المؤلفون: Gordon, Emma C., author

المصدر: Expertise : Philosophical Perspectives, 2024.

الإتاحة: https://doi.org/10.1093/oso/9780198877301.003.0013

المؤلفون: Gordon, Emma C.^{Aff1, IDs13347024007026_cor1}

المصدر: Philosophy & Technology. 37(1)

المؤلفون: Gordon, Emma, Webb, Robyn

المصدر: Humanresources (Auckland, N.Z.), Feb/Mar 2014; v.18 n.6:p.14-15
Human resources (Auckland, N.Z.)

المؤلفون: Gordon, Emma, Shearer, Odette

المصدر: Humanresources (Auckland, N.Z.), Dec 2014/Jan 2015; v.19 n.5:p.12-13
Human resources (Auckland, N.Z.)

المؤلفون: Jin, Yi, Ding, Yindi, Richards, Mark, Kaakinen, Mika, Giese, Wolfgang, Baumann, Elisabeth, Szymborska, Anna, Rosa, André, Nordling, Sofia, 1985, Schimmel, Lilian, Akmeriç, Emir Bora, Pena, Andreia, Nwadozi, Emmanuel, Jamalpour, Maria, 1981, Holstein, Katrin, Sainz-Jaspeado, Miguel, Bernabeu, Miguel O., Welsh, Michael, 1957, Gordon, Emma, Franco, Claudio A., Vestweber, Dietmar, Eklund, Lauri, Gerhardt, Holger, Claesson-Welsh, Lena

المصدر: Nature Cardiovascular Research. 1(12):1156-1173

الوصف: Vascular endothelial (VE)-cadherin in endothelial adherens junctions is an essential component of the vascular barrier, critical for tissue homeostasis and implicated in diseases such as cancer and retinopathies. Inhibitors of Src cytoplasmic tyrosine kinase have been applied to suppress VE-cadherin tyrosine phosphorylation and prevent excessive leakage, edema and high interstitial pressure. Here we show that the Src-related Yes tyrosine kinase, rather than Src, is localized at endothelial cell (EC) junctions where it becomes activated in a flow-dependent manner. EC-specific Yes1 deletion suppresses VE-cadherin phosphorylation and arrests VE-cadherin at EC junctions. This is accompanied by loss of EC collective migration and exaggerated agonist-induced macromolecular leakage. Overexpression of Yes1 causes ectopic VE-cadherin phosphorylation, while vascular leakage is unaffected. In contrast, in EC-specific Src deficiency, VE-cadherin internalization is maintained and leakage is suppressed. In conclusion, Yes-mediated phosphorylation regulates constitutive VE-cadherin turnover, thereby maintaining endothelial junction plasticity and vascular integrity.

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495591
https://doi.org/10.1038/s44161-022-00172-z
https://uu.diva-portal.org/smash/get/diva2:1732508/FULLTEXT01.pdf

المؤلفون: Gordon, Emma

المصدر: Humanresources (Auckland, N.Z.), Aug/Sep 2012; v.17 n.3:p.28-29
Human resources (Auckland, N.Z.)

المؤلفون: Gordon, Emma C.^{Aff1, IDs11229023041836_cor1}

المصدر: Synthese: An International Journal for Epistemology, Methodology and Philosophy of Science. 201(6)

المؤلفون: Noordstra, Ivar, Hermoso, Mario Díez, Schimmel, Lilian, Bonfim-Melo, Alexis, Currin-Ross, Denni, Duong, Cao Nguyen, Kalappurakkal, Joseph Mathew, Morris, Richard G., Vestweber, Dietmar, Mayor, Satyajit, Gordon, Emma, Roca-Cusachs, Pere, Yap, Alpha S.

المصدر: In Developmental Cell 25 September 2023 58(18):1748-1763

المؤلفون: Gordon, Emma C.^{Aff1, IDs10677022102869_cor1}

المصدر: Ethical Theory and Moral Practice. 25(4):557-571

المؤلفون: Gordon, Emma C.^{Aff1, IDs11019022100752_cor1}

المصدر: Medicine, Health Care and Philosophy: A European Journal. 25(2):281-288