المؤلفون: Jakob E. Brune, Michael Dickenmann, Daniel Sidler, Laura N. Walti, Déla Golshayan, Oriol Manuel, Fadi Haidar, Dionysios Neofytos, Aurelia Schnyder, Katia Boggian, Thomas F. Mueller, Thomas Schachtner, Nina Khanna, Stefan Schaub, Caroline Wehmeier, the Swiss Transplant Cohort Study, Patrizia Amico, John-David Aubert, Adrian Bachofner, Vanessa Banz, Sonja Beckmann, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Annalisa Berzigotti, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Anne Cairoli, Emmanuelle Catana, Yves Chalandon, Sabina De Geest, Sophie De Seigneux, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Sylvie Ferrari-Lacraz, Jaromil Frossard, Christian Garzoni, Nicolas Goossens, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Linard Hoessly, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Michael Koller, Andreas Kremer, Christian Kuhn, Bettina Laesser, Frédéric Lamoth, Roger Lehmann, Alexander Leichtle, Hans-Peter Marti, Michele Martinelli, Valérie McLin, Katell Mellac, Aurélia Merçay, Karin Mettler, Nicolas Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual, Jakob Passweg, Rosemarie Pazeller, Klara Posfay-Barbe, David Reineke, Juliane Rick, Anne Rosselet, Simona Rossi, Rössler, Silvia Rothlin, Frank Ruschitzka, Alexandra Scherrer, Dominik Schneidawind, Macé Schuurmans, Simon Schwab, Thierry Sengstag, Federico Simonetta, Jürg Steiger, Guido Stirniman, Ueli Stürzinger, Christian Van Delden, Jean-Pierre Venetz, Jean Villard, Julien Vionnet, Madeleine Wick, Markus Wilhlem, Patrick Yerly

المصدر: Frontiers in Medicine, Vol 11 (2024)

مصطلحات موضوعية: kidney transplantation, urinary tract infection, Enterobacterales, E. coli, Klebsiella, ESBL − extended-spectrum beta-lactamase, Medicine (General), R5-920

الوصف: BackgroundEnterobacterales are often responsible for urinary tract infection (UTI) in kidney transplant recipients. Among these, Escherichia coli or Klebsiella species producing extended-spectrum beta-lactamase (ESBL) are emerging. However, there are only scarce data on frequency and impact of ESBL-UTI on transplant outcomes.MethodsWe investigated frequency and impact of first-year UTI events with ESBL Escherichia coli and/or Klebsiella species in a prospective multicenter cohort consisting of 1,482 kidney transplants performed between 2012 and 2017, focusing only on 389 kidney transplants having at least one UTI with Escherichia coli and/or Klebsiella species. The cohort had a median follow-up of four years.ResultsIn total, 139/825 (17%) first-year UTI events in 69/389 (18%) transplant recipients were caused by ESBL-producing strains. Both UTI phenotypes and proportion among all UTI events over time were not different compared with UTI caused by non-ESBL-producing strains. However, hospitalizations in UTI with ESBL-producing strains were more often observed (39% versus 26%, p = 0.04). Transplant recipients with first-year UTI events with an ESBL-producing strain had more frequently recurrent UTI (33% versus 18%, p = 0.02) but there was no significant difference in one-year kidney function as well as longer-term graft and patient survival between patients with and without ESBL-UTI.ConclusionFirst-year UTI events with ESBL-producing Escherichia coli and/or Klebsiella species are associated with a higher need for hospitalization but do neither impact allograft function nor allograft and patient survival.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2024.1329778/full; https://doaj.org/toc/2296-858X

URL الوصول: https://doaj.org/article/8a2807b2ba0b4fa9a10786acd1fc2ce2

المؤلفون: Olivier de Rougemont, Yun Deng, Lukas Frischknecht, Caroline Wehmeier, Jean Villard, Sylvie Ferrari-Lacraz, Déla Golshayan, Monique Gannagé, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson, the Swiss Transplant Cohort Study, Patrizia Amico, Andres Axel, John David Aubert, Vanessa Banz, Beckmann Sonja, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Thierry Carrel, Emmanuelle Catana, Yves Chalandon, Sabina De Geest, Olivier De Rougemont, Michael Dickenmann, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Nicola Franscini, Christian Garzoni, Paola Gasche Soccal, Christophe Gaudet, Nicolas Goossens, Karine Hadaya, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Michael Koller, Mirjam Laager, Bettina Laesser, Roger Lehmann, Alexander Leichtle, Christian Lovis, Oriol Manuel, Hans-Peter Marti, Pierre Yves Martin, Michele Martinelli, Valérie McLin, Katell Mellac, Aurelia Mercay, Karin Mettler, Nicolas Mueller, Antonia Müller, Thomas Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual, Klara Posfay-Barbe, Juliane Rick, Anne Rosselet, Simona Rossi, Silvia Rothlin, Frank Ruschitzka, Urs Schanz, Aurelia Schnyder, Macé Schuurmans, Thierry Sengstag, Federico Simonetta, Katharina Staufer, Susanne Stampf, Jürg Steiger, Guido Stirniman, Ueli Stürzinger, Christian Van Delden, Jean-Pierre Venetz, Julien Vionnet, Madeleine Wick, Markus Wilhlem, Patrick Yerly

المصدر: Frontiers in Immunology, Vol 14 (2023)

مصطلحات موضوعية: kidney transplantation, donor specific antibodies, ABMR, graft loss, virtual cross-match, living donation, Immunologic diseases. Allergy, RC581-607

الوصف: IntroductionThe type of donation may affect how susceptible a donor kidney is to injury from pre-existing alloimmunity. Many centers are, therefore, reluctant to perform donor specific antibody (DSA) positive transplantations in the setting of donation after circulatory death (DCD). There are, however, no large studies comparing the impact of pre-transplant DSA stratified on donation type in a cohort with a complete virtual cross-match and long-term follow-up of transplant outcome.MethodsWe investigated the effect of pre-transplant DSA on the risk of rejection, graft loss, and the rate of eGFR decline in 1282 donation after brain death (DBD) transplants and compared it to 130 (DCD) and 803 living donor (LD) transplants.ResultsThere was a significant worse outcome associated with pre-transplant DSA in all of the studied donation types. DSA directed against Class II HLA antigens as well as a high cumulative mean fluorescent intensity (MFI) of the detected DSA showed the strongest association with worse transplant outcome. We could not detect a significant additive negative effect of DSA in DCD transplantations in our cohort. Conversely, DSA positive DCD transplants appeared to have a slightly better outcome, possibly in part due to the lower mean fluorescent intensity (MFI) of the pre-transplant DSA. Indeed when DCD transplants were compared to DBD transplants with similar MFI (

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1104371/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/4477ab4529c049ca9d56bbf4349cc853

المؤلفون: Lukas Frischknecht, Yun Deng, Caroline Wehmeier, Olivier de Rougemont, Jean Villard, Sylvie Ferrari-Lacraz, Déla Golshayan, Monique Gannagé, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson, the Swiss Transplant Cohort Study, Patrizia Amico, Andres Axel, John David Aubert, Vanessa Banz, Beckmann Sonja, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Thierry Carrel, Emmanuelle Catana, Yves Chalandon, Sabina De Geest, Olivier De Rougemont, Michael Dickenmann, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Nicola Franscini, Christian Garzoni, Paola Gasche Soccal, Christophe Gaudet, Nicolas Goossens, Karine Hadaya, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Michael Koller (Head of the data center), Mirjam. Laager, Bettina Laesser, Roger Lehmann, Alexander Leichtle, Christian Lovis, Oriol Manuel, Hans-Peter Marti, Pierre Yves Martin, Michele Martinelli, Valérie McLin, Katell Mellac, Aurelia Mercay, Karin Mettler, Nicolas Mueller (Chairman Scientific Committee), Antonia Müller, Thomas Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual (Executive office), Klara Posfay-Barbe, Juliane Rick, Anne Rosselet, Simona Rossi, Silvia Rothlin, Frank Ruschitzka, Urs Schanz, Aurelia Schnyder, Macé Schuurmans, Thierry Sengstag, Federico Simonetta, Katharina Staufer, Susanne Stampf, Jürg Steiger (Head, Excecutive office), Guido Stirniman, Ueli Stürzinger, Christian Van Delden (Executive office), Jean-Pierre Venetz, Julien Vionnet,Madeleine Wick (STCS coordinator), Markus Wilhlem, Patrick Yerly

المصدر: Frontiers in Immunology, Vol 13 (2022)

مصطلحات موضوعية: kidney transplantation, donor specific antibodies, abmr, graft loss, virtual cross-match, Immunologic diseases. Allergy, RC581-607

الوصف: BackgroundPre-transplant donor specific antibodies (DSA), directed at non-self human leukocyte antigen (HLA) protein variants present in the donor organ, have been associated with worse outcomes in kidney transplantation. The impact of the mean fluorescence intensity (MFI) and the target HLA antigen of the detected DSA has, however, not been conclusively studied in a large cohort with a complete virtual cross-match (vXM).MethodsWe investigated the effect of pre-transplant DSA on the risk of antibody-mediated rejection (ABMR), graft loss, and the rate of eGFR decline in 411 DSA positive transplants and 1804 DSA negative controls.ResultsPre-transplant DSA were associated with a significantly increased risk of ABMR, graft loss, and accelerated eGFR decline. DSA directed at Class I and Class II HLA antigens were strongly associated with increased risk of ABMR, but only DSA directed at Class II associated with graft loss. DSA MFI markedly affected outcome, and Class II DSA were associated with ABMR already at 500-1000 MFI, whereas Class I DSA did not affect outcome at similar low MFI values. Furthermore, isolated DSA against HLA-DP carried comparable risks for ABMR, accelerated eGFR decline, and graft loss as DSA against HLA-DR.ConclusionOur results have important implications for the construction and optimization of vXM algorithms used within organ allocation systems. Our data suggest that both the HLA antigen target of the detected DSA as well as the cumulative MFI should be considered and that different MFI cut-offs could be considered for Class I and Class II directed DSA.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1005790/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/d4470ae796694141bd821317fd2f95c7

المؤلفون: Melisa Dirchwolf, Chiara Becchetti, Sarah G. Gschwend, Christian Toso, Philipp Dutkowski, Franz Immer, Franziska Beyeler, Simona Rossi, Jonas Schropp, Jean-François Dufour, Vanessa Banz, Patrizia Amico, Andres Axel, John-David Aubert, Beckmann Sonja, Guido Beldi, Christian Benden, Christoph Berger, Isabelle Binet, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Thierry Carrel, Emmanuelle Catana, Yves Chalandon, Sabina de Geest, Olivier de Rougemont, Michael Dickenmann, Joëlle L. Dreifuss, Michel Duchosal, Thomas Fehr, Sylvie Ferrari-Lacraz, Christian Garzoni, Paola G. Soccal, Christophe Gaudet, Emiliano Giostra, Déla Golshayan, Karine Hadaya, Jörg Halter, Dimitri Hauri, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Günther Hofbauer, Uyen Huynh-Do, Michael Koller, Bettina Laesser, Brian Lang, Roger Lehmann, Alexander Leichtle, Christian Lovis, Oriol Manuel, Hans-Peter Marti, Pierre Y. Martin, Michele Martinelli, Katell Mellac, Aurélia Merçay, Karin Mettler, Pascal Meylan, Nicolas Mueller, Antonia Müller, Thomas Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Manuel Pascual, Klara Posfay-Barbe, Juliane Rick, Anne Rosselet, Silvia Rothlin, Frank Ruschitzka, Urs Schanz, Stefan Schaub, Aurelia Schnyder, Macé Schuurmans, Federico Simonetta, Katharina Staufer, Susanne Stampf, Jürg Steiger, Guido Stirniman, Ueli Stürzinger, Christian Van Delden, Jean-Pierre Venetz, Jean Villard, Julien Vionnet, Madeleine Wick, Markus Wilhlem, Patrick Yerly

المصدر: HPB : the official journal of the International Hepato Pancreato Biliary Association. 24(7)

مصطلحات موضوعية: Adult, Cohort Studies, Hepatology, Waiting Lists, Gastroenterology, Humans, Severity of Illness Index, Switzerland, Liver Transplantation

الوصف: MELD exceptions are designed to equipoise liver transplant waiting list survival. We aimed to analyze the impact of the MELD Upgrade rule and all other MELD exceptions on the liver transplant waiting list outcomes during 2012-2017 in Switzerland.We conducted a nationwide cohort study including all adult patients registered on the Swiss liver transplant waiting list between 2012 and 2017. Waiting list mortality and access to transplantation were analyzed, considering MELD exceptions as time-dependent covariates.730 patients were included. Patients with MELD Upgrade exceptions had a higher risk of dying while on the waiting list (OR 2.13; CI 95% 1.30-3.47) and also an increased likelihood of receiving a liver transplantation, when compared to patients without MELD exceptions. Patients with any type of MELD exceptions were more likely to be transplanted when compared to patients without MELD exceptions. The proportion of patients with MELD exceptions increased from 2012 to 2017 (44% vs 88%). Allocation MELD at the time of transplantation showed an annual increase (23 ± 8 points vs 32 ± 5 points, p 0.001).Only patients with MELD Upgrade exceptions had the expected combination of higher waiting list mortality and quicker access to liver transplantation.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf77e1ac1e7fa0b3bc07a30cae12e4f
https://pubmed.ncbi.nlm.nih.gov/35065891

المؤلفون: M. Schweiger, T. Erdil, S. Di Bernardo, C. Balmer, M. Yildiz, A. Kadner, Patrizia Amico, Andres Axel, John-David Aubert, Vanessa Banz, Beckmann Sonja, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Isabelle Binet, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Thierry Carrel, Emmanuelle Catana, Yves Chalandon, Sabina De Geest, Olivier De Rougemont, Michael Dickenmann, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Sylvie Ferrari-Lacraz, Christian Garzoni, Paola Gasche Soccal, Christophe Gaudet, Déla Golshayan, Nicolas Goossens, Karine Hadaya, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Michael Koller, Mirjam Laager, Bettina Laesser, Roger Lehmann, Alexander Leichtle, Christian Lovis, Oriol Manuel, Hans-Peter Marti, Pierre Yves Martin, Michele Martinelli, Valérie McLin, Katell Mellac, Aurélia Merçay, Karin Mettler, Nicolas Mueller, Antonia Müller, Thomas Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual, Klara Posfay-Barbe, Juliane Rick, Anne Rosselet, Simona Rossi, Silvia Rothlin, Frank Ruschitzka, Urs Schanz, Stefan Schaub, Aurelia Schnyder, Macé Schuurmans, Thierry Sengstag, Federico Simonetta, Katharina Staufer, Susanne Stampf, Jürg Steiger, Guido Stirniman, Ueli Stürzinger, Christian Van Delden, Jean-Pierre Venetz, Jean Villard, Julien Vionnet, Madeleine Wick, Markus Wilhlem, Patrick Yerly

المساهمون: Chalandon, Yves, University of Zurich, Schweiger, M

المصدر: Transplant immunology, Vol. 68 (2021) P. 101443

مصطلحات موضوعية: Graft Rejection, medicine.medical_specialty, 10255 Clinic for Thoracic Surgery, 2747 Transplantation, medicine.medical_treatment, Immunology, 610 Medicine & health, Induction therapy, Pediatric heart transplantation, Diabetes mellitus, Internal medicine, Interleukin-2 receptor antagonis, Immunology and Allergy, Medicine, Humans, Polyclonal antibodies, 10220 Clinic for Surgery, Renal replacement therapy, Child, Retrospective Studies, ddc:616, 2403 Immunology, Transplantation, business.industry, Background data, Significant difference, Induction Chemotherapy, medicine.disease, 10036 Medical Clinic, Median time, 10032 Clinic for Oncology and Hematology, 10209 Clinic for Cardiology, 2723 Immunology and Allergy, Chronic renal failure, Heart Transplantation, National database, business, Immunosuppressive Agents, Switzerland

الوصف: Background: Data on individualized immunosuppressive protocols for the pediatric heart recipients are missing in Europe. To contribute to this very small but specialized field, we describe the use of induction therapy (IT) in pediatric heart transplant patients in Switzerland and the retrospective outcomes. Method: This is a retrospective national database analysis of children

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9ad937dc3a0171a9216883f21c151a
https://pubmed.ncbi.nlm.nih.gov/34352365

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المؤلفون: Juliane Rick, Yves Chalandon, Dominik Heim, Jörg Halter, Michel A. Duchosal, Nicolas J. Mueller, Christoph Berger, Olivier de Rougemont, Guido Toso, Jacques Schrenzel, Dimitri Tsinalis, Frank Ruschitzka, David Nadal, Chantal Piot Ziegler, John-David Aubert, Günther F.L. Hofbauer, Madeleine Wick, Jürg Steiger, Guido Beldi, Luca Martinolli, Patrick Yerly, Christian Benden, Thierry Carell, Patrizia Amico, Antonia M.S. Müller, Nadia Gaïa, Jakob Passweg, Sabina De Geest, Michael T. Koller, Eddy Roosnek, Urs Schanz, Paola Gasche, Rita Achermann, Emiliano Giostra, Daniel Good, Philippe Morel, Richard Klaghofer, Pierre Y. Martin, Jean Villard, Beat Müllhaupt, Jean-Pierre Venetz, Isabelle Binet, Susanne Stampf, Philippe Baumann, Leo Buhler, Heiner C. Bucher, Thomas Fehr, Anne Rosselet, Bettina Laesser, Ulrike Mueller, Elsa Boely, Michael Dickenmann, Stefan Schaub, Oriol Manuel, Vladimir Lazarevic, Paul Mohacsi, Pascal Meylan, Christian Lovis, Markus J. Wilhelm, Sven Hillinger, Christian Garzoni, Roger Lehmann, Isabelle Morard, Emmanuelle Catana, Thomas Müller, Christian van Delden, Pierre-Yves Bochud, Thilo Köhler, Christian Seiler, Paola Gasche Soccal, Helen Mueller-McKenna, Manuel Pascual, Silvia Rothlin, Karine Hadaya, Franz Immer, Laurent Farinelli, Marie Beaume, Christoph Hess, Hans-Peter Marti, Cédric Hirzel, Dela Golshayan, Guido Stirnimann, Uyen Huynh-Do, Sylvie Ferrari-Lacraz, Loïc Baerlocher, Hans H. Hirsch

المساهمون: Swiss Transplant Cohort Study

المصدر: Frontiers in Microbiology, Vol. 7 (2016) P. 1749
Frontiers in Microbiology, Vol 7 (2016)
Frontiers in Microbiology
Frontiers in microbiology, vol. 7, pp. 1749

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), medicine.drug_class, Firmicutes, medicine.medical_treatment, lung allograft, 030106 microbiology, Antibiotics, lcsh:QR1-502, Biology, Microbiology, lcsh:Microbiology, 03 medical and health sciences, medicine, lung transplantation, microbiota, Lung transplantation, Respiratory system, Respiratory zone, conducting airways, Original Research, ddc:616, Lung, ddc:617, biology.organism_classification, 3. Good health, medicine.anatomical_structure, Immunology, respiratory airways, Conducting airways, Proteobacteria, Bacteria, Lung Transplantation

الوصف: Background: Lung transplantation (LT) is a recognized treatment for end-stage pulmonary disease. Bacteria from the recipient nasopharynx seed the new lungs leading to infections and allograft damage. Understanding the characteristics and topological variations of the microbiota may be important to apprehend the pathophysiology of allograft dysfunction. Objectives: To examine the characteristics and relationship of bacterial compositions between conducting and respiratory zones of the allograft. Methods: We performed 16S rRNA gene sequencing on bronchial aspirates (BAs) and bronchoalveolar lavages (BALs) collected in pairs in 19 patients at several time-points post-LT. Results: The respiratory zone was characterized independently of the time post-LT by a higher bacterial richness than the conducting zone (p = 0.041). The phyla Firmicutes and Proteobacteria dominated both sampling zones, with an inverse correlation between these two phyla (Spearman r = -0.830). Samples of the same pair, as well as pairs from the same individual clustered together (Pseudo-F = 3.8652, p < 0.01). Microbiota of BA and BAL were more closely related in samples from the same patient than each sample type across different patients, with variation in community structure being mainly inter-individual (p < 0.01). Both number of antibiotics administered (p < 0.01) and time interval post-LT (p < 0.01) contributed to the variation in global microbiota structure. Longitudinal analysis of BA-BAL pairs of two patients showed dynamic wave like fluctuations of the microbiota. Conclusions: Our results show that post-transplant respiratory zones harbor higher bacterial richness, but overall similar bacterial profiles as compared to conductive zones. They further support an individual microbial signature following LT.

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed9911a83b54f27c240a9aeb0405b4d
https://archive-ouverte.unige.ch/unige:93783

المؤلفون: Déla Golshayan, Agnieszka Wójtowicz, Stéphanie Bibert, Nitisha Pyndiah, Oriol Manuel, Isabelle Binet, Leo H. Buhler, Uyen Huynh-Do, Thomas Mueller, Jürg Steiger, Manuel Pascual, Pascal Meylan, Pierre-Yves Bochud, Rita Achermann, John-David Aubert, Philippe Baumann, Guido Beldi, Christian Benden, Christoph Berger, Elsa Boely, Heiner Bucher, Leo Bühler, Thierry Carell, Emmanuelle Catana, Yves Chalandon, Sabina de Geest, Olivier de Rougemont, Michael Dickenmann, Michel Duchosal, Thomas Fehr, Sylvie Ferrari-Lacraz, Christian Garzoni, Yvan Gasche, Paola Gasche Soccal, Emiliano Giostra, Daniel Good, Karine Hadaya, Christoph Hess, Sven Hillinger, Hans H. Hirsch, Günther Hofbauer, Franz Immer, Richard Klaghofer, Michael Koller, Thomas Kuntzen, Bettina Laesser, Roger Lehmann, Christian Lovis, Hans-Peter Marti, Pierre Yves Martin, Paul Mohacsi, Isabelle Morard, Philippe Morel, Ulrike Mueller, Nicolas J. Mueller, Helen Mueller-McKenna, Thomas Müller, Beat Müllhaupt, David Nadal, Gayathri Nair, Jakob Passweg, Chantal Piot Ziegler, Juliane Rick, Eddy Roosnek, Anne Rosselet, Silvia Rothlin, Frank Ruschitzka, Urs Schanz, Stefan Schaub, Christian Seiler, Nasser Semmo, Susanne Stampf, Christian Toso, Dimitri Tsinalis, Christian Van Delden, Jean-Pierre Venetz, Jean Villard, Madeleine Wick, Markus Wilhelm, Patrick Yerly

المصدر: Kidney international
Kidney International, Vol. 89, No 4 (2016) pp. 927-938

مصطلحات موضوعية: 0301 basic medicine, Graft Rejection, Male, Genotype, medicine.medical_treatment, 030230 surgery, Mannose-Binding Lectin, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Lectins, Medicine, Humans, Genetic Predisposition to Disease, Kidney transplantation, Mannan-binding lectin, ddc:616, Polymorphism, Genetic, business.industry, Incidence, Hazard ratio, Immunosuppression, Complement Pathway, Mannose-Binding Lectin, Middle Aged, medicine.disease, MBL deficiency, Kidney Transplantation, 3. Good health, Transplantation, 030104 developmental biology, Nephrology, Lectin pathway, Mannose-Binding Protein-Associated Serine Proteases, Immunology, Female, business, Ficolin, Switzerland

الوصف: There are conflicting data on the role of the lectin pathway of complement activation and its recognition molecules in acute rejection and outcome after transplantation. To help resolve this we analyzed polymorphisms and serum levels of lectin pathway components in 710 consecutive kidney transplant recipients enrolled in the nationwide Swiss Transplant Cohort Study, together with all biopsy-proven rejection episodes and 1-year graft and patient survival. Functional mannose-binding lectin (MBL) levels were determined in serum samples, and previously described MBL2, ficolin 2, and MBL-associated serine protease 2 polymorphisms were genotyped. Low MBL serum levels and deficient MBL2 diplotypes were associated with a higher incidence of acute cellular rejection during the first year, in particular in recipients of deceased-donor kidneys. This association remained significant (hazard ratio 1.75, 95% confidence interval 1.18-2.60) in a Cox regression model after adjustment for relevant covariates. In contrast, there was no significant association with rates of antibody-mediated rejection, patient death, early graft dysfunction or loss. Thus, results in a prospective multicenter contemporary cohort suggest that MBL2 polymorphisms result in low MBL serum levels and are associated with acute cellular rejection after kidney transplantation. Since MBL deficiency is a relatively frequent trait in the normal population, our findings may lead to individual risk stratification and customized immunosuppression.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36173712e7a550735810ad4267fa67be
https://pubmed.ncbi.nlm.nih.gov/26924055

المؤلفون: Madeleine Wick, Cristina Cerise, Olivier Bugnon, Ursula Ackermann-Liebrich

المصدر: Sozial- und Präventivmedizin SPM. 45:73-84

مصطلحات موضوعية: Political science, Public Health, Environmental and Occupational Health, Humanities

الوصف: Zusammenfassung: Mit dem Ziel, die Bevölkerung für das niederschwellige Beratungsangebot in Apotheken zu sensibilisieren, organisierte der Schweizerische Apothekerverband in 616 Apotheken die Kampagne "Künftige Nichtraucher”. Die Evaluation beurteilte die Beratungstätigkeit der Apotheken im Bereich Tabakentwöhnung und untersuchte die Einstellung der Projektverantwortlichen in den Apotheken gegenüber der Kampagne und der Tabakprävention. Die Dokumentation der Raucherberatungen erfolgte mittels Aktivitätsstatistik eine Woche vor und während der Aktion. Ein standardisierter Fragebogen erfasste an deren Ende die Einstellung gegenüber der Kampagne und der Tabakprävention. 32% der an der Kampagne teilnehmenden Apotheken führten die Aktivitätsstatistik. Der Rücklauf des Fragebogens zur Erfassung der Einstellung betrug 58%. Stärkster Prädiktor der Beratungshäufigkeit war die Variable "Apotheke mit mehrheitlich Passantenkundschaft”. Für die Beratungsintensität war es die Variable "Besuch des Workshops und Weiterbildung des Apothekenteams”, d. h. die bestmögliche Weiterbildung vor der Kampagne. Die positivste Einstellung gegenüber der Tabakprävention und das grösste Interesse an einer weiteren Kampagne zeigten Verantwortliche aus Apotheken mit mehrheitlich häufiger und intensiver Beratungstätigkeit. Mit der vorliegenden Studie kann gezeigt werden, dass Raucherentwöhnung in Apotheken durchführbar ist. Hauptvoraussetzungen dafür sind Motivation für die Prävention sowie eingehende Weiterbildung der Apothekerlnnen und des Apothekenteams

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e193c2ad73d9095824c7b795e13b6039
https://doi.org/10.1007/bf01624615

المؤلفون: Meyer H; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland., Maurer MH; Department of Radiology, Inselspital, Bern University Hospital and University of Bern, Switzerland.; Institute for Diagnostic and Interventional Radiology, University Oldenburg, Oldenburg, Germany., Staufer K; Division of Transplantation, Department of Surgery, 27271Medical University of Vienna, Vienna, Austria., Berzigotti A; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland., Banz V; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland.; The members of the Swiss Transplant Cohort Study are: Patrizia Amico, Andres Axel, John-David Aubert, Vanessa Banz, Beckmann Sonja, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Annalisa Berzigotti, Isabelle Binet, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Thierry Carrel, Emmanuelle Catana, Yves Chalandon, Sabina De Geest, Olivier De Rougemont, Sophie De Seigneux, Michael Dickenmann, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Sylvie Ferrari-Lacraz, Christian Garzoni, Paola Gasche Soccal, Christophe Gaudet, Déla Golshayan, Nicolas Goossens, Karine Hadaya, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Michael Koller (Head of the data center), Mirjam Laager, Bettina Laesser, Frédéric Lamoth, Roger Lehmann, Alexander Leichtle, Christian Lovis, Oriol Manuel, Hans-Peter Marti, Pierre Yves Martin, Michele Martinelli, Valérie McLin, Katell Mellac, Aurélia Merçay, Karin Mettler, Nicolas Mueller (Chairman Scientific Committee), Antonia Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual (Executive office), Klara Posfay-Barbe, Juliane Rick, Anne Rosselet, Simona Rossi, Silvia Rothlin, Frank Ruschitzka, Thomas Schachtner, Urs Schanz, Stefan Schaub, Aurelia Schnyder, Macé Schuurmans, Simon Schwab, Thierry Sengstag, Federico Simonetta, Susanne Stampf, Jürg Steiger (Head, Excecutive office), Guido Stirniman, Ueli Stürzinger, Christian Van Delden (Executive office), Jean-Pierre Venetz, Jean Villard, Julien Vionnet, Madeleine Wick (STCS coordinator), Markus Wilhlem, Patrick Yerly.

مؤلفون مشاركون: Swiss Transplant Cohort Study; The members of the Swiss Transplant Cohort Study are: Patrizia Amico, Andres Axel, John-David Aubert, Vanessa Banz, Beckmann Sonja, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Annalisa Berzigotti, Isabelle Binet, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Thierry Carrel, Emmanuelle Catana, Yves Chalandon, Sabina De Geest, Olivier De Rougemont, Sophie De Seigneux, Michael Dickenmann, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Sylvie Ferrari-Lacraz, Christian Garzoni, Paola Gasche Soccal, Christophe Gaudet, Déla Golshayan, Nicolas Goossens, Karine Hadaya, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Michael Koller (Head of the data center), Mirjam Laager, Bettina Laesser, Frédéric Lamoth, Roger Lehmann, Alexander Leichtle, Christian Lovis, Oriol Manuel, Hans-Peter Marti, Pierre Yves Martin, Michele Martinelli, Valérie McLin, Katell Mellac, Aurélia Merçay, Karin Mettler, Nicolas Mueller (Chairman Scientific Committee), Antonia Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual (Executive office), Klara Posfay-Barbe, Juliane Rick, Anne Rosselet, Simona Rossi, Silvia Rothlin, Frank Ruschitzka, Thomas Schachtner, Urs Schanz, Stefan Schaub, Aurelia Schnyder, Macé Schuurmans, Simon Schwab, Thierry Sengstag, Federico Simonetta, Susanne Stampf, Jürg Steiger (Head, Excecutive office), Guido Stirniman, Ueli Stürzinger, Christian Van Delden (Executive office), Jean-Pierre Venetz, Jean Villard, Julien Vionnet, Madeleine Wick (STCS coordinator), Markus Wilhlem, Patrick Yerly.

المصدر: Progress in transplantation (Aliso Viejo, Calif.) [Prog Transplant] 2022 Dec; Vol. 32 (4), pp. 321-326. Date of Electronic Publication: 2022 Aug 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Country of Publication: United States NLM ID: 100909380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-6708 (Electronic) Linking ISSN: 15269248 NLM ISO Abbreviation: Prog Transplant

مواضيع طبية MeSH: Liver Transplantation*/adverse effects , Liver Transplantation*/methods , Fatty Liver*/pathology, Humans ; Retrospective Studies ; Liver/diagnostic imaging ; Tissue Donors ; Biopsy ; Graft Survival

مستخلص: Introduction: Liver grafts with limited steatosis are currently used for liver transplantation, but the natural history of graft steatosis is not well known. Project Aims or Questions: This program evaluation aimed at assessing changes of steatosis after liver transplantation. Design: A retrospective chart review was performed assessing presence and severity of steatosis in the liver explant and in time zero donor graft biopsies carried out at the time-point of liver transplantation on histopathology and on imaging one year thereafter in 30 well characterized patients. Results: Ten patients (33%) showed steatosis on explant. Time zero biopsy revealed steatosis in 18 grafts (60%) and no steatosis in 12 (40%). One year after transplantation, 8 patients (27%) had steatosis and 22 patients (63%) had none. Fourteen patients (47%) showed changes in steatosis: 12 showed resolution and 2 showed de novo steatosis. Explant macrovesicular steatosis was associated with presence of steatosis 1 year after transplantation (binary logistic regression model, p = 0.014), but not macrovesicular steatosis in the donor graft at time-point of transplantation. Conclusion: Resolution of graft steatosis was frequent. Presence of steatosis in the recipient's liver, but not graft steatosis, was a risk factor for steatosis 1 year after transplantation. Factors related to the recipient seem to prevail over donor-related factors in determining the persistence or de novo appearance of steatosis after liver transplantation.