المؤلفون: Maria Toumpourleka, MD, MSc, Vasileios Siokas, MD, Christodoulos Papadopoulos, MD, PhD, Antigony Mitselou, MD, PhD, Leda Kovatsi, MD, PhD, Maria S. Sidiropoulou, MD, Konstantinos Triantafyllou, MD, MSc, Vassilios Vassilikos, MD, PhD

المصدر: JACC: Case Reports, Vol 29, Iss 3, Pp 102178- (2024)

مصطلحات موضوعية: hemopericardium, left ventricular wall rupture, multidetector computed tomography, myopericarditis, pericardial effusion, tamponade, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: This is a case of a 59-year-old man presenting with myopericarditis. Over a 2-week period, he developed progressive symptoms and worsening pericardial effusion, leading to cardiac tamponade. Pericardiocentesis revealed hemopericardium, and multidetector computed tomography angiography showed left ventricular free wall rupture. The patient collapsed abruptly, and autopsy confirmed the findings.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266608492300534X; https://doaj.org/toc/2666-0849

URL الوصول: https://doaj.org/article/b89e68fa048b4c5a9c701e2b2c48fb66

المؤلفون: Alexandra Katsimardou, Dimitrios Patoulias, Ioanna Zografou, Zoi Tegou, Konstantinos Imprialos, Konstantinos Stavropoulos, Maria Toumpourleka, Asterios Karagiannis, Konstantinos Petidis, Michael Doumas

المصدر: Medicina, Vol 59, Iss 5, p 969 (2023)

مصطلحات موضوعية: diabetic kidney disease, eGFR, albuminuria, type 2 diabetes mellitus, sexual dysfunction, erectile dysfunction, Medicine (General), R5-920

الوصف: Background and Objectives: Diabetic kidney disease (DKD), expressed either as albuminuria, low estimated glomerular filtration rate (eGFR) or both, and sexual dysfunction (SD), are common complications among type 2 diabetes mellitus (T2DM) patients. This study aims to assess whether an association exists between DKD and SD, erectile dysfunction (ED) or female sexual dysfunction (FSD) in a T2DM population. Materials and Methods: A cross-sectional study was designed and conducted among T2DM patients. The presence of SD was assessed using the International Index of Erectile Function and the Female Sexual Function Index questionnaires for males and females, respectively, and patients were evaluated for DKD. Results: Overall, 80 patients, 50 males and 30 females, agreed to participate. Sexual dysfunction was present in 80% of the study population. Among the participants, 45% had DKD, 38.5% had albuminuria and/or proteinuria and 24.1% had an eGFR below 60 mL/min/1.73 m2. The eGFR was associated with SD, ED and FSD. Moreover, SD and ED were proven as significant determinants for lower eGFR values in multiple linear regression analyses. DKD was associated with lower lubrication scores and eGFR was associated with lower desire, arousal, lubrication and total scores; however, the multivariate linear regression analyses showed no significant associations between them. Older age resulted in significantly lower arousal, lubrication, orgasm and total FSFI scores. Conclusions: SD is commonly encountered in older T2DM patients and DKD affects almost half of them. The eGFR has been significantly associated with SD, ED and FSD, while SD and ED were proven to be significant determinants for the eGFR levels.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1648-9144/59/5/969; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144

URL الوصول: https://doaj.org/article/50d6a83eea224b87a84a77a7e67d41f7

المؤلفون: Maria Anna Bazmpani, Alexandra Arvanitaki, Maria Toumpourleka, Georgia Pitsiou, Evangelia Panagiotidou, Sophia Anastasia Mouratoglou, Georgios Sianos, Stavros Hadjimiltiades, Antonios Pitsis, Eckhard Mayer, Ioannis Stanopoulos, Haralambos Karvounis, George Giannakoulas

المصدر: Hellenic Journal of Cardiology, Vol 59, Iss 1, Pp 16-23 (2018)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, distinct pulmonary vascular disease, and therefore, there is a lack of data regarding its clinical presentation, diagnosis, and management at a national basis. We aimed to describe the demographics and management of patients with CTEPH in Northern Greece. Methods: We conducted a retrospective, observational study by a joint collaboration between two pulmonary hypertension expert centers in Greece, and the study included patients diagnosed with CTEPH. The patient population was divided into two groups depending on their operability. Results: Overall, 27 consecutive patients were included (59% female, mean age 59.3±15.1 years). Dyspnea and fatigue were the most common presenting symptoms. History of pulmonary embolism was present in 82%. Of patients, 18 (67%) were assessed as operable, of whom 10 (55%) finally underwent pulmonary endarterectomy (PEA). There were no differences in symptoms, WHO functional class, 6-min walking test distance, and hemodynamics between the operable and nonoperable groups. At the end of follow-up, all non-operable and operable patients who did not receive surgical treatment were treated with at least one pulmonary hypertension-specific drug. Conclusion: This is the first report that presents data of patients diagnosed with CTEPH in Greece. The percentage of patients who underwent surgical treatment is lower but approaches the reported rates in large registries. Considering that PEA is a relatively safe and potentially curative surgical procedure, we emphasize the need for establishing a designated PEA center in Greece. Keywords: Chronic thromboembolic pulmonary hypertension, pulmonary endarterectomy, registry, riociguat

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1109966617300623; https://doaj.org/toc/1109-9666

URL الوصول: https://doaj.org/article/038a279fea0d4a1297e374927485a17a

المؤلفون: Dimitrios Patoulias, Alexandra Katsimardou, Maria Toumpourleka, Christodoulos Papadopoulos, Michael Doumas

المصدر: ESC Heart Failure, Vol 7, Iss 1, Pp 334-335 (2020)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2055-5822

URL الوصول: https://doaj.org/article/6d2a39378ca64e6098c8d5537362018b

المؤلفون: Chrysovalantou Nikolaidou, Maria Anna Bazmpani, Ioannis Tziatzios, Maria Toumpourleka, Charalambos Karvounis, Theodoros D. Karamitsos

المصدر: Hellenic Journal of Cardiology, Vol 58, Iss 6, Pp 459-460 (2017)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1109966617301434; https://doaj.org/toc/1109-9666

URL الوصول: https://doaj.org/article/c6ec213a846f4c0b904c28d79514ff12

المؤلفون: Dimitrios, Patoulias, Maria, Toumpourleka, Alexandra, Katsimardou, Ioanna, Zografou, Konstantinos, Stavropoulos, Konstantinos, Imprialos, Asterios, Karagiannis, Michael, Doumas, Christodoulos, Papadopoulos

المصدر: Kardiologia Polska. 80:696-698

مصطلحات موضوعية: Glucose, Diabetes Mellitus, Type 2, Symporters, Sodium, Ventricular Function, Right, Humans, Hypoglycemic Agents, Pilot Projects, Cardiology and Cardiovascular Medicine, Sodium-Glucose Transporter 2 Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95748324b6dce2d5e4cf4c49c9a429b
https://doi.org/10.33963/kp.a2022.0104

المؤلفون: Christodoulos Papadopoulos, Michael Doumas, Maria Toumpourleka, Dimitrios Patoulias

المصدر: The American Journal of Cardiology. 157:150-152

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Incidence, United States, New onset atrial fibrillation, Text mining, Risk Factors, Internal medicine, Meta-analysis, Atrial Fibrillation, Cardiology, medicine, Humans, Cardiology and Cardiovascular Medicine, Receptor, business, Mineralocorticoid Receptor Antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d47331235e2a0be3227d289a2304ad0
https://doi.org/10.1016/j.amjcard.2021.07.011

المؤلفون: Christodoulos Papadopoulos, Maria-Styliani Kalogirou, Konstantinos Imprialos, Michael Doumas, Dimitrios Patoulias, Alexandra Katsimardou, Maria Toumpourleka, Konstantinos Stavropoulos, I. Stergiou, Ioanna Zografou

المصدر: Diabetes & Metabolism. 46:272-279

مصطلحات موضوعية: Blood Glucose, Diarrhea, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Lower risk, Reproductive Tract Infections, Glucagon-Like Peptide-1 Receptor, law.invention, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Randomized controlled trial, law, Internal medicine, Internal Medicine, Humans, Hypoglycemic Agents, Medicine, Adverse effect, Sodium-Glucose Transporter 2 Inhibitors, Glucagon-like peptide 1 receptor, Glycated Hemoglobin, business.industry, digestive, oral, and skin physiology, nutritional and metabolic diseases, Type 2 Diabetes Mellitus, Nausea, General Medicine, medicine.disease, Hypoglycemia, Metformin, Discontinuation, Diabetes Mellitus, Type 2, Drug Therapy, Combination, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug

الوصف: As sodium-glucose cotransporter-2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) are second-line treatment options in type 2 diabetes mellitus (T2DM), our study sought to provide precise effect estimates regarding the role of GLP-1RAs vs SGLT-2is as add-on treatments in patients uncontrolled by metformin monotherapy.PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL) and 'grey literature' were searched from their inception up to December 2019 for randomized controlled trials (RCTs) with durations≥12weeks to evaluate the safety and efficacy of adding a GLP-1RA vs an SGLT-2i in patients with T2DM.Three eligible RCTs were identified. Administration of GLP-1RAs vs SGLT-2is resulted in significant decreases in HbA1c with no significant impact on either body weight or fasting plasma glucose. GLP-1RA treatment led to a significant increase in odds for achieving an HbA1c7% compared with SGLT-2is, whereas no difference was detected in body weight reductions of5%. Significantly greater risk for any hypoglycaemia, nausea and diarrhoea, and lower risk for genital infections, was also observed with GLP-1RAs, while no differences regarding severe hypoglycaemia, treatment discontinuation and impact on blood pressure levels were identified. No other major safety issues arose.Our meta-analysis suggests that GLP-1RAs provide better glycaemic effects than SGLT-2is in patients with T2DM uncontrolled by metformin, albeit while increasing risk for hypoglycaemia and gastrointestinal adverse events.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce3d6027343af920dadd3558513e6e5
https://doi.org/10.1016/j.diabet.2020.04.001

المؤلفون: Dimitrios Patoulias, Alexandra Katsimardou, Aristi Boulmpou, Konstantinos Imprialos, Konstantinos Stavropoulos, Maria Toumpourleka, Christodoulos Papadopoulos, Asterios Karagiannis, Michael Doumas

المصدر: Journal of Hypertension. 40:e300-e301

مصطلحات موضوعية: Physiology, Internal Medicine, Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c589a8d254bccf82aca1748948a19691
https://doi.org/10.1097/01.hjh.0000838652.68523.bc

المؤلفون: Dimitrios Patoulias, Alexandra Katsimardou, Konstantinos Imprialos, Konstantinos Stavropoulos, Konstantinos Koutsampasopoulos, Fotios Siskos, Aristi Boulmpou, Maria Toumpourleka, Christodoulos Papadopoulos, Michael Doumas

المصدر: Journal of Hypertension. 40:e188-e189

مصطلحات موضوعية: Physiology, Internal Medicine, Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f079ea1cb614b6b53fc51846b7d7ecc8
https://doi.org/10.1097/01.hjh.0000837340.53743.9e