المؤلفون: Jeffrey L. Anderson, MD, Ann Marie Navar, MD, PhD, Neeraja Balachander, MBBS, PhD, MS, Nihar R. Desai, MD, MPH, Kirk U. Knowlton, MD

المصدر: American Journal of Preventive Cardiology, Vol 15, Iss , Pp 100550- (2023)

مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701, Public aspects of medicine, RA1-1270

الوصف: Therapeutic Area: CVD Prevention – Primary and Secondary Background: Patients are at high risk for a recurrent cardiovascular (CV) event in the first year following acute coronary syndrome (ACS). Low-density lipoprotein cholesterol (LDL-C) is a modifiable risk factor for recurrent CV events. Despite the availability of lipid-lowering therapies (LLT), many patients fail to achieve guideline-recommended LDL-C

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666667723000910; https://doaj.org/toc/2666-6677

URL الوصول: https://doaj.org/article/34e58e4b80d44502a8c4683a87318e26

المؤلفون: Kamil F. Faridi, Nihar R. Desai

المصدر: American Journal of Preventive Cardiology, Vol 14, Iss , Pp 100491- (2023)

مصطلحات موضوعية: Atherosclerotic cardiovascular disease, Secondary prevention, LDL cholesterol, Diseases of the circulatory (Cardiovascular) system, RC666-701, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666667723000326; https://doaj.org/toc/2666-6677

URL الوصول: https://doaj.org/article/eb38169833724b83b8233b308bfdfa92

المؤلفون: Mohammed Essa, Joseph S. Ross, Sanket S. Dhruva, Nihar R. Desai, Robert W. Yeh, Kamil F. Faridi

المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 8 (2023)

مصطلحات موضوعية: clopidogrel, medication costs, prasugrel, ticagrelor, Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2047-9980

URL الوصول: https://doaj.org/article/60fb0200aaa643bf9d374cc13b3c95e7

المؤلفون: Ileana L. Piña, Larry A. Allen, Nihar R. Desai

المصدر: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: BPCI-advanced, Heart failure, Cost-effectiveness, Telehealth, Payment models, Value, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Background Treatment of heart failure is complex and inherently challenging. Patients traverse multiple practice settings as inpatients and outpatients, often resulting in fragmented care. The Center for Medicare and Medicaid Services is implementing payment programs that reward delivery of high-quality, cost-effective care, and one of the newer programs, the Bundled Payment for Care Improvement Advanced program, attempts to improve the coordination of care across practices for a hospitalization episode and post-acute care. The quality and cost of care contribute to its value, but value may be defined in different ways by different entities. Conclusions The rapidly changing world of digital health may contribute to or detract from the quality and cost of care. Health systems, payers, and patients are all grappling with these issues, which were reviewed at a symposium at the Heart Failure Society of America conference in Philadelphia, Pennsylvania on September 14, 2019. This article constitutes the proceedings from that symposium.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2261

URL الوصول: https://doaj.org/article/e642236230d24e379bb08cc27980eba7

المؤلفون: Avirup Guha, Cesar Caraballo, Prantesh Jain, P. Elliott Miller, Jocelyn Owusu‐Guha, Katherine A.A. Clark, Eric J. Velazquez, Tariq Ahmad, Lauren A. Baldassarre, Daniel Addison, Neal L. Weintraub, Nihar R. Desai

المصدر: ESC Heart Failure, Vol 8, Iss 4, Pp 2866-2875 (2021)

مصطلحات موضوعية: INTERMACS, Anthracycline, Continuous‐flow LVAD, Bleeding, Stroke, Mortality, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Aims Improved cancer survivorship has led to a higher number of anthracycline‐induced cardiomyopathy patients with end‐stage heart failure. We hypothesize that outcomes following continuous‐flow LVAD (CF‐LVAD) implantation in those with anthracycline‐induced cardiomyopathy are comparable with other aetiologies of cardiomyopathy. Methods and results Using the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) from 2008 to 2017, we identified patients with anthracycline‐induced cardiomyopathy who received a CF‐LVAD and compared them with those with idiopathic dilated (IDM) and ischaemic cardiomyopathies (ICM). Mortality was studied using the Cox proportional hazards model. Other adverse events were evaluated using competing risk models. Overall, 248 anthracycline‐induced cardiomyopathy patients underwent CF‐LVAD implantation, with a median survival of 48 months, an improvement compared with those before 2012 [adjusted hazards ratio (aHR): 0.53; confidence interval (CI): 0.33–0.86]. At 12 months, 85.1% of anthracycline‐induced cardiomyopathy, 86.0% of IDM, and 80.2% of ICM patients were alive (anthracycline‐induced cardiomyopathy vs. IDM: aHR: 1.12; CI: 0.88–1.43 and anthracycline‐induced cardiomyopathy vs. ICM: aHR: 0.98; CI: 0.76–1.28). Anthracycline‐induced cardiomyopathy patients had a higher major bleeding risk compared with IDM patients (aHR: 1.23; CI: 1.01–1.50), and a lower risk of stroke and prolonged respiratory support compared to ICM patients (aHR: 0.31 and 0.67 respectively; both P

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2055-5822

URL الوصول: https://doaj.org/article/7104df3c2cc7464abcfc50a3f46d9f5e

المؤلفون: Fouad Chouairi, BS, Justin Pacor, MD, P. Elliott Miller, MD, Michael A. Fuery, MD, Cesar Caraballo, MD, Sounok Sen, MD, Eric S. Leifer, PhD, G. Michael Felker, MD, MHS, Mona Fiuzat, PharmD, Christopher M. O’Connor, MD, James L. Januzzi, MD, Daniel J. Friedman, MD, Nihar R. Desai, MD, MPH, Tariq Ahmad, MD, MPH, James V. Freeman, MD, MPH, MS

المصدر: Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 2, Pp 447-455 (2021)

مصطلحات موضوعية: Medicine (General), R5-920

الوصف: Objective: To evaluate effects of atrial fibrillation (AF) on cardiac biomarkers and outcomes in a trial population of patients with heart failure (HF) with reduced ejection fraction treated with optimal guideline-directed medical therapy. Methods: We performed a secondary analysis of 894 patients in the Guiding Evidence-Based Therapy Using Biomarker-Intensified Treatment in Heart Failure (GUIDE-IT) trial (January 2013–July 2016). Patients were stratified by AF status and compared with regard to guideline-directed medical therapy use, longitudinal levels of N-terminal pro–B type natriuretic peptide (NT-proBNP), and outcomes including HF hospitalization and mortality. Results: After adjustment, AF was associated with a significant increase in the risk of HF hospitalization or cardiovascular death (hazard ratio, 1.28; 95% CI, 1.02 to 1.61; P=0.04) and HF hospitalization (hazard ratio, 1.31; 95% CI, 1.02 to 1.68; P=.03) but with no difference in mortality during a median 15 months of follow-up. There were no significant differences in medication treatment between those with and those without AF. At 90 days, a higher proportion of patients with AF (89.4% vs 81.5%; P=.002) had an NT-proBNP level above 1000 pg/mL (to convert NT-proBNP values to pmol/L, multiply by 0.1182), and AF patients had higher NT-proBNP levels at all time points through 2 years of follow-up. Conclusion: Among patients with HF with reduced ejection fraction, prevalent AF was associated with higher NT-proBNP concentrations through 2 years of follow-up and higher risk for HF hospitalization despite no substantial differences in medical therapy.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2542454821000382; https://doaj.org/toc/2542-4548

URL الوصول: https://doaj.org/article/48f75c6827664f9e8ed830056cd2819b

المؤلفون: Annika Belzer, Erin M. Yeagle, Lucille K. Kohlenberg, Muriel Solberg, Emily Gudbranson, Mariana Budge, Hannah M. Batchelor, Sarah E. Fitzpatrick, Anna Zhao, V. Diego Armengol, Samer F. Hassan, May Shum, Margaret Bia, Frank Bia, Nihar R. Desai, Peter A. Kahn

المصدر: Telemedicine Reports, Vol 2, Iss 1, Pp 56-63 (2021)

مصطلحات موضوعية: telemedicine, medical education, COVID-19, pandemic, volunteer, Computer applications to medicine. Medical informatics, R858-859.7

الوصف: Background: In response to the COVID-19 pandemic, the Yale New Haven Health System began rescheduling nonurgent outpatient appointments as virtual visits in March 2020. While Yale New Haven Health expanded its telemedicine infrastructure to accommodate this shift, many appointments were delayed and patients faced considerable uncertainty. Objective: Medical students created the Medical Student Task Force (MSTF) to help ensure continuity of care by calling patients whose appointments were delayed during this transition to telemedicine. Methods: Eighty-five student volunteers called 3765 internal medicine patients with canceled appointments, completing screening for 2197 patients. Volunteers screened for health care needs, assessed preferences for future appointments, and offered emotional support and information about COVID-19. Urgent or emergent patient concerns were triaged and escalated to providers. In this analysis, we used a mixed-methods approach: call information and provider responses were analyzed quantitatively, and patient feedback was analyzed qualitatively via thematic analysis. Results: Ninety-one percent of patients screened found the MSTF calls helpful. Twenty-one percent of patients reported health concerns, with 1% reporting urgent concerns escalated to and addressed by providers. Themes of patient comments included gratitude for outreach and social contact, utility of calls, and well-wishes for health care workers. Conclusions: By calling patients whose appointments had been canceled during a rapid transition to telemedicine, the MSTF helped bridge a potential gap in care by offering patients communication with their care teams, information, and support. We propose that this model could be used in other care systems urgently transitioning to outpatient telemedicine, whether during ongoing outbreaks of COVID-19 or other public health emergencies.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2692-4366

URL الوصول: https://doaj.org/article/8a9ebf9e79bb427b9445a9c0753fda4b

المؤلفون: Mohsin Chowdhury, MD, Bani M. Azari, MD, PhD, Nihar R. Desai, MD, MPH, Tariq Ahmad, MD, MPH

المصدر: JACC: Case Reports, Vol 2, Iss 10, Pp 1461-1465 (2020)

مصطلحات موضوعية: cardiomyopathy, DRESS, eosinophilia, myocarditis, shock, tofacitinib, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Drug rash with eosinophilia and systemic symptoms (DRESS)–associated myocarditis is a rare but life-threatening adverse drug reaction with a very high mortality rate and no effective therapies. We report a case of DRESS-associated myocarditis complicated by cardiogenic shock successfully treated with a novel targeted therapy. (Level of Difficulty: Advanced.)

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266608492030139X; https://doaj.org/toc/2666-0849

URL الوصول: https://doaj.org/article/78ec1035cdb84ee0a550737fadb32e6a

المؤلفون: Ioannis Milioglou, Avirup Guha, Fouad Chouari, Abhishek Chaturvedi, Katherine A.A. Clark, Ajar Kochar, Jonathan G. Sung, Eric J. Velazquez, Tariq Ahmad, Nihar R. Desai

المصدر: Hellenic Journal of Cardiology, Vol 65, Iss , Pp 51-52 (2022)

مصطلحات موضوعية: Myocardial infraction, Outpatient, Intervention, Epidemiology, Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1109966622000276; https://doaj.org/toc/1109-9666

URL الوصول: https://doaj.org/article/4c51072a2ffc4c5985ccaf7b5ff64ace

المؤلفون: Fouad Chouairi, Aidan Milner, Sounok Sen, Avirup Guha, James Stewart, Ania M. Jastreboff, Makoto Mori, Katherine A. Clark, P. Elliott Miller, Michael A. Fuery, Joseph G. Rogers, Andrew Notarianni, Daniel Jacoby, Christopher Maulion, Muhammad Anwer, Arnar Geirsson, Nihar R. Desai, Tariq Ahmad, Clancy W. Mullan

المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)

مصطلحات موضوعية: body mass index, heart transplantation, obesity, outcomes research, United Network for Organ Sharing, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Background Patients with obesity and advanced heart failure face unique challenges on the path to heart transplantation. There are limited data on waitlist and transplantation outcomes in this population. We aimed to evaluate the impact of obesity on heart transplantation outcomes, and to investigate the effects of the new organ procurement and transplantation network allocation system in this population. Methods and Results This cohort study of adult patients listed for heart transplant used the United Network for Organ Sharing database from January 2006 to June 2020. Patients were stratified by body mass index (BMI) (18.5–24.9, 25–29.9, 30–34.9, 35–39.9, and 40–55 kg/m2). Recipient characteristics and donor characteristics were analyzed. Outcomes analyzed included transplantation, waitlist death, and posttransplant death. BMI 18.5 to 24.9 kg/m2 was used as the reference compared with progressive BMI categories. There were 46 645 patients listed for transplantation. Patients in higher BMI categories were less likely to be transplanted. The lowest likelihood of transplantation was in the highest BMI category, 40 to 55 kg/m2 (hazard ratio [HR], 0.19 [0.05–0.76]; P=0.02). Patients within the 2 highest BMI categories had higher risk of posttransplantation death (HR, 1.29; P

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2047-9980

URL الوصول: https://doaj.org/article/897a02b68c5c44dd9614d5ffb1b8a839