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المؤلفون: Aurélie Meurette, Myriam Blanchin, Line Auneau-Enjalbert, Véronique Sébille, Emmanuel Morelon, Magali Giral, Jean-Benoit Hardouin, Laetitia Albano
المصدر: Quality of Life Research. 31:607-620
مصطلحات موضوعية: Adult, medicine.medical_specialty, medicine.medical_treatment, Kidney transplant, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Renal Dialysis, Internal medicine, medicine, Humans, Measurement invariance, Kidney transplantation, Dialysis, Health related quality of life, business.industry, 030503 health policy & services, Public Health, Environmental and Occupational Health, medicine.disease, Kidney Transplantation, Transplant Recipients, Transplantation, 030220 oncology & carcinogenesis, Quality of Life, General health, 0305 other medical science, business
الوصف: Kidney transplantation (KT) can impact patients’ evaluation of health-related quality of life (HRQoL) as they adapt to their new life with a graft and its changes. Patients may adapt to KT in a different way, depending on whether they were on dialysis prior to transplantation or not (i.e. preemptive group). This may result in lack of measurement invariance between these patients’ groups and/or over time (i.e. response shift, RS) which may invalidate the between-group comparison of HRQoL change scores. The aim of this study was to investigate and compare RS before and after KT between these two patients’ groups. Measurement invariance was investigated between groups and over time with three measurement occasions. Adult patients completed the SF-36 at the last visit before KT, and 3, 6 months after. A structural equation model-based procedure was used to (i) detect and take into account measurement non-invariance between groups and RS, if appropriate, (ii) identify the period of occurrence of RS, (iii) study the heterogeneity of RS between the two groups. Before KT (i.e. baseline), measurement invariance was not rejected between dialyzed (n = 196) and preemptive (n = 178) patients’ groups. Between baseline and 3 months after KT, similar uniform recalibration was detected on the general health domain in both groups. Uniform recalibration was found between 3- and 6 months after KT on the vitality domain for preemptive patients only. HRQoL, adjusted for RS, increased overall for preemptive and dialyzed kidney transplant patients after transplantation. RS may reflect differing adaptation processes following KT.
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المؤلفون: Magali Giral, Myriam Blanchin, Jean-Benoit Hardouin, Emmanuel Morelon, Line Auneau-Enjalbert, Aurélie Meurette, Véronique Sébille, Elisabeth Cassuto
المساهمون: MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Plateforme de Méthodologie et Biostatistique, Direction de la Recherche [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Réseau CENTAURE [Nantes], Université de Nantes (UN)-Institut de Transplantation et de Recherche en Transplantation (ITUN - Institut Transplantation Urologie Néphroplogie*)-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Transplantation, Néphrologie et Immunologie Clinique [Hôpital Edouard Herriot, HCL], Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Département de Néphrologie - Hôpital Pasteur [Nice], Hôpital Pasteur [Nice] (CHU), Biostatistique, Recherche Clinique et Mesures Subjectives en Santé, Université de Nantes (UN), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Institut de Transplantation et de Recherche en Transplantation (ITUN - Institut Transplantation Urologie Néphroplogie*), Le Bihan, Sylvie
المصدر: Quality of Life Research
Quality of Life Research, Springer Verlag, 2019, Epub ahead of print. ⟨10.1007/s11136-019-02372-w⟩
Quality of Life Research, 2019, Epub ahead of print. ⟨10.1007/s11136-019-02372-w⟩مصطلحات موضوعية: Adult, Male, Quality of life, Pediatrics, medicine.medical_specialty, Psychometrics, Waiting Lists, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Population, Emotions, Waiting list, Peritoneal dialysis, Kidney transplantation, 03 medical and health sciences, 0302 clinical medicine, Renal Dialysis, Surveys and Questionnaires, Medicine, Humans, Renal replacement therapy, education, Dialysis, education.field_of_study, business.industry, 030503 health policy & services, Public Health, Environmental and Occupational Health, Preemptive, Middle Aged, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], Transplantation, 030220 oncology & carcinogenesis, Female, Hemodialysis, 0305 other medical science, business, Peritoneal Dialysis
الوصف: International audience; PURPOSE:The waiting list period for kidney transplantation can be lengthy and associated with a deteriorated health-related quality of life (HRQoL). It might also be experienced differently depending on the experience of renal replacement therapy (preemptive or dialyzed patients), and the type of dialysis. The main objective of this study is to measure and compare HRQoL changes in preemptive, hemodialysis (HD), and peritoneal dialysis (PD) patients during the waiting list period for kidney transplantation.METHODS:A sample of adult patients on kidney transplant waiting list from three French University Hospital centers was recruited. HRQoL was measured using the SF-36 and a specific questionnaire (ReTransQol), which were collected every 6 months before transplantation in preemptive, HD, and PD patients. Mixed-effects models taking into account time and possible confounding factors were used to compare HRQoL changes between the three groups.RESULTS:Preemptive (n = 230), HD (n = 177), and PD patients (n = 39) were enrolled. The renal replacement therapy modalities, time (time on waiting list and age at registration), and gender were associated with HRQoL changes. The HD and PD patients had a significantly lower perceived HRQoL on Role Physical, Social Functioning, and Role Emotional dimensions than the preemptive patients, with lower scores for PD compared to HD patients. The HRQoL scores of all patients were lower compared to the French general population for all dimensions.CONCLUSIONS:A better understanding of pre-transplantation patients' experience can help improving patient care with adapted educational programs and psychological support depending on the type of renal replacement therapy.
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