نتائج البحث - "Lebech AM"

1

دورية أكاديمية

Long-Term Survival, Morbidity, Social Functioning and Risk of Disability in Patients with a Herpes Simplex Virus Type 1 or Type 2 Central Nervous System Infection, Denmark, 2000–2016

المؤلفون: Hansen AE, Vestergaard HT, Dessau RB, Bodilsen J, Andersen NS, Omland LH, Christiansen CB, Ellermann-Eriksen S, Nielsen L, Benfield T, Sørensen HT, Andersen CØ, Lebech AM, Obel N

المصدر: Clinical Epidemiology, Vol Volume 12, Pp 745-755 (2020)

مصطلحات موضوعية: herpes simplex virus encephalitis, herpes simplex virus meningitis, prognosis, outcome, cohort study., Infectious and parasitic diseases, RC109-216

الوصف: Ann-Brit E Hansen,1– 3 Hanne T Vestergaard,4 Ram B Dessau,5 Jacob Bodilsen,6 Nanna S Andersen,7 Lars H Omland,1 Claus B Christiansen,8 Svend Ellermann-Eriksen,9 Lene Nielsen,10 Thomas Benfield,2,3 Henrik T Sørensen,11 Christian Ø Andersen,12 Anne-Mette Lebech,1,3 Niels Obel1,3 1Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 2Department of Infectious Diseases, Amager Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; 3Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 4Department of Virus & Microbiological Special Diagnostics, Statens Serum Institute, Copenhagen, Denmark; 5Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark; 6Departments of Infectious Diseases and Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark; 7Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark; 8Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 9Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark; 10Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark; 11Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 12Department of Clinical Microbiology, Amager Hvidovre University Hospital, University of Copenhagen, Hvidovre, DenmarkCorrespondence: Ann-Brit E HansenDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen Ø DK-2100, DenmarkTel +45 30299306Email ann-brit.eg.hansen.02@regionh.dkBackground: The long-term prognosis following herpes simplex virus (HSV) central nervous system (CNS) infection is still debated.Patients and Methods: We examined outcomes in all Danish residents who, during 2000– 2016, tested PCR positive for HSV-1 (n=208) or HSV-2 (n=283) in the cerebrospinal fluid, compared to comparison cohorts from the general population (n=2080 and n=2830).Results: One-year mortality was increased among HSV-1 patients (difference 19.3%; 95% CI: 13.6% to 25.0%) and HSV-2 patients (difference 5.3%; 95% CI: 2.5% to 8.1%), but thereafter mortality was not increased. After exclusion of persons diagnosed with cancer prior to study inclusion, one-year mortality difference for HSV-2 patients was 1.7% (− 0.1% to 3.5%). After five years, HSV-1 patients had lower employment (difference − 19.8%; 95% CI: − 34.7% to − 4.8%) and higher disability pension rates (difference 22.2%; 95% CI: 8.4% to 36.0%) than the comparison cohort, but similar number of inpatient days, outpatient visits, and sick leave. HSV-2 patients had employment and disability pension rates comparable to the comparison cohort, but more inpatient days (difference 1.5/year; 95% CI: − 0.2 to 3.2), outpatient visits (difference 1.3/year; 95% CI: 0.3 to 3.2), and sick leave days (difference 9.1/year; 95% CI: 7.9 to 10.4).Conclusion: HSV-1 and HSV-2 CNS infections differ substantially with respect to prognosis. HSV-1 CNS infection is followed by increased short-term mortality and long-term risk of disability. HSV-2 CNS infection has no substantial impact on mortality or working capability but is associated with increased morbidity.Keywords: herpes simplex virus encephalitis, herpes simplex virus meningitis, prognosis, outcome, cohort study

وصف الملف: electronic resource

Relation: https://www.dovepress.com/long-term-survival-morbidity-social-functioning-and-risk-of-disability-peer-reviewed-article-CLEP; https://doaj.org/toc/1179-1349

URL الوصول: https://doaj.org/article/b8a547c1f8d04c78a8398c3f67f9049c

PDF full text from Publisher

Find this article in full text from ProQuest

Full Text Finder

2

دورية أكاديمية

Increased prevalence of coronary artery disease risk markers in patients with chronic hepatitis C – a cross-sectional study

المؤلفون: Roed T, Kristoffersen US, Knudsen A, Wiinberg N, Lebech AM, Almdal T, Thomsen RW, Kjær A, Weis N

المصدر: Vascular Health and Risk Management, Vol 2014, Iss default, Pp 55-62 (2014)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Torsten Roed,1 Ulrik Sloth Kristoffersen,2 Andreas Knudsen,1,2 Niels Wiinberg,3 Anne-Mette Lebech,1 Thomas Almdal,4 Reimar W Thomsen,5 Andreas Kjær,2 Nina Weis1,61Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark; 2Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; 3Department of Clinical Physiology, Frederiksberg Hospital, Copenhagen, Denmark; 4Steno Diabetes Center, Copenhagen, Denmark; 5Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 6Faculty of Health Sciences, University of Copenhagen, Copenhagen, DenmarkObjective: Chronic hepatitis C is a global health problem and has been associated with coronary artery disease. Our aim was to examine the prevalence of coronary artery disease risk markers including endothelial biomarkers in patients with chronic hepatitis C and matched comparisons without manifest cardiovascular disease or diabetes in a cross-sectional design.Methods: Sixty patients with chronic hepatitis C (mean age 51 years) were recruited from the Department of Infectious Diseases at Copenhagen University Hospital, and compared with 60 age-matched non-hepatitis C virus-infected individuals from a general population survey. We examined traditional coronary artery disease risk factors, metabolic syndrome, carotid intima media thickness, and a range of endothelial biomarkers.Results: Patients with chronic hepatitis C had more hypertension (40% versus 25%, prevalence ratio [PR] 1.6; 95% confidence interval [CI] 0.9–2.7) and smoked more (53% versus 38%, PR 1.4; 95% CI 0.9–2.1). The two groups had similar body mass index (mean 25.0 versus 25.7 kg/m2), whereas those with chronic hepatitis C had less dyslipidemia (including significantly lower low-density lipoprotein and cholesterol/high-density lipoprotein ratio), higher glycosylated hemoglobin level (mean 6.2 versus 5.7, difference of means 0.5; 95% CI 0.3–0.8), and a higher prevalence of metabolic syndrome (28% versus 18%, PR 1.6; 95% CI 0.8–3.0). Increased carotid intima media thickness above the standard 75th percentile was seen more frequently in chronic hepatitis C (9% versus 3%, PR 1.7; 95% CI 0.4–6.7), though difference of means was only 0.04 mm (95% CI 0.00–0.10). Patients with chronic hepatitis C had increased hsCRP (high-sensitivity C-reactive protein), sICAM-1 (soluble intercellular adhesion molecule-1), sVCAM-1 (soluble vascular cell adhesion molecule-1), and soluble E-selectin, but lower levels of tPAI-1 (tissue-type plasminogen activator inhibitor-1), MMP9 (matrix metallopeptidase 9), and MPO (myeloperoxidase) than their comparisons.Conclusion: Our findings indicate that patients with chronic hepatitis C have increased prevalence of several coronary artery disease risk markers. These results may be important when evaluating the appropriateness of screening for coronary artery disease and its risk factors in chronic hepatitis C.Keywords: risk factors, atherosclerosis, endothelial dysfunction, biomarkers, metabolic syndrome, intima media thickness

وصف الملف: electronic resource

Relation: http://www.dovepress.com/increased-prevalence-of-coronary-artery-disease-risk-markers-in-patien-a15591; https://doaj.org/toc/1178-2048

URL الوصول: https://doaj.org/article/60d49d22af7f46b3abc1695a95e5897b

PDF full text from Publisher

Find this article in full text from ProQuest

Full Text Finder