المؤلفون: Wu S, Liao G, Mao J, Yan H, Chen J, Peng J

المصدر: Infection and Drug Resistance, Vol Volume 17, Pp 1309-1319 (2024)

مصطلحات موضوعية: covid-19, omicron, severe infection, dnlr, risk factors, Infectious and parasitic diseases, RC109-216

الوصف: Shuting Wu, Guichan Liao, Jingchun Mao, Haiming Yan, Juanjuan Chen, Jie Peng Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Jie Peng, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic of China, Tel +8613802515784, Fax +86 20 87719653, Email Pjie138@163.comPurpose: The purpose of the study was to explore the potential risk factors of mortality in patients with severe pneumonia during the omicron pandemic in South China in 2022.Methods: Clinical data was collected from patients hospitalized with omicron COVID-19. Then, patients were categorized into the non-survival and survival groups. A comprehensive analysis was conducted to analyze the factors associated with negative outcome in individuals suffering from severe omicron COVID-19.Results: In this study, 155 severe COVID-19 patients were included, comprising 55 non-survivors and 100 survivors. Non-survivors, in comparison to survivors, exhibited elevated levels of various biomarkers including neutrophil count, hypersensitive troponin T, urea, creatinine, C-reactive protein, procalcitonin, interleukin-6, plasma D-dimer, and derived neutrophil-to-lymphocyte ratio (dNLR) (P < 0.05). They also displayed reduced lymphocyte count, platelet count, and albumin levels (P < 0.05) and were more prone to developing comorbidities, including shock, acute cardiac and renal injury, acute respiratory distress syndrome, coagulation disorders, and secondary infections. Platelet count (PLT) < 100 × 10^/L, interleukin-6 (IL-6) > 100 pg/mL, and dNLR > 5.0 independently contributed to the risk of death in patients suffering from severe COVID-19.Conclusion: PLT, IL-6, and dNRL independently contributed to the risk of mortality in patients with severe pneumonia during the 2022 omicron pandemic in South China.Keywords: COVID-19, omicron, severe infection, dNLR, risk factors

وصف الملف: electronic resource

Relation: https://www.dovepress.com/factors-associated-with-mortality-among-severe-omicron-patients-for-co-peer-reviewed-fulltext-article-IDR; https://doaj.org/toc/1178-6973

URL الوصول: https://doaj.org/article/f270156e40eb457c845c0e7742f6563f

المؤلفون: Yang G, Pu J, Zhu S, Shi Y, Yang Y, Mao J, Sun Y, Zhao B

المصدر: International Journal of General Medicine, Vol Volume 17, Pp 377-386 (2024)

مصطلحات موضوعية: thyroid, levothyroxine, dosage, model, prediction, Medicine (General), R5-920

الوصف: Guanghua Yang,1,* Jiaxi Pu,1,* Sibo Zhu,2 Yong Shi,3 Yi Yang,3 Jiangnan Mao,3 Yongkang Sun,1 Bin Zhao1 1Department of General Surgery, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, People’s Republic of China; 2School of Life Sciences, Fudan University, Shanghai, 200438, People’s Republic of China; 3Cinoasia Institute, Shanghai, 200438, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin Zhao, Department of General Surgery, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, No. 358, Datong Road, Gaoqiao, Pudong New Area, Shanghai, 200137, People’s Republic of China, Tel +86 13918468421, Email zhaobin0727@sina.com Yongkang Sun, Department of Ultrasound, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, No. 358, Datong Road, Gaoqiao, Pudong New Area, Shanghai, 200137, People’s Republic of China, Tel +86 13601659860, Email elangwang@126.comBackground: Thyroidectomy is commonly performed for benign or malignant thyroid tumors, often resulting in hypothyroidism. Levothyroxine (LT4) supplementation is crucial to maintain hormone levels within the normal range and suppress TSH for cancer control. However, determining the optimal dosage remains challenging, leading to uncertain outcomes and potential side effects.Methods: We analyzed clinical examination data from 510 total thyroidectomy patients, including demographic information, blood tests, and thyroid function. Using R, we applied data preprocessing techniques and identified 274 samples with 98 variables. Principal Component Analysis, correlation analysis, and regression analysis were conducted to identify factors associated with optimal LT4 dosage.Results: The analysis revealed that only eight variables significantly influenced the final satisfactory dosage of LT4 in tablets: Benign0/Malignant1 (benign or malignant), BQB (electrophoretic albumin ratio), TP (total protein), FDP (fibrin degradation products), TRAB_1 (thyroid-stimulating hormone receptor antibody), PT (prothrombin time), MONO# (monocyte count), and HCV0C (hepatitis C antibody). The resulting predictive model was: .Conclusion: Parameters such as benign/malignant status, TRAB_1, and BQB ratio during medication can serve as observational indicators for postoperative LT4 dosage. The calculated linear model can predict the LT4 dosage for patients after thyroidectomy, leading to improved treatment effectiveness and conserving medical resources.Keywords: thyroid, levothyroxine, dosage, model, prediction

وصف الملف: electronic resource

Relation: https://www.dovepress.com/optimizing-levothyroxine-replacement-a-precision-dosage-model-for-post-peer-reviewed-fulltext-article-IJGM; https://doaj.org/toc/1178-7074

URL الوصول: https://doaj.org/article/55d03268749348b6951d3c58f27438d4

المؤلفون: Zhou Z, Zhang X, Wang S, Wang X, Mao J

المصدر: International Journal of Nanomedicine, Vol Volume 18, Pp 8099-8112 (2023)

مصطلحات موضوعية: myocardial ischemia-reperfusion injury, mesenchymal stem cells, small extracellular vesicles, nanoscale modification, natural drug, Medicine (General), R5-920

الوصف: Zhou Zhou,1,2,* Xuan Zhang,1,* Shuai Wang,1 Xianliang Wang,1 Jingyuan Mao1 1Cardiovascular Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, People’s Republic of China; 2Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianliang Wang; Jingyuan Mao, Email xlwang1981@126.com; jymao@126.comAbstract: Myocardial ischemia-reperfusion injury (MI/RI) constitutes a pivotal determinant impacting the long-term prognosis of individuals afflicted by ischemic cardiomyopathy subsequent to reperfusion therapy. Stem cells have garnered extensive application within the realm of MI/RI investigation, yielding tangible outcomes. Stem cell therapy encounters certain challenges in its application owing to the complexities associated with stem cell acquisition, a diminished homing rate, and a brief in vivo lifespan. Small extracellular vesicles (sEV) originating from mesenchymal stem cells (MSCs) have been demonstrated to possess the benefits of abundant availability, reduced immunogenicity, and a diminished tumorigenic incidence. They can exert their effects on damaged organs, improving injuries by transporting a lot of constituents, including proteins, RNA, lipid droplets, and more. This phenomenon has garnered substantial attention in the context of MI/RI treatment. Simultaneously, MSC-derived sEV (MSC-sEV) can exhibit enhanced therapeutic advantages through bioengineering modifications, biomaterial incorporation, and natural drug interventions. Within this discourse, we shall appraise the utilization of MSC-sEV and their derivatives in the context of MI/RI treatment, aiming to offer valuable insights for future research endeavors related to MI/RI.Keywords: myocardial ischemia-reperfusion injury, mesenchymal stem cells, small extracellular vesicles, nanoscale modification, natural drug

وصف الملف: electronic resource

Relation: https://www.dovepress.com/a-powerful-tool-in-the-treatment-of-myocardial-ischemia-reperfusion-in-peer-reviewed-fulltext-article-IJN; https://doaj.org/toc/1178-2013

URL الوصول: https://doaj.org/article/200b40c890f94eb494c1b312e7d38952

المؤلفون: Qu W, Wang X, Liu Y, Mao J, Liu M, Zhong Y, Gao B, Zhao M, Gao Y

المصدر: Infection and Drug Resistance, Vol Volume 16, Pp 7683-7694 (2023)

مصطلحات موضوعية: antibiotic, self-medication, children, china, antibiotic knowledge, attitude, Infectious and parasitic diseases, RC109-216

الوصف: Wenjie Qu,1,2,* Xinyu Wang,1,* Yufei Liu,3 Jinfeng Mao,2 Mengchi Liu,4 Yaqin Zhong,1,2 Bella Gao,5 Miaomiao Zhao,1 Yuexia Gao1,2 1Department of Health Management, School of Public Health, Nantong University, Nantong, People’s Republic of China; 2Institute for Health Development, Nantong University, Nantong, People’s Republic of China; 3Faculty of Health Sciences, University of Macau, Macau, People’s Republic of China; 4National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China; 5Ulink College of Suzhou Industrial Park, Suzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Miaomiao Zhao; Yuexia Gao, Department of Health Management, School of Public Health, Nantong University, 9 Seyuan Road, Jiangsu, 226019, People’s Republic of China, Tel +86150 0450 1812 ; +86139 6296 8819, Email zhaomiaomiao@ntu.edu.cn; yxgao@ntu.edu.cnBackground: Self-medication with antibiotics (SMA) among children is a common practice in low-income and middle-income countries, which has accelerated antibacterial abuse.Objective: This study aimed to estimate the prevalence and associated factors of SMA among children in China, including parents’ knowledge, attitudes, and practices towards antibiotic use.Methods: A cross-sectional study based on a structured questionnaire survey of parents was conducted in Nantong between July and September 2020. A total of 1699 respondents participated. Information on participants’ demographic and family characteristics, knowledge, attitudes, and practices towards antibiotics use was collected. Hierarchical binary logistic regression was used to examine the predictors of SMA among children.Results: Among 1699 participants, 23.31% practiced SMA to their children in the past year. Cough (59.6%) was the most common symptom leading to self-medication and penicillins (85.4%) were the most commonly used drugs. Hierarchical regression indicated that parents with higher level of antibiotic knowledge scores (OR=1.163, 95% CI: 1.067– 1.268) and buying antibiotics without a prescription from pharmacy (OR=1.475, 95% CI: 1.097– 1.983) were more likely to practice SMA to their children both in urban and in rural areas. Storing antibiotics at home resulted in an increased likelihood of self-medication in urban areas but not in rural areas. In addition, there was also a higher probability of non-prescribed antibiotics in children without chronic diseases (OR=1.959, 95% CI:1.072– 3.578).Conclusion: The prevalence of SMA in children is high in China. Higher knowledge scores and practices of buying and storing non-prescribed antibiotics behaviors increased parents’ antibiotic self-medication in their children. Practical and effective education intervention for children’s rational use of antibiotics is urgently strengthened.Keywords: antibiotic, self-medication, children, China, antibiotic knowledge, attitude

وصف الملف: electronic resource

Relation: https://www.dovepress.com/self-medication-with-antibiotics-among-children-in-china-a-cross-secti-peer-reviewed-fulltext-article-IDR; https://doaj.org/toc/1178-6973

URL الوصول: https://doaj.org/article/6d2854cf6864478f812191c27cc355ed

المؤلفون: Wu J, Zhang C, He F, Wang Y, Zeng L, Liu W, Zhao D, Mao J, Gao F

المصدر: Risk Management and Healthcare Policy, Vol Volume 16, Pp 2543-2553 (2023)

مصطلحات موضوعية: icu healthcare professionals, intention to leave, cross-sectional survey, extreme gradient boosting, xgboost., Public aspects of medicine, RA1-1270

الوصف: Jiangnan Wu,1,* Chao Zhang,2,* Feng He,3,* Yuan Wang,4 Liangnan Zeng,5 Wei Liu,6 Di Zhao,7 Jingkun Mao,1 Fei Gao8 1Department of Artificial Intelligence, Tianjin University of Technology, Tianjin, People’s Republic of China; 2Sixth Department of Oncology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 4Department of Neurosurgery, Tangshan Gongren Hospital, Tangshan, People’s Republic of China; 5Department of Nursing, Chengdu Fifth People’s Hospital, The Fifth People’s Hospital Affiliated to Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 6Hebei Psychological Counselor Association, Shijiazhuang, People’s Republic of China; 7Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 8Hebei General Hospital, Shijiazhuang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Di Zhao; Fei Gao, Tel +86-13363833833 ; +86-13933173693, Email 179381749@qq.com; 27909361@qq.comBackground: The intention to leave among intensive care unit (ICU) healthcare professionals in China has become a concerning issue. Therefore, understanding the factors influencing the intention to leave and implementing appropriate measures have become urgent needs for maintaining a stable healthcare workforce.Objective: This study aims to investigate the current status of intention to leave among ICU healthcare professionals in China, explore the relevant factors affecting this intention, and provide targeted recommendations to reduce the intention to leave among healthcare professionals.Methods: A cross-sectional survey was conducted, involving ICU healthcare professionals from 3-A hospitals of the 34 provinces in China. The survey encompassed 22 indicators, including demographic information (marital status, children, income), work-related factors (weekly working hours, night shift frequency, hospital environment), and psychological assessment (using Symptom Checklist-90 (SCL-90)). The data from a sample population of 3653 individuals were analyzed using the extreme gradient boosting (XGBoost) method to predict intention to leave.Results: The survey results revealed that 62.09% (2268 individuals) of the surveyed ICU healthcare professionals expressed an intention to leave. The XGBoost model achieved a predictive accuracy of 75.38% and an Area Under the Curve (AUC) of 0.77.Conclusion: Satisfaction with income was found to be the strongest predictor of intention to leave among ICU healthcare professionals. Additionally, factors such as years of experience, night shift frequency, and pride in hospital work were found to play significant roles in influencing the intention to leave.Keywords: ICU healthcare professionals, intention to leave, cross-sectional survey, extreme gradient boosting, XGBoost

وصف الملف: electronic resource

Relation: https://www.dovepress.com/factors-affecting-intention-to-leave-among-icu-healthcare-professional-peer-reviewed-fulltext-article-RMHP; https://doaj.org/toc/1179-1594

URL الوصول: https://doaj.org/article/076ca1690aae46af8e43bb52b079161a

المؤلفون: Ma T, Zhang H, Weng Y, Tang S, Mao J, Feng X, Zhang Y, Zhang J

المصدر: International Journal of COPD, Vol Volume 18, Pp 2687-2698 (2023)

مصطلحات موضوعية: elastin peptide, dendritic cell, cluster of differentiation 40, cd40, th cell, emphysema, Diseases of the respiratory system, RC705-779

الوصف: Tingting Ma,1,2,* Hui Zhang,3,* Yuqing Weng,2,* Shudan Tang,3 Jinshan Mao,2 Xin Feng,3 Yuxin Zhang,4 Jianquan Zhang1 1Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518000, People’s Republic of China; 2Department of Respiratory and Critical Medicine, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, 519000, People’s Republic of China; 3Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China; 4The First Clinical Medical College, Southern Medical University, Guangzhou, Guangdong, 510515, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianquan Zhang, Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518000, People’s Republic of China, Tel +8613978123845, Fax +86755-23482484, Email zhangjq76@mail.sysu.edu.cnPurpose: To investigate the role of the CD40-CD40 ligand (CD40L) pathway in the regulation of Th1, Th17, and regulatory T (Treg)-cell responses in an elastin peptide (EP)-induced autoimmune emphysema mouse model.Methods: BALB/c mice were transnasally treated with EP on day 0, injected intravenously with anti-CD40 antibody via the tail vein on day 33, and sacrificed on day 40. The severity of emphysema was evaluated by determining the mean linear intercept (MLI) and destructive index (DI) from lung sections. The proportions of myeloid dendritic cells (mDCs) and Th1, Th17, and Treg cells in the blood, spleen, and lungs were determined via flow cytometry. The levels of the cytokines interleukin (IL)-6, IL-17, interferon (IFN)-γ, and transforming growth factor (TGF)-β were detected via enzyme-linked immunosorbent assay. Ifnγ, IL17a, Rorγt and Foxp3 transcription levels were detected via polymerase chain reaction.Results: CD40+ mDCs accumulated in the lungs of EP-stimulated mice. Blocking the CD40-CD40L pathway with an anti-CD40 antibody alleviated Th1 and Th17 responses; increased the proportion of Treg cells; decreased MLI and DI; reduced the levels of cytokines IL-6, IL-17, and IFN-γ as well as the transcription levels of Ifnγ, IL17a, and Rorγt; and upregulated the expression of TGF-β and Foxp3.Conclusion: The CD40-CD40L pathway could play a critical role in Th1, Th17 and Treg cell dysregulation in EP-mediated emphysema and could be a potential therapeutic target.Keywords: elastin peptide, dendritic cell, Cluster of Differentiation 40, CD40, Th cell, emphysema

وصف الملف: electronic resource

Relation: https://www.dovepress.com/blocking-cd40-alleviates-th1-and-th17-cell-responses-in-elastin-peptid-peer-reviewed-fulltext-article-COPD; https://doaj.org/toc/1178-2005

URL الوصول: https://doaj.org/article/caaaccb00cad42cf8e924419ba03b52a

المؤلفون: Peng Z, Jia Q, Mao J, Yi Q

المصدر: Neuropsychiatric Disease and Treatment, Vol Volume 19, Pp 2295-2308 (2023)

مصطلحات موضوعية: schizophrenia, scz, samidorphan, safety, metabolic parameters, meta-analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

الوصف: Zhenlei Peng,1,* Qiyu Jia,2,* Junxiong Mao,1 Qizhong Yi1 1The Psychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China; 2Department of Trauma Orthopedics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qizhong Yi, The Psychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China, Tel +86 13999138673, Email qizhongyi@126.comPurpose: This meta-analysis intended to evaluate the safety and metabolic effects of the combination of olanzapine (OLZ) and samidorphan (SAM) in the treatment of schizophrenia (SCZ) patients.Patients and Methods: We searched for the English and Chinese databases for randomized controlled trials (RCTs) on the OLZ combined with SAM for SCZ. The English databases included PubMed, Web of Science, EMbase, and Cochrane Library, however, Chinese databases included Chinese Biology Medicine (CBM), VIP, Wanfang, and China National Knowledge Infrastructure (CNKI). All database searches were due by May 31, 2023. Using Review Manager 5.4 software, a meta-analysis was conducted following a literature review and data extraction.Results: This study included five RCTs involving 1781 patients. Regarding safety, the meta-analysis revealed that the probability of weight gain was reduced in the OLZ and SAM group than in the OLZ group (RR = 0.83, 95% CI (0.69, 0.99), P < 0.05). Statistically, the incidence of severe adverse safety events, dry mouth, headache, drowsiness, death, and suicidal perception events was insignificant (P > 0.05); in terms of metabolism, compared with the OLZ group, the OLZ plus SAM group reduced total cholesterol (TC) levels (MD = − 3.58, 95% CI (− 6.81, − 0.34), P < 0.05). However, it had no significant effect on metabolic indices, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, glucose, and insulin index (P > 0.05).Conclusion: In patients with SCZ, treatment with the combination of OLZ and SAM decreased the incidence of weight gain adverse events and TC levels; nevertheless, it did not affect other adverse events or metabolic parameters. These findings provide clinicians with evidence-based guidance and support for drug selection. However, it is crucial to confirm these findings through further high-quality research.Keywords: schizophrenia, SCZ, samidorphan, safety, metabolic parameters, meta-analysis

وصف الملف: electronic resource

Relation: https://www.dovepress.com/effects-of-combined-therapy-of-olanzapine-and-samidorphan-on-safety-an-peer-reviewed-fulltext-article-NDT; https://doaj.org/toc/1178-2021

URL الوصول: https://doaj.org/article/76f67061efed48f09672852e994dfc5c

المؤلفون: Eid L, Mao X, Zhao B, Mao J, Qian S, Zhang Y, Zhang L, Cheng L, Sun X

المصدر: Clinical, Cosmetic and Investigational Dermatology, Vol Volume 16, Pp 3077-3090 (2023)

مصطلحات موضوعية: fat compartments, facial rejuvenation, face lift, facial aging, Dermatology, RL1-803

الوصف: Loy Eid,* Xiyuan Mao,* Binfan Zhao, Jiayi Mao, Shutong Qian, Yuyu Zhang, Ying Zhang, Lu Zhang, Liying Cheng, Yuguang Zhang, Xiaoming Sun Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuguang Zhang; Xiaoming Sun, Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai, People’s Republic of China, Email zhangyg18@126.com; drsunxm@126.comBackground: Facial fat compartments and their role in facial aging have gained increased recognition and are playing a significant role in facial rejuvenation. The superficial fat compartments glide inferiorly during the aging process, leading to the flattening and elongation of the face and the appearance of facial bulges, folds, and grooves.Patients and Methods: Ultrasound imaging of the facial soft tissues was performed on nine female volunteers to demonstrate the change in superficial facial fat compartments from an upright to supine position. The net suture jowl and medial cheek fat compartment repositioning technique was operated on 165 Asian patients between September 2020 and July 2021. Volume and projection change of malar and jowl regions, as well as change in elevation of malar protrusion were measured 1, 3, and 6 months postoperatively using a three-dimensional imaging system.Results: Ultrasound measurements confirmed the medial and middle cheek, nasolabial, and jowl fat compartments changed in thickness during positional changes with age-related differences. Postoperative three-dimensional imaging showed volume and projection increase in the malar region (2.23mL and 1.11mm) and decrease in the jowl region (− 0.18mL and − 0.52mm) by the 6-month follow-up date, and malar projection saw a superior displacement of 3.08mm.Conclusion: The superficial fat glide inferiorly within their compartments under the force of gravity and naturally reposition themselves when the effect of gravity is reversed. The net suture technique offers a minimally invasive method for lifting the jowl fat, volumizing the mid-cheek and achieving facial rejuvenation by repositioning the superficial fat compartments.Keywords: fat compartments, facial rejuvenation, face lift, facial aging

وصف الملف: electronic resource

Relation: https://www.dovepress.com/fat-compartment-gliding-theory--a-novel-technique-for-the-repositionin-peer-reviewed-fulltext-article-CCID; https://doaj.org/toc/1178-7015

URL الوصول: https://doaj.org/article/cbc9209dc1b44a06b9a3765f06cd72c3

المؤلفون: Zhu J, Wu F, Li C, Mao J, Wang Y, Zhou X, Xie H, Wen C

المصدر: International Journal of Nanomedicine, Vol Volume 18, Pp 5365-5376 (2023)

مصطلحات موضوعية: single extracellular vesicle analysis, heterogeneity, detection methods, disease diagnosis, new therapies, Medicine (General), R5-920

الوصف: Junquan Zhu, Feifeng Wu,* Cuifang Li,* Jueyi Mao,* Yang Wang,* Xin Zhou,* Haotian Xie,* Chuan Wen Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuan Wen, Department of Pediatrics, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, People’s Republic of China, Tel +86-13755191815, Email chuanwen@csu.edu.cnAbstract: Extracellular vesicles (EVs) are lipid containers that are actively released by cells and contain complex molecular cargoes. These cargoes include abundant material such as genomes and proteins from cells of origin. They are involved in intercellular communication and various pathological processes, showing excellent potential for diagnosing and treating diseases. Given the significant heterogeneity of EVs in complex physiopathological processes, unveiling their composition is essential to understanding their function. Bulk detection methods have been previously used to analyze EVs, but they often mask their heterogeneity, leading to the loss of valuable information. To overcome this limitation, single extracellular vesicle (SEV) analysis techniques have been developed and advanced. These techniques allow for analyzing EVs’ physical information and biometric molecules at the SEV level. This paper reviews recent advances in SEV detection methods and summarizes some clinical applications for SEV detection strategies.Keywords: single extracellular vesicle analysis, heterogeneity, detection methods, disease diagnosis, new therapies

وصف الملف: electronic resource

Relation: https://www.dovepress.com/application-of-single-extracellular-vesicle-analysis-techniques-peer-reviewed-fulltext-article-IJN; https://doaj.org/toc/1178-2013

URL الوصول: https://doaj.org/article/9f2240286eb4464b9c6694ec8e5475bf

المؤلفون: Gao R, Tang H, Mao J

المصدر: Journal of Inflammation Research, Vol Volume 16, Pp 3897-3910 (2023)

مصطلحات موضوعية: liver fibrosis, necroptosis, pyroptosis, ferroptosis, autophagy, apoptosis, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

الوصف: Ruoyu Gao,1 Haiying Tang,2 Jingwei Mao1 1Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of ChinaCorrespondence: Jingwei Mao, Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, 116011, Liaoning Province, People’s Republic of China, Email maojingwei@dmu.edu.cnAbstract: Programmed cell death (PCD) is a comprehensive term that encompasses various forms of cell death, such as apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy, which play a crucial role in the pathogenesis of liver fibrosis. PCD facilitates the elimination of aberrant cells, particularly activated hepatic stellate cells (HSCs), which are the primary producers of extracellular matrix (ECM). The removal of HSCs may impede ECM synthesis, thereby mitigating liver fibrosis. As such, PCD has emerged as a promising therapeutic target for the development of novel drugs to treat liver fibrosis. Numerous studies have been conducted to investigate the underlying mechanisms of PCD in the elimination of activated HSCs and other aberrant liver cells in fibrotic liver tissue, including hepatocytes, hepatic sinusoid endothelial cells (LSECs), and Kupffer cells (KCs). The induction of PCD, the interplay between different forms of PCD, and the potential harm or benefit of PCD in liver fibrosis are topics of ongoing research. Evidences suggest that PCD is a complex process with dual effects on liver fibrosis. The purpose of this review is to summarize the most recent advances in PCD and liver fibrosis research.Keywords: liver fibrosis, necroptosis, pyroptosis, ferroptosis, autophagy, apoptosis

وصف الملف: electronic resource

Relation: https://www.dovepress.com/programmed-cell-death-in-liver-fibrosis-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

URL الوصول: https://doaj.org/article/a321055491c54ad28d8353b9ab9ac7a4