المؤلفون: Brenno A. D. Neto, Heibbe C. B. de Oliveira, Giovana Aparecida de Souza Cintra, Wender A. Silva, Lucio H. Freitas-Junior, José Antonio Fagundes Assumpção, José R. Corrêa, Alberto A. R. Mota, Lorena P. de Andrade

المصدر: ACS Omega, Vol 3, Iss 4, Pp 3874-3881 (2018)

مصطلحات موضوعية: biology, 010405 organic chemistry, General Chemical Engineering, Selective staining, General Chemistry, 010402 general chemistry, biology.organism_classification, 01 natural sciences, Fluorescence, 0104 chemical sciences, Staining, lcsh:Chemistry, chemistry.chemical_compound, chemistry, lcsh:QD1-999, Lipid droplet, Biophysics, BODIPY, Selectivity, Derivative (chemistry), Caenorhabditis elegans

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758168747506a86e7aa9050f307c8e13
https://doaj.org/article/146eaade5e914444bac436cce5bd4d50

المؤلفون: Maria Kuzikov, Gesa Witt, Bruno dos Santos Pascoalino, Caio Haddad Franco, Luca Costantino, Rosaria Luciani, Laura M. Alcantara, Nuno Santarém, Sara Macedo, Antonio Quotadamo, Lucio H. Freitas-Junior, Bernhard Ellinger, Carolina B. Moraes, Stefania Ferrari, Maria Paola Costi, Sheraz Gul, Anabela Cordeiro-da-Silva, Pasquale Linciano

المساهمون: Publica

المصدر: European Journal of Medicinal Chemistry. 146:423-434

مصطلحات موضوعية: Thiosemicarbazones, 0301 basic medicine, Trypanosoma, Stereochemistry, hERG, Antiprotozoal Agents, Trypanosoma brucei, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Parasitic Sensitivity Tests, Thiadiazoles, Early-toxicity, Leishmania infantum, pan-anti-trypanosomatidic activity, Thiosemicarbazone, Trypanosoma cruzi, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, parasitic diseases, Drug Discovery, medicine, Humans, Chagas Disease, Amastigote, Semicarbazone, Dose-Response Relationship, Drug, Molecular Structure, biology, Macrophages, General Medicine, biology.organism_classification, medicine.disease, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, Mitochondrial toxicity, 030104 developmental biology, chemistry, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebcff45eb81d168c200819955e00630
https://doi.org/10.1016/j.ejmech.2018.01.043

المؤلفون: Joaquín María Campos Rosa, Leonardo B Federico, Carlos Henrique Tomich de Paula da Silva, Carolina B. Moraes, Laura M. Alcântara, Lucio H. Freitas-Junior

المصدر: POJ Pharmaceutical Sciences. :01-06

مصطلحات موضوعية: Virtual screening, Similarity (network science), Computer science, L-type calcium channel, Computational biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5695d6e6670261a2ec9973bb0ac0012f
https://doi.org/10.32648/pojpharmasci/01

المؤلفون: Caio Haddad Franco, Josmar R. Rocha, Carolina B. Moraes, Antonio C. B. Burtoloso, Daniel G. Silva, Daniela De Vita, Carlos A. Montanari, Peter W. Kenny, Andrei Leitão, Jean F. R. Ribeiro, Lorenzo Cianni, Lucio H. Freitas-Junior

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: 0301 basic medicine, Nitrile, Stereochemistry, Cathepsin L, Clinical Biochemistry, Pharmaceutical Science, Cysteine Proteinase Inhibitors, 01 natural sciences, Biochemistry, Aldehyde, Cyclopropane, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Catalytic Domain, Nitriles, Drug Discovery, Potency, ALDEÍDOS, Molecular Biology, chemistry.chemical_classification, Dipeptide, Covalent inhibitor, Cysteine protease, Oxime, Warhead, Cysteine Endopeptidases, Dipeptides, Drug Design, Kinetics, 010405 organic chemistry, Organic Chemistry, Orders of magnitude (mass), 0104 chemical sciences, 030104 developmental biology, chemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a458345f2b22da4227d15e544da7adc
https://doi.org/10.1016/j.bmcl.2017.10.002

المؤلفون: Monica S. Sá, Rebecca C. Wade, Claudia Danielli Pereira Bertolacini, Puneet Saxena, Bruno dos Santos Pascoalino, Markus Wolf, Ulrike Wittig, Wolfgang Müller, William N. Hunter, Anabela Cordeiro-da-Silva, Maria Paola Costi, Ina Pöhner, Jeanette Reinshagen, Véronique Hannaert, Nuno Santarém, Pasquale Linciano, Carolina B. Moraes, Philip Gribbon, Alice Dawson, Gesa Witt, Vanessa Fontana, Stefania Ferrari, Laura M. Alcântara, Giuseppe Cannazza, G. Landi, Bernhard Ellinger, Maria Kuzikov, Paul A.M. Michels, Stefano Mangani, David Costa, Erika Nerini, Birte Behrens, Sandra Lazzari, Cecilia Pozzi, Flavio Di Pisa, Lucio H. Freitas-Junior, Luca Costantino, Rosaria Luciani, Sheraz Gul

المساهمون: Publica

المصدر: ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)
'ACS Omega ', vol: 2, pages: 5666-5683 (2017)
Linciano, P, Dawson, A, Pöhner, I, Costa, D M, Sa, M S, Cordeiro-Da-Silva, A, Luciani, R, Gul, S, Witt, G, Ellinger, B, Kuzikov, M, Gribbon, P, Reinshagen, J, Wolf, M, Behrens, B, Hannaert, V, Michels, P A M, Nerini, E, Pozzi, C, Di Pisa, F, Landi, G, Santarem, N, Ferrari, S, Saxena, P, Lazzari, S, Cannazza, G, Freitas-Junior, L H, Moraes, C B, Pascoalino, B S, Alcantara, L M, Bertolacini, C P, Fontana, V, Wittig, U, Müller, W, Wade, R C, Hunter, W N, Mangani, S, Costantino, L & Costi, M P 2017, ' Exploiting the 2‑Amino-1,3,4-thiadiazole scaffold to inhibit trypanosoma brucei pteridine reductase in support of early-stage drug discovery ', ACS Omega, vol. 2, no. 9, pp. 5666-5683 . https://doi.org/10.1021/acsomega.7b00473

مصطلحات موضوعية: 0301 basic medicine, Antiparasitic, medicine.drug_class, General Chemical Engineering, Trypanosoma brucei, Pharmacology, 01 natural sciences, lcsh:Chemistry, 03 medical and health sciences, medicine, Structure–activity relationship, chemistry.chemical_classification, biology, Drug discovery, General Chemistry, biology.organism_classification, Dihydrofolate reductase inhibitor, 3. Good health, 0104 chemical sciences, Pteridine reductase, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Enzyme, lcsh:QD1-999, Biochemistry, chemistry, Pteridine, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28935a981ead5c6c4b6475eb3f00313c
https://doi.org/10.1021/acsomega.7b00473

المؤلفون: Caio Haddad Franco, Lucio H. Freitas-Junior, Denize C. Favaro, Fredson Torres Silva, Elizabeth Igne Ferreira, Carolina B. Moraes

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Chagas disease, Trypanosoma cruzi, Molecular Conformation, COMPOSTOS HETEROCÍCLICOS, Chemistry Techniques, Synthetic, Pharmacology, 01 natural sciences, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, medicine, Humans, Potency, Nifurtimox, Amastigote, Nitrofurazone, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Hydrazones, General Medicine, Triazoles, medicine.disease, biology.organism_classification, Trypanocidal Agents, 0104 chemical sciences, 030104 developmental biology, Benznidazole, biology.protein, Demethylase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c52ca13b182cc48528df23eeb4f888
https://doi.org/10.1016/j.ejmech.2016.04.065

المؤلفون: Giovana A S, Cintra, Brenno A D, Neto, Pedro H P R, Carvalho, Carolina B, Moraes, Lucio H, Freitas-Junior

المصدر: SLAS discovery : advancing life sciences RD. 24(7)

مصطلحات موضوعية: Anthelmintics, Kinetics, Molecular Structure, Parasitic Sensitivity Tests, Drug Discovery, Optical Imaging, Thiadiazoles, Animals, Caenorhabditis elegans, Fluorescent Dyes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::73a3f45c03e93359eb01a83ad536b1e9
https://pubmed.ncbi.nlm.nih.gov/31180789

المؤلفون: Lucio H. Freitas-Junior, Eric Chatelain, Carolina B. Moraes, Caio Haddad Franco, Laura M. Alcântara

المصدر: Tropical Medicine and Infectious Disease; Volume 4; Issue 2; Pages: 82
Tropical Medicine and Infectious Disease
Tropical Medicine and Infectious Disease, Vol 4, Iss 2, p 82 (2019)

مصطلحات موضوعية: 0301 basic medicine, Chagas disease, Phenotypic screening, Trypanosoma cruzi, 030106 microbiology, Cell, chagas disease drug discovery, lcsh:Medicine, Biology, Article, 03 medical and health sciences, medicine, host cells, General Immunology and Microbiology, high content screening, Drug discovery, lcsh:R, phenotypic screening, Public Health, Environmental and Occupational Health, host-parasite interactions, medicine.disease, biology.organism_classification, Virology, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Cell culture, Benznidazole, High-content screening, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6a0e1644904b7564f4337743ad5a36

المؤلفون: Lavínia Maria Dal'Mas Romera, Caio Haddad Franco, Ana Claudia Torrecilhas, Ho Y.A. Au, Carolina B. Moraes, Hai Le, Bruno dos Santos Pascoalino, Tapan Bhattacharyya, Miriam A. Giardini, Rafael Pedro Madeira, Sergio Schenkman, Lucio H. Freitas-Junior, Eric Chatelain, David C. Warhurst, Michael A. Miles

المصدر: International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss, Pp 107-120 (2020)

مصطلحات موضوعية: 0301 basic medicine, Chagas disease, Trypanosoma cruzi, 030231 tropical medicine, Genes, Protozoan, Clone (cell biology), Drug resistance, CYP51, Biology, Ravuconazole, Article, Microbiology, lcsh:Infectious and parasitic diseases, Cell Line, 03 medical and health sciences, Sterol 14-Demethylase, 0302 clinical medicine, medicine, Animals, Pharmacology (medical), lcsh:RC109-216, Chagas Disease, Nifurtimox, Pharmacology, Triazoles, biology.organism_classification, medicine.disease, Trypanocidal Agents, Drug Resistance, Multiple, Multiple drug resistance, Thiazoles, 030104 developmental biology, Infectious Diseases, Benznidazole, 14-alpha Demethylase Inhibitors, Nitroimidazoles, Mutation, Parasitology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07255fa405b4307071d0f14febe7a257
https://pubmed.ncbi.nlm.nih.gov/32688218

المؤلفون: Pedro Henrique Jatai Batista, Antonio C. B. Burtoloso, Caio Haddad Franco, Peter W. Kenny, Fernanda dos Reis Rocho, Samelyn da Costa Martins Silva, Lorenzo Cianni, Jean F. R. Ribeiro, Daniela De Vita, Lucio H. Freitas-Junior, Carlos A. Montanari, Carolina B. Moraes, Juliana C. Gomes, Andrei Leitão

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: lipophilic efficiency, nonadditivity, Nitrile, cruzain, Clinical Biochemistry, Protozoan Proteins, Substituent, Synthetic membrane, Pharmaceutical Science, 01 natural sciences, Biochemistry, chemistry.chemical_compound, group efficiency, Amide, Drug Discovery, cysteine protease, Structure–activity relationship, QUÍMICA, Molecular Biology, Biphenyl, Molecular Structure, 010405 organic chemistry, structure-activity relationship, Organic Chemistry, Amides, Combinatorial chemistry, 0104 chemical sciences, Cysteine Endopeptidases, 010404 medicinal & biomolecular chemistry, chemistry, Lipophilic efficiency, Lipophilicity, covalent inhibitor, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0e7b1097dae062cb7d3bb745832da2