المؤلفون: Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Aqeilan, Rami I, Arama, Eli, Baehrecke, Eric H, Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A, Bartek, Jiri, Bazan, Nicolas G, Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu JM, Bianchi, Marco E, Blagosklonny, Mikhail V, Blander, J Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D, Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A, Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M, Dawson, Valina L, De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J, Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J Marie, Haupt, Ygal, He, Sudan, Heery, David M, Hengartner, Michael O, Hetz, Claudio, Hildeman, David A, Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J, Kanneganti, Thirumala-Devi

المصدر: Cell Death & Differentiation. 30(5)

مصطلحات موضوعية: Digestive Diseases, Liver Disease, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Good Health and Well Being, Animals, Humans, Apoptosis, Cell Death, Caspases, Carcinogenesis, Mammals, Biological Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology

الوصف: Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3cw4p19b

المؤلفون: Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Annicchiarico-Petruzzelli, Margherita, Antonov, Alexey V, Arama, Eli, Baehrecke, Eric H, Barlev, Nickolai A, Bazan, Nicolas G, Bernassola, Francesca, Bertrand, Mathieu JM, Bianchi, Katiuscia, Blagosklonny, Mikhail V, Blomgren, Klas, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chandel, Navdeep S, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Cohen, Gerald M, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D’Angiolella, Vincenzo, Dawson, Ted M, Dawson, Valina L, De Laurenzi, Vincenzo, De Maria, Ruggero, Debatin, Klaus-Michael, DeBerardinis, Ralph J, Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M, Dixon, Scott J, Duckett, Colin S, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Fimia, Gian Maria, Fulda, Simone, García-Sáez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Golstein, Pierre, Gottlieb, Eyal, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J Marie, Harris, Isaac S, Hengartner, Michael O, Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Joseph, Bertrand, Jost, Philipp J, Juin, Philippe P, Kaiser, William J, Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N, Klionsky, Daniel J, Knight, Richard A, Kumar, Sharad, Lee, Sam W, Lemasters, John J, Levine, Beth, Linkermann, Andreas, Lipton, Stuart A, Lockshin, Richard A, López-Otín, Carlos, Lowe, Scott W, Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola

المصدر: Cell Death & Differentiation. 25(3)

مصطلحات موضوعية: Animals, Cell Death, Humans, Lysosomes, Mitochondrial Membrane Transport Proteins, Mitochondrial Permeability Transition Pore, Necrosis, Biological Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology

الوصف: Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6476p3bg

المؤلفون: Titz, Alexander, Wälti, Martin A., Olieric, Vincent, Paschinger, Katharina, Nöbauer, Katharina, Guo, Xiaoqiang, Seeberger, Peter H., Wilson, Iain B. H., Aebi, Markus, Hengartner, Michael O., Künzler, Markus, Butschi, Alex

URL الوصول: https://www.europeana.eu/item/2048441/item_RPSXW6VSQWMXDDRNYBAAIACF76PW6IHZ?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCa

المؤلفون: McColl, B., May, Elisa, Nicotera, Pierluigi, Bano, Daniele, Dinsdale, David, Cabrera-Socorro, Alfredo, Maida, Simona, Lambacher, Nils, Hengartner, Michael O.

URL الوصول: https://www.europeana.eu/item/2048441/item_FU5HSZ3RWTMTTMSL2JTXECGKXUR3AYE3?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCa

المؤلفون: Sendoel, Ataman, Subasic, Deni^{Aff1, Aff2}, Ducoli, Luca^{Aff1, Aff2, Aff3}, Keller, Martin^{Aff1, Aff2}, Michel, Erich^{Aff4, Aff11}, Kohler, Ines, Singh, Kapil Dev^{Aff1, Aff2, Aff12}, Zheng, Xue, Brümmer, Anneke, Imig, Jochen^{Aff3, Aff5, Aff13, Aff14}, Kishore, Shivendra, Wu, Yibo^{Aff6, Aff7}, Kanitz, Alexander, Kaech, Andres, Mittal, Nitish, Matia-González, Ana M., Gerber, André P., Zavolan, Mihaela, Aebersold, Ruedi^{Aff6, Aff10}, Hall, Jonathan, Allain, Frédéric H.-T., Hengartner, Michael O.^{Aff1, Aff10}

المصدر: Cell Death & Differentiation: Official journal of the ADMC Associazione Differenziamento e Morte Cellulare. 26(10):2157-2178

المؤلفون: Degtyareva, Natasha P., Greenwell, Patricia, Hofmann, E. Randal, Hengartner, Michael O., Zhang, Lijia, Culotti, Joseph G., Petes, Thomas D.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2002 Feb . 99(4), 2158-2163.

URL الوصول: https://www.jstor.org/stable/3057935

المؤلفون: Beyer, Antje^Aff1_12, Eberhard, Ralf^{Aff2_12, Aff3_12}, Piterman, Nir^Aff4_12, Hengartner, Michael O.^Aff2_12, Hajnal, Alex^Aff2_12, Fisher, Jasmin^Aff5_12

المساهمون: Goryanin, Igor I., editor^AffID1, Goryachev, Andrew B., editor^AffID2

المصدر: Advances in Systems Biology. 736:211-233

المؤلفون: Beyer, Antje^Aff20, Eberhard, Ralf^{Aff21, Aff22}, Piterman, Nir^Aff23, Hengartner, Michael O.^Aff21, Hajnal, Alex^Aff21, Fisher, Jasmin^Aff24

المساهمون: Hutchison, David, editor^Aff1, Kanade, Takeo, editor^Aff2, Kittler, Josef, editor^Aff3, Kleinberg, Jon M., editor^Aff4, Mattern, Friedemann, editor^Aff5, Mitchell, John C., editor^Aff6, Naor, Moni, editor^Aff7, Nierstrasz, Oscar, editor^Aff8, Pandu Rangan, C., editor^Aff9, Steffen, Bernhard, editor^Aff10, Sudan, Madhu, editor^Aff11, Terzopoulos, Demetri, editor^Aff12, Tygar, Doug, editor^Aff13, Vardi, Moshe Y., editor^Aff14, Weikum, Gerhard, editor^Aff15, Lones, Michael A., editor^Aff16, Smith, Stephen L., editor^Aff16, Teichmann, Sarah, editor^Aff17, Naef, Felix, editor^Aff18, Walker, James A., editor^Aff19, Trefzer, Martin A., editor^Aff19

المصدر: Information Processign in Cells and Tissues : 9th International Conference, IPCAT 2012, Cambridge, UK, March 31 – April 2, 2012. Proceedings. 7223:99-104

المؤلفون: Wohlschlager, Therese, Butschi, Alex, Grassi, Paola, Sutov, Grigorij, Gauss, Robert, Hauck, Dirk, Schmieder, Stefanie S., Knobel, Martin, Titz, Alexander, Dell, Anne, Haslam, Stuart M., Hengartner, Michael O., Aebi, Markus, Künzler, Markus

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jul 01. 111(27), 9675-9675.

URL الوصول: http://dx.doi.org/10.1073/pnas.ss11127

المؤلفون: Martinez, Jennifer, Almendinger, Johann, Oberst, Andrew, Ness, Rachel, Dillon, Christopher P., Fitzgerald, Patrick, Hengartner, Michael O., Green, Douglas R.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2011 Oct . 108(42), 17396-17401.

URL الوصول: https://www.jstor.org/stable/41352515