المؤلفون: Weaver, Nick A, Zhao, Lei, Biesbroek, J Matthijs, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee‐Joon, Caballero, Miguel ÁA, Chappell, Francesca M, Chen, Christopher PLH, Dichgans, Martin, Duering, Marco, Georgakis, Marios K, van der Giessen, Ruben S, Gyanwali, Bibek, Hamilton, Olivia KL, Hilal, Saima, Hofe, Elise M vom, de Kort, Paul LM, Koudstaal, Peter J, Lam, Bonnie YK, Lim, Jae‐Sung, Makin, Stephen DJ, Mok, Vincent CT, Shi, Lin, Hernández, Maria C Valdés, Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M, Wollenweber, Frank A, Wong, Adrian, Xin, Xu, consortium, Meta VCI Map, DeCarli, C, Fletcher, EA, Maillard, P, Barnes, J, Sudre, CH, Schott, JM, Ikram, MA, Papma, JM, Steketee, RME, Vernooij, MW, Bordet, R, Lopes, R, Huang, C‐W, Frayne, R, McCreary, CR, Smith, EE, group, Calgary Normative Study, Backes, W, Köhler, S, van Oostenbrugge, RJ, Staals, J, Verhey, F, Cheng, CY, Kalaria, RN, Werring, D, Hsu, JL, Huang, K‐L, van der Grond, J, Jukema, JW, van der Mast, RC, Nijboer, TCW, group, Framingham Heart Study, Yu, K‐H, group, The Dutch Parelsnoer Institute–Neurodegenerative diseases, Schmidt, R, Pirpamer, L, MacIntosh, BJ, Robertson, AD, de Leeuw, F‐E, Tuladhar, AM, Chaturvedi, N, Tillin, T, Brodaty, H, Sachdev, P, group, TABASCO, Barkhof, F, van der Flier, WM, Kappelle, LJ, Biessels, Geert Jan

المصدر: Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring. 11(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Atherosclerosis, Clinical Research, Brain Disorders, Acquired Cognitive Impairment, Stroke, Neurosciences, Meta VCI Map consortium, Cerebrovascular disease, Consortium, Data harmonization, Lesion location, Lesion-symptom mapping, Small vessel disease, Support vector regression, Vascular cognitive impairment, Genetics, Biological psychology

الوصف: IntroductionThe Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies.MethodsCohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage.ResultsForty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage.DiscussionMeta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3wc4q24r

المؤلفون: Wels, Jacques, Wielgoszewska, Bożena, Moltrecht, Bettina, Booth, Charlotte, Green, Michael J., Hamilton, Olivia KL, Demou, Evangelia, Di Gessa, Giorgio, Huggins, Charlotte, Zhu, Jingmin, Santorelli, Gillian, Silverwood, Richard J., Kopasker, Daniel, Shaw, Richard J., Hughes, Alun, Patalay, Praveetha, Steves, Claire, Chaturvedi, Nishi, Porteous, David J., Rhead, Rebecca

المصدر: PLoS Medicine; 4/27/2023, Vol. 19 Issue 4, p1-17, 17p, 1 Chart, 5 Graphs

مصطلحات موضوعية: LONELINESS, TELECOMMUTING, DEMOGRAPHIC surveys, EMPLOYEE well-being, COVID-19 pandemic, WELL-being

مصطلحات جغرافية: UNITED Kingdom

مستخلص: Background: Home working has increased since the Coronavirus Disease 2019 (COVID-19) pandemic's onset with concerns that it may have adverse health implications. We assessed the association between home working and social and mental wellbeing among the employed population aged 16 to 66 through harmonised analyses of 7 UK longitudinal studies. Methods and findings: We estimated associations between home working and measures of psychological distress, low life satisfaction, poor self-rated health, low social contact, and loneliness across 3 different stages of the pandemic (T1 = April to June 2020 –first lockdown, T2 = July to October 2020 –eased restrictions, T3 = November 2020 to March 2021 –second lockdown) using modified Poisson regression and meta-analyses to pool results across studies. We successively adjusted the model for sociodemographic characteristics (e.g., age, sex), job characteristics (e.g., sector of activity, pre-pandemic home working propensities), and pre-pandemic health. Among respectively 10,367, 11,585, and 12,179 participants at T1, T2, and T3, we found higher rates of home working at T1 and T3 compared with T2, reflecting lockdown periods. Home working was not associated with psychological distress at T1 (RR = 0.92, 95% CI = 0.79 to 1.08) or T2 (RR = 0.99, 95% CI = 0.88 to 1.11), but a detrimental association was found with psychological distress at T3 (RR = 1.17, 95% CI = 1.05 to 1.30). Study limitations include the fact that pre-pandemic home working propensities were derived from external sources, no information was collected on home working dosage and possible reverse association between change in wellbeing and home working likelihood. Conclusions: No clear evidence of an association between home working and mental wellbeing was found, apart from greater risk of psychological distress during the second lockdown, but differences across subgroups (e.g., by sex or level of education) may exist. Longer term shifts to home working might not have adverse impacts on population wellbeing in the absence of pandemic restrictions but further monitoring of health inequalities is required. Jacques Wels and colleagues investigate the relationship between working from home and different indicators of mental and social wellbeing in the UK. Author summary: Why was this study done?: ➢ The number of workers working from home drastically increased during the Coronavirus Disease 2019 (COVID-19) pandemic. ➢ Little is known about the relationship between home working and mental and social wellbeing before and during the pandemic. ➢ As some home working schemes are likely to remain post-pandemic, understanding this association is important. What did the researchers do and find?: ➢ We analysed data from 7 UK-based population surveys to better understand the relationship between working from home (partially or fully) and different indicators of mental and social wellbeing. ➢ We analysed these relationships over 3 time points—i.e., April to June 2020 (T1), July to October 2020 (T2), and November 2020 to March 2021 (T3)—and controlled for sociodemographic (e.g., age, sex, and ethnicity) and job characteristics (e.g., sector of activity, key worker status). ➢ We found that home working was not associated with psychological distress at T1 or T2, but at T3 it was associated with increased psychological distress (relative risk = 1.17, 95% CI = 1.05 to 1.30). No other meaningful associations were found. ➢ We stratified these associations by sex, education level, age, and full-time versus part-time employment and found that home working was associated with greater psychological distress in those with lower than degree level education. What do these findings mean?: ➢ We found no clear evidence of a lasting association between home working, mental health, and social wellbeing which may indicate that, during the pandemic, home working was not detrimental nor beneficial for workers' wellbeing. ➢ Differences across subgroups may exist and specific impacts by sex, age, and education level need to be investigated further. [ABSTRACT FROM AUTHOR]

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المؤلفون: Clancy, Una, Garcia, Daniela Jaime, Stringer, Michael S, Thrippleton, Michael J, Valdés-Hernández, Maria C, Wiseman, Stewart, Hamilton, Olivia KL, Chappell, Francesca M, Brown, Rosalind, Blair, Gordon W, Hewins, Will, Sleight, Emilie, Ballerini, Lucia, Bastin, Mark E, Maniega, Susana Munoz, MacGillivray, Tom, Hetherington, Kirstie, Hamid, Charlene, Arteaga, Carmen, Morgan, Alasdair G, Manning, Cameron, Backhouse, Ellen, Hamilton, Iona, Job, Dominic, Marshall, Ian, Doubal, Fergus N, Wardlaw, Joanna M

مصطلحات موضوعية: FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases

الوصف: Supplemental material, sj-pdf-2-eso-10.1177_2396987320929617 for Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3 by Una Clancy, Daniela Jaime Garcia, Michael S Stringer, Michael J Thrippleton, Maria C Valdés-Hernández, Stewart Wiseman, Olivia KL Hamilton, Francesca M Chappell, Rosalind Brown, Gordon W Blair, Will Hewins, Emilie Sleight, Lucia Ballerini, Mark E Bastin, Susana Munoz Maniega, Tom MacGillivray, Kirstie Hetherington, Charlene Hamid, Carmen Arteaga, Alasdair G Morgan, Cameron Manning, Ellen Backhouse, Iona Hamilton, Dominic Job, Ian Marshall, Fergus N Doubal and Joanna M Wardlaw in European Stroke Journal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c49ba5471f5645def65e8aa7eacbca

المؤلفون: Clancy, Una, Garcia, Daniela Jaime, Stringer, Michael S, Thrippleton, Michael J, Valdés-Hernández, Maria C, Wiseman, Stewart, Hamilton, Olivia KL, Chappell, Francesca M, Brown, Rosalind, Blair, Gordon W, Hewins, Will, Sleight, Emilie, Ballerini, Lucia, Bastin, Mark E, Maniega, Susana Munoz, MacGillivray, Tom, Hetherington, Kirstie, Hamid, Charlene, Arteaga, Carmen, Morgan, Alasdair G, Manning, Cameron, Backhouse, Ellen, Hamilton, Iona, Job, Dominic, Marshall, Ian, Doubal, Fergus N, Wardlaw, Joanna M

مصطلحات موضوعية: FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases

الوصف: Supplemental material, sj-pdf-1-eso-10.1177_2396987320929617 for Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3 by Una Clancy, Daniela Jaime Garcia, Michael S Stringer, Michael J Thrippleton, Maria C Valdés-Hernández, Stewart Wiseman, Olivia KL Hamilton, Francesca M Chappell, Rosalind Brown, Gordon W Blair, Will Hewins, Emilie Sleight, Lucia Ballerini, Mark E Bastin, Susana Munoz Maniega, Tom MacGillivray, Kirstie Hetherington, Charlene Hamid, Carmen Arteaga, Alasdair G Morgan, Cameron Manning, Ellen Backhouse, Iona Hamilton, Dominic Job, Ian Marshall, Fergus N Doubal and Joanna M Wardlaw in European Stroke Journal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f96dd7278c045c66fdb11f973aeb576

المؤلفون: Clancy, Una, Garcia, Daniela Jaime, Stringer, Michael S, Thrippleton, Michael J, Valdés-Hernández, Maria C, Wiseman, Stewart, Hamilton, Olivia KL, Chappell, Francesca M, Brown, Rosalind, Blair, Gordon W, Hewins, Will, Sleight, Emilie, Ballerini, Lucia, Bastin, Mark E, Maniega, Susana Munoz, MacGillivray, Tom, Hetherington, Kirstie, Hamid, Charlene, Arteaga, Carmen, Morgan, Alasdair G, Manning, Cameron, Backhouse, Ellen, Hamilton, Iona, Job, Dominic, Marshall, Ian, Doubal, Fergus N, Wardlaw, Joanna M

المصدر: European Stroke Journal; November 2021, Vol. 6 Issue: 1 p81-88, 8p

مستخلص: Background Cerebral small vessel disease is a major cause of dementia and stroke, visible on brain magnetic resonance imaging. Recent data suggest that small vessel disease lesions may be dynamic, damage extends into normal-appearing brain and microvascular dysfunctions include abnormal blood–brain barrier leakage, vasoreactivity and pulsatility, but much remains unknown regarding underlying pathophysiology, symptoms, clinical features and risk factors of small vessel disease. Patients and Methods:The Mild Stroke Study 3 is a prospective observational cohort study to identify risk factors for and clinical implications of small vessel disease progression and regression among up to 300 adults with non-disabling stroke. We perform detailed serial clinical, cognitive, lifestyle, physiological, retinal and brain magnetic resonance imaging assessments over one year; we assess cerebrovascular reactivity, blood flow, pulsatility and blood–brain barrier leakage on magnetic resonance imaging at baseline; we follow up to four years by post and phone. The study is registered ISRCTN 12113543.Summary Factors which influence direction and rate of change of small vessel disease lesions are poorly understood. We investigate the role of small vessel dysfunction using advanced serial neuroimaging in a deeply phenotyped cohort to increase understanding of the natural history of small vessel disease, identify those at highest risk of early disease progression or regression and uncover novel targets for small vessel disease prevention and therapy.

المؤلفون: Green, Mark A, McKee, Martin, Hamilton, Olivia KL, Shaw, Richard J, Macleod, John, Boyd, Andy, Katikireddi, Srinivasa Vittal

المصدر: BMJ (British Medical Journal); 2023, Vol. 382 Issue: 7 pe075133-e075133, 1p

مستخلص: ObjectivesTo examine whether there is an association between people who experienced disrupted access to healthcare during the covid-19 pandemic and risk of an avoidable hospital admission.DesignObservational analysis using evidence from seven linked longitudinal cohort studies for England.SettingStudies linked to electronic health records from NHS Digital from 1 March 2020 to 25 August 2022. Data were accessed using the UK Longitudinal Linkage Collaboration trusted research environment.ParticipantsIndividual level records for 29 276 people.Main outcome measuresAvoidable hospital admissions defined as emergency hospital admissions for ambulatory care sensitive and emergency urgent care sensitive conditions.Results9742 participants (weighted percentage 35%, adjusted for sample structure of longitudinal cohorts) self-reported some form of disrupted access to healthcare during the covid-19 pandemic. People with disrupted access were at increased risk of any (odds ratio 1.80, 95% confidence interval 1.39 to 2.34), acute (2.01, 1.39 to 2.92), and chronic (1.80, 1.31 to 2.48) ambulatory care sensitive hospital admissions. For people who experienced disrupted access to appointments (eg, visiting their doctor or an outpatient department) and procedures (eg, surgery, cancer treatment), positive associations were found with measures of avoidable hospital admissions.ConclusionsEvidence from linked individual level data shows that people whose access to healthcare was disrupted were more likely to have a potentially preventable hospital admission. The findings highlight the need to increase healthcare investment to tackle the short and long term implications of the pandemic, and to protect treatments and procedures during future pandemics.

المؤلفون: Nathan J Cheetham, Milla Kibble, Andrew Wong, Richard J Silverwood, Anika Knuppel, Dylan M Williams, Olivia KL Hamilton, Paul H Lee, Charis Bridger Staatz, Giorgio Di Gessa, Jingmin Zhu, Srinivasa Vittal Katikireddi, George B Ploubidis, Ellen J Thompson, Ruth CE Bowyer, Xinyuan Zhang, Golboo Abbasian, Maria Paz Garcia, Deborah Hart, Jeffrey Seow, Carl Graham, Neophytos Kouphou, Sam Acors, Michael H Malim, Ruth E Mitchell, Kate Northstone, Daniel Major-Smith, Sarah Matthews, Thomas Breeze, Michael Crawford, Lynn Molloy, Alex SF Kwong, Katie Doores, Nishi Chaturvedi, Emma L Duncan, Nicholas J Timpson, Claire J Steves

المساهمون: Cheetham, Nathan J [0000-0002-2259-1556], Kibble, Milla [0000-0003-1130-4010], Hamilton, Olivia KL [0000-0002-5874-0058], Lee, Paul H [0000-0002-5729-6450], Bridger Staatz, Charis [0000-0002-2872-6968], Di Gessa, Giorgio [0000-0001-6154-1845], Zhu, Jingmin [0000-0001-8325-7589], Acors, Sam [0000-0001-6428-7707], Malim, Michael H [0000-0002-7699-2064], Major-Smith, Daniel [0000-0001-6467-2023], Duncan, Emma L [0000-0002-8143-4403], Steves, Claire J [0000-0002-4910-0489], Apollo - University of Cambridge Repository

المصدر: Cheetham, N, Thompson, E J, Bowyer, R, Zhang, X, Abbasian, G, Garcia, M P, Hart, D, Seow, J, Graham, C, Kouphou, N, Acors, S, Malim, M, Doores, K, Duncan, E & Steves, C 2023, ' Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies ', eLife, vol. 12, e80428 . https://doi.org/10.7554/eLife.80428

مصطلحات موضوعية: medicine, COVID-19 Vaccines, General Immunology and Microbiology, SARS-CoV-2, General Neuroscience, Vaccination, COVID-19, global health, General Medicine, ALSPAC, Antibodies, Viral, General Biochemistry, Genetics and Molecular Biology, Coronavirus, TwinsUK, Epidemiology and Global Health, Cross-Sectional Studies, Risk Factors, London, antibodies, Humans, epidemiology, human, Longitudinal Studies, Antibody, Research Article

الوصف: Peer reviewed: True
Background: SARS-CoV-2 antibody levels can be used to assess humoral immune responses following SARS-CoV-2 infection or vaccination, and may predict risk of future infection. Higher levels of SARS-CoV-2 anti-Spike antibodies are known to be associated with increased protection against future SARS-CoV-2 infection. However, variation in antibody levels and risk factors for lower antibody levels following each round of SARS-CoV-2 vaccination have not been explored across a wide range of socio-demographic, SARS-CoV-2 infection and vaccination, and health factors within population-based cohorts. Methods: Samples were collected from 9,361 individuals from TwinsUK and ALSPAC UK population-based longitudinal studies and tested for SARS-CoV-2 antibodies. Cross-sectional sampling was undertaken jointly in April-May 2021 (TwinsUK, N = 4,256; ALSPAC, N = 4,622), and in TwinsUK only in November 2021-January 2022 (N = 3,575). Variation in antibody levels after first, second, and third SARS-CoV-2 vaccination with health, socio-demographic, SARS-CoV-2 infection and SARS-CoV-2 vaccination variables were analysed. Using multivariable logistic regression models, we tested associations between antibody levels following vaccination and: (1) SARS-CoV-2 infection following vaccination(s); (2) health, socio-demographic, SARS-CoV-2 infection and SARS-CoV-2 vaccination variables. Results: Within TwinsUK, single-vaccinated individuals with the lowest 20% of anti-Spike antibody levels at initial testing had 3-fold greater odds of SARS-CoV-2 infection over the next six to nine months (OR = 2.9, 95% CI: 1.4, 6.0), compared to the top 20%. In TwinsUK and ALSPAC, individuals identified as at increased risk of COVID-19 complication through the UK 'Shielded Patient List' had consistently greater odds (2- to 4-fold) of having antibody levels in the lowest 10%. Third vaccination increased absolute antibody levels for almost all individuals, and reduced relative disparities compared with earlier vaccinations. Conclusions: These findings quantify the association between antibody level and risk of subsequent infection, and support a policy of triple vaccination for the generation of protective antibodies. Funding: Antibody testing was funded by UK Health Security Agency. The National Core Studies program is funded by COVID-19 Longitudinal Health and Wellbeing - National Core Study (LHW-NCS) HMT/UKRI/MRC (MC_PC_20030 & MC_PC_20059). Related funding was also provided by the NIHR 606 (CONVALESCENCE grant COV-LT-0009). TwinsUK is funded by the Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation (CDRF), Zoe Ltd and the National Institute for Health Research (NIHR) Clinical Research Network (CRN) and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC.

وصف الملف: application/pdf; application/zip; text/xml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bd99414d29f6de2b7fdb290da61a4c
https://doi.org/10.7554/elife.80428

المؤلفون: Shaw RJ; MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK., Rhead R; Centre for Longitudinal Studies (CLS), UCL Social Research Institute, University College London, London, UK.; Department of Psychological Medicine, King's College London, London, UK., Silverwood RJ; Centre for Longitudinal Studies (CLS), UCL Social Research Institute, University College London, London, UK., Wels J; MRC Unit for Lifelong Health and Ageing, University College London, London, UK.; Centre Metices, Université libre de Bruxelles, Brussels, BE., Zhu J; Department of Epidemiology & Public Health, University College London, London, UK., Hamilton OK; MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK., Gessa GD; Department of Epidemiology & Public Health, University College London, London, UK., Bowyer RC; Department of Twin Research and Genetic Epidemiology, School of Life Course & Population Sciences, King's College London, London, UK.; AI For Science & Government, Alan Turing Institute, London, UK., Moltrecht B; Centre for Longitudinal Studies (CLS), UCL Social Research Institute, University College London, London, UK., Green MJ; MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.; Division of Women's Community and Population Health, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA., Demou E; MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK., Pattaro S; Scottish Centre for Administrative Data Research (SCADR), University of Glasgow, Glasgow, UK., Zaninotto P; Department of Epidemiology & Public Health, University College London, London, UK., Boyd A; Population Health Sciences, University of Bristol, Bristol, UK., Greaves F; Department of Primary Care and Public Health, Imperial College London, London, UK., Chaturvedi N; MRC Unit for Lifelong Health and Ageing, University College London, London, UK., Ploubidis GB; Centre for Longitudinal Studies (CLS), UCL Social Research Institute, University College London, London, UK., Katikireddi SV; MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.

المصدر: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Aug 25. Date of Electronic Publication: 2023 Aug 25.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE

مستخلص: Introduction: Following the acute phase of the COVID-19 pandemic, record numbers of people became economically inactive (i.e., neither working nor looking for work), or non-employed (including unemployed job seekers and economically inactive people). A possible explanation is people leaving the workforce after contracting COVID-19. We investigated whether testing positive for SARS-CoV-2 is related to subsequent economic inactivity and non-employment, among people employed pre-pandemic.
Methods: The data came from five UK longitudinal population studies held by both the UK Longitudinal Linkage Collaboration (UK LLC; primary analyses) and the UK Data Service (UKDS; secondary analyses). We pooled data from five long established studies (1970 British Cohort Study, English Longitudinal Study of Ageing, 1958 National Child Development Study, Next Steps, and Understanding Society). The study population were aged 25-65 years between March 2020 to March 2021 and employed pre-pandemic. Outcomes were economic inactivity and non-employment measured at the time of the last follow-up survey (November 2020 to March 2021, depending on study). For the UK LLC sample (n=8,174), COVID-19 infection was indicated by a positive SARS-CoV-2 test in NHS England records. For the UKDS sample we used self-reported measures of COVID-19 infection (n=13,881). Logistic regression models estimated odds ratios (ORs) with 95% confidence intervals (95%CIs) adjusting for potential confounders including sociodemographic variables, pre-pandemic health and occupational class.
Results: Testing positive for SARS-CoV-2 was very weakly associated with economic inactivity (OR 1.08 95%CI 0.68-1.73) and non-employment status (OR 1.09. 95%CI 0.77-1.55) in the primary analyses. In secondary analyses, self-reported test-confirmed COVID-19 was not associated with either economic inactivity (OR 1.01 95%CI 0.70-1.44) or non-employment status (OR 1.03 95%CI 0.79-1.35).
Conclusions: Among people employed pre-pandemic, testing positive for SARS-CoV-2 was either weakly or not associated with increased economic inactivity or non-employment. Research on the recent increases in economic inactivity should focus on other potential causes.

المؤلفون: Green MA; Geographic Data Science Lab, Department of Geography & Planning, University of Liverpool, Liverpool, UK.; MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK., McKee M; Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK., Hamilton OK; MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK., Shaw RJ; MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK., Macleod J; Population Health Sciences, University of Bristol, Bristol, UK.; The National Institute for Health and Care Research Applied Research Collaboration West (NIHR ARC West) at University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK., Boyd A; Population Health Sciences, University of Bristol, Bristol, UK., Katikireddi SV; MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.

مؤلفون مشاركون: LH&W NCS Collaborative

المصدر: BMJ (Clinical research ed.) [BMJ] 2023 Jul 19; Vol. 382, pp. e075133. Date of Electronic Publication: 2023 Jul 19.

نوع المنشور: Observational Study; Journal Article

بيانات الدورية: Publisher: British Medical Association Country of Publication: England NLM ID: 8900488 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-1833 (Electronic) Linking ISSN: 09598138 NLM ISO Abbreviation: BMJ Subsets: MEDLINE

مواضيع طبية MeSH: Pandemics* , COVID-19*/epidemiology, Humans ; Longitudinal Studies ; Self Report ; Hospitalization ; England/epidemiology ; Delivery of Health Care ; Hospitals

مستخلص: Objectives: To examine whether there is an association between people who experienced disrupted access to healthcare during the covid-19 pandemic and risk of an avoidable hospital admission.
Design: Observational analysis using evidence from seven linked longitudinal cohort studies for England.
Setting: Studies linked to electronic health records from NHS Digital from 1 March 2020 to 25 August 2022. Data were accessed using the UK Longitudinal Linkage Collaboration trusted research environment.
Participants: Individual level records for 29 276 people.
Main Outcome Measures: Avoidable hospital admissions defined as emergency hospital admissions for ambulatory care sensitive and emergency urgent care sensitive conditions.
Results: 9742 participants (weighted percentage 35%, adjusted for sample structure of longitudinal cohorts) self-reported some form of disrupted access to healthcare during the covid-19 pandemic. People with disrupted access were at increased risk of any (odds ratio 1.80, 95% confidence interval 1.39 to 2.34), acute (2.01, 1.39 to 2.92), and chronic (1.80, 1.31 to 2.48) ambulatory care sensitive hospital admissions. For people who experienced disrupted access to appointments (eg, visiting their doctor or an outpatient department) and procedures (eg, surgery, cancer treatment), positive associations were found with measures of avoidable hospital admissions.
Conclusions: Evidence from linked individual level data shows that people whose access to healthcare was disrupted were more likely to have a potentially preventable hospital admission. The findings highlight the need to increase healthcare investment to tackle the short and long term implications of the pandemic, and to protect treatments and procedures during future pandemics.
Competing Interests: Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest/ and declare: funding from the Medical Research Council, NHS Research Scotland, Scottish Government, Health Data Research UK and National Institute for Health and Care Research Applied Research Collaboration West for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work.
(© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. No commercial re-use. See rights and permissions. Published by BMJ.)

المؤلفون: Wielgoszewska B; Centre for Longitudinal Studies (CLS), University College London, United Kingdom., Booth C; Centre for Longitudinal Studies (CLS), University College London, United Kingdom., Green MJ; MRC/CSO Social & Public Health Sciences Unit, University of Glasgow, United Kingdom., Hamilton OK; MRC/CSO Social & Public Health Sciences Unit, University of Glasgow, United Kingdom., Wels J; MRC Unit for Lifelong Health and Ageing, University College London, United Kingdom.

المصدر: Industrial health [Ind Health] 2022 Jul 31; Vol. 60 (4), pp. 345-359. Date of Electronic Publication: 2022 May 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Institute of Industrial Health Country of Publication: Japan NLM ID: 2985065R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-8026 (Electronic) Linking ISSN: 00198366 NLM ISO Abbreviation: Ind Health Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19*/epidemiology , Pandemics*, Cohort Studies ; Depression/epidemiology ; Humans ; Longitudinal Studies ; Mental Health ; Middle Aged

مستخلص: Little is known about the relationship between homeworking and mental health during the Covid-19 pandemic and how it might differ by keyworker status. To understand this relationship, we use longitudinal data collected over three time points during the pandemic from three British cohort studies born in 1958 (National Child Development Study), 1970 (British Cohort Study) and 1989-90 (Next Step) as well as from a population-based study stratified by four age groups (Understanding Society). We estimate the association between life satisfaction, anxiety, depression, and psychological distress and homeworking by key worker status using mixed effects models with maximum likelihood estimation to account for repeated measurements across the pandemic, allowing intercepts to vary across individuals after controlling for a set of covariates including pre-pandemic home working propensities and loneliness. Results show that key workers working from home showed the greatest decline in mental health outcomes relative to other groups. Pre-pandemic homeworking did not significantly change the nature of such a relationship and loneliness slightly attenuated some of the effects. Finally, mental health outcomes varied across age-groups and time points. The discussion emphasises the need to pay attention to key workers when assessing the relationship between mental health and homeworking.