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المؤلفون: Shogo Tajima, Yuichi Takashi, Masaaki Takahashi, Naoya Egami, Seiji Fukumoto, Masaomi Nangaku, Manabu Taguchi, Yuka Kinoshita, Nobuaki Ito
المصدر: Internal Medicine
مصطلحات موضوعية: Fibroblast growth factor 23, Male, Pathology, medicine.medical_specialty, phosphaturic mesenchymal tumor mixed connective tissue variant, Left parotid gland, Hypophosphatemia, Paraneoplastic Syndromes, Case Report, urologic and male genital diseases, fibroblast growth factor 23, Elevated serum, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Positron Emission Tomography Computed Tomography, Internal Medicine, medicine, Biomarkers, Tumor, Humans, Radionuclide Imaging, Aged, Osteomalacia, Neoplasms, Connective Tissue, Left external jugular vein, business.industry, tumor-induced osteomalacia, technology, industry, and agriculture, General Medicine, Serum phosphate, medicine.disease, Magnetic Resonance Imaging, Parotid gland, Parotid Neoplasms, Fibroblast Growth Factors, stomatognathic diseases, Fibroblast Growth Factor-23, medicine.anatomical_structure, 030220 oncology & carcinogenesis, business, parotid gland, 030217 neurology & neurosurgery
الوصف: A 77-year-old man was suspected of having tumor-induced osteomalacia (TIO) because of hypophosphatemia (1.9 mg/dL) and elevated serum fibroblast growth factor 23 (FGF23) level (186.9 pg/mL). We detected a tumor in his left parotid gland, and the FGF23 level in the left external jugular vein indicated that the tumor overproduced FGF23. After the removal of the tumor, the serum FGF23 level rapidly decreased, and the serum phosphate normalized. This is the first case of TIO caused by a tumor in a parotid gland. This case indicates that the responsible tumors for TIO can be quite diverse.
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfbcd4db68d7782f70ff5b2879ae446
http://europepmc.org/articles/PMC5399206 -
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المؤلفون: Manabu Taguchi, Hiroe Takasu, Uwen Yeap, Tomoaki Fujii, Keisuke Furuta, Atsushi Terazawa, Tomoe Sakurai, Kenji Sugimoto
المصدر: Journal of the Japanese Society of Intensive Care Medicine. 27:119-120
مصطلحات موضوعية: business.industry, Plastic bronchitis, medicine.medical_treatment, Anesthesia, Extracorporeal membrane oxygenation, Medicine, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::91b52754e3659dc149c52ed5fcfa7642
https://doi.org/10.3918/jsicm.27_119 -
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المؤلفون: Yuka Kinoshita, Manabu Taguchi, Michiko Hori, Seiji Fukumoto, Nobuaki Ito, Yuichi Takashi
المصدر: Endocrine Research. 42:132-137
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Fibroblast growth factor 23, medicine.medical_specialty, urologic and male genital diseases, Left ventricular hypertrophy, Young Adult, 03 medical and health sciences, Endocrinology, Internal medicine, Humans, Medicine, In patient, cardiovascular diseases, Aged, Osteomalacia, business.industry, General Medicine, Middle Aged, medicine.disease, Rickets, Hypophosphatemic, Fibroblast Growth Factors, Fibroblast Growth Factor-23, stomatognathic diseases, Hypophosphatemic Rickets, 030104 developmental biology, Cardiac hypertrophy, Female, Hypertrophy, Left Ventricular, business, Hormone, Kidney disease
الوصف: Fibroblast growth factor 23 (FGF23) is a hormone regulating phosphate metabolism. Excessive actions of FGF23 cause several types of FGF23-related hypophosphatemic rickets/osteomalacia. Recently, it was reported that FGF23 levels were independently correlated with left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD). In addition, FGF23 was also shown to cause cardiac hypertrophy directly acting on cardiomyocytes. However, there is no study indicating the correlation between FGF23 and LVH in adult patients with FGF23-related hypophosphatemic rickets/osteomalacia. Therefore, we examined the existence of LVH in these patients.We recruited consecutive 24 patients with FGF23-related hypophosphatemic diseases. Their serum intact FGF23 levels and the parameters associated with LVH, including left ventricular mass index (LVMI), relative wall thickness (RWT), Sokolow-Lyon voltage, and Cornell product, were measured. The correlations between FGF23 and these parameters were examined.The participants did not show LVH on the whole. In addition, no significant correlation was observed by these examinations.It seems unlikely that FGF23 levels are the apparent determinant of the cardiac mass in patients with FGF23-related hypophosphatemic rickets/osteomalacia.
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المؤلفون: Kenji Sugimoto, Yeap Uwen, Atsushi Terazawa, Yuto Makino, Manabu Taguchi
المصدر: Journal of the Japanese Society of Intensive Care Medicine. 26:31-32
مصطلحات موضوعية: medicine.medical_specialty, Flail chest, business.industry, Medicine, Radiology, business, medicine.disease
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::14260999d70e42b409df9e2b5b34ed7a
https://doi.org/10.3918/jsicm.26_31 -
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المؤلفون: Manabu Taguchi, Seiji Fukumoto, Michiko Hori, Yuka Kinoshita
المصدر: Journal of Bone and Mineral Metabolism. 34:132-139
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Biology, urologic and male genital diseases, Cell Line, Phosphates, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Animals, Orthopedics and Sports Medicine, RNA, Messenger, Vitamin D, Extracellular Signal-Regulated MAP Kinases, Hydrogen peroxide, chemistry.chemical_classification, Messenger RNA, Reactive oxygen species, NADPH oxidase, Kinase, Hydrogen Peroxide, General Medicine, Phosphate, Molecular biology, Rats, Fibroblast Growth Factors, Fibroblast Growth Factor-23, stomatognathic diseases, 030104 developmental biology, Gene Expression Regulation, chemistry, Apocynin, biology.protein, Reactive Oxygen Species
الوصف: Fibroblast growth factor 23 (FGF23) has been shown to work as a phosphotropic hormone. Although FGF23 reduces the serum phosphate level, it has not been established that phosphate directly regulates FGF23 production. In this study, we investigated whether phosphate can enhance Fgf23 expression using the rat osteoblastic cell line UMR-106, which has been shown to express Fgf23 in response to 1,25-dihydroxyvitamin D [1,25(OH)2D]. Phosphate increased Fgf23 expression in a dose- and time-dependent manner in the presence of 1,25(OH)2D. Phosphate also increased Fgf23 promoter activity, but showed no effect on the half-life of Fgf23 messenger RNA. Phosphonoformic acid and PD98059, an inhibitor of MEK, inhibited the effects of phosphate on Fgf23 expression and promoter activity. In addition, phosphate enhanced production of reactive oxygen species (ROS) in UMR-106 cells, and hydrogen peroxide enhanced FGF23 production in a dose- and time-dependent manner. Hydrogen peroxide also enhanced Elk1 reporter activity, a target of the MEK-extracellular-signal-regulated kinase (ERK) pathway. Furthermore, the effect of phosphate on ROS production and Fgf23 expression was inhibited by apocynin, an inhibitor of NADPH oxidase. These results indicate that phosphate directly enhances Fgf23 transcription without affecting the stability of Fgf23 messenger RNA by stimulating NADPH-induced ROS production and the MEK-ERK pathway in UMR-106 cells.
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المؤلفون: Hoshiaki Nakagawa, Shigeki Takagi, Akiko Matsuura, Kenichi Asai, Atsushi Terazawa, Shunichi Shibazaki, Hibiki Shinjo, Daijo Inaguma, Minako Murata, Yuki Kuroda, Manabu Taguchi
المصدر: Nihon Toseki Igakkai Zasshi. 48:331-339
مصطلحات موضوعية: business.industry, Septic shock, Anesthesia, Medicine, business, medicine.disease, Severe sepsis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1bae8923ca9d31b06d9a008d68e2b667
https://doi.org/10.4009/jsdt.48.331 -
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المؤلفون: Seiji Fukumoto, Midori Shirota, Daigoro Hirohama, Yuzaburo Uetake, Toshiro Fujita, Kumiko Tanaka, Koji Takano, Manabu Taguchi
المصدر: Nihon Naika Gakkai Zasshi. 102:704-707
مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Bardet–Biedl syndrome, business.industry, Internal medicine, Pituitary tumors, medicine, General Medicine, medicine.disease, business, Growth hormone deficiency
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::475ed48be3af8317b918f005ec003792
https://doi.org/10.2169/naika.102.704 -
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المؤلفون: Manabu Taguchi, Michiko Hori, Toshiro Fujita, Takashi Igarashi, T. Saito, Yuichiro Shimizu, Seiji Fukumoto, Yuka Kinoshita
المصدر: European Journal of Endocrinology. 167:165-172
مصطلحات موضوعية: Adult, Male, Fibroblast growth factor 23, medicine.medical_specialty, Adolescent, Genotype, Endocrinology, Diabetes and Metabolism, DNA Mutational Analysis, Genetic analysis, Cohort Studies, Young Adult, Exon, Endocrinology, Internal medicine, medicine, Humans, Mass Screening, Pyrophosphatases, Child, Gene, Mass screening, Genetics, Extracellular Matrix Proteins, Phosphoric Diester Hydrolases, business.industry, PHEX, Infant, Newborn, Genetic Diseases, X-Linked, General Medicine, Middle Aged, Phosphoproteins, PHEX Phosphate Regulating Neutral Endopeptidase, Fibroblast Growth Factors, Fibroblast Growth Factor-23, Hypophosphatemic Rickets, Child, Preschool, Female, Familial Hypophosphatemic Rickets, business
الوصف: ObjectiveX-linked hypophosphatemic rickets (XLHR) caused by mutations in the PHEX gene is considered to be the most frequent cause of fibroblast growth factor 23 (FGF23)-related congenital hypophosphatemic rickets. In previous studies, mutations in the PHEX gene were detected in 60–70% of patients with clinical diagnoses of XLHR. This leads to the question whether current screening methods for mutations in the PHEX gene are inadequate or whether there is a substantial number of patients with other genetic causes of hypophosphatemic rickets. We conducted a genetic analysis of patients with FGF23-related hypophosphatemic rickets to clarify their etiology and evaluate the prevalence of XLHR among this group.Design and methodsWe studied 27 patients with familial and sporadic congenital hypophosphatemic rickets in whom serum FGF23 was above 30 pg/ml using an assay for the full-length protein. Exons and exon–intron junctions of genomic DNA of causative genes for FGF23-related hypophosphatemic rickets were sequenced. PHEX mRNA from peripheral blood was analyzed in some patients.ResultsDirect sequencing of genomic DNA identified 11 novel and four known mutations in the PHEX gene. Additionally, there was a large PHEX gene deletion in one case and abnormal PHEX mRNA splicing in another. In summary, 26 patients (96%) had XLHR and one patient had autosomal recessive hypophosphatemic rickets 2.ConclusionsXLHR is by far the most prevalent cause of FGF23-related hypophosphatemic rickets. We propose that analysis of PHEX mRNA from peripheral blood would be appropriate for the first screening step in determining the etiology of FGF23-related hypophosphatemic rickets.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0770dd23accbb4ea3d5cfb6b39f5eb4
https://doi.org/10.1530/eje-12-0071 -
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المؤلفون: Hirokazu Takai, Tomoki Takahashi, Shuichi Eto, Seiko Takai, Youichi Hayashida, Manabu Taguchi, Nobutake Nakane
المصدر: Orthopedics & Traumatology. 61:765-768
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::07297204c2db4d0755ed75b71ea3e0ad
https://doi.org/10.5035/nishiseisai.61.765 -
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المؤلفون: Katsutoshi Takahashi, Yuichi Takashi, Yuka Kinoshita, Seiji Fukumoto, Masaomi Nangaku, Noriko Makita, Manabu Taguchi
المصدر: Internal medicine (Tokyo, Japan). 54(17)
مصطلحات موضوعية: Adult, Male, endocrine system, medicine.medical_specialty, Lung Neoplasms, Time Factors, Adrenocorticotropic hormone, Neuroendocrine tumors, Petrosal Sinus Sampling, Cushing syndrome, Adrenocorticotropic Hormone, Internal medicine, Internal Medicine, Medicine, Humans, Cushing Syndrome, business.industry, Insulin tolerance test, General Medicine, Recovery of Function, medicine.disease, Inferior petrosal sinus sampling, ACTH Syndrome, Ectopic, Neuroendocrine Tumors, medicine.anatomical_structure, Endocrinology, Treatment Outcome, Hypothalamic pituitary axis, business, hormones, hormone substitutes, and hormone antagonists, Hypothalamic–pituitary–adrenal axis
الوصف: We describe a 30-year-old man with ectopic adrenocorticotropic hormone (ACTH) syndrome. Before the operation, there was no diurnal variation of ACTH, and ACTH did not respond to CRH or dexamethasone suppression tests. These abnormalities disappeared after the removal of a neuroendocrine tumor in the lung. In addition, plasma ACTH was measureable at as early as postoperative day 3 with ACTH levels increasing thereafter. Furthermore, an insulin tolerance test and inferior petrosal sinus sampling indicated that ACTH was secreted from the pituitary. This case indicates that the hypothalamic-pituitary function can recover within a couple of weeks after curative surgery for ectopic ACTH syndrome.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fb111d2ae555af40ecc5d614cf4fac
https://pubmed.ncbi.nlm.nih.gov/26328647
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