المؤلفون: Chuanwang Wu, Binglong Cao, Guanghui He, Yuliang Li, Wujie Wang

المصدر: BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: Stereotactic ablative brachytherapy, Microwave ablation, Percutaneous, Early stage, Non-small cell lung cancer, Comparative study, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background To analyze the efficacy of stereotactic ablative brachytherapy (SABT) and percutaneous microwave ablation (MWA) for the treatment of early-stage non-small cell lung cancer (NSCLC). Methods Patients with early-stage (T1-T2aN0M0) NSCLC who underwent CT-guided SABT or MWA between October 2014 and March 2017 at four medical centers were retrospectively analyzed. Survival, treatment response, and procedure-related complications were assessed. Results A total of 83 patients were included in this study. The median follow-up time was 55.2 months (range 7.2–76.8 months). The 1-, 3-, and 5-year overall survival (OS) rates were 96.4%, 82.3%, and 68.4% for the SABT group (n = 28), and 96.4%, 79.7%, and 63.2% for MWA group (n = 55), respectively. The 1-, 3-, and 5-year disease-free survival (DFS) rates were 92.9%, 74.6%, and 54.1% for SABT, and 92.7%, 70.5%, and 50.5% for MWA, respectively. There were no significant differences between SABT and MWA in terms of OS (p = 0.631) or DFS (p = 0.836). The recurrence rate was also similar between the two groups (p = 0.809). No procedure-related deaths occurred. Pneumothorax was the most common adverse event in the two groups, with no significant difference. No radiation pneumonia was found in the SABT group. Conclusions SABT provided similar efficacy to MWA for the treatment of stage I NSCLC. SABT may be a treatment option for unresectable early-stage NSCLC. However, future prospective randomized studies are required to verify these results.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2407

URL الوصول: https://doaj.org/article/a3a0e8137e4c441085c7e4587b223c67

المؤلفون: Ruotian Gong, Xinyi Du, Eli Janzen, Vincent Liu, Zhongyuan Liu, Guanghui He, Bingtian Ye, Tongcang Li, Norman Y. Yao, James H. Edgar, Erik A. Henriksen, Chong Zu

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)

مصطلحات موضوعية: Science

الوصف: Abstract Spin defects in van der Waals materials offer a promising platform for advancing quantum technologies. Here, we propose and demonstrate a powerful technique based on isotope engineering of host materials to significantly enhance the coherence properties of embedded spin defects. Focusing on the recently-discovered negatively charged boron vacancy center ( $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − ) in hexagonal boron nitride (hBN), we grow isotopically purified h10B15N crystals. Compared to $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − in hBN with the natural distribution of isotopes, we observe substantially narrower and less crowded $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − spin transitions as well as extended coherence time T 2 and relaxation time T 1. For quantum sensing, $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − centers in our h10B15N samples exhibit a factor of 4 (2) enhancement in DC (AC) magnetic field sensitivity. For additional quantum resources, the individual addressability of the $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − hyperfine levels enables the dynamical polarization and coherent control of the three nearest-neighbor 15N nuclear spins. Our results demonstrate the power of isotope engineering for enhancing the properties of quantum spin defects in hBN, and can be readily extended to improving spin qubits in a broad family of van der Waals materials.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/256013837b994418b489c44a7a932e21

المؤلفون: Qingmeng Zhang, Jijun Li, Guanghui He, Jun Tang, Guodong Zhang

المصدر: Diagnostic and Interventional Radiology, Vol 29, Iss 5, Pp 713-718 (2023)

مصطلحات موضوعية: 3-d, angiography, artery, cone- beam computed tomography, hemoptysis, interventional, radiculomedullary artery, radiology, therapeutic embolization, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: PURPOSETo evaluate the role of cone-beam computed tomography (CT) performed for the determination of the artery of Adamkiewicz (AKA) suspected by angiography during trans-catheter bronchial artery embolization for hemoptysis.METHODSIn this retrospective study, 17 patients with hemoptysis who underwent cone-beam CT for evaluation of the AKA prior to arterial embolization from December 2014 to March 2022 were included. During the angiographic session, two interventional radiologists selected the possible AKAs that were defined as obscured hairpin-curved vessels arising from the dorsal branch of the intercostal arteries and running towards the midline in the arterially enhanced phase. Contrast-enhanced cone-beam CT was performed as an adjunct to angiography to determine whether the indefinite AKA was a real AKA based on whether it was found to connect to the anterior spinal artery.RESULTSSelective cone-beam CT was performed at 17 possible AKAs detected by selective arteriogram of the intercostal artery (ICA). Cone-beam CT allowed for the determination of AKAs in 16 cases (94.1%). As a result of cone-beam CT findings, 9 of 16 study arteries (56.3%) were judged as definite AKAs, and the remaining 7 (43.7%) were judged as definitely not AKAs but as the musculocutaneous branching from the dorsal branch of the ICA. In 1 of 17 cases (5.9%), cone-beam CT could not determine the AKA because of poor image quality caused by inadequate breath holding. An additional anterior radiculomedullary artery arising from the dorsal branch of the lower ICA because of the inflow of the contrast medium through the anastomosis was detected in one case by conebeam CT but not by angiography.CONCLUSIONIntraprocedural enhanced cone-beam CT performed as an adjunctive technique to angiography is sufficient for confident determination of the AKA, which is essential for the operators to perform accurate and safe arterial embolization for hemoptysis.

وصف الملف: electronic resource

Relation: http://www.dirjournal.org/archives/archive-detail/article-preview/utility-of-intra-procedural-cone-beam-computed-tom/57984; https://doaj.org/toc/1305-3825; https://doaj.org/toc/1305-3612

URL الوصول: https://doaj.org/article/af2367fc3a3549a3a93375b4f504d328

المؤلفون: Dong Li, Wujie Wang, Bin Liu, Die Jin, Yang Wang, Guanghui He, Lei Guo, Wen Liu, Yuliang Li

المصدر: Cell Death Discovery, Vol 9, Iss 1, Pp 1-16 (2023)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

الوصف: Abstract Iodine-125 (I-125) radioactive seed implantation is used for the local treatment of hepatocellular carcinoma (HCC), but the molecular mechanisms regulating its anticancer effects remain incompletely understood. In this study, we report that hsa_circ_0000647 (circSEC11A) is highly expressed after I-125 treatment in HCC cell lines and tissues and is a key regulator of I-125-induced anticancer effects. CircSEC11A acts as a competing endogenous RNA (ceRNA) to sponge miR-3529-3p, promoting the expression of zinc fingers and homeoboxes 2 (ZHX2) and enhancing I-125-induced anticancer effects. Dual-luciferase reporter assay, RNA pull-down, RNA immunoprecipitation, and fluorescence in situ hybridization were thereafter performed to verify the interaction among the molecules. Anticancer effects were detected using CCK-8, flow cytometry, TUNEL, EdU, transwell, and wound healing assays. Furthermore, ZHX2 transcriptionally inhibits GADD34, a negative regulator of endoplasmic reticulum stress (ERS), to enhance I-125- induced anticancer effects in vivo and in vitro. In conclusion, we characterized circSEC11A as a novel regulator of I-125-induced anticancer effects in HCC via miR-3529-3p/ZHX2/GADD34 axis-mediated ERS. Thus, circSEC11A may act as a potential therapeutic target for I-125 implantation in the clinic.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2058-7716

URL الوصول: https://doaj.org/article/dcb34ff126604f538c8389c90c0ed29a

المؤلفون: Ruotian Gong, Guanghui He, Xingyu Gao, Peng Ju, Zhongyuan Liu, Bingtian Ye, Erik A. Henriksen, Tongcang Li, Chong Zu

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

مصطلحات موضوعية: Science

الوصف: Abstract Optically active spin defects in van der Waals materials are promising platforms for modern quantum technologies. Here we investigate the coherent dynamics of strongly interacting ensembles of negatively charged boron-vacancy ( $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − ) centers in hexagonal boron nitride (hBN) with varying defect density. By employing advanced dynamical decoupling sequences to selectively isolate different dephasing sources, we observe more than 5-fold improvement in the measured coherence times across all hBN samples. Crucially, we identify that the many-body interaction within the $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − ensemble plays a substantial role in the coherent dynamics, which is then used to directly estimate the concentration of $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − . We find that at high ion implantation dosage, only a small portion of the created boron vacancy defects are in the desired negatively charged state. Finally, we investigate the spin response of $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − to the local charged defects induced electric field signals, and estimate its ground state transverse electric field susceptibility. Our results provide new insights on the spin and charge properties of $${{{{{{{{\rm{V}}}}}}}}}_{{{{{{{{\rm{B}}}}}}}}}^{-}$$ V B − , which are important for future use of defects in hBN as quantum sensors and simulators.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/66db0625d965400cba01532da0435d73

المؤلفون: Yadong Liu, Zichang Li, Yingjie Yan, Guanghui He, Jian Fang, Kejun Li, Xiuchen Jiang

المصدر: Journal of Modern Power Systems and Clean Energy, Vol 11, Iss 3, Pp 907-916 (2023)

مصطلحات موضوعية: Distribution network, phase measurement unit, single-line-to-ground fault (SLGF), identification method, influencing factor, Production of electric energy or power. Powerplants. Central stations, TK1001-1841, Renewable energy sources, TJ807-830

الوصف: The single-line-to-ground faults with line breaks (SLGFs-LBs) occur more and more frequently in distribution networks and can cause major safety accidents. It is difficult to distinguish the single-line-to-ground faults (SLGFs) in resonant grounding systems and ungrounding systems due to the same electrical characteristics on the source side and uncertain operation conditions of distribution networks. This paper proposes a method for distinguishing SLGFs-LBs and SLGFs. First, the source-side and load-side voltage characteristics of SLGFs and SLGFs-LBs are analyzed, and the phase difference between the voltages of the fault phase and non-fault phase on the load side is selected as the identification criterion. Phasor measurement units (PMUs) are selected as measuring devices. Then, the effects of operation conditions and external devices in distribution networks on the proposed method are discussed, and the phase errors caused by them are calculated to correct the identification method. Finally, the field testing and simulation experiments are conducted to verify the effectiveness and robustness of the proposed method.

وصف الملف: electronic resource

Relation: https://ieeexplore.ieee.org/document/9755270/; https://doaj.org/toc/2196-5420

URL الوصول: https://doaj.org/article/6e46341f7583471aa7041ec9d8146662

المؤلفون: Junzhong Liu, Yuzhen Wang, Guanghui He, Xinhua Wang, Minfeng Sun

المصدر: BMC Medical Imaging, Vol 22, Iss 1, Pp 1-8 (2022)

مصطلحات موضوعية: COVID-19, Mycoplasma pneumonia, Quantitative CT, Medical technology, R855-855.5

الوصف: Abstract Objective The purpose of this study was to compare imaging features between COVID-19 and mycoplasma pneumonia (MP). Materials and methods The data of patients with mild COVID-19 and MP who underwent chest computed tomography (CT) examination from February 1, 2020 to April 17, 2020 were retrospectively analyzed. The Pneumonia-CT-LKM-PP model based on a deep learning algorithm was used to automatically quantify the number, volume, and involved lobes of pulmonary lesions, and longitudinal changes in quantitative parameters were assessed in three CT follow-ups. Results A total of 10 patients with mild COVID-19 and 13 patients with MP were included in this study. There was no difference in lymphocyte counts at baseline between the two groups (1.43 ± 0.45 vs. 1.44 ± 0.50, p = 0.279). C-reactive protein levels were significantly higher in MP group than in COVID-19 group (p

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2342

URL الوصول: https://doaj.org/article/ac3210a1cd20475589a97d224f6fd84e

المؤلفون: Xiaoli Zhu, Anjin Hong, Xihuan Sun, Weijie Wang, Guanghui He, Huan Luo, Zhenhua Wu, Qingyan Xu, Zhiyu Hu, Xiaobing Wu, Donghong Huang, Li Li, Xilin Zhao, Xianming Deng

المصدر: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

مصطلحات موضوعية: multidrug-resistant bacteria, persister, biofilm, MRSA, antibiotic, mechanism of action, Microbiology, QR1-502

الوصف: Multidrug-resistant (MDR) bacteria pose a significant clinical threat to human health, but the development of antibiotics cannot meet the urgent need for effective agents, especially those that can kill persisters and biofilms. Here, we reported that nigericin showed potent bactericidal activity against various clinical MDR Gram-positive bacteria, persisters and biofilms, with low frequencies of resistance development. Moreover, nigericin exhibited favorable in vivo efficacy in deep-seated mouse biofilm, murine skin and bloodstream infection models. With Staphylococcus aureus, nigericin disrupted ATP production and electron transport chain; cell death was associated with altered membrane structure and permeability. Obtaining nigericin-resistant/tolerant mutants required multiple rounds of challenge, and, cross-resistance to members of several antimicrobial classes was absent, probably due to distinct nigericin action with the GraSR two-component regulatory system. Thus, our work reveals that nigericin is a promising antibiotic candidate for the treatment of chronic or recurrent infections caused by Gram-positive bacteria.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.1055929/full; https://doaj.org/toc/2235-2988

URL الوصول: https://doaj.org/article/0c3a4b61daa84b25af22f8e3b6d09184

المؤلفون: Guanghui He, Tongyuan Li, Jun Tang, Guodong Zhang

المصدر: Diagnostic and Interventional Radiology, Vol 24, Iss 6, Pp 372-377 (2018)

مصطلحات موضوعية: Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: PURPOSE:We aimed to evaluate the role of cone-beam computed tomography (CT) performed as an adjunct to angiography for the determination of feeding vessels responsible for bleeding during arterial embolization for massive hemoptysis.METHODS:In this retrospective study, 23 patients with massive hemoptysis who underwent cone-beam CT evaluation prior to arterial embolization from December 2014 to December 2017 were included. During the angiographic session, two interventional radiologists selected the possible feeding vessels that were likely to supply the bleeding target lesions. Contrast-enhanced cone-beam CT was performed at the indefinite feeding arteries as an adjunct to angiography to determine whether the artery was a real feeding vessel, based on whether the target lesion was detected in the perfused territory of the study artery on images.RESULTS:Selective cone-beam CT was successfully performed in 21 patients, at 26 possible feeding vessels that were detected by selective angiography. Cone-beam CT determined the feeding vessel in 24 arteries (92.3%) in 19 patients (90.5%). As a result of cone-beam CT findings, 16 of 24 study arteries were judged as definitively not feeding vessels (66.7%) and the remaining 8 study arteries were judged as definitively feeding vessels (33.3%). In 2 of 26 study arteries, cone-beam CT could not determine the feeding vessel (7.7%).CONCLUSION:Cone-beam CT performed as an adjunctive technique to angiography is sufficient to provide adequate information for confident determination of the feeding vessel, which is essential for the operators to perform accurate embolization during arterial embolization for massive hemoptysis.

وصف الملف: electronic resource

Relation: http://www.dirjournal.org/archives/archive-detail/article-preview/utility-of-cone-beam-ct-imaging-for-the-determinat/55033; https://doaj.org/toc/1305-3825; https://doaj.org/toc/1305-3612

URL الوصول: https://doaj.org/article/34c84d3e4b5841c7a19c1d1a6eb13d7f

المؤلفون: Wei Zhang, Jian Song, Yue Zhang, Yingxue Ma, Jing Yang, Guanghui He, Song Chen

المصدر: BMC Ophthalmology, Vol 18, Iss 1, Pp 1-8 (2018)

مصطلحات موضوعية: Intermittent high glucose, HMGB1, Oxidative stress, Autophagy, Retinal pigment epithelium cell, Ophthalmology, RE1-994

الوصف: Abstract Background In this study, we evaluated the effects of intermittent high glucose on oxidative stress production in retinal pigmented epithelial (RPE) cells and explored whether the mechanisms of autophagy and apoptosis in oxidative stress are associated with high-mobility group box 1 (HMGB1) protein. Methods Cultured human RPE cell line ARPE-19 cells were exposed to intermittent high glucose-induced oxidative stress. Reactive oxygen species (ROS) was determined by 2′, 7′-dichlorofluorescin diacetate (DCFH-DA); and malonyldialdehyde (MDA), superoxide dismutase (SOD) by commercial kits. Transmission electron microscopy was used to observe the generation of autophagosome. And MTT assay was used to examine the effect of autophagy on cell viability. For the inhibition experiments, cells were pre-incubated with lysosomal inhibitors NH4Cl or N-acetyl cysteine (NAC).Western blot was used to measure the expression patterns of autophagic markers, including LC3 and p62. The expression of HMGB1 was detected by immunohistochemistry.Cells were pre-incubated with HMGB1 inhibitor ethyl pyruvate (EP) ,then detected the expression pattern of autophagic markers and level of cellular ROS. Results We found that intermittent high glucose significantly increased oxidative stress levels (as indicated by ROS, MDA, SOD), increased in the generation of autophagosome, decreased the level of p62, induced conversion of LC3 I to LC3 II. We further demonstrated that the NH4Cl/NAC inhibited intermittent high glucose-induced autophage by altered level of LC3 and p62. Intermittent high glucose-induced autophagy is independent of HMGB1 signaling, inhibition of HMGB1 release by EP decreased expression pattern of autophagic markers and level of cellular viability. Conclusions Under intermittent high glucose condition, autophagy may be required for preventing oxidative stress-induced injury in RPE. HMGB1 plays important roles in signaling for both autophagy and oxidative stress.

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12886-018-0864-5; https://doaj.org/toc/1471-2415

URL الوصول: https://doaj.org/article/a27612f036574d6bb0b39a37d93f2650