المؤلفون: Betim Redzepi, MD, Christel H. Kamani, MD, Niccolo Maurizi, MD, Marie Théaudin, MD, PhD, John Prior, MD, PhD, Pierre Monney, MD

المصدر: CJC Open, Vol 6, Iss 2, Pp 118-121 (2024)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589790X23003384; https://doaj.org/toc/2589-790X

URL الوصول: https://doaj.org/article/e6422fe52f894f71ad9d1569647b0f12

المؤلفون: Samirah Alshehri, John Prior, Mohammed Moshebah, Luis Schiappacasse, Vincent Dunet

المصدر: European Journal of Hybrid Imaging, Vol 5, Iss 1, Pp 1-6 (2021)

مصطلحات موضوعية: Radiation, Necrosis, Brain, Metastasis, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: Abstract Positron emission tomography (PET) using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET has been shown to be a useful tool for differentiating radiation therapy outcomes, such as brain metastasis recurrence or radiation necrosis. We present the case of a female patient with brain metastases from pulmonary mucinous adenocarcinoma with suspicion of tumor recurrence on follow-up magnetic resonance imaging (MRI) after radiosurgery. 18F-FET PET/computed tomography (CT) was indicative of radiation necrosis. Due to the patient's medical history and the discrepancy between the brain MRI and PET/CT results, surgical biopsies were decided, which were positive for brain metastasis recurrence. The diagnosis of metastasis recurrence may also be challenging on 18F-FET PET/CT. In case of discrepancies between MRI and PET/CT results, false-negative 18F-FET PET/CT remains a possibility and requires careful follow-up or biopsy.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2510-3636

URL الوصول: https://doaj.org/article/ef9868e2e8fe49a0a5bc78d664ad469a

المؤلفون: John Prior, Solange Peters, Krisztian Homicsko, Sarah Boughdad, Niklaus Schaefer, Antonia Digklia, Clarisse Dromain, Mounir Trimech, Ana Dolcan

المصدر: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy is a validated treatment option for patients with advanced prostate cancer. Although PSMA expression is not limited to prostate tissue, little is known about its relevance to other types of cancer. Here, we present a case report of a patient with uterine leiomyosarcoma that is progressing while on immunotherapy and treated with 177Lu-PSMA radionuclide therapy. We report for the first time that 177Lu-PSMA radionuclide therapy combined with immunotherapy outside of prostate cancer. We did observe post-treatment reduction of tumor growth rate, although we did not notice disease response based on RECIST criteria. We suggest that 177Lu-PSMA treatment especially combined with immunotherapy may be an option for patients with cancer without other therapeutic options. Insights: 177Lu-PSMA radionuclide therapy should be considered for any tumor stained positive for PSMA.

وصف الملف: electronic resource

Relation: https://jitc.bmj.com/content/10/10/e005383.full; https://doaj.org/toc/2051-1426

URL الوصول: https://doaj.org/article/50a540258e4148daa7709fb78b369abc

المؤلفون: Berardino De Bari, Thomas Breuneval, Michele Zeverino, Sarah Godin, Letizia Deantonio, Christine Geldhof, Jean Bourhis, Nicklaus Schaefer, Raphaël Moeckli, John Prior, Mahmut Ozsahin

المصدر: PLoS ONE, Vol 13, Iss 10, p e0204013 (2018)

مصطلحات موضوعية: Medicine, Science

الوصف: PURPOSE:To study the potential of (99m)Tc-Mebrofenin hepatobiliary scintigraphy (HBS) in identifying the short-term variations of liver function after stereotactic body radiotherapy (SBRT) for liver cancers. MATERIAL AND METHODS:We treated with SBRT 3 patients (pts) affected by a cholangiocarcinoma and 3 patient presenting liver metastases (3x15 Gy, 4 pts; 5x8 Gy, 1 pt; 6x5 Gy, 1 pt). All patients received HBS before and 3 months after SBRT, which were co-registered with the simulation CT-scan. Structures corresponding to isodoses from 10-90 Gy were created, with intervals of 10 Gy. Finally, the variations of the mean activity (MBq) in each isodose structure have been calculated. Then, a linear regression analysis was performed. RESULTS:We showed a linear reduction of the activity, significantly related to the delivered dose (p

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC6179216?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/a6b8f5f22d064fd19e293ef16e17b5c6

المؤلفون: Marine Gouffon, Samuel Iff, Katrin Ziegler, Maria Larche, Christiane Schwarzenbach, John Prior, Maurice Matter, Christoph Stettler, François Pralong

المصدر: Swiss Medical Weekly, Vol 144, Iss 0708 (2014)

مصطلحات موضوعية: follow-up, diagnosis, Epidemiology, Neuroendocrine neoplasma, therapy., Medicine

الوصف: BACKGROUND: Neuroendocrine neoplasms (NENs) are difficult to diagnose. We used SwissNET data to characterise NEN patients followed in the two academic centres of western Switzerland (WS), and to compare them with patients followed in eastern Switzerland (ES) as well as with international guidelines. METHOD: SwissNET is a prospective database covering data from 522 consecutive patients (285 men, 237 women) from WS (n = 99) and ES (n = 423). RESULTS: Mean ± SD age at diagnosis was 59.0 ± 15.7 years. Overall, 76/522 experienced a functional syndrome, with a median interval of 1.0 (IQR: 1.0–3.0) year between symptoms onset and diagnosis. A total of 51/522 of these tumours were incidental. The primary tumour site was the small intestine (29%), pancreas (21%), appendix (18%) and lung (11%) in both regions combined. In all, 513 functional imaging studies were obtained (139 in WS, 374 in ES). Of these, 381 were 111In-pentetreotide scintigraphies and 20 were 68Ga-DOTATOC PET. First line therapy was surgery in 87% of patients, medical therapy (biotherapy or chemotherapy) in 9% and irradiation in 3% for both regions together. CONCLUSION: Swiss NEN patients appear similar to what has been described in the literature. Imaging by somatostatin receptor scintigraphy (SRS) is widely used in both regions of Switzerland. In good accordance with published guidelines, data on first line therapy demonstrate the crucial role of surgery. The low incidence of biotherapy suggests that long-acting somatostatin analogues are not yet widely used for their anti-proliferative effects. The SwissNET initiative should help improve compliance with ENETS guidelines in the workup and care of NEN patients.

وصف الملف: electronic resource

Relation: https://www.smw.ch/index.php/smw/article/view/1826; https://doaj.org/toc/1424-3997

URL الوصول: https://doaj.org/article/6255d9a43cd547ff9e9d2bd7f2bdd3b0

المؤلفون: John Prior. Estlin

URL الوصول: https://www.europeana.eu/item/9200143/BibliographicResource_2000069445851?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCa

المؤلفون: Clément. Perrot, John Prior. Estlin

URL الوصول: https://www.europeana.eu/item/9200143/BibliographicResource_2000069445497?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCa

المؤلفون: John Prior. Estlin

URL الوصول: https://www.europeana.eu/item/9200143/BibliographicResource_2000069445474?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCa

المؤلفون: John Prior, http://data.europeana.eu/agent/base/114649, Brasenose College (University of Oxford).

URL الوصول: https://www.europeana.eu/item/9200143/BibliographicResource_2000069408025?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCa

المؤلفون: Emeline Gauthiez, Emilie Uldry, Alix T. Coste, John Prior, Matthias Cavassini, Aline Munting

المصدر: Revue Médicale Suisse. 19:708-712

مصطلحات موضوعية: General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::682c44a82ba21eaec6974f2d08684841
https://doi.org/10.53738/revmed.2023.19.822.708