المؤلفون: Yada, Susumu, 1992, Lacis, Ugis, 1988, van der Wijngaart, Wouter, Lundell, Fredrik, Amberg, Gustav, Bagheri, Shervin, 1979

المصدر: Langmuir. 38(26):7956-7964

مصطلحات موضوعية: High speed cameras, Hydrophobicity, Textures, Wetting, Anti-icing, Butterfly wings, Droplets impact, Hydrophobic surfaces, Hydrophobics, Impact speed, Liquid droplets, Self cleaning, Surface textures, Technological process, Drops, animal, food, movement (physiology), plant leaf, wettability, Animals, Movement, Plant Leaves

الوصف: Textured hydrophobic surfaces that repel liquid droplets unidirectionally are found in nature such as butterfly wings and ryegrass leaves and are also essential in technological processes such as self-cleaning and anti-icing. In many occasions, surface textures are oriented to direct rebounding droplets. Surface macrostructures (>100 μm) have often been explored to induce directional rebound. However, the influence of impact speed and detailed surface geometry on rebound is vaguely understood, particularly for small microstructures. Here, we study, using a high-speed camera, droplet impact on surfaces with inclined micropillars. We observed directional rebound at high impact speeds on surfaces with dense arrays of pillars. We attribute this asymmetry to the difference in wetting behavior of the structure sidewalls, causing slower retraction of the contact line in the direction against the inclination compared to with the inclination. The experimental observations are complemented with numerical simulations to elucidate the detailed movement of the drops over the pillars. These insights improve our understanding of droplet impact on hydrophobic microstructures and may be useful for designing structured surfaces for controlling droplet mobility.

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-325697
https://doi.org/10.1021/acs.langmuir.2c00561

المؤلفون: Stoufflet, Julie, Caillé, Isabelle

المصدر: Cells, 11 (21), 3384 (2022-10-26)

مصطلحات موضوعية: neuronal migration, primary cilium, Cell Movement/physiology, Centrosome, Neurogenesis, Cilia/metabolism, Neurons/metabolism, Cell Movement, Cilia, Neurons, Biochemistry, Genetics and Molecular Biology (all), General Medicine, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire

الوصف: The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons. The extremely severe phenotypes of ciliopathies have suggested their paramount importance for multiple developmental events, including brain formation. Neuronal migration is an essential step of neural development, with all neurons traveling from their site of birth to their site of integration. Neurons perform a unique type of cellular migration called cyclic saltatory migration, where their soma periodically jumps along with the stereotyped movement of their centrosome. We will review here how the role of the PC on cell motility was first described in non-neuronal cells as a guide pointing to the direction of migration. We will see then how these findings are extended to neuronal migration. In neurons, the PC appears to regulate the rhythm of cyclic saltatory neuronal migration in multiple systems. Finally, we will review recent findings starting to elucidate how extracellular cues sensed by the PC could be intracellularly transduced to regulate the machinery of neuronal migration. The PC of migrating neurons was unexpectedly discovered to display a rhythmic extracellular emergence during each cycle of migration, with this transient exposure to the external environment associated with periodic transduction of cyclic adenosine monophosphate (cAMP) signaling at the centrosome. The PC in migrating neurons thus uniquely appears as a beat maker, regulating the tempo of cyclic saltatory migration.

Relation: https://www.mdpi.com/2073-4409/11/21/3384/pdf; urn:issn:2073-4409

URL الوصول: https://orbi.uliege.be/handle/2268/302462

المؤلفون: Liang, Elena I, Mah, Emma J, Yee, Albert F, Digman, Michelle A

المصدر: Integrative biology : quantitative biosciences from nano to macro. 9(2)

مصطلحات موضوعية: Cell Adhesion: physiology, Cell Movement: physiology, Focal Adhesions: physiology, Mechanotransduction, Cellular: physiology, Nanoparticles: chemistry, ultrastructure, Statistics as Topic, Surface Properties

الوصف: Selective cell adhesion is desirable to control cell growth and migration on biomedical implants. Mesenchymal cell migration is regulated through focal adhesions (FAs) and can be modulated by their microenvironment, including changes in surface topography. We use the Number and Molecular Brightness (N&B) imaging analysis to provide a unique perspective on FA assembly and disassembly. This imaging analysis generates a map of real-time fluctuations of protein monomers, dimers, and higher order aggregates of FA proteins, such as paxillin during assembly and disassembly. We show a dynamic view of how nanostructured surfaces (nanoline gratings or nanopillars) regulate single molecular dynamics. In particular, we report that the smallest nanopillars (100 nm spacing) gave rise to a low population of disassembling adhesion clusters of ∼2 paxillin proteins whereas the larger nanopillars (380 nm spacing) gave rise to a much larger population of larger disassembling clusters of ∼3-5 paxillin proteins. Cells were more motile on the smaller nanopillars (spaced 100-130 nm apart) compared to all other surfaces studied. Thus, physical nanotopography influences cell motility, adhesion size, and adhesion assembly and disassembly. We report for the first time, with single molecular detection, how nanotopography influences cell motility and protein reorganization in adhesions.

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/77w3t1p6

المؤلفون: Davlet’yarova, K. V., Korshunov, S. D., Krivoshchekov, S. G., Kapilevich, L. V.^{Aff1, Aff2, Aff3}

المصدر: Human Physiology. 46(5):500-512

المؤلفون: Sevastik, John

مصطلحات موضوعية: Anatomi, Muskuloskeletala systemet, Musculoskeletal System |x anatomy & histology, Movement -- physiology, Musculoskeletal Physiological Phenomena, Biomechanical Phenomena

المؤلفون: Do, An H, Wang, Po T, King, Christine E, Abiri, Ahmad, Nenadic, Zoran

المصدر: Journal of neuroengineering and rehabilitation. 8

مصطلحات موضوعية: Adult, Ankle: physiology, Brain: physiology, Electric Stimulation Therapy: instrumentation, methods, Electroencephalography: instrumentation, methods, Female, Humans, Male, Middle Aged, Movement: physiology, Paralysis: rehabilitation, User-Computer Interface, Young Adult, Adult, Ankle: physiology, Brain: physiology, Electric Stimulation Therapy: instrumentation, methods, Electroencephalography: instrumentation, methods, Female, Humans, Male, Middle Aged, Movement: physiology, Paralysis: rehabilitation, User-Computer Interface, Young Adult

الوصف: Many neurological conditions, such as stroke, spinal cord injury, and traumatic brain injury, can cause chronic gait function impairment due to foot-drop. Current physiotherapy techniques provide only a limited degree of motor function recovery in these individuals, and therefore novel therapies are needed. Brain-computer interface (BCI) is a relatively novel technology with a potential to restore, substitute, or augment lost motor behaviors in patients with neurological injuries. Here, we describe the first successful integration of a noninvasive electroencephalogram (EEG)-based BCI with a noninvasive functional electrical stimulation (FES) system that enables the direct brain control of foot dorsiflexion in able-bodied individuals.A noninvasive EEG-based BCI system was integrated with a noninvasive FES system for foot dorsiflexion. Subjects underwent computer-cued epochs of repetitive foot dorsiflexion and idling while their EEG signals were recorded and stored for offline analysis. The analysis generated a prediction model that allowed EEG data to be analyzed and classified in real time during online BCI operation. The real-time online performance of the integrated BCI-FES system was tested in a group of five able-bodied subjects who used repetitive foot dorsiflexion to elicit BCI-FES mediated dorsiflexion of the contralateral foot.Five able-bodied subjects performed 10 alternations of idling and repetitive foot dorsifiexion to trigger BCI-FES mediated dorsifiexion of the contralateral foot. The epochs of BCI-FES mediated foot dorsifiexion were highly correlated with the epochs of voluntary foot dorsifiexion (correlation coefficient ranged between 0.59 and 0.77) with latencies ranging from 1.4 sec to 3.1 sec. In addition, all subjects achieved a 100% BCI-FES response (no omissions), and one subject had a single false alarm.This study suggests that the integration of a noninvasive BCI with a lower-extremity FES system is feasible. With additional modifications, the proposed BCI-FES system may offer a novel and effective therapy in the neuro-rehabilitation of individuals with lower extremity paralysis due to neurological injuries.

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9rv114dv

المؤلفون: Lin, Zhi-Xiong, Yang, Li-Juan, Huang, Qiang, Fu, Jin

المصدر: Chinese medical journal. 123(13)

مصطلحات موضوعية: Astrocytoma: metabolism, Brain Neoplasms: metabolism, Cell Movement: physiology, Cells, Cultured, Coculture Techniques, Enzyme-Linked Immunosorbent Assay, Fibronectins: metabolism, Glioma: metabolism, Humans, Immunohistochemistry, Reverse Transcriptase Polymerase Chain Reaction, glioma, fibronectin, neoplasm invasiveness, tumor-host microecology, cell-to-cell communicationextracellular-matrix components, nervous-system, in-vivo, brain, migration, microenvironment, glioblastoma, niche, differentiation, receptors, Astrocytoma: metabolism, Brain Neoplasms: metabolism, Cell Movement: physiology, Cells, Cultured, Coculture Techniques, Enzyme-Linked Immunosorbent Assay, Fibronectins: metabolism, Glioma: metabolism, Humans, Immunohistochemistry, Reverse Transcriptase Polymerase Chain Reaction, glioma, fibronectin, neoplasm invasiveness, tumor-host microecology, cell-to-cell communicationextracellular-matrix components, nervous-system, in-vivo, brain, migration, microenvironment, glioblastoma, niche, differentiation, receptors

الوصف: Previous researches have indicated that glioma invasion may occur within a tumor-host microecology, and that fibronectin may be involved in glioma invasion as an important component of the extracellular matrix. However, how the interaction between tumor cells and vascular endothelial cells affects glioma invasion is poorly understood. The aim of this study was to investigate the effects of the interaction between tumor cells and vascular endothelial cells on glioma invasion, and the relationship of this interaction to fibronectin.The localization of fibronectin in different brain astrocytoma tissues was determined by immunohistochemistry. Then, vascular endothelial cells and glioma cells were co-cultured in a Transwell co-culturing system. Fibronectin expression was detected by reverse transcriptase-polymerase chain reaction, immunocytochemistry, and enzyme-linked immunosorbent assay. Additionally, the influence of the interaction between tumor cells and vascular endothelial cells on glioma cell invasion was determined by an in vitro rapid invasion test.In brain astrocytoma tissues, fibronectin was present on the endothelial cells, in the extracellular matrix. Fibronectin expression was greater in higher grade tumors than in lower grade tumors. The interaction of glioma cells and vascular endothelial cells in vitro induced fibronectin release from vascular endothelial cells, which in turn stimulated glioma cell migration. This effect was inhibited by fibronectin blocking antibody.Glioma cells may induce vascular epithelial cells to express fibronectin, and in turn fibronectin could promote glioma cell invasion.

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6bn9p3n4

المؤلفون: Petersson, Per

مصطلحات موضوعية: Spinal cord -- physiology, Movement -- physiology, Muscle, skeletal -- physiology, Reflex -- physiology, Memory, Learning, Computer stimulation, Feedback -- physiology, Ryggradsskador, Forskning

Degree: Diss. (sammanfattning) Lund : Univ., 2003

المؤلفون: Feldenkrais, Moshe

المساهمون: Sandin, Gunnar, Stuart, Lippe

مصطلحات موضوعية: Feldenkraismetoden, Brain Damage, Chronic -- therapy, Cerebrovascular disorders, Exercise Therapy -- methods, Movement -- physiology, Body Image, Case Reports., Rehabilitation.

المؤلفون: Piontelli, Alessandra, 1945- author.

مصطلحات موضوعية: Fetal Movement -- physiology., Fetus.