يعرض 1 - 10 نتائج من 44 نتيجة بحث عن '"Juby Mathew"', وقت الاستعلام: 0.81s تنقيح النتائج
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    دورية أكاديمية

    المصدر: Molecular Genetics and Metabolism Reports, Vol 4, Iss C, Pp 53-61 (2015)

    الوصف: Mucopolysaccharidosis VI (MPS VI) is an autosomal recessive inborn error of metabolism caused by mutations in the arylsulfatase B gene (ARSB) and consequent deficient activity of ARSB, a lysosomal enzyme. We present here the results of a study undertaken to identify the mutations in ARSB in MPS VI patients in India. Around 160 ARSB mutations, of which just 4 are from India, have been reported in the literature. Our study covered nine MPS VI patients from eight families. Both familial mutations were found in seven families, and only one mutation was found in one family. Seven mutations were found — four novel (p.G38_G40del3, p.C91R, p.L98R and p.R315P), two previously reported from India (p.D53N and p.W450C), and one reported from outside India (p.R160Q). One mutation, p.W450C, was present in two families, and the other six mutations were present in one family each. Analysis of the molecular structure of the enzyme revealed that most of these mutations either cause loss of an active site residue or destabilize the structure of the enzyme. The only previous study on mutations in ARSB in Indian MPS VI patients, by Kantaputra et al. 2014 [1], reported four novel mutations of which two (p.D53N and p.W450C) were found in our study as well. Till date, nine mutations have been reported from India, through our study and the Kantaputra study. Eight out of these nine mutations have been found only in India. This suggests that the population studied by us might have its own typical set of mutations, with other populations equally likely to have their own set of mutations.

    وصف الملف: electronic resource

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    المؤلفون: Jilse Jacob, Dr. Juby Mathew

    الوصف: — In this paper, ML strategy for detecting phoney reviews is proposed. Using a range of feature engineering methodologies, this paper extends beyond the review's feature extraction technique to identify various examiner behaviours. The paper compares and contrasts the outcomes of various programmes. We compared the effectiveness of several classifiers in both cases using an actual dataset of restaurant ratings with and without factors derived from the user's activitiesWhen it comes to the f-score, the remaining classifiers have the highest f-score of 74.79 percent. According to the results. The f-score has grown by 14.14 percent after factoring behavioural characteristics of the reviewers.

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    المؤلفون: Jobin Joseph, Dr. Juby Mathew

    الوصف: — In today's web context, where participation and collaboration are the foundation for the development of common knowledge, the usage of Metaverses as a platform for human interaction is a worldwide trend. It's a virtual or augmented reality universe that allows you to create virtual social interactions. Neal Stephenson coined the term "metaverse" in his 1992 science fiction novel "Snow Crash," which envisioned lifelike avatars meeting in realistic 3D buildings and other virtual reality scenarios. However, the term "metaverse" was coined by Facebook, now known as Meta, to define its goal of working and playing in a virtual environment. Metaverse is all about 3D models and virtually created environment. In this paper I am going to discuss about sample implementation of metaverse by building an application based on augmented reality. It is an android application which is developed with unity framework.  

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    المصدر: Biomedical Sciences Instrumentation. 57:184-190

    الوصف: Cortical Visual Impairment (CVI) is resultant from neurological injury and damage to visual pathways or vision centers in the brain. CVI is sometimes undiagnosed in individuals with brain injuries due to the complexity of the human visual system. The International Institute for the Brain (iBrain) is a specialized school for students ages 5 to 21 who have a brain disorder or an acquired brain injury. They often present with noticeable CVI. While there are various metrics and interventions for the pediatric population, the adequacy has been lacking in terms of the vulnerability of this non-verbal population. Assessing the safety and effectiveness of rehabilitative interventions for this fragile student population can be challenging as most traditional metrics cannot be used. In this methodological review paper, available metrics were investigated and their applicability for this specific population is discussed with the end goal of identifying the best metrics that could be used to determine treatment effectiveness and providing a way for monitoring adverse effects. Combining pulse oximetry, cortisol response sensor, and galvanic skin response as biometrics theoretically offers a comprehensive assessment of autonomic activity and responses and establishes objective measures to identify treatment outcomes and adverse reactions. However, future experimental studies are needed to verify if the proposed protocol is feasible and if it is well tolerated by the iBrain students before it can be implemented to monitor adverse reaction to intervention and as a potential treatment outcome measure for children affected by CVI.

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