المؤلفون: Brenner D; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany.; Department of Neurology, University of Ulm, Ulm, Germany., Sieverding K; Department of Neurology, University of Ulm, Ulm, Germany., Srinidhi J; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Zellner S; Medical Faculty, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University München , Munich, Germany., Secker C; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Yilmaz R; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Dyckow J; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Amr S; Faculty of Medicine, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany., Ponomarenko A; Department of Neurology, University of Ulm, Ulm, Germany.; Institute of Anatomy and Cell Biology, Ulm University School of Medicine , Ulm, Germany., Tunaboylu E; Department of Neurology, University of Ulm, Ulm, Germany., Douahem Y; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Schlag JS; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Rodríguez Martínez L; Institute of Neuronal Cell Biology, Technical University Munich , Munich, Germany.; German Center for Neurodegenerative Diseases , Munich, Germany., Kislinger G; Electron Microscopy Hub, German Center for Neurodegenerative Diseases, Munich, Germany., Niemann C; Electron Microscopy Hub, German Center for Neurodegenerative Diseases, Munich, Germany., Nalbach K; Medical Faculty, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University München , Munich, Germany., Ruf WP; Department of Neurology, University of Ulm, Ulm, Germany., Uhl J; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Hollenbeck J; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Schirmer L; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Catanese A; Institute of Anatomy and Cell Biology, Ulm University School of Medicine , Ulm, Germany., Lobsiger CS; Institut du Cerveau-Paris Brain Institute-Institut du Cerveau et de la Moelle épinière, Inserm, Centre National de la Recherche Scientifique, Assistance Publique-Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Sorbonne Université , Paris, France., Danzer KM; Department of Neurology, University of Ulm, Ulm, Germany.; German Center for Neurodegenerative Diseases , Ulm, Germany., Yilmazer-Hanke D; Department of Neurology, Clinical Neuroanatomy Unit, University of Ulm, Ulm, Germany., Münch C; Institute of Anatomy and Cell Biology, Ulm University School of Medicine , Ulm, Germany., Koch P; University of Heidelberg/Medical Faculty Mannheim, Central Institute of Mental Health, Mannheim, Germany.; Hector Institute for Translational Brain Research , Mannheim, Germany.; German Cancer Research Center , Heidelberg, Germany., Freischmidt A; Department of Neurology, University of Ulm, Ulm, Germany., Fetting M; Medical Faculty, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University München , Munich, Germany.; Electron Microscopy Hub, German Center for Neurodegenerative Diseases, Munich, Germany., Behrends C; Medical Faculty, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University München , Munich, Germany., Parlato R; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Weishaupt JH; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany.

المصدر: The Journal of experimental medicine [J Exp Med] 2024 May 06; Vol. 221 (5). Date of Electronic Publication: 2024 Mar 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis*/pathology , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/metabolism , Frontotemporal Dementia*/pathology, Animals ; Humans ; Mice ; Motor Neurons/pathology ; Mutation ; Neuroinflammatory Diseases ; Phosphorylation ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism

المؤلفون: Lagarde J; Department of Neurology of Memory and Language, GHU Paris Psychiatry and Neurosciences, Hôpital Sainte Anne, Paris, France. j.lagarde@ghu-paris.fr.; Université Paris-Saclay, Service Hospitalier Frédéric Joliot CEA, CNRS, Inserm, BioMaps, Orsay, F- 91401, France. j.lagarde@ghu-paris.fr.; Université Paris-Cité, Paris, France. j.lagarde@ghu-paris.fr., Olivieri P; Department of Neurology of Memory and Language, GHU Paris Psychiatry and Neurosciences, Hôpital Sainte Anne, Paris, France., Tonietto M; Université Paris-Saclay, Service Hospitalier Frédéric Joliot CEA, CNRS, Inserm, BioMaps, Orsay, F- 91401, France., Noiray C; Department of Neurology of Memory and Language, GHU Paris Psychiatry and Neurosciences, Hôpital Sainte Anne, Paris, France., Lehericy S; Centre de NeuroImagerie de Recherche - CENIR, Institut du Cerveau et de la Moelle épinière - ICM, Paris, F-75013, France.; Sorbonne Université, UPMC Univ Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, Paris, F-75013, France., Valabrègue R; Centre de NeuroImagerie de Recherche - CENIR, Institut du Cerveau et de la Moelle épinière - ICM, Paris, F-75013, France.; Sorbonne Université, UPMC Univ Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, Paris, F-75013, France., Caillé F; Université Paris-Saclay, Service Hospitalier Frédéric Joliot CEA, CNRS, Inserm, BioMaps, Orsay, F- 91401, France., Gervais P; Université Paris-Saclay, Service Hospitalier Frédéric Joliot CEA, CNRS, Inserm, BioMaps, Orsay, F- 91401, France., Moussion M; Centre d'Evaluation Troubles Psychiques et Vieillissement, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte Anne, Paris, F-75014, France., Bottlaender M; Université Paris-Saclay, Service Hospitalier Frédéric Joliot CEA, CNRS, Inserm, BioMaps, Orsay, F- 91401, France.; UNIACT, Neurospin, Gif-sur-Yvette, CEA, F-91191, France., Sarazin M; Department of Neurology of Memory and Language, GHU Paris Psychiatry and Neurosciences, Hôpital Sainte Anne, Paris, France.; Université Paris-Saclay, Service Hospitalier Frédéric Joliot CEA, CNRS, Inserm, BioMaps, Orsay, F- 91401, France.; Université Paris-Cité, Paris, France.

المصدر: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 May 03; Vol. 16 (1), pp. 97. Date of Electronic Publication: 2024 May 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE

مواضيع طبية MeSH: Frontotemporal Dementia*/diagnostic imaging , Frontotemporal Dementia*/pathology , Locus Coeruleus*/diagnostic imaging , Locus Coeruleus*/pathology , Alzheimer Disease*/diagnostic imaging , Alzheimer Disease*/pathology , Magnetic Resonance Imaging*/methods , Basal Nucleus of Meynert*/diagnostic imaging , Basal Nucleus of Meynert*/pathology, Humans ; Male ; Female ; Aged ; Middle Aged ; Neuropsychological Tests ; Amnesia/diagnostic imaging ; Positron-Emission Tomography/methods

المؤلفون: Sevigny J; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA. sevigny_jeffrey@lilly.com., Uspenskaya O; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Heckman LD; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Wong LC; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Hatch DA; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Tewari A; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Vandenberghe R; Neurology Service, University Hospitals Leuven, Leuven, Belgium and Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium., Irwin DJ; Department of Neurology, Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA., Saracino D; Sorbonne Université, Paris Brain Institute - Institut du Cerveau, ICM, Inserm, CNRS UMR 7225 APHP - Hôpital Pitié-Salpêtrière, Paris, France., Le Ber I; Sorbonne Université, Paris Brain Institute - Institut du Cerveau, ICM, Inserm, CNRS UMR 7225 APHP - Hôpital Pitié-Salpêtrière, Paris, France., Ahmed R; Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Rohrer JD; Department of Neurodegenerative Disease, Dementia Research Center, UCL Queen Square Institute of Neurology, London, UK., Boxer AL; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Boland S; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Sheehan P; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Brandes A; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Burstein SR; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Shykind BM; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Kamalakaran S; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Daniels CW; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., David Litwack E; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Mahoney E; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Velaga J; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., McNamara I; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Sondergaard P; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Sajjad SA; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Kobayashi YM; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Abeliovich A; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA., Hefti F; Prevail Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, New York, NY, USA.

المصدر: Nature medicine [Nat Med] 2024 May; Vol. 30 (5), pp. 1406-1415. Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/therapy , Frontotemporal Dementia*/cerebrospinal fluid , Progranulins*/genetics , Genetic Therapy*/adverse effects , Genetic Therapy*/methods , Dependovirus*/genetics, Humans ; Middle Aged ; Female ; Male ; Aged ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/cerebrospinal fluid ; Genetic Vectors ; Animals ; Treatment Outcome ; Translational Research, Biomedical ; Mice ; Neurofilament Proteins/genetics ; Neurofilament Proteins/cerebrospinal fluid ; Neurofilament Proteins/blood

المؤلفون: Athanasio BS; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Oliveira ACS; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Pedrosa AL; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Borges RS; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Neto AOM; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Oliveira RA; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., de Resende EPF; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.; Grupo de Neurologia Cognitiva e do Comportamento, Faculdade de Medicina da UFMG, Belo Horizonte, Brazil., de Moraes RF; Instituto Hermes Pardini, Belo Horizonte, Brazil.; Programa de Pós-Graduação em Neurociências, UFMG, Belo Horizonte, Brazil., Caramelli P; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.; Grupo de Neurologia Cognitiva e do Comportamento, Faculdade de Medicina da UFMG, Belo Horizonte, Brazil.; Programa de Pós-Graduação em Neurociências, UFMG, Belo Horizonte, Brazil., de Souza LC; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.; Grupo de Neurologia Cognitiva e do Comportamento, Faculdade de Medicina da UFMG, Belo Horizonte, Brazil.; Programa de Pós-Graduação em Neurociências, UFMG, Belo Horizonte, Brazil.

المصدر: Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2024 May-Jun; Vol. 34 (3), pp. 308-319. Date of Electronic Publication: 2024 Jan 08.

نوع المنشور: Journal Article; Meta-Analysis; Systematic Review

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9102705 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-6569 (Electronic) Linking ISSN: 10512284 NLM ISO Abbreviation: J Neuroimaging Subsets: MEDLINE

مواضيع طبية MeSH: Brain*/diagnostic imaging , Frontotemporal Dementia*/diagnostic imaging , Sensitivity and Specificity* , Tomography, Emission-Computed, Single-Photon*/methods, Female ; Humans ; Diagnosis, Differential ; Perfusion Imaging/methods ; Prevalence ; Reproducibility of Results

المؤلفون: Nelson AT; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Cicardi ME; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Markandaiah SS; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Han JY; Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Philp NJ; Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Welebob E; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Haeusler AR; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Pasinelli P; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Manfredi G; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY, 10065, USA., Kawamata H; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY, 10065, USA., Trotti D; Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA. davide.trotti@jefferson.edu.

المصدر: EMBO reports [EMBO Rep] 2024 May; Vol. 25 (5), pp. 2479-2510. Date of Electronic Publication: 2024 Apr 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/pathology , C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/metabolism , Frontotemporal Dementia*/pathology , Glucose*/metabolism , Phenotype*, Animals ; Mice ; Humans ; Protein Biosynthesis ; Neurons/metabolism ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; DNA Repeat Expansion/genetics ; Mice, Transgenic ; Adenosine Triphosphate/metabolism

المؤلفون: Cagnin A; Neurology Unit, Department of Neuroscience (DNS) University of Padua, Padua, Italy; Padua Neuroscience Center, University of Padua, Padua, Italy. Electronic address: annachiara.cagnin@unipd.it., Pigato G; Psychiatry Unit, Department of Neuroscience (DNS), University of Padua, Padua, Italy., Pettenuzzo I; Neurology Unit, Department of Neuroscience (DNS) University of Padua, Padua, Italy., Zorzi G; Neurology Unit, Department of Neuroscience (DNS) University of Padua, Padua, Italy; Padua Neuroscience Center, University of Padua, Padua, Italy; CRIC, Azienda Ospedale-Università of Padua, Italy., Roiter B; Psychiatry Unit, Department of Neuroscience (DNS), University of Padua, Padua, Italy., Anglani MG; Neuroradiology Unit, University of Padua, Padua, Italy., Bussè C; Neurology Unit, Department of Neuroscience (DNS) University of Padua, Padua, Italy., Mozzetta S; Neurology Unit, Department of Neuroscience (DNS) University of Padua, Padua, Italy., Gabelli C; CRIC, Azienda Ospedale-Università of Padua, Italy., Campi C; Nuclear Medicine Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy; Department of Mathematics, University of Genoa and IRCCS Policlinico San Martino Hospital, Genoa., Cecchin D; Padua Neuroscience Center, University of Padua, Padua, Italy; Nuclear Medicine Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

المصدر: Neurobiology of aging [Neurobiol Aging] 2024 May; Vol. 137, pp. 47-54. Date of Electronic Publication: 2024 Feb 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE

مواضيع طبية MeSH: Frontotemporal Dementia*/psychology , Pick Disease of the Brain*, Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Frontal Lobe/diagnostic imaging ; Brain/diagnostic imaging ; Neuropsychological Tests

المؤلفون: Hung C; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, UK.; UCL Great Ormond Street Institute of Child Health, Zayed Centre for Research into Rare Disease in Children, London, UK., Patani R; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, UK.

المصدر: Autophagy [Autophagy] 2024 May; Vol. 20 (5), pp. 1201-1202. Date of Electronic Publication: 2024 Jan 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE

مواضيع طبية MeSH: Frontotemporal Dementia*/metabolism , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/pathology , Autophagy*/physiology , tau Proteins*/metabolism , Lysosomes*/metabolism, Humans ; Endosomes/metabolism ; Neurons/metabolism ; Mutation/genetics ; Valosin Containing Protein/metabolism ; Valosin Containing Protein/genetics

المؤلفون: Shellikeri S; Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA,USA., Cho S; Linguistic Data Consortium, University of Pennsylvania, Philadelphia, PA, USA., Ash S; Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA,USA., Gonzalez-Recober C; Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA,USA., Mcmillan CT; Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA,USA., Elman L; Penn ALS Clinic, University of Pennsylvania, PA, USA, and., Quinn C; Penn ALS Clinic, University of Pennsylvania, PA, USA, and., Amado DA; Penn ALS Clinic, University of Pennsylvania, PA, USA, and., Baer M; Penn ALS Clinic, University of Pennsylvania, PA, USA, and., Irwin DJ; Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA,USA., Massimo L; Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA,USA., Olm CA; Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA,USA., Liberman MY; Linguistic Data Consortium, University of Pennsylvania, Philadelphia, PA, USA.; Department of Linguistics, University of Pennsylvania, Philadelphia, PA, USA., Grossman M; Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA,USA., Nevler N; Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA,USA.

المصدر: Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2024 May; Vol. 25 (3-4), pp. 317-325. Date of Electronic Publication: 2023 Dec 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101587185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2167-9223 (Electronic) Linking ISSN: 21678421 NLM ISO Abbreviation: Amyotroph Lateral Scler Frontotemporal Degener Subsets: MEDLINE

مواضيع طبية MeSH: Frontotemporal Dementia*/diagnosis , Frontotemporal Dementia*/diagnostic imaging , Amyotrophic Lateral Sclerosis*/complications , Amyotrophic Lateral Sclerosis*/diagnosis , Dystonic Disorders*, Humans ; Speech ; Magnetic Resonance Imaging

SCR Disease Name: Dystonia, Focal, Task-Specific

المؤلفون: Sirtori R; Ryan Institute for Neuroscience, University of Rhode Island, 130 Flagg Rd, 02881, Kingston, RI, United States of America.; Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Rd, 02881, Kingston, RI, United States of America., J Gregoire M; Ryan Institute for Neuroscience, University of Rhode Island, 130 Flagg Rd, 02881, Kingston, RI, United States of America.; Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Rd, 02881, Kingston, RI, United States of America.; Interdisciplinary Neuroscience Program, University of Rhode Island, 9 Greenhouse Road, 02881, Kingston, RI, United States of America., M Potts E; Ryan Institute for Neuroscience, University of Rhode Island, 130 Flagg Rd, 02881, Kingston, RI, United States of America.; Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Rd, 02881, Kingston, RI, United States of America.; Interdisciplinary Neuroscience Program, University of Rhode Island, 9 Greenhouse Road, 02881, Kingston, RI, United States of America., Collins A; Ryan Institute for Neuroscience, University of Rhode Island, 130 Flagg Rd, 02881, Kingston, RI, United States of America.; Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Rd, 02881, Kingston, RI, United States of America.; Interdisciplinary Neuroscience Program, University of Rhode Island, 9 Greenhouse Road, 02881, Kingston, RI, United States of America., Donatelli L; Ryan Institute for Neuroscience, University of Rhode Island, 130 Flagg Rd, 02881, Kingston, RI, United States of America.; Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Rd, 02881, Kingston, RI, United States of America.; Interdisciplinary Neuroscience Program, University of Rhode Island, 9 Greenhouse Road, 02881, Kingston, RI, United States of America., Fallini C; Ryan Institute for Neuroscience, University of Rhode Island, 130 Flagg Rd, 02881, Kingston, RI, United States of America. cfallini@uri.edu.; Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Rd, 02881, Kingston, RI, United States of America. cfallini@uri.edu.; Interdisciplinary Neuroscience Program, University of Rhode Island, 9 Greenhouse Road, 02881, Kingston, RI, United States of America. cfallini@uri.edu.; Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, United States of America. cfallini@uri.edu.

المصدر: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Apr 25; Vol. 12 (1), pp. 69. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/metabolism , C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/pathology , Frontotemporal Dementia*/metabolism, Humans ; Male ; Motor Neurons/pathology ; Motor Neurons/metabolism ; Spinal Cord/pathology ; Spinal Cord/metabolism ; Nuclear Envelope/metabolism ; Nuclear Envelope/pathology ; Female ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Middle Aged ; Aged ; Motor Cortex/pathology ; Motor Cortex/metabolism

SCR Disease Name: Frontotemporal Dementia With Motor Neuron Disease

المؤلفون: Rosenthal ZC; Chemical Neurobiology Laboratory, Precision Therapeutics Unit, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA, USA., Fass DM; Chemical Neurobiology Laboratory, Precision Therapeutics Unit, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Payne NC; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA, USA.; Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Boston, MA, USA., She A; Chemical Neurobiology Laboratory, Precision Therapeutics Unit, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Patnaik D; Chemical Neurobiology Laboratory, Precision Therapeutics Unit, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Hennig KM; Chemical Neurobiology Laboratory, Precision Therapeutics Unit, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Tesla R; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX, USA., Werthmann GC; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX, USA., Guhl C; Faculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Jena, Germany., Reis SA; Chemical Neurobiology Laboratory, Precision Therapeutics Unit, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Wang X; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Chen Y; Department of Radiology, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA., Placzek M; Department of Radiology, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA., Williams NS; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hooker J; Department of Radiology, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA., Herz J; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Mazitschek R; Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Haggarty SJ; Chemical Neurobiology Laboratory, Precision Therapeutics Unit, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA. shaggarty@mgh.harvard.edu.

المصدر: Scientific reports [Sci Rep] 2024 Apr 20; Vol. 14 (1), pp. 9064. Date of Electronic Publication: 2024 Apr 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Frontotemporal Dementia*/drug therapy , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/metabolism, Humans ; Progranulins/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Nuclear Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Mutation ; Epigenesis, Genetic ; Bromodomain Containing Proteins ; Cell Cycle Proteins/metabolism