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1دورية أكاديمية
المؤلفون: Ziyu Zhu, Du Lei, Kun Qin, Maxwell J. Tallman, L. Rodrigo Patino, David E. Fleck, Qiyong Gong, John A. Sweeney, Melissa P. DelBello, Robert K. McNamara
المصدر: Translational Psychiatry, Vol 13, Iss 1, Pp 1-8 (2023)
مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Abstract Although attention-deficit/hyperactivity disorder (ADHD) and a family history of bipolar I disorder (BD) are associated with increased risk for developing BD, their neuroanatomical substrates remain poorly understood. This study compared cortical and subcortical gray matter morphology in psychostimulant-free ADHD youth with and without a first-degree relative with BD and typically developing healthy controls. ADHD youth (ages 10-18 years) with (‘high-risk’, HR) or without (‘low-risk’, LR) a first-degree relative with BD and healthy comparison youth (HC) were enrolled. High-resolution 3D T1-weighted images were acquired using a Philips 3.0 T MR scanner. The FreeSurfer image analysis suite was used to measure cortical thickness, surface area, and subcortical volumes. A general linear model evaluated group differences in MRI features with age and sex as covariates, and exploratory correlational analyses evaluated associations with symptom ratings. A total of n = 142 youth (mean age: 14.16 ± 2.54 years, 35.9% female) were included in the analysis (HC, n = 48; LR, n = 49; HR, n = 45). The HR group exhibited a more severe symptom profile, including higher mania and dysregulation scores, compared to the LR group. For subcortical volumes, the HR group exhibited smaller bilateral thalamic, hippocampal, and left caudate nucleus volumes compared to both LR and HC, and smaller right caudate nucleus compared with LR. No differences were found between LR and HC groups. For cortical surface area, the HR group exhibited lower parietal and temporal surface area compared with HC and LR, and lower orbitofrontal and superior frontal surface area compared to LR. The HR group exhibited lower left anterior cingulate surface area compared with HC. LR participants exhibited greater right pars opercularis surface area compared with the HC. Some cortical alterations correlated with symptom severity ratings. These findings suggest that ADHD in youth with a BD family history is associated with a more a severe symptom profile and a neuroanatomical phenotype that distinguishes it from ADHD without a BD family history.
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2158-3188
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المؤلفون: Du Lei, Kun Qin, Wenbin Li, Ziyu Zhu, Maxwell J. Tallman, L. Rodrigo Patino, David E. Fleck, Veronica Aghera, Qiyong Gong, John A. Sweeney, Melissa P. DelBello, Robert K. McNamara
المصدر: Journal of Affective Disorders. 334:238-245
مصطلحات موضوعية: Psychiatry and Mental health, Clinical Psychology
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3دورية أكاديمية
المؤلفون: Kun Qin, Du Lei, Jing Yang, Wenbin Li, Maxwell J. Tallman, Luis Rodrigo Patino Duran, Thomas J. Blom, Kaitlyn M. Bruns, Sian Cotton, John A. Sweeney, Qiyong Gong, Melissa P. DelBello
المصدر: BMC Psychiatry, Vol 21, Iss 1, Pp 1-10 (2021)
مصطلحات موضوعية: Resting-state functional magnetic resonance imaging, Graph theory, Emotion regulation, Psychoradiology, Bipolar disorder, Familial risk, Psychiatry, RC435-571
الوصف: Abstract Background Given that psychopharmacological approaches routinely used to treat mood-related problems may result in adverse outcomes in mood dysregulated adolescents at familial risk for bipolar disorder (BD), Mindfulness-Based Cognitive Therapy for Children (MBCT-C) provides an alternative effective and safe option. However, little is known about the brain mechanisms of beneficial outcomes from this intervention. Herein, we aimed to investigate the network-level neurofunctional effects of MBCT-C in mood dysregulated adolescents. Methods Ten mood dysregulated adolescents at familial risk for BD underwent a 12-week MBCT-C intervention. Resting-state functional magnetic resonance imaging (fMRI) was performed prior to and following MBCT-C. Topological metrics of three intrinsic functional networks (default mode network (DMN), fronto-parietal network (FPN) and cingulo-opercular network (CON)) were investigated respectively using graph theory analysis. Results Following MBCT-C, mood dysregulated adolescents showed increased global efficiency and decreased characteristic path length within both CON and FPN. Enhanced functional connectivity strength of frontal and limbic areas were identified within the DMN and CON. Moreover, change in characteristic path length within the CON was suggested to be significantly related to change in the Emotion Regulation Checklist score. Conclusions 12-week MBCT-C treatment in mood dysregulated adolescents at familial risk for BD yield network-level neurofunctional effects within the FPN and CON, suggesting enhanced functional integration of the dual-network. Decreased characteristic path length of the CON may be associated with the improvement of emotion regulation following mindfulness training. However, current findings derived from small sample size should be interpreted with caution. Future randomized controlled trials including larger samples are critical to validate our findings.
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1471-244X
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4دورية أكاديمية
المؤلفون: Duncan C. Honeycutt, Melissa P. DelBello, Jeffrey R. Strawn, Laura B. Ramsey, Luis R. Patino, Kyle Hinman, Jeffrey Welge, David J. Miklowitz, Booil Jo, Thomas J. Blom, Kaitlyn M. Bruns, Sarah K. Hamill Skoch, Nicole Starace, Maxwell J. Tallman, Manpreet K. Singh
المصدر: Journal of Personalized Medicine, Vol 12, Iss 6, p 1006 (2022)
مصطلحات موضوعية: bipolar risk, hyperarousal, depression, anxiety, adolescent, neuroimaging, Medicine
الوصف: Antidepressants are standardly used to treat moderate to severe symptoms of depression and/or anxiety in youth but may also be associated with rare but serious psychiatric adverse events such as irritability, agitation, aggression, or suicidal ideation. Adverse events are especially common in youth with a family history of bipolar disorder (BD) who are at heightened risk for dysfunction in neurobiological systems that regulate emotion and arousal. To further understand this phenomenon, this study will examine (a) baseline risk factors associated with dysfunctional arousal in a sample of youth at high-risk for BD treated with or without an antidepressant, (b) whether antidepressant-related changes in arousal are mediated by changes in prefrontal-limbic circuitry, and (c) whether pharmacogenetic factors influence antidepressant-related changes in arousal. High-risk youth (aged 12–17 years with moderate to severe depressive and/or anxiety symptoms and at least one first-degree relative with bipolar I disorder) will be randomized to receive psychotherapy plus escitalopram or psychotherapy plus placebo. Neuroimaging and behavioral measures of arousal will be collected prior to randomization and at 4 weeks. Samples for pharmacogenetic analysis (serum escitalopram concentration, CYP2C19 metabolizer phenotype, and HTR2A and SLC6A4 genotypes) will be collected at 8 weeks. Youth will be followed for up to 16 weeks to assess change in arousal measures.
وصف الملف: electronic resource
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المؤلفون: Du Lei, Wenbin Li, Kun Qin, Yuan Ai, Maxwell J. Tallman, L. Rodrigo Patino, Jeffrey A. Welge, Thomas J. Blom, Christina C. Klein, David E. Fleck, Qiyong Gong, Caleb M. Adler, Jeffrey R. Strawn, John A. Sweeney, Melissa P. DelBello
المصدر: Neuropsychopharmacology. 48:615-622
مصطلحات موضوعية: Pharmacology, Psychiatry and Mental health
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المؤلفون: Du Lei, Wenbin Li, Maxwell J. Tallman, Stephen M. Strakowski, Melissa P. DelBello, L. Rodrigo Patino, David E. Fleck, Su Lui, Qiyong Gong, John A. Sweeney, Jeffrey R. Strawn, Fabiano G. Nery, Jeffrey A. Welge, Emily Rummelhoff, Caleb M. Adler
المصدر: Neuropsychopharmacology. 47:1961-1968
مصطلحات موضوعية: Pharmacology, Psychiatry and Mental health
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المؤلفون: Jeffrey R. Strawn, Melissa P. DelBello, Du Lei, Robert K. McNamara, L. Rodrigo Patino, Wenbin Li, Qiyong Gong, Maxwell J Tallman
المصدر: J Affect Disord
مصطلحات موضوعية: medicine.medical_specialty, Bipolar Disorder, Bipolar I disorder, Adolescent, Docosahexaenoic Acids, Emotions, Article, Fish Oils, Double-Blind Method, Internal medicine, Fatty Acids, Omega-3, Connectome, medicine, Humans, chemistry.chemical_classification, business.industry, medicine.disease, Fish oil, Magnetic Resonance Imaging, Eicosapentaenoic acid, Psychiatry and Mental health, Clinical Psychology, Endocrinology, Eicosapentaenoic Acid, Mood disorders, chemistry, Docosahexaenoic acid, Dietary Supplements, Major depressive disorder, business, Polyunsaturated fatty acid
الوصف: INTRODUCTION: Mood disorders are associated with fronto-limbic structural and functional abnormalities and deficits in omega-3 polyunsaturated fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Emerging evidence also suggests that n-3 PUFA, which are enriched in fish oil, promote cortical plasticity and connectivity. The present study performed a graph-based connectome analysis to investigate the role of n-3 PUFA in emotion-related network organization in medication-free depressed adolescent bipolar offspring. METHODS: At baseline patients (n=53) were compared with healthy controls (n=53), and patients were then randomized to 12-week double-blind treatment with placebo or fish oil. At baseline and endpoint, erythrocyte EPA+DHA levels were measured and fMRI scans (4 Tesla) were obtained while performing a continuous performance task with emotional and neutral distractors (CPT-END). Graph-based analysis was used to characterize topological properties of large-scale brain network organization. RESULTS: Compared with healthy controls, patients exhibited lower erythrocyte EPA+DHA levels (p=0.0001), lower network clustering coefficients (p=0.029), global efficiency (p=0.042), and lower node centrality and connectivity strengths in frontal-limbic regions (p
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المؤلفون: Jeffrey A. Welge, Jeffrey R. Strawn, Wenbin Li, Melissa P. DelBello, Maxwell J Tallman, Du Lei, Robert K. McNamara, Luis R. Patino
المصدر: Bipolar Disord
مصطلحات موضوعية: medicine.medical_specialty, Childhood Depression, Bipolar Disorder, Bipolar I disorder, Adolescent, business.industry, medicine.disease, Placebo, Eicosapentaenoic acid, Article, Psychiatry and Mental health, Endocrinology, Risk Factors, Docosahexaenoic acid, Internal medicine, medicine, Humans, Orbitofrontal cortex, Bipolar disorder, medicine.symptom, business, Mania, Biological Psychiatry
الوصف: OBJECTIVE To evaluate the effects of fish oil (FO), a source of the omega-3 polyunsaturated fatty acids (n-3 PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on emotion-generated corticolimbic functional connectivity in depressed youth at high risk for developing bipolar I disorder. METHODS Thirty-nine antidepressant-free youth with a current depressive disorder diagnosis and a biological parent with bipolar I disorder were randomized to 12-week double-blind treatment with FO or placebo. At baseline and endpoint, fMRI (4 Tesla) scans were obtained while performing a continuous performance task with emotional and neutral distractors (CPT-END). Seed-to-voxel functional connectivity analyses were performed using bilateral orbitofrontal cortex (OFC) and amygdala (AMY) seeds. Measures of depression, mania, global symptom severity, and erythrocyte fatty acids were obtained. RESULTS Erythrocyte EPA+DHA composition increased significantly in the FO group (+47%, p ≤ 0.0001) but not in the placebo group (-10%, p = 0.11). Significant group by time interactions were found for functional connectivity between the left OFC and the left superior temporal gyrus (STG) and between the right AMY and right inferior temporal gyrus (ITG). OFC-STG connectivity increased in the FO group (p = 0.0001) and decreased in the placebo group (p = 0.0019), and AMY-ITG connectivity decreased in the FO group (p = 0.0014) and increased in the placebo group (p
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المؤلفون: Constance Chen, Maxwell J. Tallman, Kim M. Cecil, Luis Rodrigo Patino, Thomas J. Blom, Melissa P. DelBello, Robert K. McNamara
المصدر: Journal of attention disorders. 26(13)
مصطلحات موضوعية: Clinical Psychology, Bipolar Disorder, Adolescent, Attention Deficit Disorder with Hyperactivity, Developmental and Educational Psychology, Humans, Central Nervous System Stimulants, Neurochemistry, Choline
الوصف: Objective: To identify clinical and central features that differentiate ADHD youth with and without familial risk for bipolar I disorder (BD). Methods: Psychostimulant-free ADHD youth (10–18 years) with and without a first-degree relative with BD and healthy controls were enrolled. Bilateral ventrolateral prefrontal cortex (VLPFC) proton magnetic resonance spectroscopy (1H MRS) scans and a range of symptom ratings were performed. Results: A total of n = 145 youth were enrolled. ADHD youth with a family history of BD exhibited greater manic and depressive symptom severity, ADHD hyperactivity/impulsive symptom severity, and higher parent-reported ratings of dysregulation compared with ADHD youth without a BD family history. Although VLPFC metabolite levels did not differ across groups, choline levels in the left VLPFC correlated with different symptom ratings. Conclusion: Symptom profiles including more severe mood and externalizing symptoms, but not VLPFC neurochemistry, differentiate psychostimulant-free ADHD youth with and without a family history of BD.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df312a3bfa18c8e131f03a4fefcccce
https://pubmed.ncbi.nlm.nih.gov/35658594 -
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المؤلفون: Fabiano G. Nery, Caleb M. Adler, Christina Klein, Kun Qin, Melissa P. DelBello, Jeffrey R. Strawn, Jing Yang, Robert K. McNamara, Wenjing Zhang, L. Rodrigo Patino, Du Lei, Su Lui, John A. Sweeney, Yuan Ai, David E. Fleck, Wenbin Li, Qiyong Gong, Maxwell J Tallman
المصدر: Neuropsychopharmacology
مصطلحات موضوعية: Oncology, medicine.medical_specialty, Bipolar Disorder, Adolescent, Lithium (medication), Inferior frontal gyrus, Lithium, Article, law.invention, Quetiapine Fumarate, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Connectome, medicine, Humans, Prospective Studies, Bipolar disorder, Child, Pharmacology, Supplementary motor area, business.industry, Brain, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, medicine.anatomical_structure, Outcomes research, Quetiapine, business, Insula, 030217 neurology & neurosurgery, medicine.drug
الوصف: The goals of the current study were to determine whether topological organization of brain structural networks is altered in youth with bipolar disorder, whether such alterations predict treatment outcomes, and whether they are normalized by treatment. Youth with bipolar disorder were randomized to double-blind treatment with quetiapine or lithium and assessed weekly. High-resolution MRI images were collected from children and adolescents with bipolar disorder who were experiencing a mixed or manic episode (n = 100) and healthy youth (n = 63). Brain networks were constructed based on the similarity of morphological features across regions and analyzed using graph theory approaches. We tested for pretreatment anatomical differences between bipolar and healthy youth and for changes in neuroanatomic network metrics following treatment in the youth with bipolar disorder. Youth with bipolar disorder showed significantly increased clustering coefficient (Cp) (p = 0.009) and characteristic path length (Lp) (p = 0.04) at baseline, and altered nodal centralities in insula, inferior frontal gyrus, and supplementary motor area. Cp, Lp, and nodal centrality of the insula exhibited normalization in patients following treatment. Changes in these neuroanatomic parameters were correlated with improvement in manic symptoms but did not differ between the two drug therapies. Baseline structural network matrices significantly differentiated medication responders and non-responders with 80% accuracy. These findings demonstrate that both global and nodal structural network features are altered in early course bipolar disorder, and that pretreatment alterations in neuroanatomic features predicted treatment outcome and were reduced by treatment. Similar connectome normalization with lithium and quetiapine suggests that the connectome changes are a downstream effect of both therapies that is related to their clinical efficacy.
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