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1دورية أكاديمية
المؤلفون: Emanuele La Corte, Michele Dei Cas, Alberto Raggi, Monica Patanè, Morgan Broggi, Silvia Schiavolin, Chiara Calatozzolo, Bianca Pollo, Carlotta Pipolo, Maria Grazia Bruzzone, Giuseppe Campisi, Rita Paroni, Riccardo Ghidoni, Paolo Ferroli
المصدر: International Journal of Molecular Sciences, Vol 20, Iss 18, p 4480 (2019)
مصطلحات موضوعية: cancer, ceramides, chordoma, dihydroceramides, lipid targets, skull base, sphingolipids, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Background: Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied in chordomas. Our aim is to investigate chordoma behavior and the role of ceramides. Methods: Ceramides were extracted and evaluated by liquid chromatography and mass spectrometry in a cohort of patients with a skull base chordoma. Clinical data were also collected and correlated with ceramide levels. Linear regression and correlation analyses were conducted. Results: Analyzing the association between ceramides level and MIB-1, total ceramides and dihydroceramides showed a strong association (r = 0.7257 and r = 0.6733, respectively) with MIB-1 staining (p = 0.0033 and p = 0.0083, respectively). Among the single ceramide species, Cer C24:1 (r = 0.8814, p ≤ 0.0001), DHCer C24:1 (r = 0.8429, p = 0.0002) and DHCer C18:0 (r = 0.9426, p ≤ 0.0001) showed a significant correlation with MIB-1. Conclusion: Our lipid analysis showed ceramides to be promising tumoral biomarkers in skull base chordomas. Long- and very-long-chain ceramides, such as Cer C24:1 and DHCer C24:1, may be related to a prolonged tumor survival and aggressiveness, and the understanding of their effective biological role will hopefully shed light on the mechanisms of chordoma radio-resistance, tendency to recur, and use of agents targeting ceramide metabolism.
وصف الملف: electronic resource
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المؤلفون: Giulio Molon, Giuseppe Arena, Claudio Tondo, Danilo Ricciardi, Pietro Rossi, Paolo Pieragnoli, Roberto Verlato, Massimiliano Manfrin, Giulia Girardengo, Giuseppe Campisi, Domenico Pecora, Mario Luzi, Saverio Iacopino
المصدر: Journal of Interventional Cardiac Electrophysiology.
مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine
الوصف: Background Pulmonary vein isolation by cryoablation (PVI-C) is a standard therapy for the treatment of patients with symptomatic atrial fibrillation (AF). AF symptoms are highly subjective; however, they are important outcomes for the patient. The aim is to describe the use and impact of a web-based App to collect AF-related symptoms in a population of patients who underwent PVI-C in seven Italian centers. Methods A patient App to collect AF-related symptoms and general health status was proposed to all patients who underwent an index PVI-C. Patients were divided into two groups according to the utilization of the App or the non-usage. Results Out of 865 patients, 353 (41%) subjects composed the App group, and 512 (59%) composed the No-App group. Baseline characteristics were comparable between the two cohorts except for age, sex, type of AF, and body mass index. During a mean follow-up of 7.9±13.8 months, AF recurrence was found in 57/865 (7%) subjects with an annual rate of 7.36% (95% CI:5.67-9.55%) in the No-App versus 10.99% (95% CI:9.67-12.48%) in the App group, p=0.007. In total, 14,458 diaries were sent by the 353 subjects in the App group and 77.1% reported a good health status and no symptoms. In only 518 diaries (3.6%), the patients reported a bad health status, and bad health status was an independent parameter of AF recurrence during follow-up. Conclusions The use of a web App to record AF-related symptoms was feasible and effective. Additionally, a bad health status reporting in the App was associated with AF recurrence during follow-up.
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المؤلفون: Antonino Nicosia, Saverio Iacopino, Gerardo Nigro, Giulio Zucchelli, Luca Tomasi, Carlo D’Agostino, Matteo Ziacchi, Marcello Piacenti, Paolo De Filippo, Giuseppe Sgarito, Giuseppe Campisi, Daniele Nicolis, Rosario Foti, Pietro Palmisano
المصدر: Journal of Interventional Cardiac Electrophysiology. 65:103-110
مصطلحات موضوعية: Pacemaker, Artificial, Treatment Outcome, Physiology (medical), Cardiac Pacing, Artificial, Humans, Arrhythmias, Cardiac, Equipment Design, Prospective Studies, Cardiology and Cardiovascular Medicine, Aged
الوصف: Real-world safety data on the use of transcatheter pacing systems particularly in very elderly patients is still limited. The aim of this analysis was to investigate the effect of age on the safety and efficacy of leadless pacemaker implant.From May 2016 through July 2019, 577 patients were implanted with a leadless single-chamber pacemaker according to current pacing indication in 15 Italian cardiologic centers. The population was divided into age quartiles for evaluation, including (1) 70 years, (2) 70-77 years, (3) 78-83 years, and (4) ≥ 83 years. Procedural data, complications, and electrical parameters were collected at baseline and during the follow-up.Procedural-related complication occurrence was very low ( 1.0%) and similar in the four subgroups according to age even if the older patients were more frail. No cardiac tamponade was reported. Among the groups, no difference was observed in procedural time, fluoroscopy time duration, and electrical parameters (mean pacing impedance: 750 ± 192 and 599 ± 156, mean pacing threshold: 0.7 ± 0.5 and 0.7 ± 0.6, and mean right ventricular sensing 10.7 ± 6.1 and 11.5 ± 4.8 at implant and last follow-up, respectively).The reported data demonstrated a high degree of safety during leadless implant across all patient ages. Procedural complications and device electrical measurements were similar among the different ages.
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المؤلفون: Giulia Marino, Louise Ferguson, Francesco Marra, Vito Armando Laudicina, Annalisa Marchese, Tiziano Caruso, L. Macaluso, Giuseppe Campisi, P. Volo
المساهمون: Marino, G., Macaluso, L., Marra, F.P., Ferguson, L., Marchese, A., Campisi, G., Volo, P., Laudicina, V., Caruso, T.
المصدر: Scientia Horticulturae. 217:217-225
مصطلحات موضوعية: 0106 biological sciences, Canopy, Yield, Vegetative reproduction, media_common.quotation_subject, Settore AGR/13 - Chimica Agraria, Organoleptic, Horticulture, Biology, 01 natural sciences, Adaptability, Germplasm, Cultivar evaluation, Cultivar, Productivity, media_common, Olea europaea L, Super high density orchard, food and beverages, 04 agricultural and veterinary sciences, Settore AGR/03 - Arboricoltura Generale E Coltivazioni Arboree, Agronomy, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Oil quality, Orchard, Arbequina, 010606 plant biology & botany
الوصف: The super high density (SHD) model is a new olive growing system characterized by earlier and higher yields, fully mechanized harvesting and reduced orchard management costs. Until recently all commercial SHD orchards were planted primarily with three varieties: ‘Arbequina’, ‘Arbosana’ and ‘Koroneiki’. To increase variety diversity, broaden available olive oil chemical and organoleptic profiles, and olive oils for marketing, minor local varieties should be evaluated for adaptability to the SHD system. This study compares multiple Sicilian native genotypes to the three current cultivars ‘Arbequina’, ‘Arbosana’ and ‘Koroneiki’. The cumulative fruit and oil production, trunk-cross section area, canopy volume, alternate bearing behavior and oil quality were evaluated in a SHD system. Among the standard cultivars ‘Koroneiki’ had significantly higher and ‘Arbequina’ average productivity respectively compared to earlier reports and was chosen as the reference for evaluating the performance of the Sicilian genotypes. Many of the genotypes investigated had olive and oil yields equal to or higher than ‘Arbequina’; ‘Abunara’ and ‘ADE’ had very high productivity. ‘Abunara’ produced a medium-high quality oil. The ‘KALAT’ selection had high productivity and low vigor, and therefore high productive efficiency. However, the oil polyphenols were low. The ‘Cerasuola’ and ‘Piricuddara’ cultivars had good productivity and a very high quality oils. These results confirm the need to evaluate and preserve local genetic resources as a strategy for improving SHD olive management and increasing olive cultivar and oil diversity.
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المؤلفون: Tiziano Caruso, F. Costa, Francesco Marra, L. Macaluso, Annalisa Marchese, Giuseppe Campisi
المساهمون: Caruso, T, Marra, F.P., Costa, F, Campisi, G, Macaluso, L, Marchese, A
المصدر: Scientia Horticulturae. 180:130-138
مصطلحات موضوعية: Genetics, Genetic diversity, Ecotype, UPGMA, food and beverages, Horticulture, Biology, OliveOlea europaea, SSR, Clonal selection, Microsatellites, Settore AGR/03 - Arboricoltura Generale E Coltivazioni Arboree, Genotype, Microsatellite, Mantel test, Genetic variability, Cultivar
الوصف: The richness of Olea europaea (L.) genetic resources in Sicily is well documented. In the last 30 years, mostof the local cultivars, landraces and ecotypes have been gathered together in a large ex-situ collection,containing more than 300 genotypes. In this study, 45 putative clones of the main Sicilian olive cultivarswere characterized morphologically using microsatellite markers to unambiguously identify possiblesuperior genotypes. The microsatellites employed were polymorphic (observed heterozygosity = 0.71;polymorphic information content = 0.59), discriminated 52% of the genotypes and enabled the detectionof intra-cultivar polymorphism, derived from both somatic mutations, indicating the presence of poly-clonal cultivars, or from gametic origin, thus suggesting the presence of cultivar-populations. A high levelof genetic variability was detected within the ‘Biancolilla’, ‘Giarraffa’ and ‘Moresca’ genotypes, whereaslow variation was found within the ‘Cerasuola’ and ‘Tonda Iblea’ genotypes. The combination of UPGMAcluster analysis of data obtained from microsatellite analysis, with canonical discriminant analysis (CDA),based on 18 morphological variables, measured under the same conditions, enabled intra-cultivar diver-sity, attributable to genetic factors rather than to environmental ones to be identified. The goodness offit between microsatellite profiles and the CDA analysis was significantly supported by the Mantel test(r = 0.3; p < 0.001). Genotypes and clonal variants with superior traits (larger fruit size; compact tree habit,apt for high density planting; higher oleic acid content) were identified, suitable for enlarging their areaof cultivation.
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المؤلفون: Giuseppe Campisi, Concepción M. Díez, Luis Rallo, Tiziano Caruso
المصدر: Compendium of Plant Genomes ISBN: 9783319488868
مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Agroforestry, media_common.quotation_subject, Biology, 01 natural sciences, Natural resource, Mediterranean Basin, Scarcity, Crop, 03 medical and health sciences, Agricultural science, 030104 developmental biology, Yield (wine), Sustainability, Cultivar, Genetic erosion, 010606 plant biology & botany, media_common
الوصف: Since its beginning, the olive crop has been a long-lived agricultural system in the Mediterranean Basin being well adapted to this area. Traditional olive growing, still prevalent in most producing areas, is characterized by low tree density and rainfed orchards with low yield and manually harvested. The traditional olive growing technology is local, diverse, and empirically based. New high density, irrigated, and mechanically harvested orchards has been progressively planted since the end of World War II. These plantations produce high crops at low costs, but they reduce the diversity of cultivars, increase the demand of inputs and the risk of environment unbalances. The expansion and intensification of olive growing, and the perception of olive oil and table olives as healthy foods, have largely increased the production of these products. However, the intensification and expansion of olive growing to new regions is also raising some concerns related to genetic erosion, the adaptation of cultivars, the spread of biotic agents, the scarcity of water, and the increase of soil erosion, among others. New technological advances in olive growing and breeding, and the development of new disciplines such as genomics promise to be of outstanding role to guarantee the conservation and sustainable use of the olive genetic diversity and the rational use of natural resources.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::aefe22b391a80e7aed8266708b4c9321
https://doi.org/10.1007/978-3-319-48887-5_4 -
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المؤلفون: Ernesto Lombardo, Sergio Valsecchi, Giuseppe Campisi, Arnaldo Risi, Saverio Iacopino, G. Giannola, Dario Corrao, Alessandra Denaro, Giuseppe Di Stefano, Leandro G Piraino, Antonio Cesario, Riccardo Torcivia
المصدر: Europace. 13:244-250
مصطلحات موضوعية: Male, medicine.medical_specialty, Ventricular lead, Heart Ventricles, medicine.medical_treatment, Cardiac resynchronization therapy, Cardiac Resynchronization Therapy, Physiology (medical), Humans, Medicine, Cardiac Resynchronization Therapy Devices, Vein, Lead (electronics), Coronary sinus, Aged, Heart Failure, business.industry, Middle Aged, Electrodes, Implanted, Surgery, Stylet, Clinical Practice, Treatment Outcome, medicine.anatomical_structure, Equipment and Supplies, Italy, Female, Cardiology and Cardiovascular Medicine, business
الوصف: Aims The left ventricular (LV) lead for cardiac resynchronization therapy (CRT) is usually positioned in the coronary sinus via a stylet-guided or an ‘over-the-wire’ approach. Recently, a new tool has been developed, the Medtronic Attain Hybrid, that combines guide-wire and stylet features. We assessed its safety and efficacy in comparison with standard tools currently used in clinical practice. Methods and results Patients undergoing standard CRT device implantation were enrolled in seven Italian centres. In the preliminary phase of the study (Phase I), data were collected during implantation procedures performed with standard tools (three patients per centre). Subsequently, the Attain Hybrid was made available in the centres and data were collected for all consecutive patients undergoing implantation during the following year. A learning phase was considered (Phase II), and the last three patients per centre (Phase III) were used for comparison with Phase I. One hundred and seventeen patients were enrolled: 21 patients in Phase I, 75 in Phase II, and 21 in Phase III. Rates of successful implantation were similar in Phases I and III (95 vs. 100%, P = 1.000). The pre-defined target vein was reached in 15 (71%) patients in Phase I and in 21 (100%) patients in Phase III ( P = 0.021). In 10 (48%) procedures during Phase I, LV lead positioning necessitated switching from guide-wire to stylet; this proportion decreased during Phase III (14%, P = 0.043). Mean LV positioning time was 16 ± 7 min in Phase I and 11 ± 6 min in Phase III ( P = 0.040). No adverse events or lead-related complications were detected on implantation or during a follow-up of 6 ± 4 months. Conclusion The Attain Hybrid is safe and effective. It significantly improves target vein accessibility and reduces procedural time in comparison with conventional tools.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9512609e3544fc595b99b16c49d4644d
https://doi.org/10.1093/europace/euq429 -
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المؤلفون: Annalisa Marchese, Francesco Marra, Tiziano Caruso, Giuseppe Campisi, S. Pangallo, R. Mafrica, G. Guzzetta
المساهمون: Marra, FP, Marchese, A, Campisi, G, Guzzetta, G, Caruso, T, Mafrica, R, Pangallo, S
مصطلحات موضوعية: Settore AGR/03 - Arboricoltura Generale E Coltivazioni Arboree, Horticulture, Geography, media_common.quotation_subject, Cultivar, Olea europaea, clonal selection, SSR, fingerprinting, germplasm, Diversity (politics), media_common
الوصف: In this study, SSR analysis was performed on a large number of putative clones of the main olive cultivars from two Italian regions, Sicily and Calabria, in order to study the genetic relatedness, and to detect any degree of genetic diversity, which can be used to unambiguously identify possible superior clones. These putative clones have been collected and observed in the last ten years, following an extensive investigation carried out in traditional olive growing areas, thanks to the reports of farmers, millers, technician, growers and nurseries. The set of microsatellite (SSR) markers used allowed the detection of the genetic diversity, resulting from somatic mutation, indicating the presence of polyclonal cultivars, or having gametic origin, indicating a seedling origin of many clones, which thus share sibling relationships. The presence of superior clones or superior genotypes is discussed.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8784ccefbc5a6b7f2d9febbe9833c697
http://www.actahort.org/members/showpdf?booknrarnr=1057_73 -
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المؤلفون: Salvatore Camposeo, Primo Proietti, Giuseppe Campisi, L. Nasini, Francesco Marra, Tiziano Caruso, Gaetano Alessandro Vivaldi
المساهمون: Caruso, T, Campisi, G, Marra, FP, Camposeo, S, Vivaldi, GA, Proietti, P, Nasini, L
مصطلحات موضوعية: Settore AGR/03 - Arboricoltura Generale E Coltivazioni Arboree, Horticulture, mechanical harvesting, Olea europaea, mechanical harvesting, olive oil chemical and sensory characteristics, High density, Sowing, Olea europaea, olive oil chemical and sensory characteristics, Biology
الوصف: The sustainability of the traditional olive-growing sector in EU countries characterised by high production costs and a low selling price for the oil was mainly determined by EU subsidies available for the sector. With the opening of the free trade area by the Barcellona Declaration of 1995 and a cut in EU subsidies in 2014, crucial changes in the sector are now needed. In order to increase the competitiveness of EU olive production, attention should be given to new high-yielding and mechanized cultivation systems. In the 1990s, Spain introduced new high-density planting systems (1,200-2,000 trees/ha) using three low-vigour and early-fruiting cultivars ( Arbequina , Arbosana and Koroneiki ). Italian olive production lies in a geographical area that stretches for about 6° in latitude (37-43° latitude N) and in the band of altitude which ranges from sea level to 400 m a.s.l. Studies on the ecophysiology of woody plants show the importance of adapting the planting system to the climate of the cultivation site, particularly for high-density groves. The evaluation of cultivars suitable for high-density systems, based on their vegetative characteristics, branching and fruiting, together with an analysis of product quality, may contribute significantly to the development and diffusion of new crop growing systems. To achieve this aim, joint research was carried out by three different research units operating in the three main olive-growing regions of Italy (Sicily, Apulia and Umbria). This paper illustrates the first results (2010 and 2011) obtained by the PRIN Project on Biological processes and environmental factors affecting the vegetative growth, fruiting and oil quality control in a high density olive (Olea europaea L.) planting system .
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9494532d9e83a56adca598ea2c9e1d7e
http://hdl.handle.net/11391/1328110
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