi, Deepthi Vinayan Changaradil, Andrea L Benedet, Puja Mehta, Moira J. Spyer, Jonathan M. Schott, Nicholas J. Ashton, Suzanne Barker, Tom Solomon, Serge Gauthier, Ross W. Paterson, Michael Chou, Kaj Blennow, Henrik Zetterberg, Judith Heaney, Francesco Carletti, Oliver J. Ziff, Hans Rolf Jäger, Michael P. Lunn, Catherine J. Mummery, David J. Werring, Catherine F Houlihan, Laura A Benjamin, Hadi Manji, Claire A Leckey, Eleni Nastouli, Rachel Brown
المصدر: Brain communications
Brain Communicationsمصطلحات موضوعية: Nervous system, Pathology, medicine.medical_specialty, Glial fibrillary acidic protein, biology, AcademicSubjects/SCI01870, ADEM, business.industry, encephalitis, Encephalopathy, General Engineering, COVID-19, medicine.disease, NFL, medicine.anatomical_structure, Cerebrospinal fluid, Acute disseminated encephalomyelitis, medicine, biology.protein, Biomarker (medicine), Original Article, AcademicSubjects/MED00310, business, Encephalitis, Neuroinflammation
الوصف: Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where and how damage occurs, we collected serum and CSF from patients with COVID-19 and characterised neurological syndromes involving the peripheral and central nervous system (n = 34). We measured biomarkers of neuronal damage and neuroinflammation, and compared these with non-neurological control groups, which included patients with (n = 94) and without (n = 24) COVID-19. We detected increased concentrations of neurofilament light, a dynamic biomarker of neuronal damage, in the CSF of those with central nervous system inflammation (encephalitis and acute disseminated encephalomyelitis) (14800pg/mL [400, 32400]), compared to those with encephalopathy (1410pg/mL [756, 1446], peripheral syndromes (GBS) (740pg/mL [507, 881]) and controls (872pg/mL [654,1200]). Serum neurofilament light levels were elevated across patients hospitalised with COVID-19, irrespective of neurological manifestations. There was not the usual close correlation between CSF and serum neurofilament light, suggesting serum neurofilament light elevation in the non-neurological patients may reflect peripheral nerve damage in response to severe illness. We did not find significantly elevated levels of serum neurofilament light in community cases of COVID-19 arguing against significant neurological damage. Glial fibrillary acidic protein, a marker of astrocytic activation, was not elevated in the CSF or serum of any group, suggesting astrocytic activation is not a major mediator of neuronal damage in COVID-19.
Graphical Abstract Graphical Abstractوصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146a3a302265af5c12cf7e1ec15d14c5
https://doi.org/10.1093/braincomms/fcab099 -
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المؤلفون: Chandrashekar Hoskote, Michael S. Zandi, Patricia McNamara, Carmel Curtis, Sarah Weithoff, Rachel C. Brown, Tehmina Bharucha, Hans Rolf Jäger, Judith Breuer, Viva Levee, Gee Yen Shin, Hadi Manji, Cristina Marcoci, Emma C. Wall, Laura A Benjamin, Catherine F Houlihan, Francesco Carletti, Anna M. Checkley
المصدر: Journal of the Neurological Sciences. 429:117801
مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, medicine.disease, Queen (playing card), Neurology, Multidisciplinary approach, medicine, Square (unit), Neurology (clinical), business, Pre and post, Encephalitis
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