المؤلفون: Mody, Aaloke^{Aff1, IDs4305802300536x_cor1}, Filiatreau, Lindsey M., Goss, Charles W., Powell, Byron J., Geng, Elvin H.

المصدر: Implementation Science Communications. 4(1)

المؤلفون: Beigelman, Avraham ^*, Goss, Charles W., Wang, Jinli, Srinivasan, Mythili, Boomer, Jonathan, Zhou, Yanjiao, Bram, Sarah, Casper, Timothy J., Coverstone, Andrea M., Kanchongkittiphon, Watcharoot, Kuklinski, Cadence, Storch, Gregory A., Schechtman, Kenneth B., Castro, Mario, Bacharier, Leonard B.

المصدر: In Annals of Allergy, Asthma & Immunology May 2024 132(5):623-629

المؤلفون: Samant, Maanasi, Krings, James G., Lew, Daphne, Goss, Charles W., Koch, Tammy, McGregor, Mary Clare, Boomer, Jonathan, Hall, Chase S., Schechtman, Ken B., Sheshadri, Ajay, Peterson, Samuel, Erzurum, Serpil, DePew, Zachary, Morrow, Lee E., Hogarth, D. Kyle, Tejedor, Richard, Trevor, Jennifer, Wechsler, Michael E., Sam, Afshin, Shi, Xiaosong, Choi, Jiwoong, Castro, Mario

المصدر: In Chest April 2024 165(4):775-784

المؤلفون: Krings, James G, Goss, Charles W, Lew, Daphne, Samant, Maanasi, McGregor, Mary Clare, Boomer, Jonathan, Bacharier, Leonard B, Sheshadri, Ajay, Hall, Chase, Brownell, Joshua, Schechtman, Ken B, Peterson, Samuel, McEleney, Stephen, Mauger, David T, Fahy, John V, Fain, Sean B, Denlinger, Loren C, Israel, Elliot, Washko, George, Hoffman, Eric, Wenzel, Sally E, Castro, Mario, National Heart, Lung

المصدر: Journal of Allergy and Clinical Immunology. 148(3)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Lung, Asthma, Respiratory, Adult, Airway Remodeling, Disease Progression, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Prognosis, Tomography, X-Ray Computed, severe asthma, CT imaging, asthma morbidity, asthma exacerbations, longitudinal, lung function, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program Investigators, Immunology, Allergy

الوصف: BackgroundCurrently, there is limited knowledge regarding which imaging assessments of asthma are associated with accelerated longitudinal decline in lung function.ObjectivesWe aimed to assess whether quantitative computed tomography (qCT) metrics are associated with longitudinal decline in lung function and morbidity in asthma.MethodsWe analyzed 205 qCT scans of adult patients with asthma and calculated baseline markers of airway remodeling, lung density, and pointwise regional change in lung volume (Jacobian measures) for each participant. Using multivariable regression models, we then assessed the association of qCT measurements with the outcomes of future change in lung function, future exacerbation rate, and changes in validated measurements of morbidity.ResultsGreater baseline wall area percent (β = -0.15 [95% CI = -0.26 to -0.05]; P < .01), hyperinflation percent (β = -0.25 [95% CI = -0.41 to -0.09]; P < .01), and Jacobian gradient measurements (cranial-caudal β = 10.64 [95% CI = 3.79-17.49]; P < .01; posterior-anterior β = -9.14, [95% CI = -15.49 to -2.78]; P < .01) were associated with more severe future lung function decline. Additionally, greater wall area percent (rate ratio = 1.06 [95% CI = 1.01-1.10]; P = .02) and air trapping percent (rate ratio =1.01 [95% CI = 1.00-1.02]; P = .03), as well as lower decline in the Jacobian determinant mean (rate ratio = 0.58 [95% CI = 0.41-0.82]; P < .01) and Jacobian determinant standard deviation (rate ratio = 0.52 [95% CI = 0.32-0.85]; P = .01), were associated with a greater rate of future exacerbations. However, imaging metrics were not associated with clinically meaningful changes in scores on validated asthma morbidity questionnaires.ConclusionsBaseline qCT measures of more severe airway remodeling, more small airway disease and hyperinflation, and less pointwise regional change in lung volumes were associated with future lung function decline and asthma exacerbations.

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3pw8b56j

المؤلفون: Tetteh, Emmanuel K.^{Aff1, Aff2, IDs43058024005994_cor1}, Effah, William, Fuentes, Lisa de las^{Aff1, Aff3}, Steger-May, Karen, Goss, Charles W., Dowdy, David W., Huffman, Mark D.^{Aff3, Aff5}, Williams, Makeda J., Tonwe, Veronica, Bansal, Geetha P., Geng, Elvin H., Dávila-Román, Victor G., Rice, Treva, Schechtman, Kenneth B

المصدر: Implementation Science Communications. 5(1)

المؤلفون: Wang, Lihua, Western, Daniel, Timsina, Jigyasha, Repaci, Charlie, Song, Won-Min, Norton, Joanne, Kohlfeld, Pat, Budde, John, Climer, Sharlee, Butt, Omar H., Jacobson, Daniel, Garvin, Michael, Templeton, Alan R., Campagna, Shawn, O’Halloran, Jane, Presti, Rachel, Goss, Charles W., Mudd, Philip A., Ances, Beau M., Zhang, Bin, Sung, Yun Ju, Cruchaga, Carlos

المصدر: In iScience 21 April 2023 26(4)

المؤلفون: Liechti, Thomas^{Aff1, IDs41467022346382_cor1}, Iftikhar, Yaser, Mangino, Massimo^{Aff2, Aff3}, Beddall, Margaret, Goss, Charles W., O’Halloran, Jane A., Mudd, Philip A.^{Aff6, Aff7}, Roederer, Mario^{Aff1, IDs41467022346382_cor8}

المصدر: Nature Communications. 13(1)

المؤلفون: Goss, Charles W., Duncan, Jennifer G., Lou, Sunny S., Holzer, Katherine J., Evanoff, Bradley A., Kannampallil, Thomas^{Aff3, Aff5, IDs1160602107350y_cor6}

المصدر: Journal of General Internal Medicine. 37(5):1204-1210

المؤلفون: Goss, Charles W., Maricque, Brett B., Anwuri, Victoria V., Cohen, Rachel E., Donaldson, Kate, Johnson, Kimberly J., Powderly, William G., Schechtman, Kenneth B., Schmidt, Spring, Thompson, Jeannette Jackson, Trolard, Anne M., Wang, Jinli, Geng, Elvin H.

المصدر: In Annals of Epidemiology July 2022 71:31-37

المؤلفون: Sindelar, Miriam, Stancliffe, Ethan, Schwaiger-Haber, Michaela, Anbukumar, Dhanalakshmi S., Adkins-Travis, Kayla, Goss, Charles W., O’Halloran, Jane A., Mudd, Philip A., Liu, Wen-Chun, Albrecht, Randy A., García-Sastre, Adolfo, Shriver, Leah P., Patti, Gary J.

المصدر: In Cell Reports Medicine 17 August 2021 2(8)