المؤلفون: Dargél, Aroldo A, Mosconi, Elise, Masson, Marc, Plaze, Marion, Taieb, Fabien, Von Platen, Cassandra, Buivan, Tan Phuc, Pouleriguen, Guillaume, Sanchez, Marie, Fournier, Stéphane, Lledo, Pierre-Marie, Henry, Chantal

المصدر: JMIR Research Protocols, Vol 9, Iss 8, p e18818 (2020)

مصطلحات موضوعية: Medicine, Computer applications to medicine. Medical informatics, R858-859.7

الوصف: BackgroundThe diagnosis and management of bipolar disorder are limited by the absence of available biomarkers. Patients with bipolar disorder frequently present with mood instability even during remission, which is likely associated with the risk of relapse, impaired functioning, and suicidal behavior, indicating that the illness is active. ObjectiveThis research protocol aimed to investigate the correlations between clinically rated mood symptoms and mood/behavioral data automatically collected using the Toi Même app in patients with bipolar disorder presenting with different mood episodes. This study also aimed to assess the feasibility of this app for self-monitoring subjective and objective mood/behavior parameters in those patients. MethodsThis open-label, nonrandomized trial will enroll 93 (31 depressive, 31 euthymic, and 31 hypomanic) adults diagnosed with bipolar disorder type I/II (Diagnostic and Statistical Manual of Mental Disorders, 5th edition criteria) and owning an iPhone. Clinical evaluations will be performed by psychiatrists at the baseline and after 2 weeks, 1 month, 2 months, and 3 months during the follow-up. Rather than only accessing the daily mood symptoms, the Toi Même app also integrates ecological momentary assessments through 2 gamified tests to assess cognition speed (QUiCKBRAIN) and affective responses (PLAYiMOTIONS) in real-life contexts, continuously measures daily motor activities (eg, number of steps, distance) using the smartphone’s motion sensors, and performs a comprehensive weekly assessment. ResultsRecruitment began in April 2018 and the completion of the study is estimated to be in December 2021. As of April 2019, 25 participants were enrolled in the study. The first results are expected to be submitted for publication in 2020. This project has been funded by the Perception and Memory Unit of the Pasteur Institute (Paris) and it has received the final ethical/research approvals in April 2018 (ID-RCB: 2017-A02450-53). ConclusionsOur results will add to the evidence of exploring other alternatives toward a more integrated approach in the management of bipolar disorder, including digital phenotyping, to develop an ethical and clinically meaningful framework for investigating, diagnosing, and treating individuals at risk of developing bipolar disorder or currently experiencing bipolar disorder. Further prospective studies on the validity of automatically generated smartphone data are needed for better understanding the longitudinal pattern of mood instability in bipolar disorder as well as to establish the reliability, efficacy, and cost-effectiveness of such an app intervention for patients with bipolar disorder. Trial RegistrationClinicalTrials.gov NCT03508427; https://clinicaltrials.gov/ct2/show/NCT03508427 International Registered Report Identifier (IRRID)DERR1-10.2196/18818

وصف الملف: electronic resource

Relation: http://www.researchprotocols.org/2020/8/e18818/; https://doaj.org/toc/1929-0748

URL الوصول: https://doaj.org/article/6698f551854741889917e4aba7e6e7c9

المؤلفون: Haustgen, Thierry, Masson, Marc

المصدر: Actualités sur les maladies dépressives. 2018, p. 1-16.

الإتاحة: https://www.cairn.info/actualites-sur-les-maladies-depressives--9782257207333-page-1.htm

المؤلفون: Masson, Marc

المصدر: Les troubles bipolaires. 2018, p. 128.

الإتاحة: https://www.cairn.info/les-troubles-bipolaires--9782130801603.htm

المؤلفون: Servais, Aude^{Aff4, Aff5, Aff6}, Masson, Marc^Aff7, Grünfeld, Jean-Pierre^{Aff4, Aff5}

المساهمون: Malhi, Gin S., editor^Aff1, Masson, Marc, editor^Aff2, Bellivier, Frank, editor^Aff3

المصدر: The Science and Practice of Lithium Therapy. :265-276

المؤلفون: Bourgeois, Marc-Louis^Aff4, Masson, Marc^Aff5

المساهمون: Malhi, Gin S., editor^Aff1, Masson, Marc, editor^Aff2, Bellivier, Frank, editor^Aff3

المصدر: The Science and Practice of Lithium Therapy. :181-188

Degree: MD, Psycho D

المؤلفون: Mauras, Thomas^Aff4, Sportiche, Sarah^{Aff5, Aff6, Aff7}, Richa, Sami^Aff8, Masson, Marc^{Aff9, Aff10}

المساهمون: Malhi, Gin S., editor^Aff1, Masson, Marc, editor^Aff2, Bellivier, Frank, editor^Aff3

المصدر: The Science and Practice of Lithium Therapy. :125-140

Degree: MD

Alternate Title: Memory: The cornerstone of Jean Delay's work (English)

المؤلفون: Masson, Marc

المصدر: In Annales médico-psychologiques February 2018 176(2):124-128

المؤلفون: Masson, Marc

المصدر: Les troubles bipolaires. 2016, p. 128.

الإتاحة: https://www.cairn.info/les-troubles-bipolaires--9782130731801.htm

Alternate Title: Few reflexions about psychological pain: An example of the interest of the history of psychiatric semiology for the growth of a modern clinic (English)

المؤلفون: Naneix, Benjamin, Masson, Marc

المصدر: In Annales médico-psychologiques March 2016 174(2):144-147

Alternate Title: Love passion and passionate idealism: A psychiatric reading of Leon Tolstoy's novel, Anna Karenina (English)

المؤلفون: Masson, Marc

المصدر: In Annales médico-psychologiques January 2016 174(1):20-27