المؤلفون: Lasnon, Charline, Dugue, Audrey Emmanuelle, Briand, Mélanie, Blanc-Fournier, Cécile, Dutoit, Soizic, Louis, Marie-hélène, Aide, Nicolas

المصدر: Molecular Imaging and Biology. June 2015 17(3):403-412

المؤلفون: Aide, Nicolas, Visser, Eric P., Lheureux, Stéphanie, Heutte, Natacha, Szanda, Istvan, Hicks, Rodney J.

المصدر: European Journal of Nuclear Medicine and Molecular Imaging. September 2012 39(9):1497-1509

المؤلفون: Eric P. Visser, Istvan Szanda, Nicolas Aide, Natacha Heutte, Rodney J. Hicks, Stephanie Lheureux

المساهمون: Service de médecine nucléaire [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), University of Medical Center, Department of Medical Oncology [Toronto, Canada], Princess Margaret Hospital, University of Toronto-University of Toronto, Centre d’études des transformations des activités physiques et sportives (CETAPS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Department of Cancer Imaging [Melbourne, Australie], Centre for Molecular Imaging [Melbourne, Australie], Peter MacCallum Cancer Centre [Melbourne, Australie]-Peter MacCallum Cancer Centre [Melbourne, Australie]

المصدر: European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2012, 39 (9), pp.1497-1509. ⟨10.1007/s00259-012-2177-x⟩
European Journal of Nuclear Medicine and Molecular Imaging, 39, 1497-509
European Journal of Nuclear Medicine and Molecular Imaging, 39, 9, pp. 1497-509

مصطلحات موضوعية: Image quality, Clinical PET/CT, [SDV]Life Sciences [q-bio], Field of view, Image processing, [SDV.CAN]Life Sciences [q-bio]/Cancer, Review Article, Imaging phantom, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Positron, Translational research [ONCOL 3], Neoplasms, medicine, High throughput, Image Processing, Computer-Assisted, Animals, Humans, Radiology, Nuclear Medicine and imaging, Image resolution, Throughput (business), ComputingMilieux_MISCELLANEOUS, Motivation, Small-animal PET, medicine.diagnostic_test, Sample size, General Medicine, 3. Good health, Animal models, Positron emission tomography, Research Design, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Positron-Emission Tomography, Planar positron imaging systems, Cancer research, NEMA NU 4, Nuclear Medicine

الوصف: Item does not contain fulltext Over the last decade, small-animal PET imaging has become a vital platform technology in cancer research. With the development of molecularly targeted therapies and drug combinations requiring evaluation of different schedules, the number of animals to be imaged within a PET experiment has increased. This paper describes experimental design requirements to reach statistical significance, based on the expected change in tracer uptake in treated animals as compared to the control group, the number of groups that will be imaged, and the expected intra-animal variability for a given tracer. We also review how high-throughput studies can be performed in dedicated small-animal PET, high-resolution clinical PET systems and planar positron imaging systems by imaging more than one animal simultaneously. Customized beds designed to image more than one animal in large-bore small-animal PET scanners are described. Physics issues related to the presence of several rodents within the field of view (i.e. deterioration of spatial resolution and sensitivity as the radial and the axial offsets increase, respectively, as well as a larger effect of attenuation and the number of scatter events), which can be assessed by using the NEMA NU 4 image quality phantom, are detailed. 01 september 2012

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f147bdc6f906148ab8648626737fe3