المؤلفون: Wanfang You, Qian Li, Lizhou Chen, Ning He, Yuanyuan Li, Fenghua Long, Yaxuan Wang, Yufei Chen, Robert K. McNamara, John A. Sweeney, Melissa P. DelBello, Qiyong Gong, Fei Li

المصدر: BMC Medicine, Vol 22, Iss 1, Pp 1-17 (2024)

مصطلحات موضوعية: Autism spectrum disorder, Attention-deficit/hyperactivity disorder, Cortical thickness, Meta-analysis, Magnetic resonance imaging, Surface-based morphometry, Medicine

الوصف: Abstract Background Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are neurodevelopmental disorders with overlapping behavioral features and genetic etiology. While brain cortical thickness (CTh) alterations have been reported in ASD and ADHD separately, the degree to which ASD and ADHD are associated with common and distinct patterns of CTh changes is unclear. Methods We searched PubMed, Web of Science, Embase, and Science Direct from inception to 8 December 2023 and included studies of cortical thickness comparing youth (age less than 18) with ASD or ADHD with typically developing controls (TDC). We conducted a comparative meta-analysis of vertex-based studies to identify common and distinct CTh alterations in ASD and ADHD. Results Twelve ASD datasets involving 458 individuals with ASD and 10 ADHD datasets involving 383 individuals with ADHD were included in the analysis. Compared to TDC, ASD showed increased CTh in bilateral superior frontal gyrus, left middle temporal gyrus, and right superior parietal lobule (SPL) and decreased CTh in right temporoparietal junction (TPJ). ADHD showed decreased CTh in bilateral precentral gyri, right postcentral gyrus, and right TPJ relative to TDC. Conjunction analysis showed both disorders shared reduced TPJ CTh located in default mode network (DMN). Comparative analyses indicated ASD had greater CTh in right SPL and TPJ located in dorsal attention network and thinner CTh in right TPJ located in ventral attention network than ADHD. Conclusions These results suggest shared thinner TPJ located in DMN is an overlapping neurobiological feature of ASD and ADHD. This alteration together with SPL alterations might be related to altered biological motion processing in ASD, while abnormalities in sensorimotor systems may contribute to behavioral control problems in ADHD. The disorder-specific thinner TPJ located in disparate attention networks provides novel insight into distinct symptoms of attentional deficits associated with the two neurodevelopmental disorders. Trial registration PROSPERO CRD42022370620. Registered on November 9, 2022.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1741-7015

URL الوصول: https://doaj.org/article/e5208f41ecd24d8c8bc720c7bd452e79

المؤلفون: Ziyu Zhu, Du Lei, Kun Qin, Maxwell J. Tallman, L. Rodrigo Patino, David E. Fleck, Qiyong Gong, John A. Sweeney, Melissa P. DelBello, Robert K. McNamara

المصدر: Translational Psychiatry, Vol 13, Iss 1, Pp 1-8 (2023)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Abstract Although attention-deficit/hyperactivity disorder (ADHD) and a family history of bipolar I disorder (BD) are associated with increased risk for developing BD, their neuroanatomical substrates remain poorly understood. This study compared cortical and subcortical gray matter morphology in psychostimulant-free ADHD youth with and without a first-degree relative with BD and typically developing healthy controls. ADHD youth (ages 10-18 years) with (‘high-risk’, HR) or without (‘low-risk’, LR) a first-degree relative with BD and healthy comparison youth (HC) were enrolled. High-resolution 3D T1-weighted images were acquired using a Philips 3.0 T MR scanner. The FreeSurfer image analysis suite was used to measure cortical thickness, surface area, and subcortical volumes. A general linear model evaluated group differences in MRI features with age and sex as covariates, and exploratory correlational analyses evaluated associations with symptom ratings. A total of n = 142 youth (mean age: 14.16 ± 2.54 years, 35.9% female) were included in the analysis (HC, n = 48; LR, n = 49; HR, n = 45). The HR group exhibited a more severe symptom profile, including higher mania and dysregulation scores, compared to the LR group. For subcortical volumes, the HR group exhibited smaller bilateral thalamic, hippocampal, and left caudate nucleus volumes compared to both LR and HC, and smaller right caudate nucleus compared with LR. No differences were found between LR and HC groups. For cortical surface area, the HR group exhibited lower parietal and temporal surface area compared with HC and LR, and lower orbitofrontal and superior frontal surface area compared to LR. The HR group exhibited lower left anterior cingulate surface area compared with HC. LR participants exhibited greater right pars opercularis surface area compared with the HC. Some cortical alterations correlated with symptom severity ratings. These findings suggest that ADHD in youth with a BD family history is associated with a more a severe symptom profile and a neuroanatomical phenotype that distinguishes it from ADHD without a BD family history.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2158-3188

URL الوصول: https://doaj.org/article/62d9dd1247004decb06d798a0241d11d

المؤلفون: Chen Chen, Bin Huang, Michal Kouril, Jinzhong Liu, Hang Kim, Siva Sivaganisan, Jeffrey A. Welge, Melissa P. DelBello

المصدر: Frontiers in Computer Science, Vol 5 (2023)

مصطلحات موضوعية: application programming interface (API), BART, comparative effectiveness research (CER), averaged treatment effect (ATE), conditional ATE (CATE), Gaussian process (GP), Electronic computers. Computer science, QA75.5-76.95

الوصف: IntroductionMethods and tools evaluating treatment effect have been primarily developed for binary type of treatment. Yet, treatment is rarely binary outside the experimental setting, varies by dosage, frequency and time. Treatment is routinely adjusted, initiated or stopped when being administered over a period of time.MethodsBoth Gaussian Process (GP) regression and Bayesian additive regression tree (BART) have been used successfully for handling complex setting involving time-varying treatments that is either adaptive or non-adaptive. Here, we introduce an application programming interface (API) that implements both BART and GP for estimating averaged treatment effect (ATE) and conditional averaged treatment (CATE) for the two-stage time-varying treatment strategies.ResultsWe provide two real applications for evaluating comparative effectiveness of time-varying treatment strategies. The first example evaluates an early aggressive treatment strategies for caring children with newly diagnosed Juvenile Idiopathic Arthritis (JIA). The second evaluates the persistent per-protocol treatment effectiveness in a large randomized pragmatic trial. The examples demonstrate the use of the API calling from R and Python, for handling both non-adaptive or adaptive treatments, with presences of partially observed or missing data issues. Summary tables and interactive figures of the results are downloadable.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcomp.2023.1183380/full; https://doaj.org/toc/2624-9898

URL الوصول: https://doaj.org/article/150523cee15943ddb46478a8748eb300

المؤلفون: Kun Qin, Du Lei, Jing Yang, Wenbin Li, Maxwell J. Tallman, Luis Rodrigo Patino Duran, Thomas J. Blom, Kaitlyn M. Bruns, Sian Cotton, John A. Sweeney, Qiyong Gong, Melissa P. DelBello

المصدر: BMC Psychiatry, Vol 21, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: Resting-state functional magnetic resonance imaging, Graph theory, Emotion regulation, Psychoradiology, Bipolar disorder, Familial risk, Psychiatry, RC435-571

الوصف: Abstract Background Given that psychopharmacological approaches routinely used to treat mood-related problems may result in adverse outcomes in mood dysregulated adolescents at familial risk for bipolar disorder (BD), Mindfulness-Based Cognitive Therapy for Children (MBCT-C) provides an alternative effective and safe option. However, little is known about the brain mechanisms of beneficial outcomes from this intervention. Herein, we aimed to investigate the network-level neurofunctional effects of MBCT-C in mood dysregulated adolescents. Methods Ten mood dysregulated adolescents at familial risk for BD underwent a 12-week MBCT-C intervention. Resting-state functional magnetic resonance imaging (fMRI) was performed prior to and following MBCT-C. Topological metrics of three intrinsic functional networks (default mode network (DMN), fronto-parietal network (FPN) and cingulo-opercular network (CON)) were investigated respectively using graph theory analysis. Results Following MBCT-C, mood dysregulated adolescents showed increased global efficiency and decreased characteristic path length within both CON and FPN. Enhanced functional connectivity strength of frontal and limbic areas were identified within the DMN and CON. Moreover, change in characteristic path length within the CON was suggested to be significantly related to change in the Emotion Regulation Checklist score. Conclusions 12-week MBCT-C treatment in mood dysregulated adolescents at familial risk for BD yield network-level neurofunctional effects within the FPN and CON, suggesting enhanced functional integration of the dual-network. Decreased characteristic path length of the CON may be associated with the improvement of emotion regulation following mindfulness training. However, current findings derived from small sample size should be interpreted with caution. Future randomized controlled trials including larger samples are critical to validate our findings.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-244X

URL الوصول: https://doaj.org/article/058eeeb422ca40aab176aed8750fed82

المؤلفون: Fabiano G. Nery, Sheela L. Masifi, Jeffrey R. Strawn, Luis R. Duran, Wade A. Weber, Jeffrey A. Welge, Caleb M. Adler, Stephen M. Strakowski, Melissa P. DelBello

المصدر: Brazilian Journal of Psychiatry, Vol 43, Iss 1, Pp 70-74 (2020)

مصطلحات موضوعية: Bipolar disorder, antidepressants, adverse events, functional magnetic resonance imaging, amygdala, Psychiatry, RC435-571

الوصف: Objective: To investigate whether poor antidepressant tolerability is associated with functional brain changes in children and adolescents of parents with bipolar I disorder (at-risk youth). Methods: Seventy-three at-risk youth (ages 9-20 years old) who participated in a prospective study and had an available baseline functional magnetic resonance imaging (fMRI) scan were included. Research records were reviewed for the incidence of adverse reactions related to antidepressant exposure during follow-up. The sample was divided among at-risk youth without antidepressant exposure (n=21), at-risk youth with antidepressant exposure and no adverse reaction (n=12), at-risk youth with antidepressant-related adverse reaction (n=21), and healthy controls (n=20). The fMRI task was a continuous performance test with emotional distracters. Region-of-interest mean activation in brain areas of the fronto-limbic emotional circuit was compared among groups. Results: Right amygdala activation in response to emotional distracters significantly differed among groups (F3,66 = 3.1, p = 0.03). At-risk youth with an antidepressant-related adverse reaction had the lowest amygdala activation, while at-risk youth without antidepressant exposure had the highest activation (p = 0.004). Conclusions: Decreased right amygdala activation in response to emotional distracters is associated with experiencing an antidepressant-related adverse reaction in at-risk youth. Further studies to determine whether amygdala activation is a useful biomarker for antidepressant-related adverse events are needed.

وصف الملف: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462021000100013&tlng=en; http://www.scielo.br/pdf/rbp/v43n1/1516-4446-rbp-1516444620190803.pdf; https://doaj.org/toc/1809-452X

URL الوصول: https://doaj.org/article/19b4e1f5205f442782987619e348bade

المؤلفون: Fabiano G. Nery, Anna R. Wilson, Marguerite R. Schneider, Jeffrey R. Strawn, Luis R. Patino, Robert K. McNamara, Caleb M. Adler, Stephen M. Strakowski, Melissa P. DelBello

المصدر: Brazilian Journal of Psychiatry, Vol 42, Iss 5, Pp 481-488 (2020)

مصطلحات موضوعية: Bipolar disorder, mood disorders, risk factors, antidepressive agents, Psychiatry, RC435-571

الوصف: Objectives: To prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder. Methods: Youth aged 9-20 years with at least one biological parent with bipolar disorder and no prior history of mood or psychotic episodes (n=93) were prospectively evaluated and treated naturalistically during the study. Participants were divided into two groups: converters, defined as those who met DSM-IV criteria for a mood episode during follow-up (n=19); or non-converters (n=74). Logistic regression models were used to investigate associations between baseline clinical variables and medication exposure during follow-up and risk of developing a first mood episode (conversion). Results: Multivariate regression analyses showed that baseline anxiety disorders and subsyndromal mood disorders were associated with increased risk of conversion during follow-up. Adding medication exposure to the multivariate model showed that exposure to antidepressants during follow-up was associated with increased risk of conversion. Conclusions: Caution should be used when treating bipolar offspring with anxiety and/or emerging depressive symptoms using antidepressant agents, given the increased risk of developing a major mood disorder.

وصف الملف: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462020000500481&tlng=en; http://www.scielo.br/pdf/rbp/v42n5/1516-4446-rbp-1516444620190802.pdf; https://doaj.org/toc/1809-452X

URL الوصول: https://doaj.org/article/c154f513396f4b2c914f750056dabe2c

المؤلفون: Duncan C. Honeycutt, Melissa P. DelBello, Jeffrey R. Strawn, Laura B. Ramsey, Luis R. Patino, Kyle Hinman, Jeffrey Welge, David J. Miklowitz, Booil Jo, Thomas J. Blom, Kaitlyn M. Bruns, Sarah K. Hamill Skoch, Nicole Starace, Maxwell J. Tallman, Manpreet K. Singh

المصدر: Journal of Personalized Medicine, Vol 12, Iss 6, p 1006 (2022)

مصطلحات موضوعية: bipolar risk, hyperarousal, depression, anxiety, adolescent, neuroimaging, Medicine

الوصف: Antidepressants are standardly used to treat moderate to severe symptoms of depression and/or anxiety in youth but may also be associated with rare but serious psychiatric adverse events such as irritability, agitation, aggression, or suicidal ideation. Adverse events are especially common in youth with a family history of bipolar disorder (BD) who are at heightened risk for dysfunction in neurobiological systems that regulate emotion and arousal. To further understand this phenomenon, this study will examine (a) baseline risk factors associated with dysfunctional arousal in a sample of youth at high-risk for BD treated with or without an antidepressant, (b) whether antidepressant-related changes in arousal are mediated by changes in prefrontal-limbic circuitry, and (c) whether pharmacogenetic factors influence antidepressant-related changes in arousal. High-risk youth (aged 12–17 years with moderate to severe depressive and/or anxiety symptoms and at least one first-degree relative with bipolar I disorder) will be randomized to receive psychotherapy plus escitalopram or psychotherapy plus placebo. Neuroimaging and behavioral measures of arousal will be collected prior to randomization and at 4 weeks. Samples for pharmacogenetic analysis (serum escitalopram concentration, CYP2C19 metabolizer phenotype, and HTR2A and SLC6A4 genotypes) will be collected at 8 weeks. Youth will be followed for up to 16 weeks to assess change in arousal measures.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2075-4426/12/6/1006; https://doaj.org/toc/2075-4426

URL الوصول: https://doaj.org/article/65c3fdc454c04a299a797d8ee926c34a

المؤلفون: Ziyu Zhu, Du Lei, Kun Qin, Xueling Suo, Wenbin Li, Lingjiang Li, Melissa P. DelBello, John A. Sweeney, Qiyong Gong

المصدر: Diagnostics, Vol 11, Iss 8, p 1416 (2021)

مصطلحات موضوعية: graph theory, posttraumatic stress disorder, deep learning, support vector machine, salience network, neuroimaging, Medicine (General), R5-920

الوصف: Previous studies using resting-state functional MRI (rs-fMRI) have revealed alterations in graphical metrics in groups of individuals with posttraumatic stress disorder (PTSD). To explore the ability of graph measures to diagnose PTSD and capture its essential features in individual patients, we used a deep learning (DL) model based on a graph-theoretic approach to discriminate PTSD from trauma-exposed non-PTSD at the individual level and to identify its most discriminant features. Our study was performed on rs-fMRI data from 91 individuals with PTSD and 126 trauma-exposed non-PTSD patients. To evaluate our DL method, we used the traditional support vector machine (SVM) classifier as a reference. Our results showed that the proposed DL model allowed single-subject discrimination of PTSD and trauma-exposed non-PTSD individuals with higher accuracy (average: 80%) than the traditional SVM (average: 57.7%). The top 10 DL features were identified within the default mode, central executive, and salience networks; the first two of these networks were also identified in the SVM classification. We also found that nodal efficiency in the left fusiform gyrus was negatively correlated with the Clinician Administered PTSD Scale score. These findings demonstrate that DL based on graphical features is a promising method for assisting in the diagnosis of PTSD.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2075-4418/11/8/1416; https://doaj.org/toc/2075-4418

URL الوصول: https://doaj.org/article/0e7f1884a2494b5cb58f293d4eec7359

المؤلفون: Daniel J. Walker, Melissa P. DelBello, John Landry, Deborah N. D’Souza, Holland C. Detke

المصدر: Child and Adolescent Psychiatry and Mental Health, Vol 11, Iss 1, Pp 1-11 (2017)

مصطلحات موضوعية: Olanzapine fluoxetine combination, Bipolar, Depression, Quality of life, Children, Adolescents, Pediatrics, RJ1-570, Psychiatry, RC435-571

الوصف: Abstract Background We examined the efficacy of olanzapine/fluoxetine combination (OFC) in improving health-related quality of life (QoL) in the treatment of bipolar depression in children and adolescents. Methods Patients aged 10–17 years with bipolar I disorder, depressed episode, baseline children’s depression rating scale-revised (CDRS-R) total score ≥40, Young Mania Rating Scale (YMRS) total score ≤15, and YMRS-item 1 ≤ 2 were randomized to OFC (6/25–12/50 mg/day olanzapine/fluoxetine; n = 170) or placebo (n = 85) for up to 8 weeks of double-blind treatment. Patients and parents completed the revised KINDL questionnaire for measuring health-related QoL in children and adolescents (KINDL-R) at baseline and endpoint. The mean change in CDRS-R total and item scores were used to compare improvement in symptomatology in patients taking OFC and placebo. Tests were 2-sided using a Type I error cutoff of 0.05, and no adjustments for multiple comparisons were made. Results Baseline QoL as measured by the KINDL-R was substantially impaired relative to published norms for a healthy school-based sample. OFC-treated patients demonstrated an improvement over placebo at endpoint with respect to mean change from baseline in the patient-rated KINDL-R Self-esteem subscale score (p = 0.028), and in the parent KINDL-R ratings of emotional well-being (p = 0.020), Self-esteem (p = 0.030), and Family (p = 0.006). At endpoint, OFC-treated patients still had a lower QoL compared to the normative population. OFC showed significant improvement (p ≤ 0.05) versus placebo on the CDRS-R total score and on 7 of the 17 CDRS-R items. Conclusions Patients aged 10–17 years with an acute episode of bipolar depression and their parents reported greater improvements (parents noticed improvements in more areas than did their offspring) on some aspects of QoL when treated with OFC compared with placebo. However, after 8 weeks of treatment, KINDL-R endpoint scores remained lower than those of the, presumably healthy, control population. Clinical trial registration information A Study for Assessing Treatment of Patients Ages 10–17 with Bipolar Depression; http://www.clinicaltrials.gov ; NCT00844857

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s13034-017-0170-7; https://doaj.org/toc/1753-2000

URL الوصول: https://doaj.org/article/5ab9520cf9d342b19cb75c8d3c9fbf15

المؤلفون: Du Lei, Kun Qin, Wenbin Li, Ziyu Zhu, Maxwell J. Tallman, L. Rodrigo Patino, David E. Fleck, Veronica Aghera, Qiyong Gong, John A. Sweeney, Melissa P. DelBello, Robert K. McNamara

المصدر: Journal of Affective Disorders. 334:238-245

مصطلحات موضوعية: Psychiatry and Mental health, Clinical Psychology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bef6eb46d190f27a244ec8abd9debeac
https://doi.org/10.1016/j.jad.2023.04.125